CN107348156A - It is a kind of make an addition to feed be used for treat and prevent pharmaceutical composition of intestine of young pigs disease and preparation method thereof - Google Patents
It is a kind of make an addition to feed be used for treat and prevent pharmaceutical composition of intestine of young pigs disease and preparation method thereof Download PDFInfo
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- CN107348156A CN107348156A CN201710727059.4A CN201710727059A CN107348156A CN 107348156 A CN107348156 A CN 107348156A CN 201710727059 A CN201710727059 A CN 201710727059A CN 107348156 A CN107348156 A CN 107348156A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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Abstract
The invention discloses a kind of pharmaceutical composition for being used to treat and prevent intestine of young pigs disease for making an addition to feed and preparation method thereof.The pharmaceutical composition for being used to treat and prevent intestine of young pigs disease for making an addition to feed, it is characterized in that, it is made up of Chinese medicine composition and Nanometer Copper, the Chinese medicine composition is made up of 90 parts of 60 parts of nutmeg, 60 parts of myrobalan, 100 parts of dark plum and radix glycyrrhizae, based on the weight of feed, the dosage of the Chinese medicine composition is 0.4 1.5wt%, and the dosage of the Nanometer Copper is 60mg/Kg.The preparation method of the pharmaceutical composition for treating and preventing intestine of young pigs disease for making an addition to feed is:Powder or granule is made in Chinese medicine composition, is well mixed in proportion with Nanometer Copper.This makes an addition to the pharmaceutical composition prevention for being used to treat and prevent intestine of young pigs disease of feed or therapeutic effect is good.
Description
【Technical field】
The present invention relates to technical field of animal, more particularly to a kind of feed for treating and preventing intestine of young pigs disease to add
Add agent and preparation method thereof.
【Background technology】
Pig Industry, more based on scale.In order to shorten sows in lactation, sow reproductive performance is improved, reduces sow
Transmission between piglet, the pig farm of most of large-scale cultivations use early weaned technology more.But early weaning, meeting
Make piglet produce stress, can also influence growing for piglet, and bring a series of harmful effects, such as diarrhoea disease phenomenon.
There is scholar's research discovery, pathogenic microorganism may not be the sick primary disease because intestine of young pigs is anti-to the allergy of daily ration antigen
The damaging change that should trigger, it is only the basic reason of Diarrhea after Piglets " Weaning.After weaned piglet the hyposecretion of hydrochloric acid in gastric juice and
The unsound digestion that all have impact on piglet to dietary protein of development of enzyme system so that forage protein enters enteron aisle, is pathogen
Such as Escherichia coli offer nutriment, the generation for making pathogenicity suffer from diarrhoea.
Copper is required trace element in animal life activity, and pig needs copper synthetic hemoglobin and synthesis and activation normal
Some oxidases necessary to metabolism, while there is scholar's research to confirm that addition high-copper can make the reduction of grice diarrhoea rate in feed.
High-copper can promote the food-intake of pig, also with bacteriostasis, while can also improve the activity with copper relevant enzyme.Therefore high-copper is made
It is considered as efficient, cheap for root-inducing hormone and easy to use is added by current many Feed Enterprises in the feed for piglet.It is high
The use of copper can promote growth and the efficiency of feed utilization of piglet, but also can produce negative impact to suckling piglet, first, for a long time
High copper diet is fed, copper can be made to be accumulated in liver, cause slow poisoning, copper content is too high in sow diets, can also induce vagina
Inflammation, and cause to miscarry;Secondly, high zinc is added in daily ration, because copper and iron, calcium, zinc, sulphur, sodium etc. have antagonism, high-copper can drop
Low zinc and iron absorb, so as to cause the shortage of zinc and iron, as pig often occur the incomplete seborrheic keratosis of similar zinc-deficiency, skin and iron deficiency,
The symptoms such as hypoferric anemia;Again, Long-term Feeding high copper diet can dramatically increase copper residual quantity in Animal Liver, kidney and muscle,
People can cause copper to be accumulated in the tissue such as liver, brain, kidney after eating, so as to endanger the health of people;Meanwhile harm of the high-copper to environment
Also very serious, Cu-W ore deposit can destroy the physics of soil, chemistry and biology function in soil, cause the fertility of soil to reduce,
Plant growth is obstructed, and influences crop yield and nutrient content.
