CN107362342A - A kind of combination medicament and preparation method for treating pelvic congestion syndrome - Google Patents

A kind of combination medicament and preparation method for treating pelvic congestion syndrome Download PDF

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Publication number
CN107362342A
CN107362342A CN201710619292.0A CN201710619292A CN107362342A CN 107362342 A CN107362342 A CN 107362342A CN 201710619292 A CN201710619292 A CN 201710619292A CN 107362342 A CN107362342 A CN 107362342A
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parts
powder
radix
root
combination medicament
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赵海霞
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The invention discloses a kind of combination medicament and preparation method for treating pelvic congestion syndrome, belong to traditional Chinese medicine field.The Chinese medicine material that the combination medicament includes has cassia twig, Poria cocos, moutan bark, the root of herbaceous peony, peach kernel, safflower, Radix Angelicae Sinensis, radix rehmanniae recen, Ligusticum wallichii, the radix paeoniae rubrathe, Fructus Aurantii, radix bupleuri, the root of bidentate achyranthes, saltcake, rhubarb,torrefied, balloonflower root, radix glycyrrhizae, Radix Aconiti, frankincense, myrrh, cloves, schizonepeta, windproof, 8 12 parts of geranium wilfordii, 8 12 parts of cortex periplocae, centella, the rhizome of davallia, the root of Dahurain angelica, Kaempferia galanga, rhizoma zingiberis.The present invention employed when treating pelvic congestion syndrome based on externally dressing, the combination medicament mode supplemented by powder and emplastrum, three doses be applied in combination after influence each other, it is complementary to one another, it is common to play overall superposition therapeutic action, make curative effect more lasting, drug effect is stronger, inside and outside to develop simultaneously, and treats both principal and secondary aspect of disease.

Description

A kind of combination medicament and preparation method for treating pelvic congestion syndrome
Technical field
The invention belongs to traditional Chinese medicine field, and in particular to a kind of combination medicament for treating pelvic congestion syndrome and preparation Method.
Background technology
Pelvic congestion syndrome is a series of syndromes caused by a kind of chronic pelvic venous congestion, also known as pelvic veins Varicose disease.Early marriage is more common in, early childbirth, fecund, retroversion is bent, habitual constipation and long campaigns standing work or sedentary Women, tubal ligation is postoperative, long-term depressed, prolonged illness, insomniac.With lower abdominal pain, waist and sacrum pain, congestive pain It is primary symptom through, premenstrual breast pain, dyspareunia, extremely tired sense menorrhalgia, leucorrhea increasing etc..Abdomen examination has tenderness, Position is more to have deep tenderness in pubic symphysis area, or in lower abdomen both sides, typically not significantly, particularly apparent even without one Tender point, some patients, which are felt in breast, scleroma, is touched a tender spot more with different degrees of, but checks that simply diffusivity swells below nipple Big breast tissue.
Although without the corresponding name of disease of pelvic congestion syndrome in traditional medicine.But at " under stomachache, dysmenorrhoea, melancholia, band " Can be found in relevant chapters and sections Deng disease similar basin become silted up card be dispersed in record with《Synopsis Golden Chamber the miscellaneous internal diseases in woman arteries and veins is demonstrate,proved and controlled》Institute's cloud " abdominal pain of woman " " sick in married woman's abdomen "《Key to Diagnosis and Treatment married woman's door》It is described " to come through thing and suffer from abdominal pain, do not carry out abdomen also pain, all blood is not Adjust therefore.”《Practical Gynecology of Chinese Medicine》It is proposed：The etiology and pathogenesis of pelvic congestion syndrome is mainly congestion blood block, and train of thought is obstructed Caused, its pathogenic factor or because of deficiency of the spleen causing weakness of QI, blood fortune is powerless；Or because stagnation of QI due to depression of the liver, blood transport not smooth, congestion blood block；Or because of impression Heat symptoms caused by an exopathgen, invade in wet poison, stay and pour down Jiao, blood fortune is held back, congestion blood block and fall ill.
The content of the invention
The technical problems to be solved by the invention are to be directed to prior art Shortcomings, there is provided it is comprehensive that one kind treats pelvic congestion The combination medicament and preparation method of simulator sickness.
In order to achieve the above object, the present invention uses following technical scheme.
A kind of combination medicament for treating pelvic congestion syndrome, include the raw material of following parts by weight：Cassia twig 5-15 parts, Poria cocos 5-15 parts, moutan bark 5-15 parts, root of herbaceous peony 5-15 parts, peach kernel 15-35 parts, safflower 8-12 parts, Radix Angelicae Sinensis 8-12 parts, radix rehmanniae recen 8-12 Part, Ligusticum wallichii 8-12 parts, radix paeoniae rubrathe 8-12 parts, Fructus Aurantii 8-12 parts, radix bupleuri 8-12 parts, root of bidentate achyranthes 8-12 parts, saltcake 8-12 parts, rhubarb,torrefied 5- 7 parts, balloonflower root 5-7 parts, radix glycyrrhizae 4-6 parts, Radix Aconiti 4-6 parts, frankincense 4-6 parts, myrrh 4-6 parts, cloves 4-6 parts, schizonepeta 8-12 parts, Windproof 8-12 parts, geranium wilfordii 8-12 parts, cortex periplocae 8-12 parts, centella 8-12 parts, rhizome of davallia 8-12 parts, root of Dahurain angelica 12-20 parts, mountain A kind of apple 12-20 parts, rhizoma zingiberis 12-20 parts.
