CN107296860A - A kind of complex health care product of anti-oxidant nti-freckle - Google Patents

A kind of complex health care product of anti-oxidant nti-freckle Download PDF

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CN107296860A
CN107296860A CN201710480276.8A CN201710480276A CN107296860A CN 107296860 A CN107296860 A CN 107296860A CN 201710480276 A CN201710480276 A CN 201710480276A CN 107296860 A CN107296860 A CN 107296860A
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health care
care product
parts
complex health
vitamin
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黄�俊
陈旭
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Profit Line (beijing) Biological Technology Co Ltd
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Profit Line (beijing) Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23DEDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention provides a kind of complex health care product of anti-oxidant nti-freckle.A kind of complex health care product of anti-oxidant nti-freckle, is mainly made up of following component:By weight, 200 400 parts of grape-kernel oil, 100 200 parts of Boxthorn Seed Oil, 50 150 parts of Fructus Jujubae extract, 20 70 parts of chrysanthemum extract, 5 10 parts of vitamin E.The coordinated that the complex health care product of the present invention passes through various materials; from collagenous fibres, pre- anti-melanin, exogenous microbial, strengthen immunity are resisted, eliminate multiple dimensions such as superoxide radical and start with; eliminating comprehensively causes the factor of skin oxidative and raw spot; lift skin self-protection and repair function; and it is at good operating condition; skin condition is significantly improved, the effect of anti-oxidant nti-freckle is played.

Description

A kind of complex health care product of anti-oxidant nti-freckle
Technical field
The present invention relates to health product technology field, more particularly, to a kind of complex health care product of anti-oxidant nti-freckle.
Background technology
Life scientists are deep into the discovery of cellular elements level analysis, and the aging of human body is similar to the process that iron gets rusty, It is the result aoxidized.Due to long-term aerobic respiration, by internal chemical combination, body metabolism process will be produced largely " free radical " Harmful activist, it is to cause the principal element of human senility.It acts on skin and just causes " rust staining ", acts on internal organ Orga- nogenesis is similar " body rust ".At an early age under normal physiological conditions, people's physical efficiency removes unnecessary free radical, but as the age increases Long, the reason such as life stress, stress, smoking and drinking, air pollution, electromagnetic radiation, melancholy, insomnia triggers metabolic disorder, Cause internal oxygen radical superfluous.There is the free radical of normal limit in human body, play a part of maintaining total balance of the body, but body Interior free radical is once superfluous, the hereditary material DNA in the continuous attack cells of unnecessary free radical, makes the oxidisability suffered by DNA Damage is more long-pending heavier.Vigor reduces after normal cell oxidation, and deterioration vivo environment poised state is destroyed, and this is hair Raw aging and the main cause of the degenerative disease relevant with aging.
People's interior free yl is superfluous, and oxidation resistance is not enough, it may appear that following illness:Wrinkle, color spot, cutis laxa, eye Bag, the colour of skin are dark and gloomy, insomnia, fatigue, dizzy nervous, constipation, blood-fat and blood sugar rise, arthritis, flu, apoplexy, senile dementia, Endocrinopathy, vision degeneration, sexual function decline, climacteric shifts to an earlier date, hypoimmunity, cancer etc..It is superfluous by taking color spot as an example Free radical with the modes of reproduction of chain reaction, constantly aoxidizes, corrodes normal cell in vivo, causes cell metabolism obstructed, and TYR enzyme activity is caused to raise significantly, pigment synthesis speed is accelerated, pigment granule is difficult to normal decompose and drained, constantly deposition, Unpleasant color spot is gradually formed in skin surface.Domestic scholars prove in recent years, and many Chinese medicines can be with anti-oxidant nti-freckle, but not The interference emphasis that same Chinese herbal medicine combination is aoxidized to body is different, and the preventive effect of performance is also different, it is still necessary to further investigate Utilize.
In view of this, it is special to propose the present invention.
The content of the invention
It is an object of the invention to provide a kind of complex health care product of anti-oxidant nti-freckle, described complex health care product utilizes section Compatibility relationship, multicomponent synergy, with more significant anti-oxidant freckle effect, and it is natural to draw materials, nontoxic without pair Effect.
