CN105343691A - Oral liquid with stomach and intestine improving function and preparing method of oral liquid - Google Patents
Oral liquid with stomach and intestine improving function and preparing method of oral liquid Download PDFInfo
- Publication number
- CN105343691A CN105343691A CN201510895140.4A CN201510895140A CN105343691A CN 105343691 A CN105343691 A CN 105343691A CN 201510895140 A CN201510895140 A CN 201510895140A CN 105343691 A CN105343691 A CN 105343691A
- Authority
- CN
- China
- Prior art keywords
- oral liquid
- filter
- hour
- water
- gastrointestinal function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 22
- 210000002784 stomach Anatomy 0.000 title abstract description 7
- 210000000936 intestine Anatomy 0.000 title abstract 4
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 18
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 18
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000811 xylitol Substances 0.000 claims abstract description 17
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 17
- 229960002675 xylitol Drugs 0.000 claims abstract description 17
- 235000010447 xylitol Nutrition 0.000 claims abstract description 17
- 239000001509 sodium citrate Substances 0.000 claims abstract description 16
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 16
- 230000008569 process Effects 0.000 claims abstract description 15
- 230000036541 health Effects 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 80
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 70
- 239000000243 solution Substances 0.000 claims description 49
- 230000007661 gastrointestinal function Effects 0.000 claims description 37
- 238000000605 extraction Methods 0.000 claims description 28
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 23
- 239000000706 filtrate Substances 0.000 claims description 21
- 239000008213 purified water Substances 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 15
- 238000009835 boiling Methods 0.000 claims description 14
- 238000010828 elution Methods 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 14
- 230000001954 sterilising effect Effects 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 10
- 230000006872 improvement Effects 0.000 claims description 8
- 239000000341 volatile oil Substances 0.000 claims description 8
- 238000005352 clarification Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 238000013461 design Methods 0.000 claims description 7
- 239000011259 mixed solution Substances 0.000 claims description 7
- 238000011084 recovery Methods 0.000 claims description 7
- 238000004064 recycling Methods 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 238000002137 ultrasound extraction Methods 0.000 claims description 7
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 5
- 239000004927 clay Substances 0.000 claims description 4
- 239000004744 fabric Substances 0.000 claims description 4
- 239000012567 medical material Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 230000002572 peristaltic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 10
- 230000029087 digestion Effects 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract 1
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract 1
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 abstract 1
- 235000009682 Crataegus limnophila Nutrition 0.000 abstract 1
- 235000004423 Crataegus monogyna Nutrition 0.000 abstract 1
- 240000000171 Crataegus monogyna Species 0.000 abstract 1
- 235000002313 Crataegus paludosa Nutrition 0.000 abstract 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 240000000038 Ziziphus mauritiana Species 0.000 abstract 1
- 235000006545 Ziziphus mauritiana Nutrition 0.000 abstract 1
- 235000008529 Ziziphus vulgaris Nutrition 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 13
- 102000057297 Pepsin A Human genes 0.000 description 7
- 108090000284 Pepsin A Proteins 0.000 description 7
- 230000000968 intestinal effect Effects 0.000 description 7
- 229940111202 pepsin Drugs 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 238000002386 leaching Methods 0.000 description 6
- 238000001914 filtration Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 206010010774 Constipation Diseases 0.000 description 4
- 229930003944 flavone Natural products 0.000 description 4
- 235000011949 flavones Nutrition 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000038379 digestive enzymes Human genes 0.000 description 3
- 108091007734 digestive enzymes Proteins 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 235000008216 herbs Nutrition 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- -1 compound diphenoxylate Chemical class 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 229960004192 diphenoxylate Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 150000002212 flavone derivatives Chemical class 0.000 description 2
- 150000002213 flavones Chemical class 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- QGMRQYFBGABWDR-UHFFFAOYSA-M Pentobarbital sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)[N-]C1=O QGMRQYFBGABWDR-UHFFFAOYSA-M 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000035508 accumulation Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229960002275 pentobarbital sodium Drugs 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 230000000529 probiotic effect Effects 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides oral liquid with a stomach and intestine improving function and a preparing method of the oral liquid. Each 1,000 mL of the oral liquid with the stomach and intestine improving function is mainly prepared from, 100 parts of scorched hawthorn fruits, 100 parts of Chinese dates, 30 parts of poria cocos, 30 parts of Chinese yam, 30 parts of roasted malt, 30 parts of pericarpium citri reticulatae, 2 parts of oligosaccharide, 50 parts of xylitol and a proper amount of sodium citrate. Clinically-effective traditional Chinese medicine materials capable of invigorating the stomach and promoting digestion are selected and reasonably combined, the modernized phytoextraction technology is adopted, an optimal polar solvent is selected oriented to the polarity of target ingredients, effective ingredients are extracted to the maximum, and inactive substances going against the product quality are removed. In the preparing process, oligosaccharide active ingredients are selected and added, and the effect is better than that of samples, with the best effect, sold in the market; xylitol is added, so that the taste of the product is improved, and meanwhile health of the product is ensured; the oral liquid with the stomach and intestine improving function is novel.
