CN107312844B - 基于大小的基因组分析 - Google Patents
基于大小的基因组分析 Download PDFInfo
- Publication number
- CN107312844B CN107312844B CN201710549501.9A CN201710549501A CN107312844B CN 107312844 B CN107312844 B CN 107312844B CN 201710549501 A CN201710549501 A CN 201710549501A CN 107312844 B CN107312844 B CN 107312844B
- Authority
- CN
- China
- Prior art keywords
- nucleic acid
- size
- chromosome
- sequence
- computer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25907609P | 2009-11-06 | 2009-11-06 | |
| US61/259,076 | 2009-11-06 | ||
| US36039910P | 2010-06-30 | 2010-06-30 | |
| US61/360,399 | 2010-06-30 | ||
| CN201080059269.7A CN102791881B (zh) | 2009-11-06 | 2010-11-05 | 基于大小的基因组分析 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080059269.7A Division CN102791881B (zh) | 2009-11-06 | 2010-11-05 | 基于大小的基因组分析 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107312844A CN107312844A (zh) | 2017-11-03 |
| CN107312844B true CN107312844B (zh) | 2021-01-22 |
Family
ID=43530526
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710549501.9A Active CN107312844B (zh) | 2009-11-06 | 2010-11-05 | 基于大小的基因组分析 |
| CN201080059269.7A Active CN102791881B (zh) | 2009-11-06 | 2010-11-05 | 基于大小的基因组分析 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080059269.7A Active CN102791881B (zh) | 2009-11-06 | 2010-11-05 | 基于大小的基因组分析 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8620593B2 (enExample) |
| EP (3) | EP2496713B1 (enExample) |
| JP (2) | JP5770737B2 (enExample) |
| CN (2) | CN107312844B (enExample) |
| AU (1) | AU2010317019B2 (enExample) |
| CA (1) | CA2780016C (enExample) |
| EA (1) | EA034241B1 (enExample) |
| ES (1) | ES3026544T3 (enExample) |
| IL (1) | IL219545A (enExample) |
| MX (2) | MX357692B (enExample) |
| TW (1) | TWI445854B (enExample) |
| WO (1) | WO2011054936A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| EP2271772B1 (en) | 2008-03-11 | 2014-07-16 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| HUE061110T2 (hu) * | 2009-11-05 | 2023-05-28 | Univ Hong Kong Chinese | Magzati genomelemzés anyai biológiai mintából |
| MX357692B (es) * | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
| EP2516680B1 (en) | 2009-12-22 | 2016-04-06 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
| CN101921874B (zh) * | 2010-06-30 | 2013-09-11 | 深圳华大基因科技有限公司 | 基于Solexa测序法的检测人类乳头瘤病毒的方法 |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
| US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
| SG190344A1 (en) | 2010-11-30 | 2013-06-28 | Univ Hong Kong Chinese | Detection of genetic or molecular aberrations associated with cancer |
| US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
| US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
| US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| US8460872B2 (en) | 2011-04-29 | 2013-06-11 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2013060762A1 (en) * | 2011-10-25 | 2013-05-02 | Roche Diagnostics Gmbh | Method for diagnosing a disease based on plasma-dna distribution |
| US9605313B2 (en) | 2012-03-02 | 2017-03-28 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| EP3573066B1 (en) * | 2012-03-13 | 2023-09-27 | The Chinese University Of Hong Kong | Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis |
| US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| EP2872648B1 (en) | 2012-07-13 | 2019-09-04 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| CN104583421A (zh) | 2012-07-19 | 2015-04-29 | 阿瑞奥萨诊断公司 | 遗传变体的基于多重的顺序连接的检测 |
