CN107349246A - A kind of gynaecological gel of the ash containing Chinese mugwort and preparation method thereof - Google Patents
A kind of gynaecological gel of the ash containing Chinese mugwort and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to medical product field, and in particular to a kind of gynaecological gel of the ash containing Chinese mugwort and preparation method thereof.The gynaecological gel of the ash provided by the invention containing Chinese mugwort includes following components and its parts by weight：End 80 90 parts of grey 15 parts of Ultramicro-powder, 0.5 1 parts of lupulones, 0.4 0.8 parts of aloe-emodin, 0.2 0.4 parts of flavoxanthin, 0.2 0.4 parts of taraxasterol, 15 parts of ethanol, 0.005 0.015 parts of menthol, 10 20 parts of propane diols, 13 parts of L ascorbic acid, 1 1.5 parts of gelatinizing agent, 0.2 0.6 parts of triethanolamine, 0.3 0.5 parts of sorbic acid, 0.2 0.4 parts of Tween 80 and water.The gynaecological gel safe without toxic side effect of the ash provided by the invention containing Chinese mugwort, can effectively sterilize alleviation inflammation, maintain vagina normal ph, and adhesiveness is good, intravaginal holdup time length, good effect.
Description
Technical field
The invention belongs to medical product field, and in particular to a kind of gynaecological gel of the ash containing Chinese mugwort and preparation method thereof.
Technical background
Gynaecological imflammation (vaginitis, cervicitis, pelvic infecton, adnexitis) seriously endangers the health of women.Under normal circumstances, female
Property vagina in acidity, the breeding of pathogenic bacteria can be suppressed, the ability with self-cleaning antibacterial, but due to a variety of causes, wherein
40% is because cleaning mode is improper, because much cleaning washing lotion is akaline liquid, it is normally acid that long-term use can destroy vagina
Environment causes vaginitis to turn into the most common disease of gynaecology so as to cause microecology in vaginas flora to be in de-synchronization state；Abuse or make
With antibiotic germ can be made to produce drug resistance, and kill a large amount of beneficial bacteriums, the balance of vaginal flora be destroyed, so as to cause fungi to give birth to
Length is vigorous, and gynecological disease stubbornness is unreasonable, it is difficult to thoroughly radical cure.
Suppository in the market or washing lotion are more after that vaginal dryness can be caused uncomfortable due to formula and formulation defect；
Medicine active area is confined to some position, good effect can not be played at vagina fold；Gel is most active in recent years
One of medicine novel form, still, gel is vagina administration, in the presence of vaginal fluid this kind of medicine often quickly from
Discharged in vagina so that RT of the gel in vagina is shorter, largely effects on therapeutic effect.
Chinese mugwort ash refers to the ashes after moxa cone or moxa stick combustion is made with wormwood.Moxa-moxibustion is one of most ancient medical skill of China, is belonged to
External treatment of traditional Chinese medicine.Moxa-moxibustion is special into moxa cone or moxa stick by wormwood, directly outstanding moxibustion or coordinates moxibustion warmer to spread on channels and collaterals or affected part four
In week, warm and the medicine effect of moxibustion fire are borrowed, helps the comprehensive temperature three-way meridian of human body, the regulation of qi and blood, eliminating cold to stop pain, middle benefit gas of dispeling cold, especially
It is to chill cold in children, women's postpartum maintains, the fear of irregular menstruation, palace cold is cold unique curative effect；Moxa-moxibustion can also be excited and improved
The immunologic function of body, strengthen the resistance against diseases of body, so as to disease-prevention health, the effect promoted longevity.At present, moxa stick and moxa cone
Consumption increasingly increase, end ash amount also increase therewith.However, in real life, people typically can be Chinese mugwort ash directly
Discard, the utilization to Chinese mugwort ash is less.
Chinese patent application CN106265861A discloses a kind of antifungal composition containing Chinese mugwort ash and preparation method thereof,
The antifungal composition containing Chinese mugwort ash includes the preparing raw material of following parts by weight meter：10~16 parts of Chinese mugwort ash, luffa root 20~
14~18 parts of 26 parts, 18~4 parts of common bombax flower and Canton love-pea vine.The present composition is effectively antimycotic, and superficial mycoses is controlled
Therapeutic effect is obvious.