Description
Technical field
The present invention relates to a kind of preparation method of health food, specifically a kind of preparation method with the oral liquid improving gastrointestinal function.
Background technology
Fructus Crataegi (parched to brown), Fructus Jujubae, Poria, Rhizoma Dioscoreae, Fructus Hordei Germinatus (parched), Pericarpium Citri Reticulatae are Chinese crude drug used in this product, and are integration of edible and medicinal herbs, and daily life all can be used as food consumption, and this Six-element Chinese medicine does not exist incompatibility.Fructus Crataegi (parched to brown), Fructus Hordei Germinatus (parched) are dyspepsia and intestinal stasis relieving medicine, and Rhizoma Dioscoreae is stomach invigorating resistance and supplementing qi medicine, and Pericarpium Citri Reticulatae is QI regulating medicine, and Poria is damp-clearing drug, and Fructus Jujubae is tonic.In side, Fructus Crataegi (parched to brown) can disappear all eating accumulations, outstanding kind disappear carnivorous greasy long-pending; The secretion of peptic digestion enzyme can be increased, facilitating digestion.To gastrointestinal function, there is certain regulating action.Rhizoma Dioscoreae replenishing QI to invigorate the spleen, mend and not dry; Fructus Hordei Germinatus (parched) promoting digestion and removing stagnation, Poria promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing, Pericarpium Citri Reticulatae circulation of qi promoting intestinal stasis relieving, activating the spleen stomach invigorating; Fructus Jujubae air making-up and spleen enlivening.All medicines are harmonious, and become the agent of resolving and invigoration therapies being applied simultaneously altogether, food disappeared, spleen is strong, wet and dispel all diseases from removing.To dyspepsia, anorexia, gastral cavity abdominal distention is vexed etc., disease tool improves significantly.
Oligosaccharide, obviously can improve microbial population ratio in intestinal, and it is the activation and proliferation factor of enteral bacillus bifidus, can reduce and suppress the generation of enteral corrupt substance, suppresses the growth of noxious bacteria, regulating intestinal canal inner equilibrium.Sodium citrate, conventional acidity regulator, belonging to can by the food additive that need of production uses in right amount in varieties of food items.
It is excellent traditional view that this product acts on Chinese medicine decoction, but take decoction because decoction is daily comparatively to bother, consuming time longer, and invalid Related Component is more, mouthfeel is not good, weak effect, therefore for above-mentioned difficult point, need exploitation to be applicable to all kinds of crowd to take, effect is good, the improvement gastrointestinal function oral liquid that mouthfeel is good.
Compared with JIANWEI XIAOSHI PIAN in medicine river, this product is raw materials used is integration of edible and medicinal herbs, without the relevant auxiliary materials of pessimal stimulation, while improving gastrointestinal function, conditioning intestinal microbial population, strengthen intestinal motive force, mouthfeel is good, and effect is good, easy absorption, is applicable to all kinds of crowd's long-term taking, is especially applicable to children taking.
Existing Patents such as CN201310238956.0 mono-kind improves gastrointestinal function, containing the preparation method of enzyme compound probiotic plant enzyme; CN201210367035.X mono-kind contributes to health preserving health-care food formula improving gastrointestinal function and preparation method thereof; CN201310444321.6 solid beverage improving gastrointestinal function and preparation method thereof.
With existing Patent Reference, this product advantage is: formula is simply novel, successful, taking convenience; Supplementary material is originated, green health, good mouthfeel; Be applicable to all kinds of crowd's long-term taking, be especially applicable to children taking, without any side effects; Steady quality is reliable; Overcome the deficiencies in the prior art, technique is special, adopts supercritical extraction and ultrasonic wave added soak by water technology to extract, is farthest extracted effective ingredient, remove invalid components to medical material; The employing of new technique, comparatively conventional art, substantially reduce extraction time, thus farthest shorten the production cycle, saved production cost.
Animal function test result shows that this product a kind ofly has the oral liquid improving gastrointestinal function.
Summary of the invention
For Chinese medicine decoction inheriting traditional is excellent traditional view, meet each large crowd demand, overcome the deficiencies in the prior art, the object of the invention is for providing a kind of preparation method improving the oral liquid of gastrointestinal function.This oral liquid, and can the oligosaccharide perfect adaptation of regulating intestinal canal flora based on the medical material of integration of edible and medicinal herbs, regulates mouthfeel with xylitol, provide a kind of completely newly there is the oral liquid comprehensively improving gastrointestinal function.
In order to meet above-mentioned requirements, the technical solution adopted in the present invention is: every 1000mL improves gastrointestinal function oral liquid and forms primarily of following raw material: Fructus Crataegi (parched to brown) 100-350g, Fructus Jujubae 100-350g, Poria 30-200g, Rhizoma Dioscoreae 30-200g, Fructus Hordei Germinatus (parched) 30-200g, Pericarpium Citri Reticulatae 30-200g, oligosaccharide 2-6g, sodium citrate is appropriate, and the pH of oral liquid controls at 4.0-7.0.