| GB201215449D0 (en) * | 2012-08-30 | 2012-10-17 | Zoragen Biotechnologies Llp | Method of detecting chromosonal abnormalities |
| FI4056712T3 (fi) | 2012-09-20 | 2024-08-29 | Univ Hong Kong Chinese | Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3597774A1 (en) | 2013-03-13 | 2020-01-22 | Sequenom, Inc. | Primers for dna methylation analysis |
| AU2014231358A1 (en) | 2013-03-15 | 2015-09-24 | The Chinese University Of Hong Kong | Determining fetal genomes for multiple fetus pregnancies |
| EP3008215B1 (en) * | 2013-06-13 | 2020-01-01 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| EP3011051B1 (en) * | 2013-06-21 | 2019-01-30 | Sequenom, Inc. | Method for non-invasive assessment of genetic variations |
| EP4227947A1 (en) * | 2013-10-21 | 2023-08-16 | Verinata Health, Inc. | Method for improving the sensitivity of detection in determining copy number variations |
| EP3117011B1 (en) | 2014-03-13 | 2020-05-06 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| JP6659672B2 (ja) | 2014-05-30 | 2020-03-04 | ベリナタ ヘルス インコーポレイテッド | 胎児染色体部分異数性およびコピー数変動の検出 |
| CA3213538A1 (en) | 2014-06-06 | 2015-12-10 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
| US11062789B2 (en) | 2014-07-18 | 2021-07-13 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in a DNA mixture |
| US20170211143A1 (en) | 2014-07-25 | 2017-07-27 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| AU2015296602B2 (en) * | 2014-08-01 | 2021-09-16 | F. Hoffmann-La Roche Ag | Detection of target nucleic acids using hybridization |
| WO2016094853A1 (en) * | 2014-12-12 | 2016-06-16 | Verinata Health, Inc. | Using cell-free dna fragment size to determine copy number variations |
| US10364467B2 (en) * | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US11242559B2 (en) | 2015-01-13 | 2022-02-08 | The Chinese University Of Hong Kong | Method of nuclear DNA and mitochondrial DNA analysis |
| US10319463B2 (en) | 2015-01-23 | 2019-06-11 | The Chinese University Of Hong Kong | Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations |
| EP4012715B1 (en) | 2015-02-10 | 2025-09-24 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| CN104789686B (zh) * | 2015-05-06 | 2018-09-07 | 浙江安诺优达生物科技有限公司 | 检测染色体非整倍性的试剂盒和装置 |
| WO2016189388A1 (en) | 2015-05-22 | 2016-12-01 | Nipd Genetics Ltd | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing |
| EP3739061B1 (en) | 2015-07-20 | 2022-03-23 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| CN108026572B (zh) | 2015-07-23 | 2022-07-01 | 香港中文大学 | 游离dna的片段化模式的分析 |
| CN115433769A (zh) | 2015-08-12 | 2022-12-06 | 香港中文大学 | 血浆dna的单分子测序 |
| US10095831B2 (en) | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
| CN109937426A (zh) * | 2016-04-11 | 2019-06-25 | 量子生物有限公司 | 用于生物数据管理的系统和方法 |
| WO2018064486A1 (en) | 2016-09-29 | 2018-04-05 | Counsyl, Inc. | Noninvasive prenatal screening using dynamic iterative depth optimization |
| IL265769B2 (en) | 2016-10-19 | 2023-12-01 | Univ Hong Kong Chinese | Estimation of gestational age using methylation and size profile of maternal plasma DNA |
| SG11201903509QA (en) | 2016-10-24 | 2019-05-30 | Univ Hong Kong Chinese | Methods and systems for tumor detection |
| CN106591451B (zh) * | 2016-12-14 | 2020-06-23 | 北京贝瑞和康生物技术有限公司 | 测定胎儿游离dna含量的方法及其用于实施该方法的装置 |
| MY197535A (en) | 2017-01-25 | 2023-06-21 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| EP3596233B1 (en) | 2017-03-17 | 2022-05-18 | Sequenom, Inc. | Methods and processes for assessment of genetic mosaicism |
| JP2020512000A (ja) * | 2017-03-31 | 2020-04-23 | プレマイサ リミテッド | 胎児の染色体異常を検出する方法 |