Chinese patent CN102266283B discloses a kind of gynaecologic vaginal acidic buffer sterilization gel, is contained by following weight
The material composition of amount：Bactericide 0.2-0.5 parts, glycerine 12-12.5 parts, water 83-84 parts, carbomer 1-1.5 parts, Polycarbophil
1.5-2 parts, triethanolamine 0.2-0.3 parts, vitamin E 0.01-0.03 parts, peppermint 0.01-0.03 parts.The inventive gel can have
Effect kills pathogenic bacteria alleviation inflammatory symptoms, but RT of the gel in vagina is shorter, affects the treatment.
Application in the prior art on Chinese mugwort ash in gynecological gel is less, and medicine crosses short-range missile in the holdup time of vagina
Drug effect is caused to reduce, therefore it provides the gynecological gel containing Chinese mugwort ash that a kind of adhesiveness is good, curative effect is high is necessary.
The content of the invention
In order to solve problems of the prior art, the invention provides a kind of gynaecological gel and its system of the ash containing Chinese mugwort
Preparation Method.The gynaecological gel safe without toxic side effect of the ash provided by the invention containing Chinese mugwort, can effectively sterilize alleviation inflammation, remain cloudy
Road normal ph, vaginal walls elasticity is kept, vagina humidification is maintained, does not produce drug resistance and the resistance to the action of a drug.Meanwhile the present invention
The gynaecological gel preparation method simple and convenient of the ash containing Chinese mugwort provided, is adapted to industrialized production, and extend delay of the medicine in vagina
Time, improve curative effect.
The invention provides a kind of gynaecological gel of the ash containing Chinese mugwort, including following components and its parts by weight：
End grey Ultramicro-powder 1-5 parts, lupulones 0.5-1 parts, aloe-emodin 0.4-0.8 parts, flavoxanthin 0.2-0.4 parts,
Taraxasterol 0.2-0.4 parts, ethanol 1-5 parts, menthol 0.005-0.015 parts, propane diols 10-20 parts, L-AA 1-3
Part, gelatinizing agent 1-1.5 parts, triethanolamine 0.2-0.6 parts, sorbic acid 0.3-0.5 parts, Tween-80 0.2-0.4 parts and water 80-90
Part.Tween-80 CAS：9005-65-6.
Further, the gynaecological gel of the ash containing Chinese mugwort is made up of following components and its parts by weight：
End grey 4 parts of Ultramicro-powder, 0.75 part of lupulones, 0.6 part of aloe-emodin, 0.3 part of flavoxanthin, taraxasterol
0.3 part, 3 parts of ethanol, 0.01 part of menthol, 15 parts of propane diols, 2 parts of L-AA, 1.25 parts of gelatinizing agent, triethanolamine 0.4
Part, 0.4 part of sorbic acid, 0.3 part of Tween-80 and 85 parts of water.
Further, described Chinese mugwort ash Ultramicro-powder is that Chinese mugwort ash handles gained through ultramicro grinding, and particle diameter is 5-10 μm.
Further, described gelatinizing agent by xanthans, carbomer and Polycarbophil by weight (2-4):(0.5-
1.5):(1-3) is formed.Xanthans CAS：11138-66-2, carbomer are that to be purchased from the good good fortune morning health in Beijing medicinal for Carbomer-940
Auxiliary material Co., Ltd, Polycarbophil CAS：9003-97-8.
Further, described gelatinizing agent is by xanthans, carbomer and Polycarbophil by weight 3:1:2 compositions.
Meanwhile present invention provides a kind of preparation method of the gynaecological gel of the ash containing Chinese mugwort, comprise the following steps：
S1 adds gelatinizing agent in suitable quantity of water, it is fully swelled, and stirring adds propane diols and triethanolamine, and grinding well makes it
Into clear gel matrix, gel-type vehicle A is obtained；
S2 mixes ethanol with the water of surplus, and stirring adds end grey Ultramicro-powder, lupulones, aloe-emodin, buttercup yellow
Element, taraxasterol, L-AA, menthol, sorbic acid and Tween-80, stir, and obtain solution B；
S3 mixes gel-type vehicle A obtained by step S1 with step S2 resulting solutions B, stirs, produces.