In order to make product have good mouthfeel, the raw material that every 1000mL improves in gastrointestinal function oral liquid also comprises: xylitol 50-150g.
Above-mentionedly improve gastrointestinal function oral liquor, described preparation method comprises the steps:
(1) extract: Pericarpium Citri Reticulatae is dropped in extraction kettle, after reaching design temperature, pass into CO
2extract, the Pericarpium Citri Reticulatae of the volatile oil that is removed, for subsequent use.
Get the Pericarpium Citri Reticulatae after process and Fructus Crataegi (parched to brown), Fructus Jujubae, Fructus Hordei Germinatus (parched) carry out water boiling and extraction: first time soaks 0.5-1.0 hour, decoct 0.5-1.0 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter, merge three filtrates.Be concentrated into the concentrated solution that density is 1.05-1.10 (80 DEG C).Get concentrated solution by the good macroporous resin column of pretreatment, wash 2-4 column volume with water, then use an ethanol elution 2-6 column volume of 50%-70%, elution fraction carries out ethanol recovery and solution is concentrated into the concentrated solution G1 that density is 1.10-1.25 (80 DEG C), for subsequent use.
Poria and Rhizoma Dioscoreae carry out ultrasonic wave added water boiling and extraction, and first time soaks 0.5-1.0 hour, decoct 0.5-1.5 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter, merge three filtrates.Being concentrated into relative density is 1.05-1.25 (80 DEG C), adds 95% ethanol, make alcohol content reach 50-70% after cooling, place, filter, filtrate recycling ethanol is extremely without alcohol taste, be concentrated into the concentrated solution G2 that density is 1.10-1.25 (80 DEG C), for subsequent use.
(2) prepare: after extract G1 and G2 is mixed, add a certain amount of purified water, stir and add xylitol, oligosaccharide mix homogeneously again, boil 30-50 minute, placement is spent the night, and next day filters, add water to the nearly full dose of formula, appropriate with sodium citrate, regulate pH to 4.0-7.0.
(3) full dose: add the full dose of purified water to formula in the mixed solution of modulated good pH, stir, filters.
(4) sterilizing: by the solution that configures through flowing steam sterilization, namely obtains described improvement gastrointestinal function oral liquid herein.
In the leaching process of the middle Pericarpium Citri Reticulatae of step (1), temperature is set as 30 DEG C-50 DEG C, and pressure setting is 15-35mPa, and extraction time is 1.5-2.5h.The ultrasound assisted extraction power of Poria and Rhizoma Dioscoreae is 200-300W.Big pore resin is the one in D-101, AB-8, HPD-100, DM301.
Step (1-3) filter material used is the combination of one or two or more kinds in titanium rod (10-20um), clarification plate (2.5-5um), potter's clay rod (15um), nylon-tissue bag (120 order), silk fabric thin,tough silk (120 order).
Detailed description of the invention
Below in conjunction with instantiation, the present invention is described in further detail:
Embodiment 1: every 1000mL improves gastrointestinal function oral liquid and forms primarily of following raw material: Fructus Crataegi (parched to brown) 100g, Fructus Jujubae 250g, Poria 200g, Rhizoma Dioscoreae 200g, Fructus Hordei Germinatus (parched) 30g, Pericarpium Citri Reticulatae 200g, oligosaccharide 2g, xylitol 50g, sodium citrate is appropriate, the pH of solution controls 4.0, Purified Water q. s.
(1) extract: Pericarpium Citri Reticulatae is dropped in extraction kettle, after reaching design temperature, pass into CO
2extract, the Pericarpium Citri Reticulatae of the volatile oil that is removed, for subsequent use.
Get the Pericarpium Citri Reticulatae after process and Fructus Crataegi (parched to brown), Fructus Jujubae, Fructus Hordei Germinatus (parched) carry out water boiling and extraction: first time soaks 0.5 hour, decocts 1 hour, filtration; Continue in medicinal residues to decoct with water 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Be concentrated into the concentrated solution that density is 1.05 (80 DEG C).Get concentrated solution by the good macroporous resin column of pretreatment, wash 2 column volumes with water, then use ethanol elution 6 column volumes of 50%, elution fraction carries out ethanol recovery and solution is concentrated into the concentrated solution G1 that density is 1.10 (80 DEG C), for subsequent use.
Poria and Rhizoma Dioscoreae carry out ultrasonic wave added water boiling and extraction, and first time soaks 0.5 hour, decocts 1.5 hours, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Being concentrated into relative density is 1.05 (80 DEG C), adds 95% ethanol, make alcohol content reach 50 after cooling, places, and filters, and filtrate recycling ethanol, to without alcohol taste, is concentrated into the concentrated solution G2 that density is 1.25 (80 DEG C), for subsequent use.
