CN107335007A - 一种活跃生育的保健品的制备方法 - Google Patents
一种活跃生育的保健品的制备方法 Download PDFInfo
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- CN107335007A CN107335007A CN201710468279.XA CN201710468279A CN107335007A CN 107335007 A CN107335007 A CN 107335007A CN 201710468279 A CN201710468279 A CN 201710468279A CN 107335007 A CN107335007 A CN 107335007A
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Abstract
本申请公开了一种活跃生育的保健品的制备方法，称取甘露醇、玛卡、丹参、雄蚕蛾、乌蛇、蜈蚣、制大黄、牛蒡根、血竭、龙眼肉、红藤、连翘、苍术、莪术和滑石粉；滋阴补肾壮阳,养血培精益髓,增强体质,促进体内各部器官血液运作循环,除湿祛瘀生津,服用后身体健康,提高精子活率,有效恢复生育功能；对体弱阴虚,肾阳不足,神经衰弱,膝软无力的老、壮年人保健延年益寿，促进精子与卵子的增加与活力，帮助受孕，刺激生殖器官；药方中各个组分之间产生协同作用，从而带来，对男女性功能和生育障碍病患有显著疗效，调节肾上腺、胰腺、睾丸等功能，达到平衡荷尔蒙水平，长期服用对人体无副作用，可以广泛生产并不断代替现有材料。
Description
技术领域
本申请属于保健品领域，尤其涉及一种活跃生育的保健品的制备方法。
背景技术
随着社会进步和经济发展，人类对自身的健康日益关注。20世纪90年代以来，全球居民的健康保健消费逐年攀升，对营养保健品的需求十分旺盛。在按国际标准划分的15类国际化产业中，医药保健是世界贸易增长最快的五个行业之一，保健食品的销售额每年以10%以上的速度增长。
玛卡含较高量的铁，蛋白质、氨基酸、矿物质锌、牛磺酸等成分能明显对抗疲劳，增强肌肉耐力，抵抗运动性疲劳，帮助坚固免疫系统，提升机体抗病力，对抗疲劳，增强精力、体力，改善贫血症状。使肤色看起来更年轻，精气神更足。
由于MACA生在在贫瘠的高原，须有高超能量才能生长，因为其生长环境与特性，玛卡可以迅速补充体力消除疲劳，恢复精力，更是极少数通过药物检验的合格的快速体力增强剂。
现代人90%以上都在承受压力，玛卡能有效改善因压力造成的忧虑症及神经衰弱等。在秘鲁当地MACA被当做舒解压力、消除焦虑的天然草药，也是改善失眠多梦症状的佳品。
调节内分泌，对抗更年期综合症―玛卡的多种生物碱能调节肾上腺、胰腺、卵巢等功能，平衡体内的荷尔蒙水平，丰富的牛磺酸、蛋白质等能调理及修复生理机能，改善气血和缓解更年期症状，从而促进女性雌激素，容颜。
促进精子与卵子的增加与活力，帮助受孕，刺激生殖器官。使头脑清醒灵活，提高工作效率，学生学习进步，中老年记忆能力保持，使人头脑清醒，思路清晰。
抗疲劳、增强精力、体力，玛卡中氨基酸、矿物质锌、牛磺酸等成份能明显对抗疲劳。调节内分泌系统，平衡荷尔蒙，玛卡的多种生物碱作用于下丘脑和脑垂体，调节肾上腺、胰腺、睾丸等功能，达到平衡荷尔蒙水平。
调节内分泌，对抗更年期综合症，玛卡的多种生物碱能调节肾上腺、胰腺、卵巢等功能，平衡体内的荷尔蒙水平，丰富的牛磺酸、蛋白质等能调理及修复生理机能，改善气血和缓解更年期症状。增强免疫功能，抗疲劳，抗贫血，玛卡含较高量的铁，蛋白质、氨基酸、矿物质锌等可帮助坚固免疫系统，提升机体抗病力，对抗疲劳，改善贫血症状。