Folium artemisiae argyi Return liver, spleen, kidney channel, acrid flavour is bitter, warm-natured, has antibacterial, antiviral, antiallergy, eliminating cold to stop pain, warming channel for arresting bleeding
Etc. function.Inventor has carried out substantial amounts of research to Chinese mugwort ash, it is found that Chinese mugwort ash has certain antifungic action, to Candida albicans,
Trichophyton gypseum, Trichophyton rubrum etc. have obvious inhibitory action.But Chinese mugwort ash is used to but to cause it in gynecological gel
Drug effect is reduced, and inventor is had found by numerous studies, using xanthans, carbomer and Polycarbophil by weight 3:1:2 compoundings,
The adhesiveness of gel can be improved, so as to improve Chinese mugwort ash treat in gynaecological imflammation the effect of.
Lupulones (being purchased from the side Science and Technology Ltd. of Tianjin one) has in the gynaecological gel of the ash provided by the invention containing Chinese mugwort
Antibacterial action；Aloe-emodin (No. CAS：481-72-1) there is antibacterial, promote wound healing；Flavoxanthin (CAS
Number：512-29-8) there is heat-clearing, desinsection, for treating trichomonas vaginitis and eczema；Taraxasterol (No. CAS：
1059-14-9) there is anti-inflammatory and sterilization, control eczema, dermatitis outside；Menthol (No. CAS：89-78-1) have refrigerant
Antipruritic effect；L-AA (No. CAS：50-81-7) promote wound healing, improve the effect of immunity.Each group of the present invention
Split-phase interaction, collaboration play bactericidal antiphlogistic, promote the effect of wound healing, and in the presence of gelatinizing agent, extend medicine
In the holdup time of vagina, drug effect is improved.
Compared with prior art, the gynaecological gel of the ash provided by the invention containing Chinese mugwort has the advantage that：
(1) gynaecological gel of the ash provided by the invention containing Chinese mugwort, overcomes gel poor adhesion in vagina, RT
It is the defects of shorter, good using gelatinizing agent adhesiveness made of xanthans, carbomer and Polycarbophil compounding, medicine is extended in the moon
Holdup time in road, drug effect is improved, and overall clinical efficacy rate is up to 98.3%；
(2) gynaecological gel of the ash provided by the invention containing Chinese mugwort not only has the function that anti-inflammation, swelling and pain relieving, moreover it is possible to
Promote healing up of traumatic tissues, and the skin after healing recovers smooth, smooth shape；
(3) the gynaecological gel safe without toxic side effect of the ash provided by the invention containing Chinese mugwort, can effectively maintain the normal pH of vagina
Value, vaginal walls elasticity is kept, vagina humidification is maintained, does not produce drug resistance and the resistance to the action of a drug；
(4) the gynaecological gel preparation method simple and convenient of the ash provided by the invention containing Chinese mugwort, it is adapted to industrialized production, while this hair
The bright recycling for realizing the grey resource that ends, avoids the waste of resource.
Embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration
, it is in no way intended to limit protection scope of the present invention.
A kind of gynaecological gel of the ash containing Chinese mugwort of embodiment 1
The gynaecological gel of the described ash containing Chinese mugwort is made up of following components and its parts by weight：
End grey 1 part of Ultramicro-powder, 0.5 part of lupulones, 0.4 part of aloe-emodin, 0.2 part of flavoxanthin, taraxasterol 0.2
Part, 1 part of ethanol, 0.005 part of menthol, 10 parts of propane diols, 1 part of L-AA, 1 part of gelatinizing agent, 0.2 part of triethanolamine, mountain
90 parts of 0.3 part of pears acid, 0.2 part of Tween-80 and water.
Described gelatinizing agent is by xanthans, carbomer and Polycarbophil by weight 2:0.5:1 composition.
Preparation method：
S1 adds gelatinizing agent in suitable quantity of water, it is fully swelled, and stirring adds propane diols and triethanolamine, and grinding well makes it
Into clear gel matrix, gel-type vehicle A is obtained；
S2 mixes ethanol with the water of surplus, and stirring adds end grey Ultramicro-powder, lupulones, aloe-emodin, buttercup yellow
Element, taraxasterol, L-AA, menthol, sorbic acid and Tween-80, stir, and obtain solution B；
S3 mixes gel-type vehicle A obtained by step S1 with step S2 resulting solutions B, stirs, produces.
A kind of gynaecological gel of the ash containing Chinese mugwort of embodiment 2
The gynaecological gel of the described ash containing Chinese mugwort is made up of following components and its parts by weight：
End grey 4 parts of Ultramicro-powder, 0.75 part of lupulones, 0.6 part of aloe-emodin, 0.3 part of flavoxanthin, taraxasterol
0.3 part, 3 parts of ethanol, 0.01 part of menthol, 15 parts of propane diols, 2 parts of L-AA, 1.25 parts of gelatinizing agent, triethanolamine 0.4
Part, 0.4 part of sorbic acid, 0.3 part of Tween-80 and 85 parts of water.
