CN107362304A - A kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis - Google Patents
A kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis Download PDFInfo
- Publication number
- CN107362304A CN107362304A CN201710679719.6A CN201710679719A CN107362304A CN 107362304 A CN107362304 A CN 107362304A CN 201710679719 A CN201710679719 A CN 201710679719A CN 107362304 A CN107362304 A CN 107362304A
- Authority
- CN
- China
- Prior art keywords
- parts
- well mixed
- chinese medicinal
- rotating speeds
- min rotating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis, its raw material includes the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, cassia twig, rhizoma dioscoreae nipponicae, the banksia rose, the coptis, the dried immature fruit of citron orange, radish seed, Ligusticum wallichii, modified adhesive, nanometer hydroxyapatite and sustained release auxiliary agent.The Chinese medicinal granule for being used to treat acute gastritis of the present invention, by concentrating powder processed after being extracted to Chinese medicine, and add sustained release auxiliary agent and carry out rubbing up granulation, obtained Chinese medicinal granule can carry out efficiently high-quality release to traditional Chinese medicine ingredients, improve drug effect and therapeutic effect.
Description
Technical field
The present invention relates to the technical field of Chinese medicine, more particularly to a kind of Chinese medicinal granule for the high slow release for treating acute gastritis
Electuary.
Background technology
Acute gastritis refers to a kind of acute inflammatory reaction of gastric mucosa caused by a variety of causes, is divided into acute simplex stomach
Four kinds of inflammation, acute erosive gastritis, acute corrosive gastritis and acute phlegmonous gastritis.The medicine of acute gastritis of the prior art
Thing, which is entered after interior body, to be entered blood after small intestine is absorbed mostly and is absorbed, and intestinal absorption area is big, common particle
It is not in time for also being put into big enteral into blood circulation after, so drug effect is had a greatly reduced quality, can not efficiently carries out urgency
The treatment of property gastritis, a kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis is developed to solve existing skill so needing badly
The problem of in art.
The content of the invention
To solve technical problem present in background technology, the present invention proposes a kind of high slow release for treating acute gastritis
Chinese medicinal granule electuary, obtained Chinese medicinal granule can carry out efficiently high-quality release to traditional Chinese medicine ingredients, improve drug effect and treatment is imitated
Fruit.
A kind of Chinese medicinal granule electuary of high slow release for treating acute gastritis proposed by the present invention, its raw material wrap by weight
Include：Bark of official magnolia 30-50 parts, rhizoma atractylodis 15-25 parts, Pogostemon cablin 1-5 parts, dried orange peel 4-8 parts, dandelion 8-16 parts, hay 2-5 parts, the root of herbaceous peony
3-6 parts, malt 2-4 parts, cuttlebone 3-6 parts, bletilla 4-8 parts, cassia twig 2-5 parts, rhizoma dioscoreae nipponicae 1-4 parts, banksia rose 3-6 parts, coptis 2-4
Part, dried immature fruit of citron orange 1-4 parts, radish seed 3-5 parts, Ligusticum wallichii 3-6 parts, modified adhesive 8-16 parts, nanometer hydroxyapatite 2-8 parts, sustained release
Auxiliary agent 1-5 parts.
Preferably, be sustained the raw material of auxiliary agent includes by weight：Chitosan 4-8 parts, phthalic anhydride 2-4 parts, diformazan
Base formamide 1-3 parts, triphenylchloromethane 3-5 parts, pyridine 2-5 parts, hyaluronic acid 1-4 parts, chitosan oligosaccharide 3-6 parts, treatment fraction
For 15-25% polylactic-co-glycolic acid solution 4-8 parts, cyclodextrin 3-6 parts.
Preferably, sustained release auxiliary agent is prepared by following technique：By chitosan, phthalic anhydride and dimethylformamide
It is well mixed, heated up under nitrogen atmosphere, be incubated, filtered after being cooled to room temperature, material a is obtained after vacuum drying；Then to thing
Triphenylchloromethane is added in material a and pyridine is well mixed, and is stirred, is cooled to room temperature and obtains material b；Hyaluronic acid and shell is few
Sugar is well mixed, stirring, is then dried in freeze drier, is subsequently added into polylactic-co-glycolic acid solution and is well mixed, stir
Mix, then add cyclodextrin and material b is well mixed, be followed by stirring for, be then centrifuged for collecting, be freeze-dried and be sustained after washing
Auxiliary agent.
Preferably, sustained release auxiliary agent is prepared by following technique：By chitosan, phthalic anhydride and dimethylformamide
It is well mixed, 120-140 DEG C is warming up under nitrogen atmosphere, 6-8h is incubated, filters after being cooled to room temperature, obtained after vacuum drying
Material a；Then add triphenylchloromethane into material a and pyridine be well mixed, 2-4h is stirred in 650-850r/min rotating speeds,
It is cooled to room temperature and obtains material b；Hyaluronic acid and chitosan oligosaccharide are well mixed, 20- is stirred in 350-650r/min rotating speeds
30min, 20-40min is then dried in -30~-50 DEG C of freeze driers, it is the poly- of 15-25% to be subsequently added into treatment fraction
Lactic-glycolic acid solution is well mixed, and is stirred 10-20min in 4500-5500r/min rotating speeds, is then added cyclodextrin and thing
Material b is well mixed, and is then stirred 3-5h in 250-350r/min rotating speeds, is then collected by centrifugation in 8500-12000r/min rotating speeds,
Freeze-drying obtains being sustained auxiliary agent after washing.