【The content of the invention】
In order to solve the above-mentioned technical problem, the invention provides a kind of using effect it is good, can effectively prevent what high-copper from bringing
Feed addictive for the treatment of and prevention intestine of young pigs disease of harm and preparation method thereof.
The present invention is achieved by the following technical solutions:A kind of feed addition for treating and preventing intestine of young pigs disease
Agent, it is characterised in that:Including Chinese medicine composition and Nanometer Copper.
Preferably, the Chinese medicine composition is made up of 90 parts of 60 parts of nutmeg, 60 parts of myrobalan, 100 parts of dark plum and radix glycyrrhizae.
Preferably, based on the weight of feed, the dosage of the Chinese medicine composition is 0.4-1.5%wt, the Nanometer Copper
Dosage is 60mg/Kg.
Preferably, based on the weight of feed, the dosage of the Chinese medicine composition is 0.4-0.6%wt, for preventing piglet
Intestines problem.
Preferably, the dosage of the Chinese medicine composition is 0.5-1.5%wt, for treating intestine of young pigs disease.
The preparation method of the feed addictive of described treatment and prevention intestine of young pigs disease, it is characterised in that:Take feed
The 0.4-1.5% of weight Chinese medicine composition, crush, cross 300 mesh sieves;The Chinese medicine composition powder of gained is mixed with Nanometer Copper
Uniformly, the dosage of the Nanometer Copper is 60mg/Kg, based on the weight of feed.
Preferably, another preparation method of the feed addictive of described treatment and prevention intestine of young pigs disease, it is special
Sign is:The Chinese medicine composition is fabricated to after particle and is well mixed again with the Nanometer Copper;It is described based on the weight of feed
The dosage of Chinese medicine composition is 0.4-1.5%, and the dosage of the Nanometer Copper is 60mg/Kg.The system of the traditional Chinese medicine particle
Preparation Method is as follows:
S1, by formula rate weight (60 parts of nutmeg, 60 parts of myrobalan, 100 parts of dark plum, 90 parts of radix glycyrrhizae), weigh 4 kinds of the above
Medicinal material, fritter is ground into, mixing extraction 3 times, every time plus 10 times of water, refluxing extraction 2 hours, filtration, merging filtrate stand standby
With;
S2, extract solution concentration, are concentrated into relative density 1.10-1.2, concentrate dry, pulverize.Add appropriate amount of starch,
Mixing, traditional Chinese medicine particle is made.
Wherein:Nutmeg, temperature.Effect:Relieving diarrhea with astringents, middle benefit gas promoting the circulation of qi.Cure mainly:Void is rushed down, and cold dysentery, stomach cold distending pain, deficiency of food are vomitted
Tell.Usage:Decoction, 3 to 9 grams.
Myrobalan, temperature.Effect:Astringe the lung, puckery intestines, lower gas relieving diarrhea with astringents.Cure mainly:Chronic diarrhea, protracted dysentery, prolapse of the anus.Usage:Decoction, 3-
10 grams.
Dark plum is sour, puckery, puts down.Effect:Astringe the lung to stop cough, relieving diarrhea with astringents, relieving pain by calming ascaris, promote the production of body fluid to quench thirst.Cure mainly:Chronic cough of deficiency lung,
Chronic diarrhea, protracted dysentery, ascariasis of biliary tract stomachache, vomiting, abnormal heat are quenched one's thirst.Usage:Decoction, 3 to 10 grams, heavy dose can use to 30 grams.External application is fitted
Charcoal use is preferably fried in amount, antidiarrheal hemostasis.
Radix glycyrrhizae, put down.Effect:Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Cure mainly:For spleen
Stomach is weak, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviates drug toxicity, strong
Property.Usage:Decoction, 0.5~3 gram.External application:Grind and mix or decoct washing.
Nano copper particle granularity is small, has the bioavailability for improving feed, and addition is few, reduces to other mineral matters member
Plain antagonism, antibacterial, the effect of reducing environmental pollution and improving immunity of organisms.At the same time it can also utilize Nanometer Copper supplement copper coin
Element, immunity is improved, accelerate disease recovery from illness.