Described gelatinizing agent is by xanthans, carbomer and Polycarbophil by weight 3:1:2 compositions.
Preparation method is similar to Example 1.
A kind of gynaecological gel of the ash containing Chinese mugwort of embodiment 3
The gynaecological gel of the described ash containing Chinese mugwort is made up of following components and its parts by weight：
End grey 5 parts of Ultramicro-powder, 1 part of lupulones, 0.8 part of aloe-emodin, 0.4 part of flavoxanthin, taraxasterol 0.4
Part, 5 parts of ethanol, 0.015 part of menthol, 20 parts of propane diols, 3 parts of L-AA, 1.5 parts of gelatinizing agent, 0.6 part of triethanolamine,
80 parts of 0.5 part of sorbic acid, 0.4 part of Tween-80 and water.
Described gelatinizing agent is by xanthans, carbomer and Polycarbophil by weight 4:1.5:3 compositions.
Preparation method is similar to Example 1.
A kind of gynaecological gel of the ash containing Chinese mugwort of comparative example 1
The gynaecological gel of the described ash containing Chinese mugwort is made up of following components and its parts by weight：
End grey 4 parts of Ultramicro-powder, 0.75 part of lupulones, 0.6 part of aloe-emodin, 0.3 part of flavoxanthin, taraxasterol
0.3 part, 3 parts of ethanol, 0.01 part of menthol, 15 parts of propane diols, 2 parts of L-AA, 1.25 parts of gelatinizing agent, triethanolamine 0.4
Part, 0.4 part of sorbic acid, 0.3 part of Tween-80 and 85 parts of water.
Described gelatinizing agent is by xanthans, carbomer and Polycarbophil by weight 1:1:1 composition.
Preparation method is similar to Example 1.
Difference with embodiment 2 is, by gelatinizing agent by xanthans, carbomer and Polycarbophil by weight 3:1:2 groups
Into being changed to 1:1:1 composition.
A kind of gynaecological gel of the ash containing Chinese mugwort of comparative example 2
The gynaecological gel of the described ash containing Chinese mugwort is made up of following components and its parts by weight：
End grey 4 parts of Ultramicro-powder, 0.75 part of Osthole, 0.6 part of aloe-emodin, 0.3 part of flavoxanthin, taraxasterol
0.3 part, 3 parts of ethanol, 0.01 part of menthol, 15 parts of propane diols, 2 parts of L-AA, 1.25 parts of gelatinizing agent, triethanolamine 0.4
Part, 0.4 part of sorbic acid, 0.3 part of Tween-80 and 85 parts of water.
Described gelatinizing agent is by xanthans, carbomer and Polycarbophil by weight 3:1:2 compositions.
Preparation method is similar to Example 1.
Difference with embodiment 2 is, lupulones is replaced with into Osthole.
A kind of gynaecological gel of the ash containing Chinese mugwort of comparative example 3
The gynaecological gel of the described ash containing Chinese mugwort is made up of following components and its parts by weight：
End grey 4 parts of Ultramicro-powder, 0.75 part of lupulones, 0.6 part of aloe-emodin, 0.6 part of flavoxanthin, 3 parts of ethanol, peppermint
0.01 part of brain, 15 parts of propane diols, 2 parts of L-AA, 1.25 parts of gelatinizing agent, 0.4 part of triethanolamine, 0.4 part of sorbic acid, tell
85 parts of -800.3 parts of temperature and water.
Described gelatinizing agent is by xanthans, carbomer and Polycarbophil by weight 3:1:2 compositions.
Preparation method is similar to Example 1.
Difference with embodiment 2 is, is not added with taraxasterol, adds the dosage of flavoxanthin.
Test example one, safety testing
1. test material：The gynaecological gel of the obtained ashes containing Chinese mugwort of embodiment 1-3.
2. test method：
Implemented within 1st according to State Food and Drug Administration's September in 2003《The quality management of medicine non-clinical study is advised
Model》Requirement detected.Specially follow State Food and Drug Administration " Chemical induced irritation, anaphylaxis and molten
Courageous and upright investigative technique guideline " performs.