In order to realize the above object the invention provides following technical scheme:
A kind of complex health care product of anti-oxidant nti-freckle, is mainly made up of following component:By weight,
Wherein, grape-kernel oil contain linoleic acid and other a variety of unrighted acids, vitamin F, mineral matter, protein, Linoleic acid, chlorophyll etc..Linoleic acid is aliphatic acid that is needed by human and can not being synthesized for human body.In grape-kernel oil Linoleic acid can resist free radical, anti-aging, help and absorb vitamin C and E, strengthen the elasticity of the circulatory system, reduction is purple Collagen in the injury of outside line, protection skin, improves venous engorgement and oedema, prevents melanin deposition.Grape-kernel oil contains Some OPCs have a protection blood vessel elasticity, protect skin afflicting with great suffering torment from ultraviolet, prevention collagenous fibres and elastomer Destruction, makes skin keep due elasticity and tension force, it is to avoid skin sagging and wrinkle are produced.
Boxthorn Seed Oil contains abundant and comprehensive bioactive substance and oleic acid, linoleic acid, gamma linoleic acid, β carrots Element, SOD etc..Boxthorn Seed Oil has obvious effect to regulation blood fat, liver-nourishing and eyesight-improving, kidney tonifying anticancer.
CAMP in Fructus Jujubae extract participates in cell division and differentiation, form formation, glycogen and fat point in vivo A variety of physiological and biochemical procedures such as solution, Steroidgenesis, and genetic transcription is may act on, influence the synthesis of protein.It is rich in jujube Rich vitamin C plays the role of very strong antioxidation activity and promotion collagen synthesis, may participate in histiocytic oxidation also Original reaction.Soap-like matter contained by Fructus Jujubae extract has regulation body metabolism, the effect of strengthen immunity.
Various active ingredients contained by chrysanthemum extract can anti-bacteria and anti-virus, heat clearing and inflammation relieving, anti-oxidant prevention skin declines Always.Especially the anti-grease composition of meadow sweet elite triple effect, can suppress the activity of 5a- reductases, and convergence pore reduces grease, had again very Good hypotensive activity.
Vitamin E is that life continues one of required nutrient.It can promote sex hormone to secrete, and improve fecundity, protect T lymphocytes, protection red blood cell, Green Tea Extract oxidation are protected, the lipid peroxidation reaction in ocular lens body can be suppressed, make peripheral blood Enlargement of pipe, improves blood circulation.
In the present invention, grape-kernel oil can prevent the destruction of collagenous fibres and elastomer, moreover it is possible to reduce the injury of ultraviolet, Prevent melanin deposition;Boxthorn Seed Oil is except that can remove the rubbish in blood, moreover it is possible to reduce vascular wall cholesterol deposition, prevent The SOD contained in blood fat atherosclerosis, Boxthorn Seed Oil, cooperates together with vitamin E, free with very strong elimination super oxygen The effect of base;Fructus Jujubae extract can promote synthesis and the strengthen immunity of collagen, chrysanthemum by adjusting physiological and biochemical procedure Extract can resist damage of the exogenous microbial to human body, so that skin aging shows caused by avoiding or alleviating external environment As.It can be seen that, in the Halth-care composition that the present invention is provided, the emphasis of each component is different, but passes through the association of various materials With coordinate, from collagenous fibres, elastomer, pre- anti-melanin, resist exogenous microbial, strengthen immunity, eliminate super oxygen from Started with by multiple dimensions such as base, eliminating comprehensively causes the factor of skin oxidative and raw spot, lifting skin self-protection and repair machine Can, and good operating condition is at, skin condition is significantly improved, the effect of anti-oxidant nti-freckle is played.
In addition, not introducing the medicinal material or auxiliary material of any toxic side effect in the formula of the present invention, therefore it is used for a long time more Safety.
Formula can also further optimize above, and to obtain more preferable anti-oxidant freckle effect, such as formula is:By weight Meter,
Oily composition has a major impact to the health-care effect of formula in all formulas described above, in order to improve health care effect The oil of fruit preferably following quality:
Preferably, the grape-kernel oil contains linoleic acid, OPC, vitamin B1, vitamin B3, vitamin B5, dimension Raw element F, vitamin C and chlorophyll;Wherein, by weight, linoleic acid accounting >=70%.
The grape-kernel oil of the quality can be through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described super to face The temperature that boundary's extraction is used is 20-40MPa for 25-35 DEG C, pressure.
In the present invention, grape pip is after ultramicro grinding, and the particle diameter of grape pip powder is less than 100 μm, and powder diameter is uniform, carefully Cell wall is broken, surface area and porosity increase, afterwards by CO2Supercritical extract, CO2The temperature that supercritical extraction is used For normal temperature, grape pip is in CO2Atmosphere in, should under the conditions of can ensure that the active component in grape pip is particularly temperature sensitive Active material and oxidizable active material do not degraded by high-temperature oxygen, and the recovery rate of active component is high, obtains Grape-kernel oil quality better.
Preferably, the Boxthorn Seed Oil includes following component:Weight percentage, linoleic acid >=61.5%, α-Asia Numb acid >=3.1%, gamma-Linolenic acid >=3.0%, vitamin E >=0.452% and selenium >=0.44/100000.
The Boxthorn Seed Oil of the quality can be through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, described super to face The temperature that boundary's extraction is used is 20-40MPa for 25-35 DEG C, pressure.
In the present invention, matrimony vine seed is after ultramicro grinding, and the particle diameter at matrimony vine seed powder end is less than 100 μm, and powder diameter is uniform, carefully Cell wall is broken, surface area and porosity increase, afterwards by CO2Supercritical extract, CO2The temperature that supercritical extraction is used For normal temperature, matrimony vine seed is in CO2Atmosphere in, should under the conditions of can ensure that the active component in matrimony vine seed is particularly temperature sensitive Active material and oxidizable active material do not degraded by high-temperature oxygen, and the recovery rate of active component is high, obtains Boxthorn Seed Oil quality better.There is low recovery rate, dissolvent residual, active component destructible in squeezing, the organic solvent extraction of routine The problems such as, and CO of the present invention2Supercritical extraction process completely avoid problem above.
Wherein, degumming, depickling for example can add alkali depickling (to be determined with crude oil acid value after alkali number, plus alkali using conventional means Need to stir 10 minutes with 90rpm speed), heating is needed in deacidification, and heating rate preferably is 1 DEG C/min.
Fructus Jujubae extract used above, chrysanthemum extract can be using conventional extracting methods, but preferably following extract work Skill:
The Fructus Jujubae extract is made using following methods:Using water as solvent, multiple, backflow extraction every time is extracted to jujube When temperature be 90-100 DEG C, solid-to-liquid ratio be 1:5-9;Concentrate afterwards, then plus after 70-80% alcohol-water separate out sediment, Gained sediment is dried;
Preferably, the chrysanthemum extract is made using following methods:
Using water as solvent, chrysanthemum is extracted it is multiple, every time temperature during backflow extraction be 90-100 DEG C, solid-to-liquid ratio be 1: 15-20;Concentrate afterwards, then plus after 70-80% alcohol-water separate out sediment, gained sediment is dried.
In order to improve the effect of alcohol precipitation, it is concentrated into relative density and is advisable for 1.1-1.2 (60 DEG C).
Fructus Jujubae extract obtained above, chrysanthemum extract powder obtain fine powder, more conducively absorption of human body through 100 mesh sieves.
To sum up, compared with prior art, the present invention achieves following technique effect:
(1) grape-kernel oil, Boxthorn Seed Oil, Fructus Jujubae extract, five kinds of composition science of chrysanthemum extract and vitamin E are matched somebody with somebody 5, cooperate with, significantly enhance anti-oxidant freckle effect;
(2) auxiliary material of science species and proportioning is introduced, the absorptivity of health products is improved, so as to improve indirectly anti-oxidant Freckle effect;
(3) pigment conventional in capsule shells is removed, the security and quality of health products is improved;
(4) by improving CO2The operating condition of supercritical extraction process, not only improves the ratio of main active component in oil Example, and avoid introduce caused by the material such as organic solvent a series of problems (for example remove solvent cost, it is blowdown flow rate, molten Agent residual etc.);
(5) yield is improved by improving the aqueous extraction-alcohol precipitation technology of jujube and chrysanthemum, improves product quality.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, but ability Field technique personnel will be understood that following described embodiment is a part of embodiment of the invention, rather than whole embodiments, The present invention is merely to illustrate, and is not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected Enclose.Unreceipted actual conditions person in embodiment, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument Unreceipted production firm person, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1
Grape-kernel oil is extracted from grape pip:
1st, pre-process:Grape pip is cleaned, dust and other impurity is screened out.