Preferably, the combination medicament of described treatment pelvic congestion syndrome, include the raw material of following parts by weight：Cassia twig 10 parts, 10 parts of Poria cocos, 10 parts of moutan bark, 10 parts of the root of herbaceous peony, 25 parts of peach kernel, 10 parts of safflower, 10 parts of Radix Angelicae Sinensis, 10 parts of radix rehmanniae recen, Ligusticum wallichii 10 parts, 10 parts of the radix paeoniae rubrathe, 10 parts of Fructus Aurantii, 10 parts of radix bupleuri, 10 parts of the root of bidentate achyranthes, 10 parts of saltcake, 6 parts of rhubarb,torrefied, 6 parts of balloonflower root, 5 parts of radix glycyrrhizae, 5 parts of Radix Aconiti, 5 parts of frankincense, 5 parts of myrrh, 5 parts of cloves, 10 parts of schizonepeta, windproof 10 parts, 10 parts of geranium wilfordii, 10 parts of cortex periplocae, product 10 parts of snow grass, 10 parts of the rhizome of davallia, 15 parts of the root of Dahurain angelica, 15 parts of Kaempferia galanga, 15 parts of rhizoma zingiberis.
The pharmacological property for each herbal medicine that the present invention uses is as follows：
Cassia twig：It is acrid flavour, sweet, it is warm-natured；Return lung, the heart, bladder warp；There are inducing sweat and dispelling exogenous evils, eliminating cold to stop pain, activating YANG and prormoting functioning of QI effect；With In anemofrigid cold, all pains of congealing cold with blood stasis, phlegm and retained fluid, blood stagnation syndrome and palpitaition.
Poria cocos：It is sweet, light, it is mild-natured；The thoughts of returning home, lung, spleen, kidney channel；There are clearing damp and promoting diuresis, invigorating the spleen, calming heart effect；Urinated for oedema Less, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried and insomnia of palpitating with fear.
Moutan bark：Bitter, pungent, cold nature；The thoughts of returning home, liver and kidney channel；There are clearing heat and cooling blood, blood circulation invigorating efficacies；Joined the army for heat Blood, febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, the pain of injury caused by falling and tumbling and carbuncle sore tumefacting virus.
The root of herbaceous peony：Bitter, acid, cold nature；Return liver, the spleen channel；There are nourishing blood for regulating menstruation, astringing YIN to stop sweating, the analgesic of soft liver, suppressing liver-YANG work( Effect；For blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, four limbs contraction pain and dizziness of having a headache.
Peach kernel：It is bitter, sweet, it is mild-natured；The thoughts of returning home, liver, large intestine channel；There is promoting blood circulation, relax bowel, cough and asthma relieving efficacy；With In closed dysmenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle acute appendicitis, injury from falling down, dry constipation of intestines and cough and asthma.
Safflower：Acrid flavour, it is warm-natured；The thoughts of returning home, Liver Channel；There are invigorate blood circulation, blood stasis removing analgesic effect；For Amenorrhea, dysmenorrhoea, lochia not Row, abdominal mass lump in the abdomen, chest impediment and cardialgia, stasis of blood, chest side of body shouting pain, injury from falling down and sore swell and ache curative.
Radix Angelicae Sinensis：It is sweet, pungent, it is warm-natured；Return liver, the heart, the spleen channel；There are replenishing and activating blood, menstruction regulating and pain relieving, effect of relaxing bowel；For Blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sores and intestinal dryness Constipation.
Radix rehmanniae recen：It is sweet, bitter, it is cool in nature；The thoughts of returning home, liver and kidney channel；There are clearing heat and promoting fluid enriching yin, blood-nourishing effect；Sent out for the deficiency of Yin Heat, quench one's thirst, spit blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia, irregular menstruation, fetal irritability and impairment of yin constipation.
Ligusticum wallichii：Acrid flavour, it is warm-natured；Return liver, courage, the heart channel of Hang-Shaoyin；There are blood-activating and qi-promoting, wind-expelling pain-stopping effect；For irregular menstruation, pain Through, Amenorrhea, difficult labour, placenta retension, lochia stomachache, lump, heart pain in chest and hypochondrium, traumatic injury swelling and pain, dizziness of having a headache mesh it is dark, Wind-cold-dampness arthralgia, extremity numbness and ulcer sores.
The radix paeoniae rubrathe：Bitter, cold nature；Return liver warp；There are clearing heat and cooling blood, blood stasis removing analgesic effect；Sent out for thermal man's ying blood, epidemic heat syndrome Spot, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea, addiction lump in the abdomen stomachache, injury from falling down and carbuncle swells sore.
Fructus Aurantii：Bitter, pungent, sour, cold nature；Returns spleen, stomach；There are regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling effect of row；For chest side of body gas Stagnant, turgor pain, accumulation of food in the stomach and intes tine due to indigestion, stop in phlegm and retained fluid and visceral organ ptosis.