中国保健品产业经过多年快速发展，已经逐渐壮大。虽然仍面临诸多挑战，但是，中国保健食品产业的发展前景是光明的。在市场需求、技术进步和管理更新的推动下，中国保健品产业发展空间巨大。未来发展将呈现消费者群体多元化、保健品销售模式专营化、宣传模式推陈出新以及保健品成日常消费四大趋势。设计一种安全性高、崩解时间短，分解状态好，易吸收，起效快且没有发现明显的毒副作用的活跃生育的保健品的制备方法是非常必要的。
发明内容
解决的技术问题：
本申请针对上述技术问题，提供一种活跃生育的保健品的制备方法，解决现有保健品活跃生育效果差、崩解时间长和不易吸收等技术问题。
技术方案：
一种活跃生育的保健品的制备方法，包括如下步骤：
第一步：按照重量份数配比称取甘露醇100份、玛卡33-35份、丹参16-20份、雄蚕蛾15-20份、乌蛇8-12份、蜈蚣7-9份、制大黄12-14份、牛蒡根8-10份、血竭3-7份、龙眼肉11-13份、红藤8-10份、连翘1-5份、苍术1-3份、莪术2-4份和滑石粉0.5-4.5份；
第二步：将净制、切制后的玛卡和丹参按照2010年版一部中国药典附录IID的蒸法，制成饮片；
第三步：将乌蛇、制大黄、血竭、连翘、红藤、苍术和龙眼肉经乙醇回流提取，乙醇量是药材质量的8-10倍量，乙醇体积浓度为80%，分2次回流提取，每次回流90-120min，合并提取液，过滤，滤液减压浓缩回收乙醇，得醇提浓缩液；
第四步：再加入蜈蚣、牛蒡根、雄蚕蛾和莪术晒干，粉碎后过100目筛，与玛卡饮片、丹参饮片和经体积浓度为80%的乙醇回流提取后的药渣合并，经水煎煮，过滤，浓缩，冷却，加乙醇，醇沉后离心，将离心液与第三步的醇提浓缩液合并，减压浓缩后在95-105℃条件下进行真空干燥，得浸膏干粉，混合均匀后加入甘露醇，再加入水润湿后制成混合均匀的稠膏；
第五步：将上述稠膏干燥后粉碎做成颗粒，控制颗粒的水分在3-5%，最后加入滑石粉，混合后压制成咀嚼片。
作为本发明的一种优选技术方案：所述第四步所加水的量是原料药质量的16-18倍，浸泡50-70min，煎煮2-3次，每次60-100min，合并三次水煎液，过滤，将滤液减压浓缩至60℃时测相对密度为1g/ml，冷却，加乙醇至含醇量达40%，搅拌均匀，放置40-50小时后离心，离心机速度4900-5100转/分，弃去沉淀，回收离心液。
作为本发明的一种优选技术方案：所述第一步中活跃生育的保健品的原料按重量份数配比如下：甘露醇100份、玛卡33份、丹参16份、雄蚕蛾15份、乌蛇8份、蜈蚣7份、制大黄12份、牛蒡根8份、血竭3份、龙眼肉11份、红藤8份、连翘1份、苍术1份、莪术2份和滑石粉0.5份。
作为本发明的一种优选技术方案：所述第一步中活跃生育的保健品的原料按重量份数配比如下：甘露醇100份、玛卡35份、丹参20份、雄蚕蛾20份、乌蛇12份、蜈蚣9份、制大黄14份、牛蒡根10份、血竭7份、龙眼肉13份、红藤10份、连翘5份、苍术3份、莪术4份和滑石粉4.5份。
作为本发明的一种优选技术方案：所述第一步中活跃生育的保健品的原料按重量份数配比如下：甘露醇100份、玛卡34份、丹参18份、雄蚕蛾18份、乌蛇10份、蜈蚣8份、制大黄13份、牛蒡根9份、血竭5份、龙眼肉12份、红藤9份、连翘3份、苍术2份、莪术3份和滑石粉2.5份。
有益效果：