2、CO2Supercritical extract:Temperature be 25 DEG C, pressure be to extract once under conditions of 30MPa or so, collect respectively Oil and the dregs of fat.
3rd, degumming, depickling:Plus alkali depickling, determine to need after alkali number, plus alkali with crude oil acid value to stir 10 with 90rpm speed Minute, heated in deacidification with 1 DEG C/min heating rates.
The component content of detection gained grape-kernel oil, it is as a result as follows:By weight percentage,
Linoleic acid accounting 70%, and OPC, vitamin B1, vitamin B3, vitamin B5, vitaminF, vitamin C and chlorophyll.
Embodiment 2
Grape-kernel oil is extracted from grape pip:
1st, pre-process:Grape pip is cleaned, dust and other impurity is screened out.
2、CO2Supercritical extract:Temperature be 35 DEG C, pressure be to extract once under conditions of 20MPa, collect respectively oil and The dregs of fat.
3rd, degumming, depickling:Plus alkali depickling, determine to need after alkali number, plus alkali with crude oil acid value to stir 10 with 90rpm speed Minute, heated in deacidification with 1 DEG C/min heating rates.
The component content of detection gained grape-kernel oil, it is as a result as follows:By weight percentage,
Linoleic acid accounting 70%, and OPC, vitamin B1, vitamin B3, vitamin B5, vitaminF, vitamin C and chlorophyll.
Embodiment 3
Boxthorn Seed Oil is extracted from matrimony vine seed:
Step and condition be the same as Example 1.
The component content of detection gained Boxthorn Seed Oil, it is as a result as follows:
By weight percentage, linoleic acid 61.5%, alpha-linolenic acid 3.1%, gamma-Linolenic acid 3.0%, vitamin E 0.452% and selenium 0.44/100000.
Embodiment 4
Prepare Fructus Jujubae extract:
1st, pre-process:Jujube is cleaned, dust and impurity is understood, crushed.
2nd, add water extraction for the first time:The water of 9 times of amounts is added, 100 DEG C are heated to, extracts 3 hours, is filtrated to get filtrate, is received Collect filter residue and carry out next step extraction.
3rd, add water extraction for the second time:The water of 5 times of amounts is added into filter residue, 100 DEG C are heated to, extracts 1 hour, is filtrated to get Filtrate.
4th, concentrate:Relative density is concentrated into for 1.1 (60 DEG C).
5th, alcohol precipitation:The alcohol-water for plus 80%, stands 20 hours, separates out sediment.
6th, dry:Gained sediment is dried under reduced pressure, vacuum is that -0.07kPa, temperature are 60 DEG C.
Embodiment 5
Prepare chrysanthemum extract:
1st, pre-process:Chrysanthemum is cleaned, dust and impurity is understood, crushed.
2nd, add water extraction for the first time:The water of 20 times of amounts is added, 100 DEG C are heated to, extracts 1 hour, is filtrated to get filtrate, is received Collect filter residue and carry out next step extraction.
3rd, add water extraction for the second time:The water of 15 times of amounts is added into filter residue, 100 DEG C are heated to, extracts 1 hour, filters To filtrate.
4th, concentrate:Relative density is concentrated into for 1.2 (60 DEG C).
5th, alcohol precipitation:The alcohol-water for plus 80%, stands 30 hours, separates out sediment.
6th, dry:Gained sediment is dried under reduced pressure, vacuum is that -0.03kPa, temperature are 80 DEG C.
Embodiment 6
Prepare capsule shells:
1st, feeding:Gelatin 400g, glycerine 200g, purified water 250g.
2nd, prepare:First glycerine, purified water are mixed, gained mixture after gelatin is added and is stirred 2 hours at 65 DEG C, then it is quiet Put 2 hours, cast molding afterwards obtains rubber, be molded using capsule machine pelleting.
Embodiment 7
From embodiment 6 to differ only in formula different, be:Gelatin 500g, glycerine 150g, purified water 500g.