Radix bupleuri：Acrid flavour, hardship, cold nature；Return liver, courage, lung channel；Have with inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, bring down a fever cut Malaria effect；For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, the prolapse of uterus and prolapse of the anus.
The root of bidentate achyranthes：It is bitter, sweet, sour, it is mild-natured；Return liver and kidney channel；There are dispelling stasis of blood and stimulating the menstrual flow, filling liver kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia, draw blood Descending effect；For Amenorrhea, dysmenorrhoea, soreness of waist and knee joint, muscles and bones be powerless, stranguria, oedema, headache, dizziness, toothache, day sore, spit blood and Bleeding from five sense organs or subcutaneous tissue.
Saltcake：Taste is salty, bitter, cold in nature；Return stomach, large intestine channel；There are relieving constipation by purgation, moistening for dryness and softening hard mass, detumescence effect of relieving inflammation or internal heat；For reality Heat is stagnant, the full distending pain of abdomen, dry feces, acute appendicitis swell and ache, and controls acute mastitis, hemorrhoid gall outside.
Rheum officinale：Bitter, it is cold in nature；Returns spleen, stomach, large intestine, liver, pericardium channel；There are the logical intestines that purge heat, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow work( Effect；For real heat constipation, stagnate not well stomachache, rush down dysentery, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells malignant boil Sore, blood stasis closed, traumatic injury, scald；Prepared RADIX ET RHIZOMA RHEI, which rushes down, exerts oneself to delay, purging intense heat and detonicating.
Balloonflower root：It is bitter, pungent, it is mild-natured；Return lung passes through；There are facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis；For coughing with a lot of sputum, it is uncomfortable in chest it is not smooth, Pharyngalgia sound is mute and lung carbuncle pyemesis.
Radix glycyrrhizae：It is sweet, it is mild-natured；The thoughts of returning home, lung, spleen, stomach；Invigorate the spleen and benefit qi, be clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, Coordinating the drug actions of a prescription effect；For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle swells sore Poison, alleviate drug toxicity, be strong.
Radix Aconiti：Acrid flavour, hardship, property heat；It is very toxic.The thoughts of returning home, liver,kidney,spleen warp；There are dispelling wind and eliminating dampness, antalgic effect；With Have a pain in wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia.
Frankincense：Acrid flavour, hardship, it is warm-natured；The thoughts of returning home, liver, the spleen channel；There are blood-activating and qi-promoting analgesic, detumescence and promoting granulation effect；For the obstruction of qi in the chest heart Bitterly, gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis, abdominal mass stomachache, arthralgia pain due to rheumatism, muscle arteries and veins contraction, traumatic injury and carbuncle swells sore.
Myrrh：Acrid flavour, hardship, it is mild-natured；The thoughts of returning home, liver, the spleen channel；There are scattered stasis pain, detumescence and promoting granulation effect；For chest impediment and cardialgia, The treatment of the illnesss such as gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis, Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore.
Cloves：Acrid flavour, it is warm-natured；Returns spleen, stomach, lung, kidney channel；There is middle benefit gas to drop inverse, effect of tonifying the kidney and support yang；For deficiency-cold in spleen and stomach, Hiccup vomiting, deficiency of food are vomited and diarrhoea, trusted subordinate's crymodynia mixes impotence due to deficiency of the kidney.
Schizonepeta：Acrid flavour, slightly warm in nature；Return lung, Liver Channel；Have that inducing diaphoresis dissipates wind, promoting eruption, disappear sore；For catching a cold, headache, measles, wind Rash, sore from the beginning of.
It is windproof：Acrid flavour, sweet, slightly warm in nature；Return bladder, lung, spleen, Liver Channel；Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion and only convulsion effect； For diseases caused by external factors exterior syndrome, rubella itch, arthralgia pain due to rheumatism, lockjaw just, the insufficiency of the spleen with overabundance of dampness.
Geranium wilfordii：Bitter, micro-pungent, it is mild-natured；Return liver, large intestine channel；There are dispelling wind and removing obstruction in the meridians, activating blood and clearing heat dampness removing effect；For wind Arthritis with fixed pain caused by dampness pain, numbness, muscles and bones are miserable, traumatic injury, diarrhea, dysentery and sore.
Cortex periplocae：Acrid flavour, hardship, it is warm-natured；Return liver, kidney, the heart channel of Hang-Shaoyin；There are inducing diuresis for removing edema, wind-damp dispelling, strengthening the bones and muscles effect；For controlling Treat edema of lower extremity, palpitation, wind-cold-dampness arthralgia, soreness and weakness of waist and knees.
Centella：It is bitter, pungent, it is cold in nature；Return liver, spleen, kidney channel；There are clearing heat and promoting diuresis, removing toxicity for detumescence effect；For damp and hot Huang Subcutaneous ulcer, heatstroke diarrhoea, urolithiasis blood strangury, carbuncle sore tumefacting virus and injury from falling down.
The rhizome of davallia：Bitter, it is warm-natured；Return liver and kidney channel；There are kidney tonifying, promoting blood circulation, hemostasia effect；Control kidney deficiency chronic diarrhea and pain in the back, rheumatism Numbness pain, dentalgia, tinnitus, the bruise sudden strain of a muscle, bone fracture, appendicitis, alopecia areata and corn.
The root of Dahurain angelica：Acrid flavour, it is warm-natured；Return lung, spleen, stomach；There are relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness stops band, detumescence Apocenosis and dispelling wind and arresting itching effect；For anemofrigid cold, headache, toothache, arthralgia pain due to rheumatism, nasosinusitis, with lower card and sore and toxic.
Kaempferia galanga：Acrid flavour, it is warm-natured；Return stomach；There is promoting the circulation of qi middle benefit gas, help digestion, analgesic efficacy；For fullness in chest, coldness and pain in the epigastrium Do not disappear with diet.
Rhizoma zingiberis：Acrid flavour, property heat；Returns spleen, stomach, kidney, the heart, lung channel；There are warming spleen and stomach for dispelling cold, Back to Yang Tongmai, Wenfei of drink effect；With Breathed with cough in coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb and cold drink.
The preparation method of the combination medicament of the treatment pelvic congestion syndrome, comprises the following steps：
First by formula weigh cassia twig, Poria cocos, moutan bark, the root of herbaceous peony, peach kernel, safflower, Radix Angelicae Sinensis, radix rehmanniae recen, Ligusticum wallichii, the radix paeoniae rubrathe, Fructus Aurantii, radix bupleuri, the root of bidentate achyranthes, saltcake, rhubarb,torrefied, balloonflower root, radix glycyrrhizae, Radix Aconiti, frankincense, myrrh, cloves, schizonepeta, windproof, geranium wilfordii, Cortex periplocae, centella, the rhizome of davallia, the root of Dahurain angelica, Kaempferia galanga, rhizoma zingiberis, it is crushed to 150 mesh respectively after solar exposure；Then by peach kernel powder By 2:3 weight ratio is divided into two parts, wherein few a peach kernel powder and the cassia twig powder of equivalent, Poria cocos powder, moutan bark powder, herbaceous peony powder Powder directly for oral administration is made after mixing, loaded on closed preservation in brown bottle；
By another peach kernel powder and safflower powder, angelica powder, dried rhizome of rehmannia bloom, Rhizoma Chuanxiong power, radix paeoniae rubrathe powder, Fructus Aurantii powder, radix bupleuri powder, The externally dressing of pasty state is tuned into after root of bidentate achyranthes powder, mirabilite powder, rhubarb,torrefied powder, balloonflower powder and licorice powder mixing with warm yellow rice wine, loaded on palm fibre Closed preservation in color bottle；
By Radix Aconiti powder, frankincense powder, do not have medicinal powder, Ground Cloves, schizonepeta powder, windproof powder, geranium wilfordii powder, cortex periplocae powder, product The ethanol that snow grass meal, Drynaria rhizome powder, angelica dahurica powder and Kaempferia galanga powder measure 70% with 8 times respectively is heated to 65 DEG C of refluxing extractions 3 times, every time 1.5h is extracted, filtering, merging filtrate, the thick paste of relative density 1.20 is concentrated into 65 DEG C, each thick paste is mixed, obtained mixing is thick Cream presses 2 with natural rubber, beeswax:6:1 weight ratio mixes under 75 DEG C of water-baths, adds ginger powder, stirs, made after tabletting Into emplastrum.
The combination medicament of the treatment pelvic congestion syndrome is in use, first by above-mentioned steps, (1) manufactured powder is opened with temperature Mixing in water for oral taking, three times a day, then (2) manufactured externally dressing is coated on Guanyuan point by above-mentioned steps, then that above-mentioned steps are (3) manufactured Emplastrum is covered on the externally dressing of coating.
The advantageous effects of the present invention：The present invention is employed when treating pelvic congestion syndrome based on externally dressing, is dissipated Combination medicament mode supplemented by agent and emplastrum；There is promoting blood circulationization with external traditional Chinese medicinal application made of the taste Chinese medicine of peach kernel, safflower etc. 13 It the stasis of blood, clearing heat and cooling blood, liver-smoothing, qi-regulating and effect of removing obstruction in channels to relieve pain, can effectively alleviate pelvic congestion state, strengthen local organization blood Circulation and oxygen supply, improve Abwehrkraft des Koepers to reach therapeutic effect, wherein, peach kernel, safflower, the root of bidentate achyranthes, Fructus Aurantii have significantly emerging Put forth energy the effect in uterus, Radix Angelicae Sinensis is in bidirectional modulation to uterus, and radix rehmanniae recen can accelerate the propagation of myeloid element, differentiation, promote red Cell, hemoglobin reparation, Ligusticum wallichii can strengthen uterine contraction, radix paeoniae rubrathe clearing heat and cooling blood, promoting blood circulation and removing blood stasis；The traditional Chinese medicine of the five flavours such as cassia twig Emplastrum made of the taste Chinese medicine of manufactured powder and Radix Aconiti etc. 13 inside and outside can aid in externally dressing to play drug effect, three doses of combinations Influence each other, be complementary to one another after use, it is common to play overall superposition therapeutic action, make curative effect more lasting, drug effect is stronger, inside and outside Develop simultaneously, treat both principal and secondary aspect of disease.
Embodiment
With reference to embodiment further make detailed elaboration to technical scheme, but the not all present invention in pairs Scope limits.