3. result of the test：
As a result show, the gynaecological gel of the ash produced by the present invention containing Chinese mugwort, to no skin irritation, showed this in 7 days
The gynaecological gel for the ash containing Chinese mugwort that invention provides has higher security.
Test example two, bacteriostatic test
1. test material：The gynaecological gel of the ash containing Chinese mugwort prepared by embodiment 1-3 and comparative example 1-3.
2. subjects：Escherichia coli ATCC25922, staphylococcus aureus ATCC6538, Candida albicans
ATCC10231。
3. test method：
1) experiment bacteria suspension is prepared
Concentration is：With 100 μ L drops on to photo, recovery clump count is 1 × 106-1×109Cfu/ pieces.
2) microbiological contamination print is prepared
Above-mentioned bacteria suspension is taken, 100 μ L is added dropwise in coupons and control print each respectively, acts on 20min.
3) print is put into the test tube of the phosphate buffer solution containing 5mL respectively, fully mixed, diluted 2-3 dilution factor, take
0.5mL is placed in plate, is poured into 40-50 DEG C of nutrient agar (bacterium) 15mL, rotates plate, makes it fully mixed
It is even, flat board is overturn after agar solidification, culture is inverted, 37 DEG C, cultivates 48h.
4) bacteriostasis rate is calculated, formula is as follows：
Wherein, X- bacteriostasis rates, %；A- compares print average colony number；B- is by coupons average colony number.
4. result of the test：Bacteriostasis rate the results are shown in Table 1.
The bacteriostasis rate result of table 1
Known by table 1, the gynaecological gel good antimicrobial effect of the ash containing Chinese mugwort prepared by the present invention.Compared with comparative example 1-3, this hair
The gynaecological gel fungistatic effect of the ash containing Chinese mugwort prepared by bright embodiment 1-3 is preferable, and bacteriostasis rate is up to more than 95.8%, illustrates this
Invention compatibility is reasonable, science, each component synergy, has cooperateed with antibacterial effect.
Test example three, anti-inflammatory experiment
1. test material：The gynaecological gel of the ash containing Chinese mugwort prepared by embodiment 1-3 and comparative example 1-3.
2. subjects：Mouse 70, body weight 28-34g, female.
3. content of the test：
1) mouse is randomly divided into 7 groups, every group 10, is denoted as blank control group, embodiment 1-3 groups and comparative example 1-3 groups；
2) dimethylbenzene 0.04ml drops are caused into inflammation in mouse right ear, left ear is as control；
3) without any processing after the cause of blank control group auris dextra is scorching, embodiment 1-3 groups and comparative example 1-3 groups are causing inflammation respectively
30min smears gynaecological gel afterwards, that is, takes each 0.3g of gynaecological gel to be added on 2.0cm × 3.5cm 4 layers of gauze, be affixed on the right side
Ear, after being covered with one layer of oilpaper, use immobilization with adhesive tape.Mouse is dislocated after 2 hours and put to death, two ears are cut along auricle baseline, with straight
Footpath 6mm card punch lays round auricle at the same position of left and right ear respectively, weighs, and the difference of left and right auricle weight is sought, as ear
The method of double differences, i.e. swelling, the significance of difference between comparative group.The index for weighing antiphlogistic activity, the smaller table of swelling are used as using swelling
The antiphlogistic activity of bright medicine is better.
4. result of the test：Each group gynaecological gel anti-inflammatory the results are shown in Table 2.
The gynaecological gel anti-inflammatory result of table 2
| Group | Left ear weight/mg | Auris dextra weight/mg | The ear method of double differences (swelling)/mg |
| Blank control group | 14.4±1.3 | 29.2±1.9 | 16.2±1.8 |
| 1 group of embodiment | 14.5±1.4 | 23.2±2.3 | 9.6±2.1**●▲▲◆ |
| 2 groups of embodiment | 14.5±1.6 | 21.6±1.7 | 8.6±1.6**●●▲▲◆◆ |
| 3 groups of embodiment | 14.6±1.5 | 23.3±1.8 | 10.3±1.7**●▲◆ |
| 1 group of comparative example | 14.7±1.4 | 26.7±2.1 | 12.9±2.1* |
| 2 groups of comparative example | 14.5±1.2 | 27.6±2.2 | 13.9±2.0* |
| 3 groups of comparative example | 14.6±1.4 | 28.1±2.3 | 13.0±1.8* |
Note：* compared with blank control group, P<0.05；* is compared with blank control group, P<0.01；●▲With 1 group of phase of comparative example
Than P<0.05；●●Compared with 1 group of comparative example, P<0.01；▲Compared with 2 groups of comparative example, P<0.05；▲▲Compared with 2 groups of comparative example,
P<0.01；◆Compared with 3 groups of comparative example, P<0.05；◆◆Compared with 3 groups of comparative example, P<0.01；.