(2) prepare: after extract G1 and G2 is mixed, add a certain amount of purified water, stir, add 50g xylitol, the mixing of 2g oligosaccharide again, boil 30 minutes, placement is spent the night, next day filters, and adds water to the nearly full dose of formula, regulates pH to 4.0 by proper amount of sodium citrate.
(3) full dose: add the full dose of purified water to formula in the mixed solution of modulated good pH, stir, filters.
(4) sterilizing: by the solution that configures through steam sterilization, temperature 100 DEG C, 30 minutes time.Namely described improvement gastrointestinal function oral liquid is obtained herein.
In the leaching process of the middle Pericarpium Citri Reticulatae of step (1), temperature is set as 30 DEG C, and pressure setting is 35mPa, and extraction time is 1.5h.The ultrasound assisted extraction power of Poria and Rhizoma Dioscoreae is 200w.Macroporous resin model used is AB-8, and filter material used is potter's clay rod (15um), and step (2-3) filter material used is nylon-tissue bag (120 order), clarification plate (2.5um).
Embodiment 2: every 1000mL improves gastrointestinal function oral liquid and forms primarily of following raw material: Fructus Crataegi (parched to brown) 300g, Fructus Jujubae 200g, Poria 150g, Rhizoma Dioscoreae 100g, Fructus Hordei Germinatus (parched) 100g, Pericarpium Citri Reticulatae 30g, oligosaccharide 4g, xylitol 100g, sodium citrate is appropriate, the pH of solution controls 4.5, Purified Water q. s.
(1) extract: Pericarpium Citri Reticulatae is dropped in extraction kettle, after reaching design temperature, pass into CO
2extract, the Pericarpium Citri Reticulatae of the volatile oil that is removed, for subsequent use.
Get the Pericarpium Citri Reticulatae after process and Fructus Crataegi (parched to brown), Fructus Jujubae, Fructus Hordei Germinatus (parched) carry out water boiling and extraction: first time soaks 1 hour, decocts 1 hour, filtration; Continue in medicinal residues to decoct with water 1 hour, filter; Continue in medicinal residues to decoct with water 1 hour, filter, merge three filtrates.Be concentrated into the concentrated solution that density is 1.10 (80 DEG C).Get concentrated solution by the good macroporous resin column of pretreatment, wash 3 column volumes with water, then use ethanol elution 2 column volumes of 70%, elution fraction carries out ethanol recovery and solution is concentrated into the concentrated solution G1 that density is 1.25 (80 DEG C), for subsequent use.
Poria and Rhizoma Dioscoreae carry out ultrasonic wave added water boiling and extraction, and first time soaks 1 hour, decocts 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Being concentrated into relative density is 1.25 (80 DEG C), adds 95% ethanol, make alcohol content reach 55% after cooling, places, and filters, and filtrate recycling ethanol, to without alcohol taste, is concentrated into the concentrated solution G2 that density is 1.10 (80 DEG C), for subsequent use.
(2) prepare: add a certain amount of purified water after being mixed by extract G1 and G2, stir, then add 100g xylitol, the mixing of 4g oligosaccharide, boil 40 minutes, placement is spent the night, and next day filters, add water to the nearly full dose of formula, regulate pH to 4.5 in right amount with sodium citrate.
(3) full dose: add the full dose of purified water to formula in the mixed solution of modulated good pH, stir, filters.
(4) sterilizing: by the solution that configures through steam sterilization, temperature 100 DEG C, 40 minutes time.Namely described improvement gastrointestinal function oral liquid is obtained herein.
In the leaching process of the middle Pericarpium Citri Reticulatae of step (1), temperature is set as 50 DEG C, and pressure setting is 15mPa, and extraction time is 2.5h.The ultrasound assisted extraction power of Poria and Rhizoma Dioscoreae is 300w.Macroporous resin model is D-101.Filter material used is clarification plate (5um), and step (2-3) filter material used is nylon-tissue bag (120 order), clarification plate (2.5um).
Embodiment 3: every 1000mL improves gastrointestinal function oral liquid and forms primarily of following raw material: Fructus Crataegi (parched to brown) 250g, Fructus Jujubae 100g, Poria 30g, Rhizoma Dioscoreae 200g, Fructus Hordei Germinatus (parched) 200g, Pericarpium Citri Reticulatae 150g, oligosaccharide 6g, xylitol 150g, sodium citrate is appropriate, the pH of solution controls 5.5, Purified Water q. s.
(1) extract: Pericarpium Citri Reticulatae is dropped in extraction kettle, after reaching design temperature, pass into CO
2extract, the Pericarpium Citri Reticulatae of the volatile oil that is removed, for subsequent use.