Embodiment 1
A kind of combination medicament for treating pelvic congestion syndrome, include the raw material of following parts by weight：5 parts of cassia twig, Poria cocos 5 Part, 5 parts of moutan bark, 5 parts of the root of herbaceous peony, 15 parts of peach kernel, 8 parts of safflower, 8 parts of Radix Angelicae Sinensis, 8 parts of radix rehmanniae recen, 8 parts of Ligusticum wallichii, 8 parts of the radix paeoniae rubrathe, Fructus Aurantii 8 Part, 8 parts of radix bupleuri, 8 parts of the root of bidentate achyranthes, 8 parts of saltcake, 5 parts of rhubarb,torrefied, 5 parts of balloonflower root, 4 parts of radix glycyrrhizae, 4 parts of Radix Aconiti, 4 parts of frankincense, myrrh 4 Part, 4 parts of cloves, 8 parts of schizonepeta, windproof 8 parts, 8 parts of geranium wilfordii, 8 parts of cortex periplocae, 8 parts of centella, 8 parts of the rhizome of davallia, 12 parts of the root of Dahurain angelica, 12 parts of Kaempferia galanga, 12 parts of rhizoma zingiberis.
The preparation method of the combination medicament of the treatment pelvic congestion syndrome, comprises the following steps：
First by formula weigh cassia twig, Poria cocos, moutan bark, the root of herbaceous peony, peach kernel, safflower, Radix Angelicae Sinensis, radix rehmanniae recen, Ligusticum wallichii, the radix paeoniae rubrathe, Fructus Aurantii, radix bupleuri, the root of bidentate achyranthes, saltcake, rhubarb,torrefied, balloonflower root, radix glycyrrhizae, Radix Aconiti, frankincense, myrrh, cloves, schizonepeta, windproof, geranium wilfordii, Cortex periplocae, centella, the rhizome of davallia, the root of Dahurain angelica, Kaempferia galanga, rhizoma zingiberis, it is crushed to 150 mesh respectively after solar exposure；Then by peach kernel powder By 2:3 weight ratio is divided into two parts, wherein few a peach kernel powder and the cassia twig powder of equivalent, Poria cocos powder, moutan bark powder, herbaceous peony powder Powder directly for oral administration is made after mixing, loaded on closed preservation in brown bottle；
By another peach kernel powder and safflower powder, angelica powder, dried rhizome of rehmannia bloom, Rhizoma Chuanxiong power, radix paeoniae rubrathe powder, Fructus Aurantii powder, radix bupleuri powder, The externally dressing of pasty state is tuned into after root of bidentate achyranthes powder, mirabilite powder, rhubarb,torrefied powder, balloonflower powder and licorice powder mixing with warm yellow rice wine, loaded on palm fibre Closed preservation in color bottle；
By another peach kernel powder and safflower powder, angelica powder, dried rhizome of rehmannia bloom, Rhizoma Chuanxiong power, radix paeoniae rubrathe powder, Fructus Aurantii powder, radix bupleuri powder, The externally dressing of pasty state is tuned into after root of bidentate achyranthes powder, mirabilite powder, rhubarb,torrefied powder, balloonflower powder and licorice powder mixing with warm yellow rice wine；
By Radix Aconiti powder, frankincense powder, do not have medicinal powder, Ground Cloves, schizonepeta powder, windproof powder, geranium wilfordii powder, cortex periplocae powder, product The ethanol that snow grass meal, Drynaria rhizome powder, angelica dahurica powder and Kaempferia galanga powder measure 70% with 8 times respectively is heated to 65 DEG C of refluxing extractions 3 times, every time 1.5h is extracted, filtering, merging filtrate, the thick paste of relative density 1.20 is concentrated into 65 DEG C, each thick paste is mixed, obtained mixing is thick Cream presses 2 with natural rubber, beeswax:6:1 weight ratio mixes under 75 DEG C of water-baths, adds ginger powder, stirs, made after tabletting Into emplastrum.
Embodiment 2
A kind of combination medicament for treating pelvic congestion syndrome, include the raw material of following parts by weight：15 parts of cassia twig, Poria cocos 15 Part, 15 parts of moutan bark, 15 parts of the root of herbaceous peony, 35 parts of peach kernel, 12 parts of safflower, 12 parts of Radix Angelicae Sinensis, 12 parts of radix rehmanniae recen, 12 parts of Ligusticum wallichii, the radix paeoniae rubrathe 12 Part, 12 parts of Fructus Aurantii, 12 parts of radix bupleuri, 12 parts of the root of bidentate achyranthes, 12 parts of saltcake, 7 parts of rhubarb,torrefied, 7 parts of balloonflower root, 6 parts of radix glycyrrhizae, 6 parts of Radix Aconiti, breast Fragrant 6 parts, myrrh 4-6 parts, 6 parts of cloves, 12 parts of schizonepeta, windproof 12 parts, 12 parts of geranium wilfordii, 12 parts of cortex periplocae, 12 parts of centella, bone Broken 12 parts of benefit, 20 parts of the root of Dahurain angelica, 20 parts of Kaempferia galanga, 20 parts of rhizoma zingiberis.
The preparation method of the combination medicament of the treatment pelvic congestion syndrome is the same as embodiment 1.