本发明所述一种活跃生育的保健品的制备方法采用以上技术方案与现有技术相比，具有以下技术效果：1、制备方法简单，成本低廉，配方简单，配伍合理，遵循中医辨证施治的原则，配方各味药相辅相成，具有明显的活跃生育的功效，对人体无毒无害，有提高免疫力的保健作用，产品的安全性高；2、滋阴补肾壮阳,养血培精益髓,增强体质,促进体内各部器官血液运作循环,除湿祛瘀生津,服用后身体健康,提高精子活率,有效恢复生育功能；3、对体弱阴虚,肾阳不足,神经衰弱,膝软无力的老、壮年人保健延年益寿，促进精子与卵子的增加与活力，帮助受孕，刺激生殖器官；4、药方中各个组分之间产生协同作用，从而带来，对男女性功能和生育障碍病患有显著疗效，调节肾上腺、胰腺、睾丸等功能，达到平衡荷尔蒙水平，长期服用对人体无副作用，可以广泛生产并不断代替现有材料。
具体实施方式
实施例1:
按照重量份数配比称取甘露醇100份、玛卡33份、丹参16份、雄蚕蛾15份、乌蛇8份、蜈蚣7份、制大黄12份、牛蒡根8份、血竭3份、龙眼肉11份、红藤8份、连翘1份、苍术1份、莪术2份和滑石粉0.5份。
将净制、切制后的玛卡和丹参按照2010年版一部中国药典附录IID的蒸法，制成饮片。
将乌蛇、制大黄、血竭、连翘、红藤、苍术和龙眼肉经乙醇回流提取，乙醇量是药材质量的8倍量，乙醇体积浓度为80%，分2次回流提取，每次回流90min，合并提取液，过滤，滤液减压浓缩回收乙醇，得醇提浓缩液。
再加入蜈蚣、牛蒡根、雄蚕蛾和莪术晒干，粉碎后过100目筛，与玛卡饮片、丹参饮片和经体积浓度为80%的乙醇回流提取后的药渣合并，经水煎煮，所加水的量是原料药质量的16倍，浸泡50min，煎煮2次，每次60min，合并三次水煎液，过滤，将滤液减压浓缩至60℃时测相对密度为1g/ml，冷却，加乙醇至含醇量达40%，搅拌均匀，放置40小时后离心，离心机速度4900转/分，弃去沉淀，回收离心液，将离心液与第三步的醇提浓缩液合并，减压浓缩后在95℃条件下进行真空干燥，得浸膏干粉，混合均匀后加入甘露醇，再加入水润湿后制成混合均匀的稠膏。
将上述稠膏干燥后粉碎做成颗粒，控制颗粒的水分在3-5%，最后加入滑石粉，混合后压制成咀嚼片。
制备方法简单，成本低廉，配方简单，配伍合理，遵循中医辨证施治的原则，配方各味药相辅相成，具有明显的活跃生育的功效，对人体无毒无害，有提高免疫力的保健作用，产品的安全性高；滋阴补肾壮阳,养血培精益髓,增强体质,促进体内各部器官血液运作循环,除湿祛瘀生津,服用后身体健康,提高精子活率,有效恢复生育功能；对体弱阴虚,肾阳不足,神经衰弱,膝软无力的老、壮年人保健延年益寿，促进精子与卵子的增加与活力，帮助受孕，刺激生殖器官；药方中各个组分之间产生协同作用，从而带来，对男女性功能和生育障碍病患有显著疗效，调节肾上腺、胰腺、睾丸等功能，达到平衡荷尔蒙水平，长期服用对人体无副作用，可以广泛生产并不断代替现有材料。
实施例2:
按照重量份数配比称取甘露醇100份、玛卡35份、丹参20份、雄蚕蛾20份、乌蛇12份、蜈蚣9份、制大黄14份、牛蒡根10份、血竭7份、龙眼肉13份、红藤10份、连翘5份、苍术3份、莪术4份和滑石粉4.5份。
将净制、切制后的玛卡和丹参按照2010年版一部中国药典附录IID的蒸法，制成饮片。
将乌蛇、制大黄、血竭、连翘、红藤、苍术和龙眼肉经乙醇回流提取，乙醇量是药材质量的10倍量，乙醇体积浓度为80%，分2次回流提取，每次回流120min，合并提取液，过滤，滤液减压浓缩回收乙醇，得醇提浓缩液。
再加入蜈蚣、牛蒡根、雄蚕蛾和莪术晒干，粉碎后过100目筛，与玛卡饮片、丹参饮片和经体积浓度为80%的乙醇回流提取后的药渣合并，经水煎煮，所加水的量是原料药质量的18倍，浸泡70min，煎煮3次，每次100min，合并三次水煎液，过滤，将滤液减压浓缩至60℃时测相对密度为1g/ml，冷却，加乙醇至含醇量达40%，搅拌均匀，放置40-50小时后离心，离心机速度5100转/分，弃去沉淀，回收离心液，将离心液与第三步的醇提浓缩液合并，减压浓缩后在105℃条件下进行真空干燥，得浸膏干粉，混合均匀后加入甘露醇，再加入水润湿后制成混合均匀的稠膏。
将上述稠膏干燥后粉碎做成颗粒，控制颗粒的水分在5%，最后加入滑石粉，混合后压制成咀嚼片。
制备方法简单，成本低廉，配方简单，配伍合理，遵循中医辨证施治的原则，配方各味药相辅相成，具有明显的活跃生育的功效，对人体无毒无害，有提高免疫力的保健作用，产品的安全性高；滋阴补肾壮阳,养血培精益髓,增强体质,促进体内各部器官血液运作循环,除湿祛瘀生津,服用后身体健康,提高精子活率,有效恢复生育功能；对体弱阴虚,肾阳不足,神经衰弱,膝软无力的老、壮年人保健延年益寿，促进精子与卵子的增加与活力，帮助受孕，刺激生殖器官；药方中各个组分之间产生协同作用，从而带来，对男女性功能和生育障碍病患有显著疗效，调节肾上腺、胰腺、睾丸等功能，达到平衡荷尔蒙水平，长期服用对人体无副作用，可以广泛生产并不断代替现有材料。
实施例3:
按照重量份数配比称取甘露醇100份、玛卡34份、丹参18份、雄蚕蛾18份、乌蛇10份、蜈蚣8份、制大黄13份、牛蒡根9份、血竭5份、龙眼肉12份、红藤9份、连翘3份、苍术2份、莪术3份和滑石粉2.5份。
将净制、切制后的玛卡和丹参按照2010年版一部中国药典附录IID的蒸法，制成饮片。
将乌蛇、制大黄、血竭、连翘、红藤、苍术和龙眼肉经乙醇回流提取，乙醇量是药材质量的9倍量，乙醇体积浓度为80%，分2次回流提取，每次回流100min，合并提取液，过滤，滤液减压浓缩回收乙醇，得醇提浓缩液。
再加入蜈蚣、牛蒡根、雄蚕蛾和莪术晒干，粉碎后过100目筛，与玛卡饮片、丹参饮片和经体积浓度为80%的乙醇回流提取后的药渣合并，经水煎煮，所加水的量是原料药质量的17倍，浸泡60min，煎煮3次，每次80min，合并三次水煎液，过滤，将滤液减压浓缩至60℃时测相对密度为1g/ml，冷却，加乙醇至含醇量达40%，搅拌均匀，放置45小时后离心，离心机速度5000转/分，弃去沉淀，回收离心液，将离心液与第三步的醇提浓缩液合并，减压浓缩后在100℃条件下进行真空干燥，得浸膏干粉，混合均匀后加入甘露醇，再加入水润湿后制成混合均匀的稠膏。
将上述稠膏干燥后粉碎做成颗粒，控制颗粒的水分在4%，最后加入滑石粉，混合后压制成咀嚼片。
制备方法简单，成本低廉，配方简单，配伍合理，遵循中医辨证施治的原则，配方各味药相辅相成，具有明显的活跃生育的功效，对人体无毒无害，有提高免疫力的保健作用，产品的安全性高；滋阴补肾壮阳,养血培精益髓,增强体质,促进体内各部器官血液运作循环,除湿祛瘀生津,服用后身体健康,提高精子活率,有效恢复生育功能；对体弱阴虚,肾阳不足,神经衰弱,膝软无力的老、壮年人保健延年益寿，促进精子与卵子的增加与活力，帮助受孕，刺激生殖器官；药方中各个组分之间产生协同作用，从而带来，对男女性功能和生育障碍病患有显著疗效，调节肾上腺、胰腺、睾丸等功能，达到平衡荷尔蒙水平，长期服用对人体无副作用，可以广泛生产并不断代替现有材料。
以300例临床试验，最大年龄60岁，最小年龄20岁，其中男性患者200例，女性患者100例，口服，一日1-3次，一次2-4片，连续需用15天，有效率85.45%，连续服用30天，有效率89.98%，连续服用半年有效率96.46%，连续服用一年，有效率99.9%。
以上实施例中的配方所有药材均可以商业购买。
上述实施例只是用于对本发明的内容进行阐述，而不是限制，因此在与本发明的权利要求书相当的含义和范围内的任何改变，都应该认为是包括在权利要求书的范围内。
Claims (5)
1.一种活跃生育的保健品的制备方法，其特征在于，包括如下步骤：
第一步：按照重量份数配比称取甘露醇100份、玛卡33-35份、丹参16-20份、雄蚕蛾15-20份、乌蛇8-12份、蜈蚣7-9份、制大黄12-14份、牛蒡根8-10份、血竭3-7份、龙眼肉11-13份、红藤8-10份、连翘1-5份、苍术1-3份、莪术2-4份和滑石粉0.5-4.5份；
第二步：将净制、切制后的玛卡和丹参按照2010年版一部中国药典附录IID的蒸法，制成饮片；
第三步：将乌蛇、制大黄、血竭、连翘、红藤、苍术和龙眼肉经乙醇回流提取，乙醇量是药材质量的8-10倍量，乙醇体积浓度为80%，分2次回流提取，每次回流90-120min，合并提取液，过滤，滤液减压浓缩回收乙醇，得醇提浓缩液；
第四步：再加入蜈蚣、牛蒡根、雄蚕蛾和莪术晒干，粉碎后过100目筛，与玛卡饮片、丹参饮片和经体积浓度为80%的乙醇回流提取后的药渣合并，经水煎煮，过滤，浓缩，冷却，加乙醇，醇沉后离心，将离心液与第三步的醇提浓缩液合并，减压浓缩后在95-105℃条件下进行真空干燥，得浸膏干粉，混合均匀后加入甘露醇，再加入水润湿后制成混合均匀的稠膏；
第五步：将上述稠膏干燥后粉碎做成颗粒，控制颗粒的水分在3-5%，最后加入滑石粉，混合后压制成咀嚼片。
2.根据权利要求1所述的一种活跃生育的保健品的制备方法，其特征在于：所述第四步所加水的量是原料药质量的16-18倍，浸泡50-70min，煎煮2-3次，每次60-100min，合并三次水煎液，过滤，将滤液减压浓缩至60℃时测相对密度为1g/ml，冷却，加乙醇至含醇量达40%，搅拌均匀，放置40-50小时后离心，离心机速度4900-5100转/分，弃去沉淀，回收离心液。
3.根据权利要求1所述的一种活跃生育的保健品的制备方法，其特征在于：所述第一步中活跃生育的保健品的原料按重量份数配比如下：甘露醇100份、玛卡33份、丹参16份、雄蚕蛾15份、乌蛇8份、蜈蚣7份、制大黄12份、牛蒡根8份、血竭3份、龙眼肉11份、红藤8份、连翘1份、苍术1份、莪术2份和滑石粉0.5份。
4.根据权利要求1所述的一种活跃生育的保健品的制备方法，其特征在于：所述第一步中活跃生育的保健品的原料按重量份数配比如下：甘露醇100份、玛卡35份、丹参20份、雄蚕蛾20份、乌蛇12份、蜈蚣9份、制大黄14份、牛蒡根10份、血竭7份、龙眼肉13份、红藤10份、连翘5份、苍术3份、莪术4份和滑石粉4.5份。
5.根据权利要求1所述的一种活跃生育的保健品的制备方法，其特征在于：所述第一步中活跃生育的保健品的原料按重量份数配比如下：甘露醇100份、玛卡34份、丹参18份、雄蚕蛾18份、乌蛇10份、蜈蚣8份、制大黄13份、牛蒡根9份、血竭5份、龙眼肉12份、红藤9份、连翘3份、苍术2份、莪术3份和滑石粉2.5份。
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| CN1368371A (zh) * | 2001-02-06 | 2002-09-11 | 周俊 | 一种妇科中药组合物 |
| CN1368370A (zh) * | 2001-02-06 | 2002-09-11 | 周俊 | 经直肠、阴道粘膜给药的妇科中药组合物 |
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