Preferably, the raw material of modified adhesive includes by weight：It is amylose 12-24 parts, sodium hydroxide 4-8 parts, different
Propyl alcohol 2-5 parts, bromination dodecane 1-4 parts, hydrochloric acid solution 3-6 parts, Thioglycolic acid 2-5 parts, 1- ethyls-(3- front threes aminopropyl) carbon
Diimmonium salt hydrochlorate 1-5 parts, acetum 3-6 parts, acetaldehyde 2-5 parts, sodium borohydride 1-5 parts.
Preferably, modified adhesive is prepared by following technique：Amylose, sodium hydroxide and isopropanol are mixed equal
It is even, heat up, insulation, be subsequently added into bromination dodecane and be well mixed, stirring obtains material A；Into material A add hydrochloric acid solution,
Thioglycolic acid and 1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride are well mixed, stirring, and regulation pH obtains material B；So
Acetum is added in backward material B, is stirred at room temperature, acetaldehyde is then added and is well mixed, heat up, insulation, adjust pH, add
Sodium borohydride is well mixed, and heating stirring, is adjusted pH, is cooled to room temperature and obtains modified adhesive.
Preferably, modified adhesive is prepared by following technique：Amylose, sodium hydroxide and isopropanol are mixed equal
It is even, 60-80 DEG C is warming up to, 5-15min is incubated, is subsequently added into bromination dodecane and is well mixed, stirred in 650-850r/min rotating speeds
Mix 20-40min and obtain material A；The hydrochloric acid solution, thin base second that substance withdrawl syndrome is 0.5-1.5mol/L are added into material A
Acid and 1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride are well mixed, and 20- is stirred in 450-650r/min rotating speeds
40min, regulation pH to 4.5-5.5 obtain material B；Then acetum is added into material B, stirs 20-28h at room temperature, so
Acetaldehyde is added afterwards to be well mixed, 60-80 DEG C is warming up to, is incubated 15-35min, adjust pH to 4.0-5.0, is added sodium borohydride and is mixed
Close uniformly, be warming up to 650-850r/min rotating speeds stirring 20-40min, adjust pH to 9.5-10.5, be cooled to room temperature and be modified
Adhesive.
The preparation method of the present invention, comprises the following steps：
S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, cassia twig, wear
Mountain dragon, the banksia rose, the coptis, the dried immature fruit of citron orange, radish seed and Ligusticum wallichii add 10 times of amount water immersion 0.5-1.5h, are volatilized with extraction by steam distillation
Oily 4-6h, filtration, the dregs of a decoction add water to cook secondary, and each decocting time be 1-3h, add the water extractions acquirement of 11.5 times of amounts for the first time
To first time extract solution, second of addition, 10 times of amount water extractions obtain to second of extract solution, merge extract solution, filtration, depressurize dense
Shorten the clear cream that relative density is 1.15 into, add ethanol alcohol content is reached 65-75%, stir evenly, stand 20-26h, take supernatant, subtract
Receipts ethanol is pushed back, the thick paste that relative density is 1.25-1.35 is condensed into, dry extract is dried under reduced pressure into 65-75 DEG C, is ground into thin
Powder, cross 70-90 mesh sieves and obtain material a；
S2, material a and sustained release auxiliary agent be well mixed, be warming up to 80-90 DEG C, 20-40min be incubated, in 650-850r/
Min rotating speeds stir 1-3h, then add modified adhesive and nanometer hydroxyapatite is well mixed, be 75-80%'s with concentration
Alcohol granulation, in 55-65 DEG C of dry 2-4h, be cooled to room temperature obtain medical treatment acute gastritis high slow release Chinese medicinal granule punching
Agent.
The present invention a kind of high slow release for treating acute gastritis Chinese medicinal granule electuary, its raw material include the bark of official magnolia, rhizoma atractylodis,
Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, cassia twig, rhizoma dioscoreae nipponicae, the banksia rose, the coptis, the dried immature fruit of citron orange, radish
Son, Ligusticum wallichii, modified adhesive, nanometer hydroxyapatite and sustained release auxiliary agent.Wherein, auxiliary agent is sustained by by chitosan, adjacent benzene two
Formic anhydride and dimethylformamide are well mixed, and are heated up under nitrogen atmosphere, insulation, are filtered after being cooled to room temperature, are dried in vacuo
After obtain material a；Then add triphenylchloromethane into material a and pyridine is well mixed, stir, be cooled to room temperature and obtain thing
Expect b；Hyaluronic acid and chitosan oligosaccharide are well mixed, stirred, is then dried in freeze drier, is subsequently added into polylactic
Acetic acid solution is well mixed, and stirring, then adds cyclodextrin and material b is well mixed, be followed by stirring for, be then centrifuged for collecting, water
Freeze-drying obtains being sustained auxiliary agent after washing, and applies in the Chinese medicinal granule electuary for being used to treat acute gastritis of the present invention, can
The raising of electuary Curing Effect of Chinese medicine substance release efficiency is effectively improved, the therapeutic effect to acute gastritis can be effectively improved.Wherein,
Modified adhesive heats up by the way that amylose, sodium hydroxide and isopropanol are well mixed, insulation, is subsequently added into bromination 12
Alkane is well mixed, and stirring obtains material A；Hydrochloric acid solution, Thioglycolic acid and 1- ethyls-(3- front threes ammonia third are added into material A
Base) carbodiimide hydrochloride is well mixed, and stirs, and regulation pH obtains material B；Then acetum, room temperature are added into material B
Lower stirring, then add acetaldehyde and be well mixed, heat up, insulation, adjust pH, add sodium borohydride and be well mixed, heating stirring, adjust
PH is saved, room temperature is cooled to and obtains modified adhesive, is applied in the Chinese medicinal granule electuary for being used to treat acute gastritis of the present invention,
The ratio of briquetting of particle electuary can be effectively improved, effectively increases the drug effect of particle electuary, and then is improved to acute gastritis
Mass effect.The Chinese medicinal granule for being used to treat acute gastritis of the present invention, by concentrating powder processed after being extracted to Chinese medicine, and adds
Sustained release auxiliary agent is added to carry out rubbing up granulation, obtained Chinese medicinal granule can carry out efficiently high-quality release to traditional Chinese medicine ingredients, improve medicine
Effect and therapeutic effect.
Embodiment
The present invention is described in detail with reference to specific embodiment, it should be appreciated that embodiment is served only for illustrating this hair
It is bright, rather than for limiting the invention, any modification made on the basis of the present invention, equivalent substitution etc. are in this hair
In bright protection domain.
In embodiment, the parts by weight of the bark of official magnolia can be 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts,
37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts；Rhizoma atractylodis
Parts by weight can be 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts；The weight of Pogostemon cablin
It can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts to measure part；The parts by weight of dried orange peel can be 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5
Part, 7 parts, 7.5 parts, 8 parts；The parts by weight of dandelion can be 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16
Part；The parts by weight of hay can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts；The parts by weight of the root of herbaceous peony can be 3 parts,
3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；The parts by weight of malt can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；Extra large Piao
The parts by weight of octopus can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；The parts by weight of bletilla can be 4 parts, 4.5
Part, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts；The parts by weight of cassia twig can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5
Part；The parts by weight of rhizoma dioscoreae nipponicae can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；The parts by weight of the banksia rose can be 3
Part, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；The parts by weight of the coptis can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；Trifoliate orange
Real parts by weight can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；The parts by weight of radish seed can be 3 parts, 3.5
Part, 4 parts, 4.5 parts, 5 parts；The parts by weight of Ligusticum wallichii can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；Modification is gluing
The parts by weight of agent can be 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts；The weight of nanometer hydroxyapatite
It can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts to measure part；Be sustained auxiliary agent parts by weight can be 1 part, 2 parts, 3 parts, 4 parts, 5
Part.
Embodiment 1
A kind of Chinese medicinal granule electuary of high slow release for treating acute gastritis proposed by the present invention, its raw material wrap by weight
Include：40 parts of the bark of official magnolia, 20 parts of rhizoma atractylodis, 3 parts of Pogostemon cablin, 6 parts of dried orange peel, 12 parts of dandelion, 3.5 parts of hay, 4.5 parts of the root of herbaceous peony, malt 3
Part, 4.5 parts of cuttlebone, 6 parts of bletilla, 3.5 parts of cassia twig, 2.5 parts of rhizoma dioscoreae nipponicae, 4.5 parts of the banksia rose, 3 parts of the coptis, 2.5 parts of the dried immature fruit of citron orange, radish
3 parts 4 parts of son, 4.5 parts of Ligusticum wallichii, 12 parts of modified adhesive, 5 parts of nanometer hydroxyapatite, sustained release of auxiliary agent.
Sustained release auxiliary agent is prepared by following technique：By weight by 6 parts of chitosans, 3 parts of phthalic anhydrides and 2 part two
NMF is well mixed, and 130 DEG C are warming up under nitrogen atmosphere, is incubated 7h, is filtered after being cooled to room temperature, after vacuum drying
Obtain material a；Then 4 parts of triphenylchloromethanes are added into material a and 3.5 parts of pyridines is well mixed, in 750r/min rotating speeds
3h is stirred, room temperature is cooled to and obtains material b；2.5 parts of hyaluronic acids and 4.5 parts of chitosan oligosaccharides are well mixed, turned in 500r/min
Speed stirring 25min, then dries 30min in -40 DEG C of freeze driers, is subsequently added into the poly- breast that 6 parts for the treatment of fractions are 20%
Sour hydroxyacetic acid solution is well mixed, and is stirred 15min in 5000r/min rotating speeds, is then added 4.5 parts of cyclodextrin and material b is mixed
Close uniformly, then stir 4h in 300r/min rotating speeds, be then collected by centrifugation in 9000r/min rotating speeds, be freeze-dried after washing
To sustained release auxiliary agent.
Modified adhesive is prepared by following technique：By weight by 18 portions of amyloses, 6 parts of sodium hydroxides and 3.5
Part isopropanol is well mixed, and is warming up to 70 DEG C, is incubated 10min, is subsequently added into 2.5 parts of bromination dodecanes and is well mixed, in 750r/
Min rotating speeds stirring 30min obtains material A；Added into material A hydrochloric acid solution that 4.5 parts of substance withdrawl syndromes are 1mol/L,
3.5 parts of Thioglycolic acids and 3 parts of 1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride are well mixed, in 550r/min rotating speeds
30min is stirred, regulation pH to 5.0 obtains material B；Then 4.5 parts of acetums are added into material B, stir 24h at room temperature,
Then 3.5 parts of acetaldehyde are added to be well mixed, 70 DEG C is warming up to, is incubated 25min, adjust pH to 4.5,3 parts of sodium borohydrides is added and mixes
Close uniformly, be warming up to 750r/min rotating speeds stirring 30min, adjust pH to 10, be cooled to room temperature and obtain modified adhesive.
Embodiment 2
A kind of Chinese medicinal granule electuary of high slow release for treating acute gastritis proposed by the present invention, its raw material wrap by weight
Include：30 parts of the bark of official magnolia, 25 parts of rhizoma atractylodis, 1 part of Pogostemon cablin, 8 parts of dried orange peel, 8 parts of dandelion, 5 parts of hay, 3 parts of the root of herbaceous peony, 4 parts of malt, extra large Piao
3 parts of octopus, 8 parts of bletilla, 2 parts of cassia twig, 4 parts of rhizoma dioscoreae nipponicae, 3 parts of the banksia rose, 4 parts of the coptis, 1 part of the dried immature fruit of citron orange, 5 parts of radish seed, 3 parts of Ligusticum wallichii, change
Property 16 parts of adhesive, 2 parts of nanometer hydroxyapatite, sustained release 5 parts of auxiliary agent.
Sustained release auxiliary agent is prepared by following technique：By weight by 4 parts of chitosans, 4 parts of phthalic anhydrides and 1 part two
NMF is well mixed, and 140 DEG C are warming up under nitrogen atmosphere, is incubated 6h, is filtered after being cooled to room temperature, after vacuum drying
Obtain material a；Then 5 parts of triphenylchloromethanes are added into material a and 2 parts of pyridines is well mixed, stirred in 850r/min rotating speeds
2h is mixed, room temperature is cooled to and obtains material b；4 parts of hyaluronic acids and 3 parts of chitosan oligosaccharides are well mixed, stirred in 650r/min rotating speeds
20min, 20min is then dried in -50 DEG C of freeze driers, be subsequently added into the polylactic that 8 parts for the treatment of fractions are 15%
Acetic acid solution is well mixed, and is stirred 10min in 5500r/min rotating speeds, is then added 6 parts of cyclodextrin and material b is well mixed, connect
And stir 5h in 250r/min rotating speeds, be then collected by centrifugation in 8500r/min rotating speeds, after washing freeze-drying obtain sustained release and help
Agent.
Modified adhesive is prepared by following technique：By weight by 12 portions of amyloses, 8 parts of sodium hydroxides and 2 parts
Isopropanol is well mixed, and is warming up to 80 DEG C, is incubated 5min, is subsequently added into 4 parts of bromination dodecanes and is well mixed, and is turned in 650r/min
Speed stirring 40min obtains material A；Hydrochloric acid solution, the 2 parts of thin bases that 3 parts of substance withdrawl syndromes are 1.5mol/L are added into material A
Acetic acid and 5 parts of 1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride are well mixed, and 40min is stirred in 450r/min rotating speeds,
Regulation pH to 4.5 obtains material B；Then 6 parts of acetums are added into material B, stir 20h at room temperature, then add 5 parts of second
Aldehyde is well mixed, and is warming up to 60 DEG C, is incubated 35min, adjusts pH to 4.0, is added 5 parts of sodium borohydrides and is well mixed, is warming up to
650r/min rotating speeds stir 40min, adjust pH to 9.5, are cooled to room temperature and obtain modified adhesive.
Embodiment 3
A kind of Chinese medicinal granule electuary of high slow release for treating acute gastritis proposed by the present invention, its raw material wrap by weight
Include：50 parts of the bark of official magnolia, 15 parts of rhizoma atractylodis, 5 parts of Pogostemon cablin, 4 parts of dried orange peel, 16 parts of dandelion, 2 parts of hay, 6 parts of the root of herbaceous peony, 2 parts of malt, sea
6 parts of the egg capsule of a mantis, 4 parts of bletilla, 5 parts of cassia twig, 1 part of rhizoma dioscoreae nipponicae, 6 parts of the banksia rose, 2 parts of the coptis, 4 parts of the dried immature fruit of citron orange, 3 parts of radish seed, 6 parts of Ligusticum wallichii,
1 part 8 parts of modified adhesive, 8 parts of nanometer hydroxyapatite, sustained release of auxiliary agent.
Sustained release auxiliary agent is prepared by following technique：By weight by 8 parts of chitosans, 2 parts of phthalic anhydrides and 3 part two
NMF is well mixed, and 120 DEG C are warming up under nitrogen atmosphere, is incubated 8h, is filtered after being cooled to room temperature, after vacuum drying
Obtain material a；Then 3 parts of triphenylchloromethanes are added into material a and 5 parts of pyridines is well mixed, stirred in 650r/min rotating speeds
4h is mixed, room temperature is cooled to and obtains material b；1 part of hyaluronic acid and 6 parts of chitosan oligosaccharides are well mixed, stirred in 350r/min rotating speeds
30min, 40min is then dried in -30 DEG C of freeze driers, be subsequently added into the polylactic that 4 parts for the treatment of fractions are 25%
Acetic acid solution is well mixed, and is stirred 20min in 4500r/min rotating speeds, is then added 3 parts of cyclodextrin and material b is well mixed, connect
And stir 3h in 350r/min rotating speeds, be then collected by centrifugation in 12000r/min rotating speeds, after washing freeze-drying obtain sustained release and help
Agent.
Modified adhesive is prepared by following technique：By weight by 24 portions of amyloses, 4 parts of sodium hydroxides and 5 parts
Isopropanol is well mixed, and is warming up to 60 DEG C, is incubated 15min, is subsequently added into 1 part of bromination dodecane and is well mixed, in 850r/min
Rotating speed stirring 20min obtains material A；Added into material A 6 parts of substance withdrawl syndromes be 0.5mol/L hydrochloric acid solution, 5 parts dredge
Guanidine-acetic acid and 1 part of 1- ethyl-(3- front threes aminopropyl) carbodiimide hydrochloride are well mixed, and are stirred in 650r/min rotating speeds
20min, regulation pH to 5.5 obtain material B；Then 3 parts of acetums are added into material B, stir 28h, Ran Houjia at room temperature
Enter 2 parts of acetaldehyde to be well mixed, be warming up to 80 DEG C, be incubated 15min, adjust pH to 5.0, add 1 part of sodium borohydride and be well mixed, rise
Temperature to 850r/min rotating speeds stir 20min, adjust pH to 10.5, are cooled to room temperature and obtain modified adhesive.
Embodiment 4
A kind of Chinese medicinal granule electuary of high slow release for treating acute gastritis proposed by the present invention, its raw material wrap by weight
Include：35 parts of the bark of official magnolia, 22 parts of rhizoma atractylodis, 2 parts of Pogostemon cablin, 7 parts of dried orange peel, 9 parts of dandelion, 4 parts of hay, 4 parts of the root of herbaceous peony, 3.5 parts of malt, sea
4 parts of the egg capsule of a mantis, 7 parts of bletilla, 3 parts of cassia twig, 3 parts of rhizoma dioscoreae nipponicae, 4 parts of the banksia rose, 3.5 parts of the coptis, 2 parts of the dried immature fruit of citron orange, 4.5 parts of radish seed, Ligusticum wallichii 4
4 parts part, 15 parts of modified adhesive, 3 parts of nanometer hydroxyapatite, sustained release of auxiliary agent.
Sustained release auxiliary agent is prepared by following technique：By weight by 5 parts of chitosans, 3.5 parts of phthalic anhydrides and 1.5
Part dimethylformamide is well mixed, and 135 DEG C are warming up under nitrogen atmosphere, is incubated 6.5h, is filtered after being cooled to room temperature, vacuum
Material a is obtained after drying；Then 4.5 parts of triphenylchloromethanes are added into material a and 3 parts of pyridines is well mixed, in 820r/
Min rotating speeds stir 2.5h, are cooled to room temperature and obtain material b；3 parts of hyaluronic acids and 4 parts of chitosan oligosaccharides are well mixed, in 620r/
Min rotating speeds stir 22min, and 25min is then dried in -45 DEG C of freeze driers, and it is 18% to be subsequently added into 7 parts for the treatment of fractions
Polylactic-co-glycolic acid solution is well mixed, and is stirred 12min in 5200r/min rotating speeds, is then added 5 parts of cyclodextrin and material b
It is well mixed, 4.5h then is stirred in 280r/min rotating speeds, is then collected by centrifugation in 8800r/min rotating speeds, is freezed after washing dry
It is dry to obtain being sustained auxiliary agent.
Modified adhesive is prepared by following technique：By weight by 14 portions of amyloses, 7 parts of sodium hydroxides and 3 parts
Isopropanol is well mixed, and is warming up to 75 DEG C, is incubated 8min, is subsequently added into 3 parts of bromination dodecanes and is well mixed, and is turned in 680r/min
Speed stirring 35min obtains material A；Hydrochloric acid solution, the 3 parts of thin bases that 4 parts of substance withdrawl syndromes are 1.2mol/L are added into material A
Acetic acid and 4 parts of 1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride are well mixed, and 35min is stirred in 480r/min rotating speeds,
Regulation pH to 4.8 obtains material B；Then 5 parts of acetums are added into material B, stir 22h at room temperature, then add 4 parts of second
Aldehyde is well mixed, and is warming up to 65 DEG C, is incubated 32min, adjusts pH to 4.2, is added 4 parts of sodium borohydrides and is well mixed, is warming up to
680r/min rotating speeds stir 35min, adjust pH to 9.8, are cooled to room temperature and obtain modified adhesive.
Embodiment 5
A kind of Chinese medicinal granule electuary of high slow release for treating acute gastritis proposed by the present invention, its raw material wrap by weight
Include：45 parts of the bark of official magnolia, 18 parts of rhizoma atractylodis, 4 parts of Pogostemon cablin, 5 parts of dried orange peel, 15 parts of dandelion, 3 parts of hay, 5 parts of the root of herbaceous peony, 2.5 parts of malt,
5 parts of cuttlebone, 5 parts of bletilla, 4 parts of cassia twig, 2 parts of rhizoma dioscoreae nipponicae, 5 parts of the banksia rose, 2.5 parts of the coptis, 3 parts of the dried immature fruit of citron orange, 3.5 parts of radish seed, river
2 parts 5 parts of rhizome of chuanxiong, 9 parts of modified adhesive, 7 parts of nanometer hydroxyapatite, sustained release of auxiliary agent.
Sustained release auxiliary agent is prepared by following technique：By weight by 7 parts of chitosans, 2.5 parts of phthalic anhydrides and 2.5
Part dimethylformamide is well mixed, and 125 DEG C are warming up under nitrogen atmosphere, is incubated 7.5h, is filtered after being cooled to room temperature, vacuum
Material a is obtained after drying；Then 3.5 parts of triphenylchloromethanes are added into material a and 4 parts of pyridines is well mixed, in 680r/
Min rotating speeds stir 3.5h, are cooled to room temperature and obtain material b；2 parts of hyaluronic acids and 5 parts of chitosan oligosaccharides are well mixed, in 380r/
Min rotating speeds stir 28min, and 35min is then dried in -35 DEG C of freeze driers, and it is 22% to be subsequently added into 5 parts for the treatment of fractions
Polylactic-co-glycolic acid solution is well mixed, and is stirred 18min in 4800r/min rotating speeds, is then added 4 parts of cyclodextrin and material b
It is well mixed, 3.5h then is stirred in 320r/min rotating speeds, is then collected by centrifugation in 11500r/min rotating speeds, is freezed after washing dry
It is dry to obtain being sustained auxiliary agent.
Modified adhesive is prepared by following technique：By weight by 22 portions of amyloses, 5 parts of sodium hydroxides and 4 parts
Isopropanol is well mixed, and is warming up to 65 DEG C, is incubated 12min, is subsequently added into 2 parts of bromination dodecanes and is well mixed, in 820r/min
Rotating speed stirring 25min obtains material A；Added into material A 5 parts of substance withdrawl syndromes be 0.8mol/L hydrochloric acid solution, 4 parts dredge
Guanidine-acetic acid and 2 parts of 1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride are well mixed, and are stirred in 620r/min rotating speeds
25min, regulation pH to 5.2 obtain material B；Then 4 parts of acetums are added into material B, stir 26h, Ran Houjia at room temperature
Enter 3 parts of acetaldehyde to be well mixed, be warming up to 75 DEG C, be incubated 18min, adjust pH to 4.8, add 2 parts of sodium borohydrides and be well mixed, rise
Temperature to 820r/min rotating speeds stir 25min, adjust pH to 10.2, are cooled to room temperature and obtain modified adhesive.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (7)
1. a kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis, it is characterised in that its raw material includes by weight：
Bark of official magnolia 30-50 parts, rhizoma atractylodis 15-25 parts, Pogostemon cablin 1-5 parts, dried orange peel 4-8 parts, dandelion 8-16 parts, hay 2-5 parts, root of herbaceous peony 3-6
Part, malt 2-4 parts, cuttlebone 3-6 parts, bletilla 4-8 parts, cassia twig 2-5 parts, rhizoma dioscoreae nipponicae 1-4 parts, banksia rose 3-6 parts, coptis 2-4 parts,
Dried immature fruit of citron orange 1-4 parts, radish seed 3-5 parts, Ligusticum wallichii 3-6 parts, modified adhesive 8-16 parts, nanometer hydroxyapatite 2-8 parts, sustained release auxiliary agent
1-5 parts.
2. the Chinese medicinal granule electuary of the high slow release for the treatment of acute gastritis according to claim 1, it is characterised in that sustained release
The raw material of auxiliary agent includes by weight：Chitosan 4-8 parts, phthalic anhydride 2-4 parts, dimethylformamide 1-3 parts, triphenyl
The polylactic that chloromethanes 3-5 parts, pyridine 2-5 parts, hyaluronic acid 1-4 parts, chitosan oligosaccharide 3-6 parts, treatment fraction are 15-25%
Acetic acid solution 4-8 parts, cyclodextrin 3-6 parts.
3. the Chinese medicinal granule electuary of the high slow release for the treatment of acute gastritis according to claim 1 or 2, it is characterised in that
Sustained release auxiliary agent is prepared by following technique：Chitosan, phthalic anhydride and dimethylformamide are well mixed, in nitrogen
Heated up under atmosphere, be incubated, filtered after being cooled to room temperature, material a is obtained after vacuum drying；Then triphenyl is added into material a
Chloromethanes and pyridine are well mixed, and stirring, are cooled to room temperature and are obtained material b；Hyaluronic acid and chitosan oligosaccharide are well mixed, stirred
Mix, then dried in freeze drier, be subsequently added into polylactic-co-glycolic acid solution and be well mixed, stir, then add ring
Dextrin and material b are well mixed, and are followed by stirring for, and are then centrifuged for collecting, and are freeze-dried after washing and are obtained being sustained auxiliary agent.
4. the Chinese medicinal granule electuary of the high slow release of the treatment acute gastritis according to claim any one of 1-3, its feature
It is, sustained release auxiliary agent is prepared by following technique：Chitosan, phthalic anhydride and dimethylformamide are well mixed,
120-140 DEG C is warming up under nitrogen atmosphere, 6-8h is incubated, is filtered after being cooled to room temperature, material a is obtained after vacuum drying；So
Triphenylchloromethane is added in backward material a and pyridine is well mixed, and is stirred 2-4h in 650-850r/min rotating speeds, is cooled to room
Temperature obtains material b；Hyaluronic acid and chitosan oligosaccharide are well mixed, in 350-650r/min rotating speeds stir 20-30min, then in-
20-40min is dried in 30~-50 DEG C of freeze driers, it is molten to be subsequently added into the polylactic-co-glycolic acid that treatment fraction is 15-25%
Liquid is well mixed, and is stirred 10-20min in 4500-5500r/min rotating speeds, is then added cyclodextrin and material b is well mixed, connect
And stir 3-5h in 250-350r/min rotating speeds, be then collected by centrifugation in 8500-12000r/min rotating speeds, be freeze-dried after washing
Obtain being sustained auxiliary agent.
5. the Chinese medicinal granule electuary of the high slow release of the treatment acute gastritis according to claim any one of 1-4, its feature
It is, the raw material of modified adhesive includes by weight：Amylose 12-24 parts, sodium hydroxide 4-8 parts, isopropanol 2-5 parts,
Bromination dodecane 1-4 parts, hydrochloric acid solution 3-6 parts, Thioglycolic acid 2-5 parts, 1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride
Salt 1-5 parts, acetum 3-6 parts, acetaldehyde 2-5 parts, sodium borohydride 1-5 parts.
6. the Chinese medicinal granule electuary of the high slow release of the treatment acute gastritis according to claim any one of 1-5, its feature
It is, modified adhesive is prepared by following technique：Amylose, sodium hydroxide and isopropanol are well mixed, heated up, is protected
Temperature, it is subsequently added into bromination dodecane and is well mixed, stirring obtains material A；Into material A add hydrochloric acid solution, Thioglycolic acid and
1- ethyls-(3- front threes aminopropyl) carbodiimide hydrochloride is well mixed, stirring, and regulation pH obtains material B；Then to material B
Middle addition acetum, is stirred at room temperature, is then added acetaldehyde and is well mixed, heat up, insulation, adjust pH, adds sodium borohydride
It is well mixed, heating stirring, pH is adjusted, room temperature is cooled to and obtains modified adhesive.
7. the Chinese medicinal granule electuary of the high slow release of the treatment acute gastritis according to claim any one of 1-6, its feature
It is, modified adhesive is prepared by following technique：Amylose, sodium hydroxide and isopropanol are well mixed, are warming up to
60-80 DEG C, 5-15min is incubated, bromination dodecane is subsequently added into and is well mixed, 20-40min is stirred in 650-850r/min rotating speeds
Obtain material A；Hydrochloric acid solution, Thioglycolic acid and the 1- ethyls that addition substance withdrawl syndrome is 0.5-1.5mol/L into material A-
(3- front threes aminopropyl) carbodiimide hydrochloride is well mixed, in 450-650r/min rotating speeds stir 20-40min, regulation pH to
4.5-5.5 obtain material B；Then acetum is added into material B, stirs 20-28h at room temperature, then adds acetaldehyde mixing
Uniformly, 60-80 DEG C is warming up to, is incubated 15-35min, adjusts pH to 4.0-5.0, sodium borohydride is added and is well mixed, be warming up to
650-850r/min rotating speeds stir 20-40min, adjust pH to 9.5-10.5, are cooled to room temperature and obtain modified adhesive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710679719.6A CN107362304A (en) | 2017-08-10 | 2017-08-10 | A kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710679719.6A CN107362304A (en) | 2017-08-10 | 2017-08-10 | A kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107362304A true CN107362304A (en) | 2017-11-21 |
Family
ID=60309648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710679719.6A Pending CN107362304A (en) | 2017-08-10 | 2017-08-10 | A kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107362304A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113367247A (en) * | 2021-01-05 | 2021-09-10 | 安徽科技学院 | Feed additive for preventing broiler chicken myogastric and glandular gastritis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101190314A (en) * | 2006-11-30 | 2008-06-04 | 曹明成 | Traditional Chinese medicine formula for treating acute or chronic gastritis and preparation method |
| CN102266514A (en) * | 2011-07-06 | 2011-12-07 | 曹明成 | Chinese medicinal composition for treating acute and chronic gastritis and preparation method thereof |
-
2017
- 2017-08-10 CN CN201710679719.6A patent/CN107362304A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101190314A (en) * | 2006-11-30 | 2008-06-04 | 曹明成 | Traditional Chinese medicine formula for treating acute or chronic gastritis and preparation method |
| CN102266514A (en) * | 2011-07-06 | 2011-12-07 | 曹明成 | Chinese medicinal composition for treating acute and chronic gastritis and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 徐菲菲等: "苍藿平胃颗粒对大鼠慢性胃炎及胆汁反流性胃炎的治疗作用研究", 《中药材》 * |
| 白欣: "新型基因载体巯基烷基化壳聚糖的制备及体外性质的初步探究", 《中国优秀硕士学位论文全文数据库-医药卫生科技辑》 * |
| 石晓磊，等: "酰化改性壳聚糖的合成及其性质考察", 《沈阳药科大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113367247A (en) * | 2021-01-05 | 2021-09-10 | 安徽科技学院 | Feed additive for preventing broiler chicken myogastric and glandular gastritis |
| CN113367247B (en) * | 2021-01-05 | 2023-11-14 | 安徽科技学院 | Feed additive for preventing stomach proventriculitis of broiler chickens |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107158063A (en) | Enteric-coated micro-pill that a kind of utilization honeysuckle effective part composition is made and preparation method thereof | |
| CN107595893A (en) | A kind of enzyme treated prepared slices of Chinese crude drugs and preparation method thereof | |
| CN100581564C (en) | Yang-nourishing five-saponins medicine for preventing and curing cardiovascular or cerebrovascular disease, and the prepartion and the method for preparing the same | |
| CN107519445A (en) | A kind of spacetabs type chronic gastritis Chinese medicinal granule and preparation method thereof | |
| CN107362304A (en) | A kind of Chinese medicinal granule electuary for the high slow release for treating acute gastritis | |
| CN105232601A (en) | Preparation method and application of decoction-free traditional Chinese fruit medicine preparation | |
| CN103919860A (en) | Honeysuckle cold curing granule and preparation method thereof | |
| CN107441437A (en) | It is a kind of to be used to treat Chinese medicine powder of acute and chronic gastritis and preparation method thereof | |
| CN105707702A (en) | Oatmeal for regulating qi and blood and preparation method thereof | |
| CN106473995A (en) | The extracting method of Herba Bidentis Bipinnatae effective ingredient and its purposes preparing facial film | |
| CN115844937A (en) | Preparation method and application of sonchus oleraceus extract with functions of dispelling effects of alcohol and protecting brain | |
| CN104906366A (en) | Pharmaceutical preparation for treating delayed menorrhea | |
| CN113713004A (en) | Radix isatidis granules and preparation method thereof | |
| CN107519444A (en) | It is a kind of to be used to treat coated slow-release Chinese medicinal granule of acute gastritis and preparation method thereof | |
| CN103638384B (en) | A kind of pharmaceutical composition of enema treatment cancer patients abdominal distention and application thereof | |
| CN104940236A (en) | Taste modifying method for traditional Chinese medicine | |
| CN107536978A (en) | A kind of acute gastritis treatment particle with high slow release and preparation method thereof | |
| CN105343691A (en) | Oral liquid with stomach and intestine improving function and preparing method of oral liquid | |
| CN104606559B (en) | A kind of Camellia Leaves antipruritic | |
| NL2025507B1 (en) | Method for preparing burdock soluble dietary fiber micro powder by taking burdock root as raw material | |
| CN108186874B (en) | A Chinese medicinal composition for treating diabetes | |
| CN105693878A (en) | Method for extracting lentinan from shiitake mushrooms and shiitake mushroom product | |
| CN108904722A (en) | A kind of high-performance bio preparation suitable for acute gastroenteritis | |
| CN106579003A (en) | Processing method of Radix Echinopsis sausages | |
| CN107362305A (en) | A kind of chronic gastritis treatment particle with high-selenium corn efficiency |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171121 |
|
| RJ01 | Rejection of invention patent application after publication |