Embodiment 3
A kind of combination medicament for treating pelvic congestion syndrome, include the raw material of following parts by weight：10 parts of cassia twig, Poria cocos 10 Part, 10 parts of moutan bark, 10 parts of the root of herbaceous peony, 25 parts of peach kernel, 10 parts of safflower, 10 parts of Radix Angelicae Sinensis, 10 parts of radix rehmanniae recen, 10 parts of Ligusticum wallichii, the radix paeoniae rubrathe 10 Part, 10 parts of Fructus Aurantii, 10 parts of radix bupleuri, 10 parts of the root of bidentate achyranthes, 10 parts of saltcake, 6 parts of rhubarb,torrefied, 6 parts of balloonflower root, 5 parts of radix glycyrrhizae, 5 parts of Radix Aconiti, breast Fragrant 5 parts, 5 parts of myrrh, 5 parts of cloves, 10 parts of schizonepeta, windproof 10 parts, 10 parts of geranium wilfordii, 10 parts of cortex periplocae, 10 parts of centella, bone are broken 10 parts of benefit, 15 parts of the root of Dahurain angelica, 15 parts of Kaempferia galanga, 15 parts of rhizoma zingiberis.
The preparation method of the combination medicament of the treatment pelvic congestion syndrome is the same as embodiment 1.
Clinical data
1st, general information
It is our hospital OPD of Obs ＆ Gyn patient that case is collected in this research, is randomly divided into treatment group and each 42 of control group.Control Treatment group age 25-46 year, average 30.5 ± 5.8 years old, the course of disease is 2-8, average 3.2 ± 2.9,18 of final recognition >=2 time, and knot Postoperative 15 are pricked, upper 9, ring.Control group age 26-47 year, average 31.6 ± 4.9 years old, the course of disease is 2-7, average 3.1 ± 3.0, wherein final recognition >=2 time 20,15 after ligation, upper 7, ring.Two groups are compared indifference in terms of age, the course of disease, symptom Different P>0.5, there is comparativity.
2nd, diagnostic criteria
Meet《Difficult gynecotokology》The age of middle pelvic congestion syndrome diagnostic criteria in 25-47 year patient, knows same Meaning adds this experimenter.
(1) symptom：Lower abdominal pain, waist and sacrum pain, congestive dysmenorrhoea, premenstrual breast pain, dyspareunia are extremely tired The diseases such as labor sense menorrhalgia, leucorrhea increasing, such as autonomic nerves system symptom, palpitaition, shortness of breath, headache, agitation, bladder, rectum thorn Swash symptom.
(2) sign:The visible vulva of gynecologial examination, vagina are in hyacinthine, and partly with varication, cervix is loose, soft, It is in slightly hyacinthine, there is act pain sometimes；Corpus uteri increase and it is soft, often in rear position；The accessible property softness in attachment area thickens sense, very To the unclear soft lump of accessible boundary.There is tenderness in bimanual examination, if slowly intensified pressure, it is anti-with tenderness to thicken sense It can disappear.Often there is deep tenderness area or lower abdomen both sides to abdomen examination on pubic symphysis, but without tension of abdominal muscle and Blumberg's sign.Body Position experiment is positive.
(3) auxiliary examination：Transvaginal Color Doppler Flow Imaging inspection, it is the first choice side for diagnosing pelvic congestion syndrome Method；Pelvic diseases inspection；Via vagina palace bottom muscle layer punctures pelvic phlebography；Laparoscope；Pelvic blood flow diagram；Radionuclide Scanning.
3rd, treatment method
Control group 42 takes GUIZHI FULING JIAONANG (Chinese medicines quasi-word Z10950005 Jiangsu Kang Yuan medicine companies after clean period Limited company) 3 tablets/time, 3 times/d, it is 1 course for the treatment of continuously to take 20 days.42 combination medicines using embodiment 3 for the treatment of group Agent, first powder is taken with warm water, three times a day, externally dressing is coated on Guanyuan point, and then emplastrum is covered in the outer of coating On application.Before external application first with 75% cotton ball soaked in alcohol scrape skin with reach sterilization and degreasing purpose.Tobacco and wine are avoided during external application, it is raw It is cold, it is greasy, it is pungent.Sticking area skin has wound, ulcer, and the infected avoids use.Small number of patients has allergic reaction to plaster, occurs Part is burnt and itch, avoids scratching, then alleviates after removal.
4th, criterion of cure：Pain disappears, and Working Life, spirit normally disappear substantially for recovery from illness pain, and other symptoms are delayed Solution, menstrual period can adhere to that work is effective.Pain substantially mitigates, but it is effective still to have pain during tired or menstrual period.Pain, which has no, to be changed It is apt to be invalid.
5th, result
5.1st, following table is that two groups of curative effects compare
Packet n Recovery from illness It is effective Effectively It is invalid Total effective rate
Treatment group 42 16 13 9 4 90.5%
Control group 42 12 11 8 11 73.8%
5.2nd, two groups of curative effects compare
Treatment group fully recovers 16, effective 13, effective 9, invalid 4 total effective rates 90.5%.Control group is fully recovered 12, Effective 11, effective 8 invalid 11, total effective rate 73.8%.Two groups of total effective rates compare, and difference has significant P< 0.05, treatment group's curative effect is better than control group.