Known by table 2, compared with blank control group, embodiment 1-3 groups and comparative example 1-3 groups are respectively provided with significant difference.With
Comparative example 1-3 groups are compared, and the anti-inflammatory effects of the gynaecological gel of the ash containing Chinese mugwort prepared by 1-3 of the embodiment of the present invention are preferable, difference tool
Have conspicuousness, illustrate compatibility of the present invention rationally, science, each component interaction, collaboration play anti-inflammatory.
Test example four, viscosity test
1. test material：The gynaecological gel of the obtained ashes containing Chinese mugwort of embodiment 1-3 and comparative example 1-3.
2. test method：
Commercially available Radix Polygalae Crotalarioidis are taken, Radix Polygalae Crotalarioidis are turned over, the oil and dirt of the inside are all plucked totally, with vinegar and alum
Rubbing 2-3 times, then with clear water rinse for several times, be cut into long 6cm, wide 2cm rectangle it is sliced, the water on surface is blotted with filter paper
With residual attached grease, M is weighed as0, it is fixed on glass, large intestine inner surface outwardly, tilts 30 °, smears the solidifying of 3g different viscosities
Glue, spray 0.5mL physiological saline to gel surface with sprayer within every 5 minutes, it is continuous to spray 10 times, after having sprayed 5 minutes after the 10th time
The gel of Radix Polygalae Crotalarioidis section and its surface adhesion is removed, the water on surface is gently adsorbed away with filter paper, is weighed as M1, calculated for gel
Adhesive capacity W, formula are as follows：
Calculate, and record result.
3. result of the test：The gynaecological gel adhesive capacity result of calculation of the ash containing Chinese mugwort is shown in Table 3.
The gynecological gel adhesive capacity result of the ash containing Chinese mugwort of table 3
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Adhesive capacity/% | 49.8 | 55.6 | 43.7 | 35.4 | 38.3 | 40.1 |
As shown in Table 3, the gynecological gel of the ash containing Chinese mugwort prepared by the present invention has preferable adhesiveness.With comparative example 1-3 phases
Than the gynecological gel adhesive capacity of the ash containing Chinese mugwort prepared by 1-3 of the embodiment of the present invention is larger, illustrates the present invention using xanthans, card ripple
Nurse and Polycarbophil compounding can form a kind of gelatinizing agent with very strong adhesion, and xanthans, carbomer and Polycarbophil
Weight ratio be 3:1:When 2, the gynecological gel adhesiveness of the ash produced by the present invention containing Chinese mugwort is optimal.
Test example five, clinical test
1. test material：The gynecological gel of the ash containing Chinese mugwort prepared by embodiment 1-3 and comparative example 1-3.
2. subjects：Vaginitis patient, women, 360.
3. test method：
Subject is randomly divided into 6 groups, every group of 60 people, is designated as embodiment 1-3 groups and comparative example 1-3 groups, and smear respectively
The gynecological gel of the ash containing Chinese mugwort prepared by embodiment 1-3 and comparative example 1-3.All medicines are using special container injection vagina
It is interior, retain more than 20min, once a night, 7 days as one therapeutic course.After 3 courses for the treatment of, effect is counted.Wherein, cure as symptom
Disappear；Effectively it is clearly better for symptom；It is invalid for symptom without significant change.And total effective rate is calculated, calculation formula is as follows：
Total effective rate=(curing number+significant figure)/subject sum × 100%
Total effective rate is calculated, and is recorded.
4. result of the test：The gynecological gel clinical treatment outcome of the ash containing Chinese mugwort is shown in Table 4.