The beneficial effects of the invention are as follows:Contain substantial amounts of tannin in Chinese medicine composition of the present invention, there are puckery intestines
The effect of antidiarrheal, diarrhoea caused by weaned piglet can be effectively treated or prevented with nano copper particle compounding.The present invention is by Chinese medicine
For composition with being added to after Nanometer Copper compounding as additive in feed, prevention and treatment effect is more preferable, and treats required time
It is obvious to shorten, the death rate is reduced, using effect is more preferable.
【Embodiment】
Below by specific embodiment, the present invention is described in further detail:
Embodiment 1:By the Chinese traditional medicine composition composition powders of 0.4% feed relative and Nanometer Copper (per kilogram feed adds 60mg)
Mix in proportion, obtain feed addictive, used after being stirred with feed.The preparation method of the Chinese traditional medicine composition composition powders is:
The parts by weight of nutmeg 60, the parts by weight of myrobalan 60, the parts by weight of dark plum 100 and the parts by weight of radix glycyrrhizae 90 are weighed, are mixed, are crushed, cross 300 mesh
Sieve, you can obtain Chinese traditional medicine composition composition powders.
Embodiment 2:By the Chinese medicinal composition granules of 0.48% feed relative and Nanometer Copper, (per kilogram feed adds
60mg) mix in proportion, obtain feed addictive, used after being stirred with feed.
The preparation method of the Chinese medicinal composition granules is:Weigh the parts by weight of nutmeg 60, the parts by weight of myrobalan 60, dark plum
100 parts by weight and the parts by weight of radix glycyrrhizae 90, fritter is ground into, mixing extraction 3 times, adds gross weight 10 after 4 kinds of Chinese medicine mixing every time
The water of times weight, refluxing extraction 2 hours, filtering, merging filtrate stand for standby use;Resulting extract solution is concentrated into relatively close
1.1-1.2 is spent, dries concentrate, is crushed;Appropriate amount of starch is added, is well mixed, you can obtains Chinese medicinal composition granules.
Embodiment 3:By the Chinese traditional medicine composition composition powders of 0.54% feed relative and Nanometer Copper (per kilogram feed adds 60mg)
Mix in proportion, obtain feed addictive, used after being stirred with feed.The preparation method of the Chinese traditional medicine composition composition powders is:
The parts by weight of nutmeg 60, the parts by weight of myrobalan 60, the parts by weight of dark plum 100 and the parts by weight of radix glycyrrhizae 90 are weighed, are mixed, are crushed, cross 300 mesh
Sieve, you can obtain Chinese traditional medicine composition composition powders.
Embodiment 4:By the Chinese medicinal composition granules of 0.6% feed relative and Nanometer Copper (per kilogram feed adds 60mg)
Mix in proportion, obtain feed addictive, used after being stirred with feed.
The preparation method of the Chinese medicinal composition granules is:Weigh the parts by weight of nutmeg 60, the parts by weight of myrobalan 60, dark plum
100 parts by weight and the parts by weight of radix glycyrrhizae 90, fritter is ground into, mixing extraction 3 times, adds gross weight 10 after 4 kinds of Chinese medicine mixing every time
The water of times weight, refluxing extraction 2 hours, filtering, merging filtrate stand for standby use;Resulting extract solution is concentrated into relatively close
1.1-1.2 is spent, dries concentrate, is crushed;Appropriate amount of starch is added, is well mixed, you can obtains Chinese medicinal composition granules.
Embodiment 5:By the Chinese traditional medicine composition composition powders of 0.5% feed relative and Nanometer Copper (per kilogram feed adds 60mg)
Mix in proportion, obtain feed addictive, used after being stirred with feed.The preparation method of the Chinese traditional medicine composition composition powders is:
The parts by weight of nutmeg 60, the parts by weight of myrobalan 60, the parts by weight of dark plum 100 and the parts by weight of radix glycyrrhizae 90 are weighed, are mixed, are crushed, cross 300 mesh
Sieve, you can obtain Chinese traditional medicine composition composition powders.
Embodiment 6:By the Chinese medicinal composition granules of 0.85% feed relative and Nanometer Copper, (per kilogram feed adds
60mg) mix in proportion, obtain feed addictive, used after being stirred with feed.