| US11342047B2 (en) | 2017-04-21 | 2022-05-24 | Illumina, Inc. | Using cell-free DNA fragment size to detect tumor-associated variant |
| DK3658684T3 (da) | 2017-07-26 | 2023-10-09 | Univ Hong Kong Chinese | Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer |
| US11168356B2 (en) | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
| CN108827887B (zh) * | 2018-03-19 | 2021-05-18 | 陕西学前师范学院 | 一种商陆基因组大小估计方法及基因组大小测量系统 |
| TWI854979B (zh) | 2018-05-03 | 2024-09-11 | 香港中文大學 | 用於測量游離(cell-free)混合物之特性之經尺寸標記之偏好末端及取向感知分析 |
| EP3947717A4 (en) | 2019-03-25 | 2022-12-28 | The Chinese University Of Hong Kong | DETERMINATION OF LINEAR AND ROUND SHAPES OF CIRCULATION NUCLEIC ACIDS |
| EP4020484A4 (en) * | 2019-08-19 | 2023-08-30 | Green Cross Genome Corporation | METHOD FOR DETECTING A CHROMOSOME ABNORMALITY USING INFORMATION CONCERNING THE DISTANCE BETWEEN NUCLEIC ACID FRAGMENTS |
| CA3164433A1 (en) | 2020-02-05 | 2021-08-12 | Yuk-Ming Dennis Lo | Molecular analyses using long cell-free fragments in pregnancy |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452665A (zh) * | 2000-07-10 | 2003-10-29 | 赛姆格有限公司 | 在母体样品中鉴定胎儿dna的诊断方法 |
| CN1469932A (zh) * | 2000-10-17 | 2004-01-21 | 香港中文大学 | 非侵入的出生前监测 |
| CN1498276A (zh) * | 2001-03-23 | 2004-05-19 | ��������I�����ɷ� | 通过三螺旋相互作用纯化与检测双链dna靶序列的方法 |
| EP1524321A1 (en) * | 2003-10-16 | 2005-04-20 | Sinuhe Dr. Hahn | Non-invasive detection of fetal genetic traits |
| CN1798974A (zh) * | 2003-04-02 | 2006-07-05 | 阿德莱德研究及创新控股有限公司 | 基因组比较杂交 |
| WO2007028155A3 (en) * | 2005-09-01 | 2007-06-21 | New England Medical Center Inc | Fragment size distribution pattern of amniotic fluid cell-free fetal dna for prenatal diagnosis |
| CN101137760A (zh) * | 2005-03-18 | 2008-03-05 | 香港中文大学 | 检测染色体非整倍性的方法 |
| WO2008070862A3 (en) * | 2006-12-07 | 2008-11-20 | Biocept Inc | Non-invasive prenatal genetic screen |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| TR201910868T4 (tr) | 2006-02-02 | 2019-08-21 | Univ Leland Stanford Junior | Dijital analizle invazif olmayan fetal genetik tarama. |
| WO2007100911A2 (en) | 2006-02-28 | 2007-09-07 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| US8835110B2 (en) | 2008-11-04 | 2014-09-16 | The Johns Hopkins University | DNA integrity assay (DIA) for cancer diagnostics, using confocal fluorescence spectroscopy |
| WO2010112316A1 (en) | 2009-03-31 | 2010-10-07 | Oridis Biomed Forschungs- Und Entwicklungs Gmbh | Method for diagnosis of cancer and monitoring of cancer treatments |
| WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
| MX357692B (es) * | 2009-11-06 | 2018-07-19 | Univ Hong Kong Chinese | Analisis genomico a base de tamaño. |
| EP4074838A1 (en) | 2010-01-19 | 2022-10-19 | Verinata Health, Inc. | Novel protocol for preparing sequencing libraries |
| US10662474B2 (en) | 2010-01-19 | 2020-05-26 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
| EP2536854B1 (en) | 2010-02-18 | 2017-07-19 | The Johns Hopkins University | Personalized tumor biomarkers |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
-
2010
- 2010-11-05 MX MX2015002302A patent/MX357692B/es unknown
- 2010-11-05 JP JP2012537410A patent/JP5770737B2/ja active Active
- 2010-11-05 WO PCT/EP2010/066935 patent/WO2011054936A1/en not_active Ceased
- 2010-11-05 MX MX2012005217A patent/MX2012005217A/es active IP Right Grant
- 2010-11-05 EP EP10779290.5A patent/EP2496713B1/en active Active
- 2010-11-05 EP EP18182983.9A patent/EP3406737B1/en active Active
