CA2793526C - Naphthofuran compounds and compositions for targeting cancer stem cells - Google Patents

Naphthofuran compounds and compositions for targeting cancer stem cells Download PDF

Info

Publication number
CA2793526C
CA2793526C CA2793526A CA2793526A CA2793526C CA 2793526 C CA2793526 C CA 2793526C CA 2793526 A CA2793526 A CA 2793526A CA 2793526 A CA2793526 A CA 2793526A CA 2793526 C CA2793526 C CA 2793526C
Authority
CA
Canada
Prior art keywords
cancer
compound
polymorph
furan
degrees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2793526A
Other languages
English (en)
French (fr)
Other versions
CA2793526A1 (en
Inventor
Chiang Jia Li
David Leggett
Youzhi Li
Wei Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Oncology Inc
Original Assignee
Boston Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Biomedical Inc filed Critical Boston Biomedical Inc
Priority to CA2946899A priority Critical patent/CA2946899C/en
Priority to CA2959931A priority patent/CA2959931A1/en
Priority to CA2946890A priority patent/CA2946890A1/en
Priority to CA2959951A priority patent/CA2959951A1/en
Publication of CA2793526A1 publication Critical patent/CA2793526A1/en
Application granted granted Critical
Publication of CA2793526C publication Critical patent/CA2793526C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
CA2793526A 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells Expired - Fee Related CA2793526C (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2946899A CA2946899C (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells
CA2959931A CA2959931A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells
CA2946890A CA2946890A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells
CA2959951A CA2959951A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31589010P 2010-03-19 2010-03-19
US31588610P 2010-03-19 2010-03-19
US61/315,890 2010-03-19
US61/315,886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029281 WO2011116398A1 (en) 2010-03-19 2011-03-21 Novel compounds and compositions for targeting cancer stem cells

Related Child Applications (4)

Application Number Title Priority Date Filing Date
CA2946899A Division CA2946899C (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells
CA2959951A Division CA2959951A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells
CA2946890A Division CA2946890A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells
CA2959931A Division CA2959931A1 (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Publications (2)

Publication Number Publication Date
CA2793526A1 CA2793526A1 (en) 2011-09-22
CA2793526C true CA2793526C (en) 2018-05-01

Family

ID=47678419

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2793526A Expired - Fee Related CA2793526C (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells
CA2946899A Expired - Fee Related CA2946899C (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2946899A Expired - Fee Related CA2946899C (en) 2010-03-19 2011-03-21 Naphthofuran compounds and compositions for targeting cancer stem cells

Country Status (15)

Country Link
US (4) US9084766B2 (enExample)
EP (1) EP2547334B1 (enExample)
JP (1) JP5602935B2 (enExample)
KR (2) KR101908208B1 (enExample)
CN (3) CN103002890A (enExample)
AU (2) AU2011227022C1 (enExample)
BR (2) BR112012023661A2 (enExample)
CA (2) CA2793526C (enExample)
DK (1) DK2547334T3 (enExample)
ES (1) ES2659541T3 (enExample)
MX (2) MX370721B (enExample)
NZ (1) NZ602328A (enExample)
RU (1) RU2571661C2 (enExample)
SG (1) SG184063A1 (enExample)
WO (1) WO2011116398A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20160430T1 (hr) 2007-09-10 2016-05-20 Boston Biomedical, Inc. Nova grupa inhibitora stat3 puta i inhibitora puta matičnih stanica karcinoma
CA2793526C (en) * 2010-03-19 2018-05-01 Boston Biomedical, Inc. Naphthofuran compounds and compositions for targeting cancer stem cells
CA2959951A1 (en) * 2010-03-19 2011-09-22 Boston Biomedical, Inc. Naphthofuran compounds and compositions for targeting cancer stem cells
KR20150139955A (ko) 2013-04-09 2015-12-14 보스톤 바이오메디칼, 인크. 암 치료에 사용하기 위한 2-아세틸나프토[2,3-b]푸란-4,9-디온
EP3102036A4 (en) * 2014-02-07 2017-09-20 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-b]furane derivative or pharmaceutically acceptable salt thereof
AU2015272560B2 (en) * 2014-06-09 2019-02-14 Kyoto Pharmaceutical Industries, Ltd. Novel anticancer agent
TW201713327A (zh) 2015-04-17 2017-04-16 波士頓生醫公司 治療癌症之方法
JP2018511645A (ja) 2015-04-17 2018-04-26 ボストン バイオメディカル, インコーポレイテッド 癌を治療するための方法
BR112017026025A2 (pt) 2015-06-03 2018-08-14 Boston Biomedical Inc composições que compreendem um inibidor de stemness de câncer e um agente imunoterápico para uso no tratamento de câncer
WO2017013865A1 (ja) * 2015-07-17 2017-01-26 大日本住友製薬株式会社 2-アセチル-4H,9H-ナフト[2,3-b]フラン-4,9-ジオンの製造方法
WO2017079864A1 (en) * 2015-11-12 2017-05-18 Hangzhou Yier Biotech Co., Ltd. Treatment of cancers related to chronically active ras
WO2017132049A1 (en) 2016-01-20 2017-08-03 Boston Biomedical, Inc. Methods for treating cancer
WO2017160978A1 (en) 2016-03-15 2017-09-21 Boston Biomedical, Inc. Cell cultures and use thereof
CA3029596A1 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
WO2018183089A1 (en) 2017-03-30 2018-10-04 Boston Biomedical, Inc. Compositions for treating and/or preventing cancer
US10646464B2 (en) 2017-05-17 2020-05-12 Boston Biomedical, Inc. Methods for treating cancer
WO2020074010A1 (zh) 2018-10-12 2020-04-16 北京强新生物科技有限公司 治疗化疗难治性癌症的新联合用药方案

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1049490A1 (ru) * 1982-05-18 1983-10-23 Ордена Трудового Красного Знамени Институт Химии Ан Мсср (3 @ ,9 @ ,9 @ )-6,6,9 @ -Триметилтранспергидронафто(2,1- @ )фуран,в качестве душистого компонента парфюмерной композиции
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
AU2003275056A1 (en) * 2002-09-17 2004-04-08 Arqule, Inc. Novel lapacho compounds and methods of use thereof
US20070238770A1 (en) * 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
HRP20160430T1 (hr) 2007-09-10 2016-05-20 Boston Biomedical, Inc. Nova grupa inhibitora stat3 puta i inhibitora puta matičnih stanica karcinoma
US20100298402A1 (en) 2007-11-06 2010-11-25 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
CA2793526C (en) * 2010-03-19 2018-05-01 Boston Biomedical, Inc. Naphthofuran compounds and compositions for targeting cancer stem cells

Also Published As

Publication number Publication date
AU2011227022C1 (en) 2016-04-21
JP5602935B2 (ja) 2014-10-08
KR20160135375A (ko) 2016-11-25
AU2016200953A1 (en) 2016-03-03
MX370721B (es) 2019-12-20
AU2011227022A1 (en) 2012-09-27
US9084766B2 (en) 2015-07-21
AU2011227022B2 (en) 2015-11-19
US20130034591A1 (en) 2013-02-07
CA2946899A1 (en) 2011-09-22
DK2547334T3 (en) 2018-02-19
CN103002890A (zh) 2013-03-27
NZ602328A (en) 2014-11-28
JP2013522325A (ja) 2013-06-13
CN107721958B (zh) 2024-08-23
US20150183756A1 (en) 2015-07-02
KR101714819B1 (ko) 2017-03-09
AU2016200953B2 (en) 2017-07-27
CA2793526A1 (en) 2011-09-22
SG184063A1 (en) 2012-10-30
BR122021025776B1 (pt) 2022-12-27
CN107721958A (zh) 2018-02-23
RU2571661C2 (ru) 2015-12-20
KR20130056227A (ko) 2013-05-29
RU2012144421A (ru) 2014-04-27
ES2659541T3 (es) 2018-03-16
MX2012010434A (es) 2013-01-29
US20160271099A1 (en) 2016-09-22
CA2946899C (en) 2018-03-06
KR101908208B1 (ko) 2018-10-15
CN107375260A (zh) 2017-11-24
MX394137B (es) 2025-03-24
US9381184B2 (en) 2016-07-05
EP2547334A4 (en) 2013-08-14
US20180193303A1 (en) 2018-07-12
EP2547334B1 (en) 2017-11-15
EP2547334A1 (en) 2013-01-23
WO2011116398A1 (en) 2011-09-22
BR112012023661A2 (pt) 2020-11-24
CN107375260B (zh) 2023-10-24

Similar Documents

Publication Publication Date Title
CA2793526C (en) Naphthofuran compounds and compositions for targeting cancer stem cells
AU2011227023B2 (en) Novel methods for targeting cancer stem cells
US10543189B2 (en) 2-acetylnaphtho[2,3-b]furan -4,9-dione for use on treating cancer
DK3108750T3 (en) NEW RELATIONS AND COMPOSITIONS TARGETED FOR CANCER STAM CELLS
AU2015218436B9 (en) Novel Methods For Targeting Cancer Stem Cells
HK1179478A (en) Novel methods for targeting cancer stem cells
HK1179478B (en) Novel methods for targeting cancer stem cells
HK1179535A (en) Novel compounds and compositions for targeting cancer stem cells
HK1179535B (en) Novel compounds and compositions for targeting cancer stem cells

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150812

MKLA Lapsed

Effective date: 20220321