The preparation method of the Chinese medicinal composition granules is:Weigh the parts by weight of nutmeg 60, the parts by weight of myrobalan 60, dark plum
100 parts by weight and the parts by weight of radix glycyrrhizae 90, fritter is ground into, mixing extraction 3 times, adds gross weight 10 after 4 kinds of Chinese medicine mixing every time
The water of times weight, refluxing extraction 2 hours, filtering, merging filtrate stand for standby use;Resulting extract solution is concentrated into relatively close
1.1-1.2 is spent, dries concentrate, is crushed;Appropriate amount of starch is added, is well mixed, you can obtains Chinese medicinal composition granules.
Embodiment 7:By the Chinese traditional medicine composition composition powders of 1.2% feed relative and Nanometer Copper (per kilogram feed adds 60mg)
Mix in proportion, obtain feed addictive, used after being stirred with feed.The preparation method of the Chinese traditional medicine composition composition powders is:
The parts by weight of nutmeg 60, the parts by weight of myrobalan 60, the parts by weight of dark plum 100 and the parts by weight of radix glycyrrhizae 90 are weighed, are mixed, are crushed, cross 300 mesh
Sieve, you can obtain Chinese traditional medicine composition composition powders.
Embodiment 8:By the Chinese medicinal composition granules of 1.5% feed relative and Nanometer Copper (per kilogram feed adds 60mg)
Mix in proportion, obtain feed addictive, used after being stirred with feed.
The preparation method of the Chinese medicinal composition granules is:Weigh the parts by weight of nutmeg 60, the parts by weight of myrobalan 60, dark plum
100 parts by weight and the parts by weight of radix glycyrrhizae 90, fritter is ground into, mixing extraction 3 times, adds gross weight 10 after 4 kinds of Chinese medicine mixing every time
The water of times weight, refluxing extraction 2 hours, filtering, merging filtrate stand for standby use;Resulting extract solution is concentrated into relatively close
1.1-1.2 is spent, dries concentrate, is crushed;Appropriate amount of starch is added, is well mixed, you can obtains Chinese medicinal composition granules.
The basal diet that feed addictive obtained by embodiment 1-8 is respectively added to piglet (uses corn-soybean meal base
Plinth daily ration, it is formulated with reference to U.S. NRC (1998) pork pig nutritional need) in, verify the feed addictive prevention of gained or control
Treat the effect of grice diarrhoea.
Feed addictive corresponding to embodiment 1-8 is added separately to the feed as experimental group 1-8 in basal diet, and
Blank group and 1 group of control, 2 groups of control and 3 groups of control are set;The feed of blank group is only with basal diet;Compare 1 group of feed
For:Basal diet mixes with colistin sulfate (per kilogram basal diet adds 20mg colistin sulfates);Compare 2 groups of feed
For:Basal diet and quinocetone (per kilogram basal diet 2g) mixture;The feed for compareing 3 groups is:Added into basal diet
Nanometer Copper (per kilogram basal diet adds 60mg).
First, the experimental design of prevention of diarrhea in piglets:Uniform body weight, the wean of 30 ages in days, the piglet totally 700 of health are chosen,
7 groups are divided into, every group 100, male and female half and half, experimental group 1-5 groups, blank group and control 1 are supplied respectively to from weaning certainly
Corresponding feed is organized, and the incidence of each group piglet is observed in subsequent 20 days, carries out data statistics.
Statistical result is as shown in table 1 below:
Table 1
It was found from the statistics of table 1, the feed addictives of embodiment 1-5 groups is for preventing the effect of Diarrhea after Piglets " Weaning
Fruit is substantially better than blank group and control group.
2nd, the experimental design of grice diarrhoea is treated:Choose body weight and uniformly, after the wean of 30 ages in days supply basal diet, disconnected
The piglet suffered from diarrhoea in 20 days after milk totally 800,8 groups are divided into, every group 100, male and female half and half, observes each group piglet
Whether suffer from diarrhoea, and experimental group 3-8 groups and 3 groups of 2 groups of control, control corresponding feeds are supplied respectively to after suffering from diarrhoea, examine
The effect treated after grice diarrhoea is examined, carries out data statistics.Statistical result is as shown in table 2 below:
Table 2
From the statistics of table 2, the feed addictive of embodiment 3-8 groups is for hair diarrhoea after treatment weaned piglet
3 groups of the control of equivalent Nanometer Copper is added in positive effect better than antibiotics and only, and the time used in treatment is shorter, dies of illness
Rate is lower.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (7)
- A kind of 1. feed addictive for treating and preventing intestine of young pigs disease, it is characterised in that:By Chinese medicine composition and Nanometer Copper Composition.
- 2. the feed addictive according to claim 1 for treating and preventing intestine of young pigs disease, it is characterised in that:In described Drug composition is made up of 90 parts of 60 parts of nutmeg, 60 parts of myrobalan, 100 parts of dark plum and radix glycyrrhizae.
- 3. the feed addictive according to claim 1 for treating and preventing intestine of young pigs disease, it is characterised in that:By feed Weight meter, the dosage of the Chinese medicine composition is 0.4-1.5wt%, and the dosage of the Nanometer Copper is 60mg/Kg.
- 4. the feed addictive according to claim 1 for treating and preventing intestine of young pigs disease, it is characterised in that:By feed Weight meter, the dosage of the Chinese medicine composition is 0.4-0.6wt%, for preventing intestine of young pigs disease.
- 5. the feed addictive according to claim 1 for treating and preventing intestine of young pigs disease, it is characterised in that:In described The dosage of drug composition is 0.5-1.5wt%, for treating intestine of young pigs disease.
- 6. the preparation side of the feed addictive of the treatment and prevention intestine of young pigs disease according to claim any one of 1-5 Method, it is characterised in that:The 0.4-1.5% of feed relative Chinese medicine composition is taken, is crushed, crosses 300 mesh sieves;By the Chinese medicine group of gained Compound powder is well mixed with Nanometer Copper, and the dosage of the Nanometer Copper is 60mg/Kg, based on the weight of feed.
- 7. the preparation side of the feed addictive of the treatment and prevention intestine of young pigs disease according to claim any one of 1-5 Method, it is characterised in that:The Chinese medicine composition is fabricated to after particle and is well mixed again with the Nanometer Copper;By the weight of feed Meter, the dosage of the Chinese medicine composition is 0.4-1.5%, and the dosage of the Nanometer Copper is 60mg/Kg.The preparation method of the traditional Chinese medicine particle is as follows:S1, by formula rate weight (60 parts of nutmeg, 60 parts of myrobalan, 100 parts of dark plum, 90 parts of radix glycyrrhizae), weigh 4 kinds of medicines of the above Material, fritter is ground into, mixing extraction 3 times, adds 10 times of water, refluxing extraction 2 hours, filtration, merging filtrate stand for standby use every time;S2, extract solution concentration, are concentrated into relative density 1.10-1.2, concentrate dry, pulverize.Appropriate amount of starch is added, is mixed, Traditional Chinese medicine particle is made.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112471337A (en) * | 2020-11-26 | 2021-03-12 | 江西省三汇科技有限公司 | Animal husbandry feed additive containing sodium humate and application thereof |
Citations (1)
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CN103689276A (en) * | 2013-12-16 | 2014-04-02 | 双胞胎(集团)股份有限公司 | Chinese herbal medicine feed additive capable of effectively preventing and treating piglet diarrhea |
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2017
- 2017-08-23 CN CN201710727059.4A patent/CN107348156A/en active Pending
Patent Citations (1)
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CN103689276A (en) * | 2013-12-16 | 2014-04-02 | 双胞胎(集团)股份有限公司 | Chinese herbal medicine feed additive capable of effectively preventing and treating piglet diarrhea |
Non-Patent Citations (2)
Title |
---|
王艳华: "纳米铜和硫酸铜对断奶仔猪生长、腹泻和消化的影响及作用机理探讨", 《中国优秀硕士学位论文全文数据库(电子期刊)》 * |
苗明三等主编: "《中药大辞典》", 30 June 2017, 太原:山西科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112471337A (en) * | 2020-11-26 | 2021-03-12 | 江西省三汇科技有限公司 | Animal husbandry feed additive containing sodium humate and application thereof |
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