5.3 two groups of courses for the treatment of compare
Treatment group is effective 22 after 1 course of therapy, effective 11 of 2 courses for the treatment of, effective 5 of 3 courses for the treatment of；Control group passes through Effective 8 after 1 course of therapy, effective 15 of 2 courses for the treatment of, effective 8 of 3 courses for the treatment of.
6th, discuss
The etiology and pathogenesis of pelvic congestion syndrome is mainly congestion blood block, caused by train of thought is obstructed, its pathogenic factor or because of spleen Empty gas is weak, and blood fortune is powerless；Or because stagnation of QI due to depression of the liver, blood transport not smooth, congestion blood block；Or because experiencing heat symptoms caused by an exopathgen, invaded in wet poison, stay and pour down Jiao, blood fortune is held back, congestion blood block and fall ill.
The combination medicament of the present invention is that medicine is wanted based on externally dressing, wherein, peach kernel is promoting blood circulation and removing blood stasis, and ease constipation is led to Just；Safflower is promoting blood circulation and removing blood stasis, removes obstruction in channels to relieve pain；Modern pharmacology thinks peach kernel, and safflower plays the role of notable excited uterus.Radix Angelicae Sinensis, it is raw Glutinous rehmannia replenishing the vital essence and removing heat cool blood, modern pharmacology think that Radix Angelicae Sinensis is in bidirectional modulation to uterus, and radix rehmanniae recen can accelerate myeloid element Propagation, differentiation, promote red blood cell, hemoglobin reparation.Ligusticum wallichii blood-activating and qi-promoting, modern pharmacology think that Ligusticum wallichii can receive isolated uterine Contracting power is strengthened, and RADIX PAEONIAE RUBRA clearing heat and cooling blood is promoting blood circulation and removing blood stasis.The wide middle de-swelling modern pharmacology of Fructus Aurantii promoting the circulation of qi is thought to exist to pregnant unpregnancy in vitro Excitability is presented in seat palace.Radix bupleuri soothing liver-qi stagnation.Root of bidentate achyranthes promoting blood circulation, priming is descending, and modern pharmacology thinks that the root of bidentate achyranthes has significantly The effect of the effect in excited uterus, also anti-aging.The pungent scattered hardship of balloonflower root is let out, and a surname opens lung qi, and saltcake has softening and resolving hard mass swelling and pain relieving The effect of, rhubarb,torrefied has the effect of row extravasated blood, balloonflower root, radix bupleuri, and rheum officinale modern pharmacology thinks there is antipyretic-antalgic, inhibiting bacteria and diminishing inflammation, It is antifatigue, improve body's immunity, antineoplastic action, radix glycyrrhizae relieving spasm to stop pain.Warm yellow rice wine, which is adjusted, sticks medicine, plays promoting the circulation of qi, leads to The effects such as network, detumescence, analgesic, though delay medicine forever, swash its property.Therefore externally dressing has promoting blood circulation and removing blood stasis, clearing heat and cooling blood, liver reason of relaxing Gas, it is effective to alleviate pelvic congestion state the effect of removing obstruction in channels to relieve pain, strengthen local organization blood circulation and oxygen supply, improve machine Body resistance is to reach therapeutic effect.
Guanyuan point is located at lower three cun of navel, and Guanyuan point is the Mu-front acupoints of small intestine, and the depressed of small intestine gathers this cave and through defeated turn of this cave To skin zone, it is congenital Qihai, is that health is told and receives the place of air-breathing with fixed attention, and ancients are referred to as personal nephroyin and nephroyang and handed over to close part； I is referred to as " extremely mysterious and abstruse, many wonderful doors ", has the work(of Jiao under element culturing fixed folder, help, is clinically used for uropoiesis, reproduction System illness.Point application therapy, it is using Chinese medicine meridian theory as theoretical foundation, is a set of unique effective treatment side Method, the corresponding skin zone of body surface acupuncture points on the human body is stimulated and acts on, by the conduction and adjustment of channels and collaterals, the inclined Sheng of correction internal organs negative and positive or inclined Decline, " swollen to dissipate stasis to lead to the gas ... of closing " improves the operation of meridian qi and blood, to the physiological function and pathology of the vital organs of the human body State, good treatment and corrective action are produced, it is logical dirty with warp with table eliminating toxic so as to reach with the solid table of skin, got rid of evils and helped with cave The purpose of positive salubrity.
In summary, combination medicament of the invention has simple to operate for pelvic congestion syndrome treatment, and effect is direct, It is rapid-action, curative for effect, economical and practical, noninvasive painless, drug safety, the characteristics of having no toxic side effect.Do not only have endo-medicine Effect, and the also effect of liniment, channels and collaterals, acupuncture points on the human body, influence each other between several treatment factors, interact, mutually Supplement, it is common to play overall superposition therapeutic action, make curative effect more lasting, drug effect is stronger, inside and outside to develop simultaneously, and treats both principal and secondary aspect of disease.With list Pure GUIZHI FULING JIAONANG group of taking compares, and curative effect is substantially better than control group.And the effective percentage of first course for the treatment of of treatment is higher than control group. There is preferable clinical value, be worthy to be popularized.