The gynecological gel clinical treatment outcome of the ash containing Chinese mugwort of table 4
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Healing/people | 53 | 56 | 55 | 45 | 46 | 47 |
| Effectively/people | 6 | 4 | 5 | 10 | 11 | 9 |
| Invalid/people | 1 | 0 | 0 | 5 | 3 | 4 |
| Total effective rate/% | 98.3 | 100 | 100 | 91.7 | 95.0 | 93.3 |
Known by table 4, the effect of gynecological gel of the ash containing Chinese mugwort prepared by the present invention is in clinical treatment vaginitis is notable, and always
Effective percentage up to more than 98.3%.Compared with comparative example 1-3, the gynecological gel of the ash containing Chinese mugwort prepared by 1-3 of the embodiment of the present invention exists
The total effective rate treated in vaginitis is higher, illustrates the gynecological gel of the ash containing Chinese mugwort prepared by the present invention in the intravaginal holdup time
Long, anti-inflammation effect is good.Meanwhile the gynecological gel grey containing Chinese mugwort prepared by the present invention can be the healing for promoting wound tissue, from
And effectively raise therapeutic effect.
Claims (6)
1. a kind of gynaecological gel of the ash containing Chinese mugwort, it is characterised in that including following components and its parts by weight：
End grey Ultramicro-powder 1-5 parts, lupulones 0.5-1 parts, aloe-emodin 0.4-0.8 parts, flavoxanthin 0.2-0.4 parts, Pu Gong
English sterol 0.2-0.4 parts, ethanol 1-5 parts, menthol 0.005-0.015 parts, propane diols 10-20 parts, L-AA 1-3 parts,
Gelatinizing agent 1-1.5 parts, triethanolamine 0.2-0.6 parts, sorbic acid 0.3-0.5 parts, Tween-80 0.2-0.4 parts and water 80-90 parts.
2. the gynaecological gel of the ash containing Chinese mugwort as claimed in claim 1, it is characterised in that by following components and its parts by weight group
Into：
End grey 4 parts of Ultramicro-powder, 0.75 part of lupulones, 0.6 part of aloe-emodin, 0.3 part of flavoxanthin, 0.3 part of taraxasterol,
3 parts of ethanol, 0.01 part of menthol, 15 parts of propane diols, 2 parts of L-AA, 1.25 parts of gelatinizing agent, 0.4 part of triethanolamine, sorb
85 parts of 0.4 part of acid, 0.3 part of Tween-80 and water.
3. the gynaecological gel of the ash containing Chinese mugwort as claimed in claim 1 or 2, it is characterised in that described Chinese mugwort ash Ultramicro-powder is Chinese mugwort
Ash handles gained through ultramicro grinding, and particle diameter is 5-10 μm.
4. as claimed in claim 1 or 2 containing Chinese mugwort ash gynaecological gel, it is characterised in that described gelatinizing agent by xanthans,
Carbomer and Polycarbophil are by weight (2-4):(0.5-1.5):(1-3) is formed.
5. the gynaecological gel of the ash containing Chinese mugwort as claimed in claim 4, it is characterised in that described gelatinizing agent is by xanthans, card
Ripple nurse and Polycarbophil are by weight 3:1:2 compositions.
6. the preparation method of the gynaecological gel of the ash containing Chinese mugwort as described in claim 1-5 is any, it is characterised in that including following
Step：
S1 adds gelatinizing agent in suitable quantity of water, it is fully swelled, and stirring adds propane diols and triethanolamine, and grinding well makes it into saturating
Bright gel-type vehicle, obtain gel-type vehicle A；
S2 mixes ethanol with the water of surplus, and stirring adds end grey Ultramicro-powder, lupulones, aloe-emodin, flavoxanthin, Pu
Public English sterol, L-AA, menthol, sorbic acid and Tween-80, stir, obtain solution B；
S3 mixes gel-type vehicle A obtained by step S1 with step S2 resulting solutions B, stirs, produces.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012818A (en) * | 2015-08-10 | 2015-11-04 | 吴万有 | Composition for treating gynecological inflammation and preparation and preparation method thereof |
| CN106265861A (en) * | 2016-08-19 | 2017-01-04 | 广州暨南生物医药研究开发基地有限公司 | Antifungal composition containing Chinese mugwort ash and preparation method thereof |
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2017
- 2017-07-10 CN CN201710557391.0A patent/CN107349246A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012818A (en) * | 2015-08-10 | 2015-11-04 | 吴万有 | Composition for treating gynecological inflammation and preparation and preparation method thereof |
| CN106265861A (en) * | 2016-08-19 | 2017-01-04 | 广州暨南生物医药研究开发基地有限公司 | Antifungal composition containing Chinese mugwort ash and preparation method thereof |
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Application publication date: 20171117 |