Get the Pericarpium Citri Reticulatae after process and Fructus Crataegi (parched to brown), Fructus Jujubae, Fructus Hordei Germinatus (parched) carry out water boiling and extraction: first time soaks 1 hour, decocts 0.5 hour, filtration; Continue in medicinal residues to decoct with water 1 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Be concentrated into the concentrated solution that density is 1.08 (80 DEG C).Get concentrated solution by the good macroporous resin column of pretreatment, wash 4 column volumes with water, then use ethanol elution 4 column volumes of 65%, elution fraction carries out ethanol recovery and solution is concentrated into the concentrated solution G1 that density is 1.15 (80 DEG C), for subsequent use.
Poria and Rhizoma Dioscoreae carry out ultrasonic wave added water boiling and extraction, and first time soaks 1 hour, decocts 1 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Being concentrated into relative density is 1.20 (80 DEG C), adds 95% ethanol, make alcohol content reach 60% after cooling, places, and filters, and filtrate recycling ethanol, to without alcohol taste, is concentrated into the concentrated solution G2 that density is 1.15 (80 DEG C), for subsequent use.
(2) prepare: add a certain amount of purified water after being mixed by extract G1 and G2, stir, then add 150g xylitol, the mixing of 4g oligosaccharide, boil 50 minutes, placement is spent the night, and next day filters, add water to the nearly full dose of formula, regulate pH to 5.5 in right amount with sodium citrate.
(3) full dose: add the full dose of purified water to formula in the mixed solution of modulated good pH, stir, filters.
(4) sterilizing: by the solution that configures through steam sterilization, temperature 100 DEG C, 50 minutes time.Namely described improvement gastrointestinal function oral liquid is obtained herein.
In the leaching process of the middle Pericarpium Citri Reticulatae of step (1), temperature is set as 40 DEG C, and pressure setting is 25mPa, and extraction time is 2h.The ultrasound assisted extraction power of Poria and Rhizoma Dioscoreae is 200w.Macroporous resin model used is HPD-100.Filter material used is potter's clay rod (15um), and step (2-3) filter material used is silk fabric thin,tough silk (120 order), titanium rod (10um).
Embodiment 4: every 1000mL improves gastrointestinal function oral liquid and forms primarily of following raw material: Fructus Crataegi (parched to brown) 350g, Fructus Jujubae 200g, Poria 150g, Rhizoma Dioscoreae 30g, Fructus Hordei Germinatus (parched) 100g, Pericarpium Citri Reticulatae 100g, oligosaccharide 4g, xylitol 150g, sodium citrate is appropriate, the pH of solution controls 6.0, Purified Water q. s.
(1) extract: Pericarpium Citri Reticulatae is dropped in extraction kettle, after reaching design temperature, pass into CO
2extract, the Pericarpium Citri Reticulatae of the volatile oil that is removed, for subsequent use.
Get the Pericarpium Citri Reticulatae after process and Fructus Crataegi (parched to brown), Fructus Jujubae, Fructus Hordei Germinatus (parched) carry out water boiling and extraction: first time soaks 0.5 hour, decocts 1 hour, filtration; Continue in medicinal residues to decoct with water 1 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Be concentrated into the concentrated solution that density is 1.06 (80 DEG C).Get concentrated solution by the good macroporous resin column of pretreatment, wash 3 column volumes with water, then use ethanol elution 4 column volumes of 55%, elution fraction carries out ethanol recovery and solution is concentrated into the concentrated solution G1 that density is 1.20 (80 DEG C), for subsequent use.
Poria and Rhizoma Dioscoreae carry out ultrasonic wave added water boiling and extraction, and first time soaks 1 hour, decocts 1 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Being concentrated into relative density is 1.10 (80 DEG C), adds 95% ethanol, make alcohol content reach 65% after cooling, places, and filters, and filtrate recycling ethanol, to without alcohol taste, is concentrated into the concentrated solution G2 that density is 1.15 (80 DEG C), for subsequent use.
(2) prepare: add a certain amount of purified water after being mixed by extract G1 and G2, stir, then add 150g xylitol, the mixing of 4g oligosaccharide, boil 40 minutes, placement is spent the night, and next day filters, add water to the nearly full dose of formula, regulate pH to 6.0 in right amount with sodium citrate.
(3) full dose: add the full dose of purified water to formula in the mixed solution of modulated good pH, stir, filters.
(4) sterilizing: by the solution that configures through steam sterilization, temperature 100 DEG C, 40 minutes time.Namely described improvement gastrointestinal function oral liquid is obtained herein.
In the leaching process of the middle Pericarpium Citri Reticulatae of step (1), temperature is set as 45 DEG C, and pressure setting is 20mPa, and extraction time is 1.5h.The ultrasound assisted extraction power of Poria and Rhizoma Dioscoreae is 250w.Macroporous resin used is DM-301.Filter material used is clarification plate (5um), and step (2-3) filter material used is silk fabric thin,tough silk (120 order), titanium rod (20um).