Embodiment 8
From embodiment 6 to differ only in formula different, be:Gelatin 400g, glycerine 200g, purified water 400g.
Embodiment 9
Prepare complex health care product:
1st, draw materials:Grape-kernel oil 300g, Boxthorn Seed Oil 150g, Fructus Jujubae extract 150g, chrysanthemum extract 40g, vitamin E8g, beeswax 15g.
2nd, capsule is prepared:All raw materials in 1st step are mixed, homogeneous, in the capsule shells that the offer of embodiment 8 is provided.
Embodiment 10
From embodiment 9 to differ only in beeswax consumption different, be 30g.
Embodiment 11
Different from the proportioning for differing only in primary raw material of embodiment 9, i.e., grape-kernel oil, Boxthorn Seed Oil, jujube are extracted The proportioning of thing, chrysanthemum extract and vitamin E, be:Grape-kernel oil 400g, Boxthorn Seed Oil 100g, Fructus Jujubae extract 150g, chrysanthemum Extract 20g, vitamin e1 0g, beeswax 15g.
Embodiment 12
Different from the proportioning for differing only in primary raw material of embodiment 9, i.e., grape-kernel oil, Boxthorn Seed Oil, jujube are extracted The proportioning of thing, chrysanthemum extract and vitamin E, be:Grape-kernel oil 200g, Boxthorn Seed Oil 200g, Fructus Jujubae extract 50g, chrysanthemum Extract 70g, vitamin e1 0g, beeswax 15g.
Embodiment 13
With differing only in without beeswax for embodiment 9.
Comparative example 1
Different from the proportioning for differing only in primary raw material of embodiment 9, i.e., proportioning is:Grape-kernel oil 420g, matrimony vine Seed oil 90g, Fructus Jujubae extract 160g, chrysanthemum extract 75g, vitamin E 8g, auxiliary material 10g.
Comparative example 2
Comparative example 2 is commercial glucose seed oil and Boxthorn Seed Oil in mass ratio 2:1 is made into, and manufacturing process is with comparative example 1.
Comparative example 3
Comparative example 3 is commercially available Boxthorn Seed Oil and commercially available Fructus Jujubae extract in mass ratio 1:1 is made into, the same comparative example of manufacturing process 1。
Comparative example 4
Comparative example 4 is that commercial glucose seed is oily with commercially available chrysanthemum extract in mass ratio 15:2 are made into, and manufacturing process is same to be compared Example 1.
Comparative example 5
Comparative example 5 is commercially available Boxthorn Seed Oil, Fructus Jujubae extract, chrysanthemum extract and vitamin E in mass ratio 15:15:4: 0.8 is made into.
Comparative example 6
Comparative example 6 is different from the source for differing only in grape-kernel oil of embodiment 9, and it uses patent application The method of CN1237618A embodiment 2 is extracted, and remaining formula and method are identical.
Hunan Ya Mei bio tech ltd of commercial glucose Zi You producers used in the comparative example of the present invention, it is commercially available Boxthorn Seed Oil producer prays for blessings in Ningxia medlar biological Science and Technology Ltd., and Xi'an Tianrui of commercially available Fructus Jujubae extract producer biotechnology has Limit company, Xi'an Sai Ao Bioisystech Co., Ltd of commercially available chrysanthemum extract producer.
Experimental example
DPPH free radical scavenging activities
Embodiment 9-13 and comparative example 1-6 DPPH free radical scavenging activities are detected, as a result such as table 1 below.
Table 1
Group Clearance rate/%
Embodiment 9 93.7
Embodiment 10 91.5
Embodiment 11 89.3
Embodiment 12 88.7
Embodiment 13 83.5
Comparative example 1 61.2
Comparative example 2 65.9
Comparative example 3 69.5
Comparative example 4 67.2
Comparative example 5 71.1
Comparative example 6 72.4
As a result show, the antioxidant effect of embodiment 9 is most notable, and 32.5% is improved compared to comparative example 1, and add Plus the anti-oxidation efficacy of beeswax is significantly better than un-added, thus it can determine that, the present invention necessarily has significant color spot effect of dispelling.
Finally it should be noted that:Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations;To the greatest extent The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that:Its according to The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered Row equivalent substitution;And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology The scope of scheme.