Claims (4)

1. a kind of combination medicament for treating pelvic congestion syndrome, it is characterised in that include the raw material of following parts by weight：Cassia twig 5- 15 parts, Poria cocos 5-15 parts, moutan bark 5-15 parts, root of herbaceous peony 5-15 parts, peach kernel 15-35 parts, safflower 8-12 parts, Radix Angelicae Sinensis 8-12 parts, life Glutinous rehmannia 8-12 parts, Ligusticum wallichii 8-12 parts, radix paeoniae rubrathe 8-12 parts, Fructus Aurantii 8-12 parts, radix bupleuri 8-12 parts, root of bidentate achyranthes 8-12 parts, saltcake 8-12 parts, Rhubarb,torrefied 5-7 parts, balloonflower root 5-7 parts, radix glycyrrhizae 4-6 parts, Radix Aconiti 4-6 parts, frankincense 4-6 parts, myrrh 4-6 parts, cloves 4-6 parts, chaste tree Mustard 8-12 parts, windproof 8-12 parts, geranium wilfordii 8-12 parts, cortex periplocae 8-12 parts, centella 8-12 parts, rhizome of davallia 8-12 parts, the root of Dahurain angelica 12-20 parts, Kaempferia galanga 12-20 parts, rhizoma zingiberis 12-20 parts.
2. the combination medicament of pelvic congestion syndrome is treated according to claim 1, it is characterised in that including following parts by weight Raw material：10 parts of cassia twig, 10 parts of Poria cocos, 10 parts of moutan bark, 10 parts of the root of herbaceous peony, 25 parts of peach kernel, 10 parts of safflower, 10 parts of Radix Angelicae Sinensis, the dried rhizome of rehmannia Yellow 10 parts, 10 parts of Ligusticum wallichii, 10 parts of the radix paeoniae rubrathe, 10 parts of Fructus Aurantii, 10 parts of radix bupleuri, 10 parts of the root of bidentate achyranthes, 10 parts of saltcake, 6 parts of rhubarb,torrefied, balloonflower root 6 Part, 5 parts of radix glycyrrhizae, 5 parts of Radix Aconiti, 5 parts of frankincense, 5 parts of myrrh, 5 parts of cloves, 10 parts of schizonepeta, windproof 10 parts, 10 parts of geranium wilfordii, perfume Add 10 parts of skin, 10 parts of centella, 10 parts of the rhizome of davallia, 15 parts of the root of Dahurain angelica, 15 parts of Kaempferia galanga, 15 parts of rhizoma zingiberis.
A kind of 3. preparation method of the combination medicament of the pelvic congestion syndrome for the treatment of as claimed in claim 1, it is characterised in that bag Include following steps：
First by formula weigh cassia twig, Poria cocos, moutan bark, the root of herbaceous peony, peach kernel, safflower, Radix Angelicae Sinensis, radix rehmanniae recen, Ligusticum wallichii, the radix paeoniae rubrathe, Fructus Aurantii, Radix bupleuri, the root of bidentate achyranthes, saltcake, rhubarb,torrefied, balloonflower root, radix glycyrrhizae, Radix Aconiti, frankincense, myrrh, cloves, schizonepeta, windproof, geranium wilfordii, perfume add Skin, centella, the rhizome of davallia, the root of Dahurain angelica, Kaempferia galanga, rhizoma zingiberis, it is crushed to 150 mesh respectively after solar exposure；Then peach kernel powder is pressed 2:3 Weight ratio be divided into two parts, wherein the cassia twig powder of few a peach kernel powder and equivalent, Poria cocos powder, moutan bark powder, herbaceous peony powder mix Powder directly for oral administration is made afterwards, loaded on closed preservation in brown bottle；
(2) by another peach kernel powder and safflower powder, angelica powder, dried rhizome of rehmannia bloom, Rhizoma Chuanxiong power, radix paeoniae rubrathe powder, Fructus Aurantii powder, radix bupleuri powder, the root of bidentate achyranthes The externally dressing of pasty state is tuned into after powder, mirabilite powder, rhubarb,torrefied powder, balloonflower powder and licorice powder mixing with warm yellow rice wine, loaded on brown bottle In closed preservation；
By Radix Aconiti powder, frankincense powder, do not have medicinal powder, Ground Cloves, schizonepeta powder, windproof powder, geranium wilfordii powder, cortex periplocae powder, centella Powder, Drynaria rhizome powder, angelica dahurica powder and Kaempferia galanga powder are heated to 65 DEG C of refluxing extractions 3 times with the ethanol of 8 times of amounts 70% respectively, extraction every time 1.5h, filtering, merging filtrate, the thick paste of relative density 1.20 is concentrated into 65 DEG C, each thick paste is mixed, obtained mixing thick paste with Natural rubber, beeswax press 2:6:1 weight ratio mixes under 75 DEG C of water-baths, adds ginger powder, stirs, patch is made after tabletting Paste.
4. the preparation method of the combination medicament of pelvic congestion syndrome is treated according to claim 3, it is characterised in that：Use When first by above-mentioned steps, (1) manufactured powder is taken with warm water, three times a day, then (2) manufactured externally dressing applies by above-mentioned steps Guanyuan point is spread on, then (3) manufactured emplastrum is covered on the externally dressing of coating by above-mentioned steps.
CN201710619292.0A 2017-07-26 2017-07-26 A kind of combination medicament and preparation method for treating pelvic congestion syndrome Pending CN107362342A (en)

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