CN107335090A - 一种具有创面修复作用的生物相容性止血材料及其制备方法 - Google Patents
一种具有创面修复作用的生物相容性止血材料及其制备方法 Download PDFInfo
- Publication number
- CN107335090A CN107335090A CN201710558877.6A CN201710558877A CN107335090A CN 107335090 A CN107335090 A CN 107335090A CN 201710558877 A CN201710558877 A CN 201710558877A CN 107335090 A CN107335090 A CN 107335090A
- Authority
- CN
- China
- Prior art keywords
- starch
- parts
- preparation
- geniposide
- wound repair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 230000000694 effects Effects 0.000 title claims abstract description 24
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 22
- 230000037314 wound repair Effects 0.000 title claims abstract description 21
- 229920002472 Starch Polymers 0.000 claims abstract description 86
- 235000019698 starch Nutrition 0.000 claims abstract description 86
- 239000008107 starch Substances 0.000 claims abstract description 86
- 239000002105 nanoparticle Substances 0.000 claims abstract description 41
- IBFYXTRXDNAPMM-BVTMAQQCSA-N Geniposide Chemical compound O([C@@H]1OC=C([C@@H]2[C@H]1C(=CC2)CO)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O IBFYXTRXDNAPMM-BVTMAQQCSA-N 0.000 claims abstract description 22
- IBFYXTRXDNAPMM-FZEIBHLUSA-N Geniposide Natural products COC(=O)C1=CO[C@@H](O[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@H]2[C@@H]1CC=C2CO IBFYXTRXDNAPMM-FZEIBHLUSA-N 0.000 claims abstract description 22
- VGLLGNISLBPZNL-RBUKDIBWSA-N arborescoside Natural products O=C(OC)C=1[C@@H]2C([C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)OC=1)=C(CO)CC2 VGLLGNISLBPZNL-RBUKDIBWSA-N 0.000 claims abstract description 22
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 20
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 20
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims abstract description 19
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 claims abstract description 16
- 238000004132 cross linking Methods 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 9
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims abstract description 7
- 239000002585 base Substances 0.000 claims description 44
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14
- 239000012153 distilled water Substances 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 229920002261 Corn starch Polymers 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
- 230000033228 biological regulation Effects 0.000 claims description 7
- 239000008120 corn starch Substances 0.000 claims description 7
- 229940099112 cornstarch Drugs 0.000 claims description 7
- 238000005189 flocculation Methods 0.000 claims description 7
- 230000016615 flocculation Effects 0.000 claims description 7
- 238000005469 granulation Methods 0.000 claims description 7
- 230000003179 granulation Effects 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 230000023597 hemostasis Effects 0.000 abstract description 12
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
- 238000005516 engineering process Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 29
- 208000027418 Wounds and injury Diseases 0.000 description 29
- 239000000243 solution Substances 0.000 description 19
- 239000007788 liquid Substances 0.000 description 11
- 210000004185 liver Anatomy 0.000 description 10
- 208000032843 Hemorrhage Diseases 0.000 description 9
- 230000000740 bleeding effect Effects 0.000 description 8
- 241000700159 Rattus Species 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000005406 washing Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241001582888 Lobus Species 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- QGMRQYFBGABWDR-UHFFFAOYSA-N sodium;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O QGMRQYFBGABWDR-UHFFFAOYSA-N 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- -1 ammonia Acid amides Chemical class 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229960000182 blood factors Drugs 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000012930 cell culture fluid Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/624—Nanocapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710558877.6A CN107335090B (zh) | 2017-07-11 | 2017-07-11 | 一种具有创面修复作用的生物相容性止血材料及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710558877.6A CN107335090B (zh) | 2017-07-11 | 2017-07-11 | 一种具有创面修复作用的生物相容性止血材料及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107335090A true CN107335090A (zh) | 2017-11-10 |
CN107335090B CN107335090B (zh) | 2020-09-01 |
Family
ID=60219789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710558877.6A Expired - Fee Related CN107335090B (zh) | 2017-07-11 | 2017-07-11 | 一种具有创面修复作用的生物相容性止血材料及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107335090B (zh) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050226916A1 (en) * | 1998-11-12 | 2005-10-13 | Cochrum Kent C | Hemostatic polymer useful for RAPID blood coagulation and hemostasis |
CN102302796A (zh) * | 2011-09-08 | 2012-01-04 | 江苏天麟生物医药科技有限公司 | 吸收性止血生物材料及制备方法 |
CN102740862A (zh) * | 2009-12-04 | 2012-10-17 | 美格乐控股公司 | 具有内源性带电配体的水解淀粉微球 |
CN104606723A (zh) * | 2014-12-12 | 2015-05-13 | 重庆联佰博超医疗器械有限公司 | 可吸收性淀粉止血粉及其制备方法、应用 |
CN104888263A (zh) * | 2008-01-14 | 2015-09-09 | 纪欣 | 生物相容性止血、防粘连、促愈合、外科封闭的变性淀粉材料 |
CN105778126A (zh) * | 2016-03-31 | 2016-07-20 | 中国人民解放军军事医学科学院野战输血研究所 | 一种京尼平交联生物凝胶及其制备方法与应用 |
-
2017
- 2017-07-11 CN CN201710558877.6A patent/CN107335090B/zh not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050226916A1 (en) * | 1998-11-12 | 2005-10-13 | Cochrum Kent C | Hemostatic polymer useful for RAPID blood coagulation and hemostasis |
CN104888263A (zh) * | 2008-01-14 | 2015-09-09 | 纪欣 | 生物相容性止血、防粘连、促愈合、外科封闭的变性淀粉材料 |
CN102740862A (zh) * | 2009-12-04 | 2012-10-17 | 美格乐控股公司 | 具有内源性带电配体的水解淀粉微球 |
CN102302796A (zh) * | 2011-09-08 | 2012-01-04 | 江苏天麟生物医药科技有限公司 | 吸收性止血生物材料及制备方法 |
CN104606723A (zh) * | 2014-12-12 | 2015-05-13 | 重庆联佰博超医疗器械有限公司 | 可吸收性淀粉止血粉及其制备方法、应用 |
CN105778126A (zh) * | 2016-03-31 | 2016-07-20 | 中国人民解放军军事医学科学院野战输血研究所 | 一种京尼平交联生物凝胶及其制备方法与应用 |
Non-Patent Citations (3)
Title |
---|
宋修军: "《临床骨科药物学》", 31 May 2010, 科学技术文献出版社 * |
李廷荃: "《老药新用》", 31 December 2012, 山西科学技术出版社 * |
王艳玲: "新型淀粉基止血材料的制备及生物相容性研究", 《生物医学工程研究》 * |
Also Published As
Publication number | Publication date |
---|---|
CN107335090B (zh) | 2020-09-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Pang et al. | Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel | |
EP1981511B1 (en) | Hemostatic material | |
EP2626092B1 (en) | Medical absorbable hemostatic material for bone wounds and preparation method therefor | |
EP2037972B1 (de) | Verwendung von gelatine und transglutaminase zur herstellung eines vernetzenden medizinischen klebers | |
Cao et al. | Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis | |
CN101053669B (zh) | 一种水溶性壳聚糖基止血愈创海绵及其制备方法和应用 | |
CN107929816A (zh) | 一种具有止血、抗菌、促愈合功能的防粘连材料及其制备方法 | |
CN104307052B (zh) | 医用可注射防粘连凝胶及其制备方法 | |
Xiang et al. | A novel hydrogel based on Bletilla striata polysaccharide for rapid hemostasis: Synthesis, characterization and evaluation | |
CN104906626A (zh) | 可吸收降解的生物相容性止血材料及其制备方法 | |
CN107158452A (zh) | 一种骨创面止血组合物及其制备方法和应用 | |
CN109701069A (zh) | 一种抗菌组织粘合剂及其制备方法 | |
CN107823699A (zh) | 止血防粘连膜及其制备方法 | |
Ke et al. | A silk fibroin based bioadhesive with synergistic photothermal-reinforced antibacterial activity | |
WO2008038864A1 (en) | Low toxic, biocompatible film using chitosan and polyethylene glycol | |
Cheng et al. | Biomass-derived ultrafast cross-linked hydrogels with double dynamic bonds for hemostasis and wound healing | |
US11890392B2 (en) | Absorbable bone wax and preparation method thereof | |
CN107335090A (zh) | 一种具有创面修复作用的生物相容性止血材料及其制备方法 | |
CN107243085A (zh) | 一种体内降解时间可控的止血材料及其制备方法 | |
CN112843323A (zh) | 一种添加羟基磷灰石的聚乳酸结扎夹及其制备方法 | |
CN106730047B (zh) | 一种止血防粘连膜及其制备方法 | |
CN105963769B (zh) | 医用卵清蛋白水凝胶粘合剂及其制备方法和用途 | |
CN115887741B (zh) | 一种可吸收骨蜡及其制备方法 | |
CN102078641A (zh) | 一种制备肌腱韧带防粘连膜的方法 | |
CN109758604A (zh) | 一种皮肤修复制剂及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Xuqi Inventor after: Xu Qinhong Inventor after: Wei Guangbing Inventor after: Wang Yan Inventor after: Hu Junxi Inventor after: Fan Xing Inventor before: Wang Yan Inventor before: Hu Junxi Inventor before: Fan Xing |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20200804 Address after: 710061, Yanta Road, Yanta District, Shaanxi, 277, Xi'an Applicant after: Li Xuqi Address before: 211198 No. 1009 Tianyuan East Road, High-tech Park, Jiangning District, Nanjing City, Jiangsu Province Applicant before: NANJING XUHANG BIOLOGICAL MATERIAL TECHNOLOGY Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210825 Address after: 710061 No. 277, Yanta West Road, Shaanxi, Xi'an Patentee after: THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XI'AN JIAOTONG University Address before: 710061, Yanta Road, Yanta District, Shaanxi, 277, Xi'an Patentee before: Li Xuqi |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200901 |