Embodiment 5: every 1000mL improves gastrointestinal function oral liquid and forms primarily of following raw material: Fructus Crataegi (parched to brown) 100g, Fructus Jujubae 350g, Poria 150g, Rhizoma Dioscoreae 100g, Fructus Hordei Germinatus (parched) 100g, Pericarpium Citri Reticulatae 100g, oligosaccharide 4g, xylitol 100g, sodium citrate is appropriate, the pH of solution controls 7.0, Purified Water q. s.
(1) extract: Pericarpium Citri Reticulatae is dropped in extraction kettle, after reaching design temperature, pass into CO
2extract, the Pericarpium Citri Reticulatae of the volatile oil that is removed, for subsequent use.
Get the Pericarpium Citri Reticulatae after process and Fructus Crataegi (parched to brown), Fructus Jujubae, Fructus Hordei Germinatus (parched) carry out water boiling and extraction: first time soaks 0.5 hour, decocts 1 hour, filtration; Continue in medicinal residues to decoct with water 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Be concentrated into the concentrated solution that density is 1.09 (80 DEG C).Get concentrated solution by the good macroporous resin column of pretreatment, wash 3 column volumes with water, then use ethanol elution 4 column volumes of 60%, elution fraction carries out ethanol recovery and solution is concentrated into the concentrated solution G1 that density is 1.20 (80 DEG C), for subsequent use.
Poria and Rhizoma Dioscoreae carry out ultrasonic wave added water boiling and extraction, and first time soaks 0.5 hour, decocts 1.5 hours, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter; Continue in medicinal residues to decoct with water 0.5 hour, filter, merge three filtrates.Being concentrated into relative density is 1.15 (80 DEG C), adds 95% ethanol, make alcohol content reach 70% after cooling, places, and filters, and filtrate recycling ethanol, to without alcohol taste, is concentrated into the concentrated solution G2 that density is 1.20 (80 DEG C), for subsequent use.
(2) prepare: add a certain amount of purified water after being mixed by extract G1 and G2, stir, then add 100g xylitol, the mixing of 5g oligosaccharide, boil 30 minutes, placement is spent the night, and next day filters, add water to the nearly full dose of formula, regulate pH to 7.0 in right amount with sodium citrate.
(3) full dose: add the full dose of purified water to formula in the mixed solution of modulated good pH, stir, filters.
(4) sterilizing: by the solution that configures through steam sterilization, temperature 100 DEG C, 40 minutes time.Namely described improvement gastrointestinal function oral liquid is obtained herein.
In the leaching process of the middle Pericarpium Citri Reticulatae of step (1), temperature is set as 35 DEG C, and pressure setting is 25mPa, and extraction time is 2h.The ultrasound assisted extraction power of Poria and Rhizoma Dioscoreae is 300w.Macroporous resin model used is AB-8 filter material used is titanium rod (20um), and step (2-3) filter material used is nylon-tissue bag (120 order), clarification plate (2.5um).
For above example, the functional component total flavones improving gastrointestinal function oral liquid is measured.Assay method: perform by " mensuration of total flavonoids in health food " method in " health food inspection and assessment technical specification " (version in 2003), after flavone in sample is purified, under 360nm wavelength, its absorbance is measured with spectrophotography, compare with rutin standard substance, carry out the quantitative assay of total flavones in determinand.Testing result, as following table:
| Test item | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| General flavone content (mg/100mL) | 79 | 80 | 78 | 84 | 82 |
The evaluation test of this product animal function assessment:
Test 1: mouse small intestine exercise test
Experimental animal: SPF level male mice in kunming 50, body weight 18 ~ 22g, for carrying out intestinal motility test.Positive controls reference substance used is R-1132 (every sheet is containing compound diphenoxylate 2.5mg).Negative control group is distilled water.Experiment starts, Constipation Model matched group and three dosage group (0.5ml/kgBW, 1.0ml/kgBW, 2.0ml/kgBW) animals per os gavage 5mg/kgBW compound diphenoxylate (gavage amount is 0.2ml/10gBW) respectively, negative control group gives distilled water.
Result of the test sees the following form:
The impact that tested material is moved on mouse small intestine
* compare with negative control group, P < 0.05
#compare with model control group, P < 0.05
As seen from the above table, the ink progradation of negative control group compares with Constipation Model matched group, and difference has statistical significance (P < 0.05), illustrates that Constipation Model is set up.The ink progradation of high dose group mice is higher than Constipation Model matched group, and difference has statistical significance (P < 0.05).
Test 2: rat digestive enzyme determination test
Experimental animal: SPF level Wistar male rat 40, body weight 130 ~ 150g, for carrying out digestive enzyme determination experiment.Before experiment terminates, each group Rat Fast can't help water 24h, adopts pentobarbital sodium anesthetized rat, pylorus ligature law collects the gastric juice amount of discharging in 5h, 1500 revs/min of centrifugal 15min, get the conical flask that supernatant 1ml puts into 50ml, add 0.05mol/L hydrochloric acid solution 15ml and shake up, the protein pipe putting into made fresh (gets fresh albumen, beat with after filtered through gauze, utilize 10 μ l capillary siphonings to fill, in 70 ~ 85 DEG C of hot water, make protein coagulating, now do existing use) two pieces.Be stoppered bottleneck, in 37 DEG C of calorstats, hatch 24h, take out protein pipe, measure the length (mm) of protein pipe two ends transparent part, ask its meansigma methods with the value of four ends, calculate pepsin activity and pepsin output.
