KR101908208B1 - 암 줄기 세포를 표적화하는 신규 화합물 및 조성물 - Google Patents

암 줄기 세포를 표적화하는 신규 화합물 및 조성물 Download PDF

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KR101908208B1
KR101908208B1 KR1020167032280A KR20167032280A KR101908208B1 KR 101908208 B1 KR101908208 B1 KR 101908208B1 KR 1020167032280 A KR1020167032280 A KR 1020167032280A KR 20167032280 A KR20167032280 A KR 20167032280A KR 101908208 B1 KR101908208 B1 KR 101908208B1
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polymorph
cancer
furan
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KR20160135375A (ko
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치앙 지아 리
데이비드 리겟트
유쯔이 리
웨이 리
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보스톤 바이오메디칼, 인크.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
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    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

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  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
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  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
KR1020167032280A 2010-03-19 2011-03-21 암 줄기 세포를 표적화하는 신규 화합물 및 조성물 Active KR101908208B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31589010P 2010-03-19 2010-03-19
US31588610P 2010-03-19 2010-03-19
US61/315,886 2010-03-19
US61/315,890 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325,814 2010-04-19
PCT/US2011/029281 WO2011116398A1 (en) 2010-03-19 2011-03-21 Novel compounds and compositions for targeting cancer stem cells

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KR1020127027267A Division KR101714819B1 (ko) 2010-03-19 2011-03-21 암 줄기 세포를 표적화하는 신규 화합물 및 조성물

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KR20160135375A KR20160135375A (ko) 2016-11-25
KR101908208B1 true KR101908208B1 (ko) 2018-10-15

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KR1020127027267A Active KR101714819B1 (ko) 2010-03-19 2011-03-21 암 줄기 세포를 표적화하는 신규 화합물 및 조성물
KR1020167032280A Active KR101908208B1 (ko) 2010-03-19 2011-03-21 암 줄기 세포를 표적화하는 신규 화합물 및 조성물

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US (4) US9084766B2 (enExample)
EP (1) EP2547334B1 (enExample)
JP (1) JP5602935B2 (enExample)
KR (2) KR101714819B1 (enExample)
CN (3) CN107721958B (enExample)
AU (2) AU2011227022C1 (enExample)
BR (2) BR122021025776B1 (enExample)
CA (2) CA2793526C (enExample)
DK (1) DK2547334T3 (enExample)
ES (1) ES2659541T3 (enExample)
MX (2) MX394137B (enExample)
NZ (1) NZ602328A (enExample)
RU (1) RU2571661C2 (enExample)
SG (1) SG184063A1 (enExample)
WO (1) WO2011116398A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20160949T1 (hr) 2007-09-10 2016-10-07 Boston Biomedical, Inc. Novi sastavi i metode za liječenje karcinoma
DK3108750T3 (en) * 2010-03-19 2018-10-22 1Globe Biomedical Co Ltd NEW RELATIONS AND COMPOSITIONS TARGETED FOR CANCER STAM CELLS
KR101714819B1 (ko) * 2010-03-19 2017-03-09 보스톤 바이오메디칼, 인크. 암 줄기 세포를 표적화하는 신규 화합물 및 조성물
WO2014169078A2 (en) 2013-04-09 2014-10-16 Boston Biomedical, Inc. Methods for treating cancer
EP3102036A4 (en) 2014-02-07 2017-09-20 Boston Biomedical, Inc. 3-substituted carbonyl-naphtho[2,3-b]furane derivative or pharmaceutically acceptable salt thereof
ES2792851T3 (es) 2014-06-09 2020-11-12 Kyoto Pharma Ind Derivados de naftofurano para uso como agentes antineoplásicos
HK1250942A1 (zh) 2015-04-17 2019-01-18 Boston Biomedical, Inc. 用於治疗癌症的方法
JP2018511643A (ja) 2015-04-17 2018-04-26 ボストン バイオメディカル, インコーポレイテッド 癌を治療するための方法
CN107847481A (zh) 2015-06-03 2018-03-27 波士顿生物医药有限公司 包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂
WO2017013865A1 (ja) * 2015-07-17 2017-01-26 大日本住友製薬株式会社 2-アセチル-4H,9H-ナフト[2,3-b]フラン-4,9-ジオンの製造方法
WO2017079864A1 (en) * 2015-11-12 2017-05-18 Hangzhou Yier Biotech Co., Ltd. Treatment of cancers related to chronically active ras
CA3011800A1 (en) 2016-01-20 2017-08-03 Boston Biomedical, Inc. Methods for treating cancer
WO2017160978A1 (en) 2016-03-15 2017-09-21 Boston Biomedical, Inc. Cell cultures and use thereof
WO2018005444A2 (en) 2016-06-28 2018-01-04 Boston Biomedical, Inc. Methods for treating cancer
WO2018098352A2 (en) 2016-11-22 2018-05-31 Jun Oishi Targeting kras induced immune checkpoint expression
CA3045306A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
WO2018183089A1 (en) 2017-03-30 2018-10-04 Boston Biomedical, Inc. Compositions for treating and/or preventing cancer
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル, インコーポレイテッド がんを処置するための方法
CN113164438B (zh) 2018-10-12 2025-03-18 北京强新生物科技有限公司 治疗化疗难治性癌症的新联合用药方案

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036099A1 (en) 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1049490A1 (ru) * 1982-05-18 1983-10-23 Ордена Трудового Красного Знамени Институт Химии Ан Мсср (3 @ ,9 @ ,9 @ )-6,6,9 @ -Триметилтранспергидронафто(2,1- @ )фуран,в качестве душистого компонента парфюмерной композиции
JPH1121284A (ja) 1997-06-30 1999-01-26 Kotobuki:Kk フラノナフトキノン誘導体及びこれを含有する医薬
WO2004026253A2 (en) * 2002-09-17 2004-04-01 Arqule, Inc. Novel lapacho compounds and methods of use thereof
US20070238770A1 (en) * 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
WO2009060282A2 (en) 2007-11-06 2009-05-14 Orchid Research Laboratories Limited Stilbene derivatives as pstat3/il-6 inhibitors
KR101714819B1 (ko) * 2010-03-19 2017-03-09 보스톤 바이오메디칼, 인크. 암 줄기 세포를 표적화하는 신규 화합물 및 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009036099A1 (en) 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

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CA2946899A1 (en) 2011-09-22
EP2547334A4 (en) 2013-08-14
AU2016200953A1 (en) 2016-03-03
CA2946899C (en) 2018-03-06
BR122021025776B1 (pt) 2022-12-27
RU2012144421A (ru) 2014-04-27
MX2012010434A (es) 2013-01-29
MX394137B (es) 2025-03-24
JP5602935B2 (ja) 2014-10-08
AU2011227022C1 (en) 2016-04-21
CN107375260A (zh) 2017-11-24
US20150183756A1 (en) 2015-07-02
CN103002890A (zh) 2013-03-27
EP2547334B1 (en) 2017-11-15
ES2659541T3 (es) 2018-03-16
US20160271099A1 (en) 2016-09-22
AU2011227022B2 (en) 2015-11-19
AU2011227022A1 (en) 2012-09-27
MX370721B (es) 2019-12-20
NZ602328A (en) 2014-11-28
RU2571661C2 (ru) 2015-12-20
CN107375260B (zh) 2023-10-24
CN107721958B (zh) 2024-08-23
CA2793526A1 (en) 2011-09-22
SG184063A1 (en) 2012-10-30
WO2011116398A1 (en) 2011-09-22
US9084766B2 (en) 2015-07-21
AU2016200953B2 (en) 2017-07-27
BR112012023661A2 (pt) 2020-11-24
KR101714819B1 (ko) 2017-03-09
KR20160135375A (ko) 2016-11-25
JP2013522325A (ja) 2013-06-13
EP2547334A1 (en) 2013-01-23
US9381184B2 (en) 2016-07-05
US20180193303A1 (en) 2018-07-12
CA2793526C (en) 2018-05-01
KR20130056227A (ko) 2013-05-29
CN107721958A (zh) 2018-02-23
US20130034591A1 (en) 2013-02-07
DK2547334T3 (en) 2018-02-19

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