Claims (10)

1. a kind of complex health care product of anti-oxidant nti-freckle, it is characterised in that be mainly made up of following component:By weight,
2. complex health care product according to claim 1, it is characterised in that by weight,
3. complex health care product according to claim 1, it is characterised in that the grape-kernel oil contains linoleic acid, former cyanine Element, vitamin B1, vitamin B3, vitamin B5, vitaminF, vitamin C and chlorophyll;Wherein, weight percentage, Linoleic acid accounting >=70%;
Preferably, the grape-kernel oil is through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, the overcritical extraction It is 20-40MPa for 25-35 DEG C, pressure to follow the example of the temperature used.
4. complex health care product according to claim 1, it is characterised in that the Boxthorn Seed Oil includes following component:By weight Percentage composition meter is measured,
Linoleic acid >=61.5%, alpha-linolenic acid >=3.1%, gamma-Linolenic acid >=3.0%, vitamin E >=0.452% and selenium >= 0.44/100000;
Preferably, the Boxthorn Seed Oil is through ultramicro grinding, CO2Supercritical extract, degumming, depickling are prepared from, the overcritical extraction It is 20-40MPa for 25-35 DEG C, pressure to follow the example of the temperature used.
5. complex health care product according to claim 1, it is characterised in that the Fructus Jujubae extract uses following methods system :
Using water as solvent, jujube is extracted it is multiple, every time temperature during backflow extraction be 90-100 DEG C, solid-to-liquid ratio be 1:5-9;It After concentrate, then plus 70-80% alcohol-water after separate out sediment, gained sediment is dried;
Preferably, the chrysanthemum extract is made using following methods:
Using water as solvent, chrysanthemum is extracted it is multiple, every time temperature during backflow extraction be 90-100 DEG C, solid-to-liquid ratio be 1:15-20; Concentrate afterwards, then plus after 70-80% ethanol separate out sediment, gained sediment is dried.
6. complex health care product according to claim 1, it is characterised in that the formulation of the complex health care product is soft capsule Agent.
7. complex health care product according to claim 6, it is characterised in that also contain emulsifying agent in the soft capsule, described The consumption of emulsifying agent is preferably 15-30 parts.
8. complex health care product according to claim 7, it is characterised in that the emulsifying agent is beeswax.
9. complex health care product according to claim 6, it is characterised in that soft capsule shell master used in the soft capsule To be made up of following component:By weight,
200-500 parts of gelatin, preferably 400-500 parts,
150-300 parts of glycerine, preferably 150-200 parts,
250-500 parts, preferably 400-500 parts of purified water.
10. complex health care product according to claim 9, it is characterised in that the preparation method of the soft capsule shell is:First will Glycerine, purified water mixing, add gained mixture after gelatin and are stirred 1-2 hours at 65-75 DEG C, then stand 2-3 hours, afterwards Cast molding obtains rubber, is molded using capsule machine pelleting.
CN201710480276.8A 2017-06-22 2017-06-22 A kind of complex health care product of anti-oxidant nti-freckle Pending CN107296860A (en)

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Citations (4)

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Publication number Priority date Publication date Assignee Title
CN1463743A (en) * 2002-06-29 2003-12-31 王勇智 Capsule possessing antisenescent and spot dispelling effect and method for making the same
CN101828714A (en) * 2010-05-13 2010-09-15 山东森健生物科技发展有限公司 Health food for delaying senescence
KR20140021894A (en) * 2012-08-13 2014-02-21 김미향 Preparation of antioxidation chilli sauce
CN104738215A (en) * 2015-04-01 2015-07-01 福建拓天生物科技有限公司 Camellia oil capable of improving immunity and processing method of camellia oil

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1463743A (en) * 2002-06-29 2003-12-31 王勇智 Capsule possessing antisenescent and spot dispelling effect and method for making the same
CN101828714A (en) * 2010-05-13 2010-09-15 山东森健生物科技发展有限公司 Health food for delaying senescence
KR20140021894A (en) * 2012-08-13 2014-02-21 김미향 Preparation of antioxidation chilli sauce
CN104738215A (en) * 2015-04-01 2015-07-01 福建拓天生物科技有限公司 Camellia oil capable of improving immunity and processing method of camellia oil

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