Pepsin activity unit (U/mL)=tetra-end protein pipe transparent part length average
2× 16
Pepsin output (U/h)=pepsin activity × gastric juice amount per hour
Result of the test sees the following form:
The impact that tested material is tested rat digestive enzyme
*: compare with matched group, P < 0.05.
As seen from the above table, the tested material 30 days of rat various dose is given with 0.5ml/kgBW, 1.0ml/kgBW, 2.0ml/kgBW tri-dosage per os gavages, middle and high dosage group pepsin activity unit is higher than matched group, high dose group animal pepsin output, is higher than matched group, and difference has statistical significance (P < 0.05).
Improve the criterion of gastrointestinal function relevant animal function test result according to " health food inspection and assessment technical specification " (version in 2003), and learn in conjunction with this product animal function test result: this product a kind ofly has the oral liquid improving gastrointestinal function.
Claims (6)
1. one kind is improved the preparation method of the oral liquid of gastrointestinal function, it is characterized in that: every 1000mL improves gastrointestinal function oral liquid and forms primarily of following raw material: Fructus Crataegi (parched to brown) 100-350g, Fructus Jujubae 100-350g, Poria 30-200g, Rhizoma Dioscoreae 30-200g, Fructus Hordei Germinatus (parched) 30-200g, Pericarpium Citri Reticulatae 30-200g, oligosaccharide 2-6g, sodium citrate is appropriate, and the pH of oral liquid controls at 4.0-7.0; In order to make product have good mouthfeel, the raw material that every 1000mL improves in gastrointestinal function oral liquid also comprises: xylitol 50-150g.
2. the preparation method improving the oral liquid of gastrointestinal function according to claim 1, is characterized in that, described method comprises the steps:
Extract: Pericarpium Citri Reticulatae is dropped in extraction kettle, after reaching design temperature, pass into CO
2extract, the Pericarpium Citri Reticulatae of the volatile oil that is removed, for subsequent use.
Get the Pericarpium Citri Reticulatae after process and Fructus Crataegi (parched to brown), Fructus Jujubae, Fructus Hordei Germinatus (parched) carry out water boiling and extraction: first time soaks 0.5-1.0 hour, decoct 0.5-1.0 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter, merge three filtrates.Be concentrated into the concentrated solution that density is 1.05-1.10 (80 DEG C).Get concentrated solution by the good macroporous resin column of pretreatment, wash 2-4 column volume with water, then use an ethanol elution 2-6 column volume of 50%-70%, elution fraction carries out ethanol recovery and solution is concentrated into the concentrated solution G1 that density is 1.10-1.25 (80 DEG C), for subsequent use.
Poria and Rhizoma Dioscoreae carry out ultrasonic wave added water boiling and extraction, and first time soaks 0.5-1.0 hour, decoct 0.5-1.5 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter; Continue in medicinal residues to decoct with water 0.5-1.0 hour, filter, merge three filtrates.Being concentrated into relative density is 1.05-1.25 (80 DEG C), adds 95% ethanol, make alcohol content reach 50-70% after cooling, place, filter, filtrate recycling ethanol is extremely without alcohol taste, be concentrated into the concentrated solution G2 that density is 1.10-1.25 (80 DEG C), for subsequent use.
Preparation: add a certain amount of purified water after being mixed by extract G1 and G2, stir and add xylitol, oligosaccharide mix homogeneously again, boil 30-50 minute, placement is spent the night, and next day filters, and adds water to the nearly full dose of formula, appropriate with sodium citrate, regulate pH to 4.0-7.0.
Full dose: add the full dose of purified water to formula in the mixed solution of modulated good pH, stir, filters.
Sterilizing: by the solution that configures through flowing steam sterilization, namely obtains the oral liquid of described improvement gastrointestinal function herein.
3. the preparation method improving the oral liquid of gastrointestinal function according to claim 2, is characterized in that: in the process of described Pericarpium Citri Reticulatae removing volatile oil, temperature is set as 30 DEG C-50 DEG C, and pressure setting is 15-35mPa, and the time is 1.5-2.5h.
4. the preparation method improving the oral liquid of gastrointestinal function according to claim 2, is characterized in that: the ultrasound assisted extraction power of all the other medical materials described is 200-300W.
5. the preparation method improving the oral liquid of gastrointestinal function according to claim 2, it is characterized in that: described in be filtered into use filter material to be titanium rod (10-20um), clarification plate (2.5-5um), potter's clay rod (15um), nylon-tissue bag (120 order), the combination of one or two or more kinds in silk fabric thin,tough silk (120 order), adopt peristaltic pump or mechanical pump, the filter type of the medicinal pump of health filter.
6. the preparation method improving the oral liquid of gastrointestinal function according to claim 2, is characterized in that: big pore resin is the one in D-101, AB-8, HPD-100, DM-301.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510895140.4A CN105343691B (en) | 2015-12-08 | 2015-12-08 | It is a kind of that there is oral liquid for improving gastrointestinal function and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510895140.4A CN105343691B (en) | 2015-12-08 | 2015-12-08 | It is a kind of that there is oral liquid for improving gastrointestinal function and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105343691A true CN105343691A (en) | 2016-02-24 |
| CN105343691B CN105343691B (en) | 2018-06-29 |
Family
ID=55319850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510895140.4A Active CN105343691B (en) | 2015-12-08 | 2015-12-08 | It is a kind of that there is oral liquid for improving gastrointestinal function and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105343691B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109106836A (en) * | 2018-09-30 | 2019-01-01 | 芜湖张恒春药业有限公司 | A kind of food digesting stomach fortifying side and preparation method thereof |
| CN114886998A (en) * | 2022-05-19 | 2022-08-12 | 皖西学院 | Compound oral liquid of stachys and dendrobium and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101268832A (en) * | 2008-04-22 | 2008-09-24 | 杏林苑投资管理（北京）有限公司 | Health product with function of accelerating assimilation and method for preparing the same |
| CN102362994A (en) * | 2011-11-02 | 2012-02-29 | 杨立君 | Zinc gluconate oral liquid for strengthening spleen and stomach |
-
2015
- 2015-12-08 CN CN201510895140.4A patent/CN105343691B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101268832A (en) * | 2008-04-22 | 2008-09-24 | 杏林苑投资管理（北京）有限公司 | Health product with function of accelerating assimilation and method for preparing the same |
| CN102362994A (en) * | 2011-11-02 | 2012-02-29 | 杨立君 | Zinc gluconate oral liquid for strengthening spleen and stomach |
Non-Patent Citations (1)
| Title |
|---|
| 周保国: "中医治疗功能性消化不良进展概况", 《内蒙古中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109106836A (en) * | 2018-09-30 | 2019-01-01 | 芜湖张恒春药业有限公司 | A kind of food digesting stomach fortifying side and preparation method thereof |
| CN114886998A (en) * | 2022-05-19 | 2022-08-12 | 皖西学院 | Compound oral liquid of stachys and dendrobium and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105343691B (en) | 2018-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN103393121B (en) | Preparation method of enzyme-containing compound probiotic plant ferment able to improve gastrointestinal functions | |
| CN103087885A (en) | Health-care wine material, health-care wine and preparation method of health-care wine | |
| CN106954843A (en) | A kind of composite plant enzyme stoste, feature composite plant enzyme stoste and preparation method thereof and functional food | |
| CN1895575A (en) | Medicine for treating infantile anorexia and its preparation | |
| CN110051815A (en) | A kind of auxiliary hyperglycemic food ball and preparation method thereof | |
| CN114075497A (en) | Polygonatum sibiricum wine | |
| CN105853884A (en) | Health medicinal liquor for invigorating spleen and eliminating dampness and preparation method thereof | |
| CN105343691A (en) | Oral liquid with stomach and intestine improving function and preparing method of oral liquid | |
| CN102511876B (en) | Hawthorn red jujube thick syrup and production process thereof | |
| CN104397717B (en) | Healthy anti-constipation corn weight-losing food and making method thereof | |
| CN107596112A (en) | A kind of kidney tonifying tea prescription and preparation method thereof | |
| KR20100024244A (en) | Method of manufacturing herbal chungkugjang with increased effect on lowering the blood glucose content | |
| CN104824765A (en) | Fermentation hawthorn juice beverage and preparation method thereof | |
| CN104403913A (en) | Lipid-lowering and weight-reducing persimmon vinegar | |
| CN108684992A (en) | A kind of alcohol-decomposing beverage of plant formula and preparation method thereof of energy Quick sobering | |
| CN107125521A (en) | A kind of fermenting plant beverage for improving sleep and preparation method thereof | |
| CN104338002A (en) | Lily plant fermentation liquor and preparation method thereof | |
| CN104814372A (en) | Health guiling jelly based on sweet potatoes and preparation method of healthy guiling jelly | |
| CN109999149A (en) | A kind of preparation method of Chinese medicine composition and its preparation with reinforcing spleen to promote digestion effect | |
| CN112957386B (en) | Processing method of traditional Chinese medicine decoction pieces | |
| CN108077171A (en) | A kind of cultural method of reed catkins chicken | |
| CN104524323A (en) | Codonopsis pilosula, poria and bighead atractylodes rhizome health maintenance traditional Chinese medicine wine and preparation method thereof | |
| CN100490874C (en) | Chinese medicine composition for treating diabetes and method for preparing the same | |
| CN106616372A (en) | Inonotus obliquus polysaccharide composite bean flour and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |