CN107519444A

CN107519444A - It is a kind of to be used to treat coated slow-release Chinese medicinal granule of acute gastritis and preparation method thereof

Info

Publication number: CN107519444A
Application number: CN201710679718.1A
Authority: CN
Inventors: 曹明成; 黄美容; 解启慧; 马永兰; 董宠
Original assignee: HEFEI CHUANGXIN MEDICAL TECHNOLOGY Co Ltd
Current assignee: HEFEI CHUANGXIN MEDICAL TECHNOLOGY Co Ltd
Priority date: 2017-08-10
Filing date: 2017-08-10
Publication date: 2017-12-29

Abstract

The invention discloses a kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis, its raw material includes the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, the bighead atractylodes rhizome, corydalis tuber, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose, Ligusticum wallichii, alkylation modification chitosan, aspartame and sustained release auxiliary agent.The present invention also proposes a kind of above-mentioned preparation method for being used to treat the coated slow-release Chinese medicinal granule of acute gastritis.The Chinese medicinal granule for quality acute gastritis of the present invention, by concentrating powder processed after being extracted to Chinese medicine, and add sustained release auxiliary agent and carry out rubbing up granulation, obtained Chinese medicinal granule can carry out efficiently high-quality release to traditional Chinese medicine ingredients, improve drug effect and therapeutic effect.

Description

It is a kind of to be used to treat coated slow-release Chinese medicinal granule of acute gastritis and preparation method thereof

Technical field

The present invention relates to the technical field of Chinese medicine, more particularly to a kind of coated slow-release Chinese medicine for being used to treat acute gastritis Grain and preparation method thereof.

Background technology

As the improvement of people's living standards, the quickening of paces, the number of gastritis sufferer is also increasing, in addition patient couple The consistent ignorance of gastritis, takes related potential therapeutic not in time, will aggravate disease.The medicine of acute gastritis of the prior art Thing, which is entered after interior body, to be entered blood after small intestine is absorbed mostly and is absorbed, and intestinal absorption area is big, common particle It is not in time for also being put into big enteral into blood circulation after, so drug effect is had a greatly reduced quality, can not efficiently carries out urgency Property gastritis treatment, a kind of be used to treat the coated slow-release Chinese medicinal granule of acute gastritis to solve prior art so needing badly to develop The problem of middle.

The content of the invention

To solve technical problem present in background technology, the present invention proposes that a kind of coating for being used to treat acute gastritis delays Chinese medicinal granule and preparation method thereof is released, obtained Chinese medicinal granule can carry out efficiently high-quality release to traditional Chinese medicine ingredients, improve medicine Effect and therapeutic effect.

A kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis proposed by the present invention, its raw material wrap by weight Include：Bark of official magnolia 30-50 parts, rhizoma atractylodis 15-25 parts, Pogostemon cablin 1-5 parts, dried orange peel 4-8 parts, dandelion 8-16 parts, hay 2-5 parts, the root of herbaceous peony 3-6 parts, malt 2-4 parts, cuttlebone 3-6 parts, bletilla 4-8 parts, tuber of pinellia 4-6 parts, bighead atractylodes rhizome 2-4 parts, corydalis tuber 3-6 parts, Buddha's hand 2-5 Part, Amomum cardamomum 1-4 parts, jujube 4-8 parts, Poria cocos 3-5 parts, hawthorn 2-6 parts, rhizoma cyperi 1-4 parts, Fructus Aurantii 3-5 parts, coix seed 2-5 parts, Cuttle bone 3-6 parts, balloonflower root 1-4 parts, banksia rose 2-5 parts, Ligusticum wallichii 3-6 parts, alkylation modification chitosan 8-16 parts, aspartame 2-8 Part, sustained release auxiliary agent 1-5 parts.

Preferably, be sustained the raw material of auxiliary agent includes by weight：Soil dynamic test 15-25 parts, nano-attapulgite stone micro mist 4-8 Part, ammonium persulfate 3-6 parts, vinyl acetate 2-5 parts, PLA 4-8 parts.

Preferably, sustained release auxiliary agent is prepared by following technique：By soil dynamic test and nano-attapulgite stone micro mist by grinding After sieving, dry, then add deionized water and be well mixed, then heat up, be incubated, then adjust pH to neutrality, then add Ammonium persulfate is well mixed, and is heated up, and insulation, is subsequently added into vinyl acetate and is well mixed, and is cooled, insulation, after washing, is dried, Then add PLA to be well mixed, be kneaded, be cooled to room temperature and obtain being sustained auxiliary agent.

Preferably, sustained release auxiliary agent is prepared by following technique：By soil dynamic test and nano-attapulgite stone micro mist by grinding After crossing 40-60 mesh sieves, in 45-55 DEG C of dry 7-9h, then add deionized water and be well mixed, be then warming up to 70-90 DEG C, protect Warm 0.5-1.5h, then regulation pH to neutrality, then adds ammonium persulfate and is well mixed, be warming up to 90-110 DEG C, be incubated 1-3h, It is subsequently added into vinyl acetate to be well mixed, is cooled to 65-75 DEG C, be incubated 2-4h, after washing, in 55-65 DEG C of dry 1-2h, so Add PLA afterwards to be well mixed, in 130-150 DEG C, 30-50r/min rotating speeds are kneaded 5-15min, are cooled to room temperature and are sustained Auxiliary agent.

Preferably, alkylation modification chitosan is prepared by following technique：It is 1.5-3.5mol/ by substance withdrawl syndrome L chitosan solution adds in the acetic acid solution that mass fraction is 0.5-1.5% and stirs 20- in 650-850r/min rotating speeds 40min, it is subsequently added into the sodium hydroxide solution that substance withdrawl syndrome is 0.5-1.5mol/L and adjusts pH to 12, precipitate, filtering, so Dimethylformamide, laurate, sodium triacetoxy borohydride and distilled water are added in backward filter cake to be well mixed, and are protected in nitrogen Under shield, 1-3h is stirred with 850-1050r/min rotating speeds, room temperature is cooled to and obtains alkylation modification chitosan.

Preferably, in the preparation technology of alkylation modification chitosan, substance withdrawl syndrome is that 1.5-3.5mol/L shell gathers Sugar juice, mass fraction be 0.5-1.5% acetic acid solution, dimethylformamide, laurate, sodium triacetoxy borohydride and The weight ratio of distilled water is 5-15：2-5：1-3：2-4：3-5：10-20.

A kind of preparation method for being used to treat the coated slow-release Chinese medicinal granule of acute gastritis of the present invention, including following step Suddenly：

S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, white Art, corydalis tuber, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose and Ligusticum wallichii Add 10 times of amount water immersion 0.5-1.5h, with extraction by steam distillation volatile oil 4-6h, filtration, the dregs of a decoction add water to cook it is secondary, often Secondary decocting time is 1-3h, and the water extraction for adding 11.5 times of amounts for the first time is obtained to first time extract solution, adds 10 times of amounts for the second time Water extraction is obtained to second of extract solution, is merged extract solution, filtration, is concentrated under reduced pressure into the clear cream that relative density is 1.15, adds ethanol Alcohol content is reached 65-75%, stir evenly, stand 20-26h, take supernatant, ethanol is recovered under reduced pressure, it is 1.25- to be condensed into relative density 1.35 thick paste, dry extract is dried under reduced pressure into 65-75 DEG C, is ground into fine powder, crossed 70-90 mesh sieves and obtain material a；

S2, material a and sustained release auxiliary agent be well mixed, be warming up to 80-90 DEG C, 20-40min be incubated, in 650-850r/ Min rotating speeds stir 1-3h, then add alkylation modification chitosan and aspartame is well mixed, be 75-80%'s with concentration Alcohol granulation, in 55-65 DEG C of dry 2-4h, it is cooled to room temperature and obtains the coated slow-release Chinese medicinal granule for treating acute gastritis.

The a kind of of the present invention is used to treating the coated slow-release Chinese medicinal granule of acute gastritis, and its raw material includes the bark of official magnolia, rhizoma atractylodis, wide It is wrinkled giant hyssop, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, the bighead atractylodes rhizome, corydalis tuber, Buddha's hand, Amomum cardamomum, red Jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose, Ligusticum wallichii, alkylation modification chitosan, aspartame With sustained release auxiliary agent.Wherein, auxiliary agent is sustained by the way that soil dynamic test and nano-attapulgite stone micro mist after grinding is sieved, are dried, so Deionized water is added afterwards to be well mixed, then heats up, is incubated, and then adjusts pH to neutrality, it is equal then to add ammonium persulfate mixing It is even, heat up, insulation, be subsequently added into vinyl acetate and be well mixed, cool, insulation, after washing, dry, then add PLA It is well mixed, be kneaded, be cooled to room temperature and obtain being sustained auxiliary agent, apply to the present invention be used for treat acute gastritis Chinese medicinal granule In, the release efficiency of its Curing Effect of Chinese medicine material can be effectively improved, improves the therapeutic effect to acute gastritis.Wherein, alkane Base modification of chitosan is stirred by the way that chitosan solution is added in acetic acid solution, is subsequently added into sodium hydroxide solution regulation pH, Precipitation, filtering, dimethylformamide, laurate, sodium triacetoxy borohydride and distilled water mixing are then added into filter cake Uniformly, nitrogen protection under, stirring, be cooled to room temperature and obtain alkylation modification chitosan, apply to the present invention be used for treat urgency In property gastritis Chinese medicinal granule, the release efficiency of its Curing Effect of Chinese medicine material can be further effectively improved, is improved to acute stomach Scorching therapeutic effect.The Chinese medicinal granule for quality acute gastritis of the present invention, by concentrating powder processed after being extracted to Chinese medicine, And add sustained release auxiliary agent and carry out rubbing up granulation, obtained Chinese medicinal granule can carry out efficiently high-quality release to traditional Chinese medicine ingredients, improve Drug effect and therapeutic effect.

Embodiment

The present invention is described in detail with reference to specific embodiment, it should be appreciated that embodiment is served only for illustrating this hair It is bright, rather than for limiting the invention, any modification made on the basis of the present invention, equivalent substitution etc. are in this hair In bright protection domain.

In embodiment, the parts by weight of the bark of official magnolia can be 30 parts, 31 parts, 32 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts；The parts by weight of rhizoma atractylodis It can be 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts；The parts by weight of Pogostemon cablin can Think 1 part, 2 parts, 3 parts, 4 parts, 5 parts；The parts by weight of dried orange peel can be 4 parts, 5 parts, 6 parts, 7 parts, 8 parts；The parts by weight of dandelion It can be 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts；The parts by weight of hay can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts；The parts by weight of the root of herbaceous peony can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts； The parts by weight of malt can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；The parts by weight of cuttlebone can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；The parts by weight of bletilla can be 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 Part, 8 parts；The parts by weight of the tuber of pinellia can be 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；The parts by weight of the bighead atractylodes rhizome can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；The parts by weight of corydalis tuber can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；The weight of Buddha's hand It can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts to measure part；The parts by weight of Amomum cardamomum can be 1 part, 1.5 parts, 2 Part, 2.5 parts, 3 parts, 3.5 parts, 4 parts；The parts by weight of jujube can be 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts；The parts by weight of Poria cocos can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts；The parts by weight of hawthorn can be 2 parts, 3 Part, 4 parts, 5 parts, 6 parts；The parts by weight of rhizoma cyperi can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；The weight of Fructus Aurantii Part can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts；The parts by weight of coix seed can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts；The parts by weight of cuttle bone can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；The parts by weight of balloonflower root It can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts；The parts by weight of the banksia rose can be 2 parts, 2.5 parts, 3 parts, 3.5 Part, 4 parts, 4.5 parts, 5 parts；The parts by weight of Ligusticum wallichii can be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts；Alkylation changes Property chitosan parts by weight can be 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts；The weight of aspartame It can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts to measure part；Be sustained auxiliary agent parts by weight can be 1 part, 2 parts, 3 parts, 4 parts, 5 Part.

Embodiment 1

A kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis proposed by the present invention, its raw material wrap by weight Include：40 parts of the bark of official magnolia, 20 parts of rhizoma atractylodis, 3 parts of Pogostemon cablin, 6 parts of dried orange peel, 12 parts of dandelion, 3.5 parts of hay, 4.5 parts of the root of herbaceous peony, malt 3 Part, 4.5 parts of cuttlebone, 6 parts of bletilla, 5 parts of the tuber of pinellia, 3 parts of the bighead atractylodes rhizome, 4.5 parts of corydalis tuber, 3.5 parts of Buddha's hand, 2.5 parts of Amomum cardamomum, jujube 6 parts, 4 parts of Poria cocos, 4 parts of hawthorn, 2.5 parts of rhizoma cyperi, 4 parts of Fructus Aurantii, 3.5 parts of coix seed, 4.5 parts of cuttle bone, 2.5 parts of balloonflower root, the banksia rose 3.5 parts, 4.5 parts of Ligusticum wallichii, 12 parts of alkylation modification chitosan, 5 parts of aspartame, sustained release 3 parts of auxiliary agent.

Sustained release auxiliary agent is prepared by following technique：By weight by 20 parts of soil dynamic tests and 6 parts of nano-attapulgite stone micro mists After ground 50 mesh sieve, in 50 DEG C of dry 8h, then add deionized water and be well mixed, be then warming up to 80 DEG C, insulation 1h, pH is then adjusted to neutrality, 4.5 parts of ammonium persulfates is then added and is well mixed, be warming up to 100 DEG C, be incubated 2h, be subsequently added into 3.5 parts of vinyl acetates are well mixed, and are cooled to 70 DEG C, are incubated 3h, after washing, in 60 DEG C of dry 1.5h, are then added 6 parts and are gathered Lactic acid is well mixed, and in 140 DEG C, 40r/min rotating speeds are kneaded 10min, is cooled to room temperature and is obtained being sustained auxiliary agent.

Alkylation modification chitosan is prepared by following technique：It is by 10 parts of substance withdrawl syndromes by weight 2.5mol/L chitosan solution is added in the acetic acid solution that 3.5 parts of mass fractions are 1% and stirred in 750r/min rotating speeds 30min, it is subsequently added into the sodium hydroxide solution that substance withdrawl syndrome is 1mol/L and adjusts pH to 12, precipitate, filtering, then to filter 2 parts of dimethylformamides, 3 parts of laurate, 4 parts of sodium triacetoxy borohydrides and 15 parts of distilled water are added in cake to be well mixed, Under nitrogen protection, 2h is stirred in 950r/min rotating speeds, room temperature is cooled to and obtains alkylation modification chitosan.

S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, white Art, corydalis tuber, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose and Ligusticum wallichii Add 10 times of amount water immersion 1h, with extraction by steam distillation volatile oil 5h, filtration, the dregs of a decoction add water to cook it is secondary, when decocting every time Between be 2h, the water extractions for adding 11.5 times of amounts for the first time are obtained to first time extract solution, are added 10 times of amount water extractions second and are obtained and arrive Second of extract solution, merge extract solution, filtration, be concentrated under reduced pressure into the clear cream that relative density is 1.15, add ethanol to reach alcohol content 70%, stir evenly, stand 23h, take supernatant, ethanol is recovered under reduced pressure, be condensed into the thick paste that relative density is 1.3, in 70 DEG C of decompressions Dry extract is dried to, is ground into fine powder, 80 mesh sieves is crossed and obtains material a；

S2, material a and sustained release auxiliary agent be well mixed, be warming up to 85 DEG C, be incubated 30min, stirred in 750r/min rotating speeds 2h, then add alkylation modification chitosan and aspartame is well mixed, it is dry in 60 DEG C with the alcohol granulation that concentration is 78% Dry 3h, it is cooled to room temperature and obtains the coated slow-release Chinese medicinal granule for treating acute gastritis.

Embodiment 2

A kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis proposed by the present invention, its raw material wrap by weight Include：30 parts of the bark of official magnolia, 25 parts of rhizoma atractylodis, 1 part of Pogostemon cablin, 8 parts of dried orange peel, 8 parts of dandelion, 5 parts of hay, 3 parts of the root of herbaceous peony, 4 parts of malt, extra large Piao 3 parts of octopus, 8 parts of bletilla, 4 parts of the tuber of pinellia, 4 parts of the bighead atractylodes rhizome, 3 parts of corydalis tuber, 5 parts of Buddha's hand, 1 part of Amomum cardamomum, 8 parts of jujube, 3 parts of Poria cocos, mountain 6 parts of short, bristly hair or beard, 1 part of rhizoma cyperi, 5 parts of Fructus Aurantii, 2 parts of coix seed, 6 parts of cuttle bone, 1 part of balloonflower root, 5 parts of the banksia rose, 3 parts of Ligusticum wallichii, alkylation modification 5 parts 16 parts of chitosan, 2 parts of aspartame, sustained release of auxiliary agent.

Sustained release auxiliary agent is prepared by following technique：By weight by 15 parts of soil dynamic tests and 8 parts of nano-attapulgite stone micro mists After ground 40 mesh sieve, in 55 DEG C of dry 7h, then add deionized water and be well mixed, be then warming up to 90 DEG C, insulation 0.5h, pH is then adjusted to neutrality, 6 parts of ammonium persulfates is then added and is well mixed, be warming up to 90 DEG C, be incubated 3h, be subsequently added into 2 Part vinyl acetate is well mixed, and is cooled to 75 DEG C, is incubated 2h, after washing, in 65 DEG C of dry 1h, then adds 8 parts of PLAs Well mixed, in 130 DEG C, 50r/min rotating speeds are kneaded 5min, are cooled to room temperature and obtain being sustained auxiliary agent.

Alkylation modification chitosan is prepared by following technique：It is 3.5mol/ by weight by 5 parts of substance withdrawl syndromes L chitosan solution adds in the acetic acid solution that 2 parts of mass fractions are 1.5% and stirs 40min in 650r/min rotating speeds, then adds Enter the sodium hydroxide solution that substance withdrawl syndrome is 0.5mol/L and adjust pH to 12, precipitate, filtering, 3 are then added into filter cake Part dimethylformamide, 2 parts of laurate, 5 parts of sodium triacetoxy borohydrides and 10 parts of distilled water are well mixed, nitrogen protection Under, 1h is stirred in 1050r/min rotating speeds, room temperature is cooled to and obtains alkylation modification chitosan.

S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, white Art, corydalis tuber, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose and Ligusticum wallichii Add 10 times of amount water immersion 0.5h, with extraction by steam distillation volatile oil 6h, filtration, the dregs of a decoction add water to cook secondary, decoction every time Time is 1h, and the water extraction for adding 11.5 times of amounts for the first time is obtained to first time extract solution, adds 10 times of amount water extractions for the second time and obtains To second of extract solution, merge extract solution, filtration, be concentrated under reduced pressure into the clear cream that relative density is 1.15, add ethanol to make alcohol content Up to 75%, stir evenly, stand 20h, take supernatant, ethanol is recovered under reduced pressure, be condensed into the thick paste that relative density is 1.35, subtract in 65 DEG C Pressure is dried to dry extract, is ground into fine powder, crosses 90 mesh sieves and obtains material a；

S2, material a and sustained release auxiliary agent be well mixed, be warming up to 80 DEG C, be incubated 40min, stirred in 650r/min rotating speeds 3h, then add alkylation modification chitosan and aspartame is well mixed, it is dry in 65 DEG C with the alcohol granulation that concentration is 75% Dry 2h, it is cooled to room temperature and obtains the coated slow-release Chinese medicinal granule for treating acute gastritis.

Embodiment 3

A kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis proposed by the present invention, its raw material wrap by weight Include：50 parts of the bark of official magnolia, 15 parts of rhizoma atractylodis, 5 parts of Pogostemon cablin, 4 parts of dried orange peel, 16 parts of dandelion, 2 parts of hay, 6 parts of the root of herbaceous peony, 2 parts of malt, sea 6 parts of the egg capsule of a mantis, 4 parts of bletilla, 6 parts of the tuber of pinellia, 2 parts of the bighead atractylodes rhizome, 6 parts of corydalis tuber, 2 parts of Buddha's hand, 4 parts of Amomum cardamomum, 4 parts of jujube, 5 parts of Poria cocos, 2 parts of hawthorn, 4 parts of rhizoma cyperi, 3 parts of Fructus Aurantii, 5 parts of coix seed, 3 parts of cuttle bone, 4 parts of balloonflower root, 2 parts of the banksia rose, 6 parts of Ligusticum wallichii, alkylation change Property 8 parts of chitosan, 8 parts of aspartame, sustained release 1 part of auxiliary agent.

Sustained release auxiliary agent is prepared by following technique：By weight by 25 parts of soil dynamic tests and 4 parts of nano-attapulgite stone micro mists After ground 60 mesh sieve, in 45 DEG C of dry 9h, then add deionized water and be well mixed, be then warming up to 70 DEG C, insulation 1.5h, pH is then adjusted to neutrality, 3 parts of ammonium persulfates is then added and is well mixed, be warming up to 110 DEG C, be incubated 1h, be subsequently added into 5 parts of vinyl acetates are well mixed, and are cooled to 65 DEG C, are incubated 4h, after washing, in 55 DEG C of dry 2h, then add 4 parts of PLAs Well mixed, in 150 DEG C, 30r/min rotating speeds are kneaded 15min, are cooled to room temperature and obtain being sustained auxiliary agent.

Alkylation modification chitosan is prepared by following technique：It is by 15 parts of substance withdrawl syndromes by weight 1.5mol/L chitosan solution is added in the acetic acid solution that 5 parts of mass fractions are 0.5% and stirred in 850r/min rotating speeds 20min, it is subsequently added into the sodium hydroxide solution that substance withdrawl syndrome is 1.5mol/L and adjusts pH to 12, precipitate, filtering, Ran Houxiang It is equal that 1 part of dimethylformamide, 4 parts of laurate, 3 parts of sodium triacetoxy borohydrides and 20 parts of distilled water mixing are added in filter cake It is even, under nitrogen protection, 3h is stirred in 850r/min rotating speeds, room temperature is cooled to and obtains alkylation modification chitosan.

S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, white Art, corydalis tuber, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose and Ligusticum wallichii Add 10 times of amount water immersion 1.5h, with extraction by steam distillation volatile oil 4h, filtration, the dregs of a decoction add water to cook secondary, decoction every time Time is 3h, and the water extraction for adding 11.5 times of amounts for the first time is obtained to first time extract solution, adds 10 times of amount water extractions for the second time and obtains To second of extract solution, merge extract solution, filtration, be concentrated under reduced pressure into the clear cream that relative density is 1.15, add ethanol to make alcohol content Up to 65%, stir evenly, stand 26h, take supernatant, ethanol is recovered under reduced pressure, be condensed into the thick paste that relative density is 1.25, subtract in 75 DEG C Pressure is dried to dry extract, is ground into fine powder, crosses 70 mesh sieves and obtains material a；

S2, material a and sustained release auxiliary agent be well mixed, be warming up to 90 DEG C, be incubated 20min, stirred in 850r/min rotating speeds 1h, then add alkylation modification chitosan and aspartame is well mixed, it is dry in 55 DEG C with the alcohol granulation that concentration is 80% Dry 4h, it is cooled to room temperature and obtains the coated slow-release Chinese medicinal granule for treating acute gastritis.

Embodiment 4

A kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis proposed by the present invention, its raw material wrap by weight Include：35 parts of the bark of official magnolia, 22 parts of rhizoma atractylodis, 2 parts of Pogostemon cablin, 7 parts of dried orange peel, 9 parts of dandelion, 4 parts of hay, 4 parts of the root of herbaceous peony, 3.5 parts of malt, sea 4 parts of the egg capsule of a mantis, 7 parts of bletilla, 4.5 parts of the tuber of pinellia, 3.5 parts of the bighead atractylodes rhizome, 4 parts of corydalis tuber, 4 parts of Buddha's hand, 2 parts of Amomum cardamomum, 7 parts of jujube, Poria cocos 3.5 parts, 5 parts of hawthorn, 2 parts of rhizoma cyperi, 4.5 parts of Fructus Aurantii, 3 parts of coix seed, 5 parts of cuttle bone, 2 parts of balloonflower root, 4 parts of the banksia rose, 4 parts of Ligusticum wallichii, 4 parts 15 parts of alkylation modification chitosan, 3 parts of aspartame, sustained release of auxiliary agent.

Sustained release auxiliary agent is prepared by following technique：By weight by 18 parts of soil dynamic tests and 7 parts of nano-attapulgite stone micro mists After ground 45 mesh sieve, in 52 DEG C of dry 7.5h, then add deionized water and be well mixed, be then warming up to 85 DEG C, protect Warm 0.8h, pH is then adjusted to neutrality, 5 parts of ammonium persulfates is then added and is well mixed, be warming up to 95 DEG C, be incubated 2.5h, then Add 3 parts of vinyl acetates to be well mixed, be cooled to 72 DEG C, be incubated 2.5h, after washing, in 62 DEG C of dry 1.2h, then add 7 Part PLA is well mixed, and in 135 DEG C, 45r/min rotating speeds are kneaded 8min, is cooled to room temperature and is obtained being sustained auxiliary agent.

Alkylation modification chitosan is prepared by following technique：It is 3.2mol/ by weight by 8 parts of substance withdrawl syndromes L chitosan solution adds in the acetic acid solution that 3 parts of mass fractions are 1.2% and stirs 35min in 680r/min rotating speeds, then adds Enter the sodium hydroxide solution that substance withdrawl syndrome is 0.8mol/L and adjust pH to 12, precipitate, filtering, then added into filter cake 2.5 parts of dimethylformamides, 2.5 parts of laurate, 4.5 parts of sodium triacetoxy borohydrides and 12 parts of distilled water are well mixed, nitrogen Under gas shielded, 1.5h is stirred in 1020r/min rotating speeds, room temperature is cooled to and obtains alkylation modification chitosan.

S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, white Art, corydalis tuber, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose and Ligusticum wallichii Add 10 times of amount water immersion 0.8h, with extraction by steam distillation volatile oil 5.5h, filtration, the dregs of a decoction add water to cook secondary, decoct every time It is 1.5h to boil the time, and the water extraction for adding 11.5 times of amounts for the first time is obtained to first time extract solution, adds 10 times of amount water extractions for the second time Obtain to second of extract solution, merge extract solution, filtration, be concentrated under reduced pressure into the clear cream that relative density is 1.15, add ethanol to make to contain Alcohol amount stirs evenly up to 72%, stands 21h, take supernatant, ethanol is recovered under reduced pressure, the thick paste that relative density is 1.32 is condensed into, in 68 DEG C dry extract is dried under reduced pressure into, is ground into fine powder, crossed 85 mesh sieves and obtain material a；

S2, material a and sustained release auxiliary agent be well mixed, be warming up to 82 DEG C, be incubated 35min, stirred in 680r/min rotating speeds 2.5h, then add alkylation modification chitosan and aspartame and be well mixed, with the alcohol granulation that concentration is 76%, in 62 DEG C 2.5h is dried, room temperature is cooled to and obtains the coated slow-release Chinese medicinal granule for treating acute gastritis.

Embodiment 5

A kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis proposed by the present invention, its raw material wrap by weight Include：45 parts of the bark of official magnolia, 18 parts of rhizoma atractylodis, 4 parts of Pogostemon cablin, 5 parts of dried orange peel, 15 parts of dandelion, 3 parts of hay, 5 parts of the root of herbaceous peony, 2.5 parts of malt, 5 parts of cuttlebone, 5 parts of bletilla, 5.5 parts of the tuber of pinellia, 2.5 parts of the bighead atractylodes rhizome, 5 parts of corydalis tuber, 3 parts of Buddha's hand, 3 parts of Amomum cardamomum, 5 parts of jujube, Fu 4.5 parts of Siberian cocklebur, 3 parts of hawthorn, 3 parts of rhizoma cyperi, 3.5 parts of Fructus Aurantii, 4 parts of coix seed, 4 parts of cuttle bone, 3 parts of balloonflower root, 3 parts of the banksia rose, Ligusticum wallichii 5 2 parts part, 9 parts of alkylation modification chitosan, 7 parts of aspartame, sustained release of auxiliary agent.

Sustained release auxiliary agent is prepared by following technique：By weight by 22 parts of soil dynamic tests and 5 parts of nano-attapulgite stone micro mists After ground 55 mesh sieve, in 48 DEG C of dry 8.5h, then add deionized water and be well mixed, be then warming up to 75 DEG C, protect Warm 1.2h, pH is then adjusted to neutrality, 4 parts of ammonium persulfates is then added and is well mixed, be warming up to 105 DEG C, be incubated 1.5h, then Add 4 parts of vinyl acetates to be well mixed, be cooled to 68 DEG C, be incubated 3.5h, after washing, in 58 DEG C of dry 1.8h, then add 5 Part PLA is well mixed, and in 145 DEG C, 35r/min rotating speeds are kneaded 12min, is cooled to room temperature and is obtained being sustained auxiliary agent.

Alkylation modification chitosan is prepared by following technique：It is by 12 parts of substance withdrawl syndromes by weight 1.8mol/L chitosan solution is added in the acetic acid solution that 4 parts of mass fractions are 0.8% and stirred in 820r/min rotating speeds 25min, it is subsequently added into the sodium hydroxide solution that substance withdrawl syndrome is 1.2mol/L and adjusts pH to 12, precipitate, filtering, Ran Houxiang 1.5 parts of dimethylformamides, 3.5 parts of laurate, 3.5 parts of sodium triacetoxy borohydrides and 18 parts of distilled water are added in filter cake to mix Close uniformly, under nitrogen protection, stir 2.5h in 880r/min rotating speeds, be cooled to room temperature and obtain alkylation modification chitosan.

S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, white Art, corydalis tuber, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose and Ligusticum wallichii Add 10 times of amount water immersion 1.2h, with extraction by steam distillation volatile oil 4.5h, filtration, the dregs of a decoction add water to cook secondary, decoct every time It is 2.5h to boil the time, and the water extraction for adding 11.5 times of amounts for the first time is obtained to first time extract solution, adds 10 times of amount water extractions for the second time Obtain to second of extract solution, merge extract solution, filtration, be concentrated under reduced pressure into the clear cream that relative density is 1.15, add ethanol to make to contain Alcohol amount stirs evenly up to 68%, stands 25h, take supernatant, ethanol is recovered under reduced pressure, the thick paste that relative density is 1.28 is condensed into, in 72 DEG C dry extract is dried under reduced pressure into, is ground into fine powder, crossed 75 mesh sieves and obtain material a；

S2, material a and sustained release auxiliary agent be well mixed, be warming up to 88 DEG C, be incubated 25min, stirred in 820r/min rotating speeds 1.5h, then add alkylation modification chitosan and aspartame and be well mixed, with the alcohol granulation that concentration is 79%, in 58 DEG C 3.5h is dried, room temperature is cooled to and obtains the coated slow-release Chinese medicinal granule for treating acute gastritis.

The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto, Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.

Claims

1. a kind of coated slow-release Chinese medicinal granule for being used to treat acute gastritis, it is characterised in that its raw material includes by weight：It is thick Plain 30-50 parts, rhizoma atractylodis 15-25 parts, Pogostemon cablin 1-5 parts, dried orange peel 4-8 parts, dandelion 8-16 parts, hay 2-5 parts, root of herbaceous peony 3-6 parts, It is malt 2-4 parts, cuttlebone 3-6 parts, bletilla 4-8 parts, tuber of pinellia 4-6 parts, bighead atractylodes rhizome 2-4 parts, corydalis tuber 3-6 parts, Buddha's hand 2-5 parts, white Cardamom 1-4 parts, jujube 4-8 parts, Poria cocos 3-5 parts, hawthorn 2-6 parts, rhizoma cyperi 1-4 parts, Fructus Aurantii 3-5 parts, coix seed 2-5 parts, cuttlefish It is bone 3-6 parts, balloonflower root 1-4 parts, banksia rose 2-5 parts, Ligusticum wallichii 3-6 parts, alkylation modification chitosan 8-16 parts, aspartame 2-8 parts, slow Release auxiliary agent 1-5 parts.

2. the coated slow-release Chinese medicinal granule according to claim 1 for being used to treat acute gastritis, it is characterised in that sustained release helps The raw material of agent includes by weight：Soil dynamic test 15-25 parts, nano-attapulgite stone micro mist 4-8 parts, ammonium persulfate 3-6 parts, acetic acid second Alkene ester 2-5 parts, PLA 4-8 parts.

3. the coated slow-release Chinese medicinal granule according to claim 1 or 2 for being used to treat acute gastritis, it is characterised in that slow Auxiliary agent is released to be prepared by following technique：By soil dynamic test and nano-attapulgite stone micro mist after grinding is sieved, dry, Ran Houjia Enter deionized water to be well mixed, then heat up, be incubated, then adjust pH to neutrality, then add ammonium persulfate and be well mixed, rise Temperature, insulation, is subsequently added into vinyl acetate and is well mixed, and cools, insulation, after washing, dries, and it is equal then to add PLA mixing It is even, it is kneaded, is cooled to room temperature and obtains being sustained auxiliary agent.

4. the coated slow-release Chinese medicinal granule for being used to treat acute gastritis according to claim any one of 1-3, its feature exist In sustained release auxiliary agent is prepared by following technique：Soil dynamic test and nano-attapulgite stone micro mist are passed through into ground 40-60 mesh sieves Afterwards, in 45-55 DEG C of dry 7-9h, then add deionized water and be well mixed, be then warming up to 70-90 DEG C, be incubated 0.5-1.5h, Then pH is adjusted to neutrality, is then added ammonium persulfate and is well mixed, is warming up to 90-110 DEG C, is incubated 1-3h, is subsequently added into second Vinyl acetate is well mixed, and is cooled to 65-75 DEG C, is incubated 2-4h, after washing, in 55-65 DEG C of dry 1-2h, then adds poly- breast Acid is well mixed, and in 130-150 DEG C, 30-50r/min rotating speeds are kneaded 5-15min, is cooled to room temperature and obtains being sustained auxiliary agent.

5. the coated slow-release Chinese medicinal granule for being used to treat acute gastritis according to claim any one of 1-4, its feature exist In alkylation modification chitosan is prepared by following technique：Substance withdrawl syndrome is molten for 1.5-3.5mol/L chitosan Liquid adds in the acetic acid solution that mass fraction is 0.5-1.5% and stirs 20-40min in 650-850r/min rotating speeds, is subsequently added into The sodium hydroxide solution that substance withdrawl syndrome is 0.5-1.5mol/L adjusts pH to 12, precipitates, and filtering, is then added into filter cake Dimethylformamide, laurate, sodium triacetoxy borohydride and distilled water are well mixed, under nitrogen protection, with 850- 1050r/min rotating speeds stir 1-3h, are cooled to room temperature and obtain alkylation modification chitosan.

6. the coated slow-release Chinese medicinal granule for being used to treat acute gastritis according to claim any one of 1-5, its feature exist In in the preparation technology of alkylation modification chitosan, substance withdrawl syndrome is 1.5-3.5mol/L chitosan solution, quality point The weight of acetic acid solution, dimethylformamide, laurate, sodium triacetoxy borohydride and distilled water that number is 0.5-1.5% Than for 5-15：2-5：1-3：2-4：3-5：10-20.

A kind of 7. preparation for being used to treat the coated slow-release Chinese medicinal granule of acute gastritis according to claim any one of 1-6 Method, it is characterised in that comprise the following steps：

S1, by the bark of official magnolia, rhizoma atractylodis, Pogostemon cablin, dried orange peel, dandelion, hay, the root of herbaceous peony, malt, cuttlebone, bletilla, the tuber of pinellia, the bighead atractylodes rhizome, prolong Hu Suo, Buddha's hand, Amomum cardamomum, jujube, Poria cocos, hawthorn, rhizoma cyperi, Fructus Aurantii, coix seed, cuttle bone, balloonflower root, the banksia rose and Ligusticum wallichii add 10 times Water immersion 0.5-1.5h is measured, with extraction by steam distillation volatile oil 4-6h, filtration, the dregs of a decoction add water to cook secondary, decoction every time Time is 1-3h, and the water extraction for adding 11.5 times of amounts for the first time is obtained to first time extract solution, adds 10 times of amount water extractions for the second time Second of extract solution is obtained, merges extract solution, filtration, is concentrated under reduced pressure into the clear cream that relative density is 1.15, adds ethanol to make containing alcohol Amount reaches 65-75%, stirs evenly, and stands 20-26h, takes supernatant, ethanol is recovered under reduced pressure, and it is 1.25-1.35's to be condensed into relative density Thick paste, dry extract is dried under reduced pressure into 65-75 DEG C, is ground into fine powder, crossed 70-90 mesh sieves and obtain material a；

S2, material a and sustained release auxiliary agent be well mixed, be warming up to 80-90 DEG C, be incubated 20-40min, turn in 650-850r/min Speed stirring 1-3h, then adds alkylation modification chitosan and aspartame is well mixed, with the ethanol system that concentration is 75-80% Grain, in 55-65 DEG C of dry 2-4h, is cooled to room temperature and obtains the coated slow-release Chinese medicinal granule for treating acute gastritis.