- 2010-11-05 CA CA2780016A patent/CA2780016C/en active Active
- 2010-11-05 US US12/940,992 patent/US8620593B2/en active Active
- 2010-11-05 EA EA201200701A patent/EA034241B1/ru unknown
- 2010-11-05 TW TW099138272A patent/TWI445854B/zh active
- 2010-11-05 AU AU2010317019A patent/AU2010317019B2/en active Active
- 2010-11-05 EP EP23160186.5A patent/EP4212630B1/en active Active
- 2010-11-05 CN CN201710549501.9A patent/CN107312844B/zh active Active
- 2010-11-05 ES ES23160186T patent/ES3026544T3/es active Active
- 2010-11-05 CN CN201080059269.7A patent/CN102791881B/zh active Active
-
2012
- 2012-05-02 IL IL219545A patent/IL219545A/en active IP Right Grant
-
2013
- 2013-11-25 US US14/089,720 patent/US9982300B2/en active Active
-
2015
- 2015-04-27 JP JP2015090264A patent/JP6001721B2/ja active Active
-
2018
- 2018-04-20 US US15/958,376 patent/US11365448B2/en active Active
-
2022
- 2022-05-12 US US17/742,749 patent/US20220282332A1/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452665A (zh) * | 2000-07-10 | 2003-10-29 | 赛姆格有限公司 | 在母体样品中鉴定胎儿dna的诊断方法 |
| CN1469932A (zh) * | 2000-10-17 | 2004-01-21 | 香港中文大学 | 非侵入的出生前监测 |
| CN1498276A (zh) * | 2001-03-23 | 2004-05-19 | ��������I�����ɷ� | 通过三螺旋相互作用纯化与检测双链dna靶序列的方法 |
| CN1798974A (zh) * | 2003-04-02 | 2006-07-05 | 阿德莱德研究及创新控股有限公司 | 基因组比较杂交 |
| EP1524321A1 (en) * | 2003-10-16 | 2005-04-20 | Sinuhe Dr. Hahn | Non-invasive detection of fetal genetic traits |
| CN101137760A (zh) * | 2005-03-18 | 2008-03-05 | 香港中文大学 | 检测染色体非整倍性的方法 |
| WO2007028155A3 (en) * | 2005-09-01 | 2007-06-21 | New England Medical Center Inc | Fragment size distribution pattern of amniotic fluid cell-free fetal dna for prenatal diagnosis |
| WO2008070862A3 (en) * | 2006-12-07 | 2008-11-20 | Biocept Inc | Non-invasive prenatal genetic screen |
Non-Patent Citations (1)
| Title |
|---|
| Microarray Analysis of Cell-Free Fetal DNA in Amniotic Fluid:A Prenatal Molecular Karyotyne;PaigeB.Larrabee等;《Am.J.Hum.Genet》;20041231;第485-491页 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107312844B (zh) | 基于大小的基因组分析 | |
| US11401551B2 (en) | Identifying a de novo fetal mutation from a maternal biological sample | |
| HK1240282A1 (en) | Size-based genomic analysis | |
| HK40097683A (en) | Size‑based genomic analysis for prenatal diagnosis | |
| HK40097683B (en) | Size‑based genomic analysis for prenatal diagnosis | |
| AU2015200462B2 (en) | Size-based genomic analysis | |
| HK40001037A (en) | Size-based genomic analysis | |
| HK40001037B (en) | Size-based genomic analysis | |
| HK1240282B (zh) | 基於大小的基因组分析 | |
| HK1175818A (en) | Size-based genomic analysis | |
| HK1175818B (en) | Size-based genomic analysis | |
| EA042606B1 (ru) | Геномный анализ на основе размеров | |
| EA050583B1 (ru) | Геномный анализ на основе размеров | |
| BR112012010708B1 (pt) | Método para realizar diagnóstico pré-natal, e, meio de armazenamento legível por computador | |
| BR122020014914B1 (pt) | Métodos para identificar uma mutação de novo no genoma de um feto não nascido de uma fêmea grávida, para determinar uma concentração fracionária de dna fetal em uma amostra biológica tirada de uma fêmea grávida e para determinar uma proporção de um genoma fetal que foi sequenciado a partir de uma amostra biológica tirada de uma fêmea grávida, e, meio legível por computador não transitório | |
| EA050163B1 (ru) | Анализ генома плода из материнского биологического образца |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1240282 Country of ref document: HK |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |