CN107281225A - A kind of Chinese medicine composition and preparation method thereof - Google Patents
A kind of Chinese medicine composition and preparation method thereof Download PDFInfo
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- CN107281225A CN107281225A CN201710515443.8A CN201710515443A CN107281225A CN 107281225 A CN107281225 A CN 107281225A CN 201710515443 A CN201710515443 A CN 201710515443A CN 107281225 A CN107281225 A CN 107281225A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/40—Shell-fish
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/50—Molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Marine Sciences & Fisheries (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention provides a kind of Chinese medicine composition and preparation method thereof, it the described method comprises the following steps：(A) abalone, raw oyster and Crassostrea rivularis, are handled in the following manner：A1, it will break into slurry by pretreated raw material and filter；A2, pre-freeze：By the thickness control of slurry in 5~10mm, at 50~10 DEG C, 1~2h of pre-freeze；A3, distillation：It is that 30~50Pa, temperature are under conditions of 65~75 DEG C, to dry 12~20 hours, produce freeze-dried powder in pressure by the thickness control of material after pre-freeze in 5~10mm；A4, freeze-dried powder is subjected to dispersion and fining, obtains homogeneous digested tankage；(B) abalone powder, raw oyster powder and the Crassostrea rivularis powder for, obtaining step (A) are mixed.The method of the invention processes abalone, Crassostrea rivularis and raw oyster by the way of vacuum freeze drying, and the active ingredient and nutritional ingredient that can save from damage in above-mentioned raw materials are not damaged, and rehydration is good, is widely used.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine composition and preparation method thereof.
Background technology
Abalone (Abalone) is called extra large ear, abalone, minute surface fish, nine hole spiral shells, belongs to the original abdominal foot of Mollusca Gastropoda
Mu Bao sections, abalone contains abundant protein, rich in abundant globulin, the battalion such as also more calcium, iron, iodine and vitamin A
Support element.Modern study shows：Contain fresh plain I and Bao Ling elements II in abalone meat, there is stronger suppression cancer cell.Bao
Fish is mended without dry, nourishes the liver to improve visual acuity.The traditional Chinese medical science claims abalone effect calming the liver, antipyretic improving eyesight, quenches the thirst treating stranguria；The hot superinverse of liver is cured mainly,
Have a dizzy spell, hectic fever due to yin labor is hot, blue or green the region between the heart and the diaphragm cataract or glaucoma, the disease such as Hypertensive Fundus bleeding.
Crassostrea rivularis (Ostrea rivularis Gould), category Ostreidae, bivalve, rich in zinc albuminate,
Taste is salty, is slightly cold, Return liver, courage, kidney channel.Calcined oyster shell：The effect for restraining astringent or styptic treatment for spontaneous sweating deacidification is strong, and treatment has a stomach-ache, hydrochloric acid in gastric juice etc..Raw oyster：On
Accept and hold back, treat dizzy, just dilute.Modern study shows：The acidic extraction thing of oyster has in live body to poliovirus
There is inhibitory action, making the mouse death rate of infection reduces.
Raw oyster is that head is than one of larger kind in oyster kind, and raw oyster is traditional invigorant, according to《Compendium of Materia Medica》Note
Carry：" raw oyster, governance wasting, establishing-Yang, removing toxic substances, mend men and women's qi and blood, make skin delicate, health care labor." it is usually growth or supported
Grow in place of rivers and sea blending, on half salty half light inner bay shallow sea.Due to being adapted to the limitation of growth conditions, its quantity
On it is fewer than other kinds, therefore its economic price is typically higher.It can also eat something rare, and have kidney tonifying, the effect of beauty.
At present, the fresh-keeping mode of the abalone of in the market is more traditional, is dried in the shade after the general leaching using salt, reduces its nutritional quality
And medical active.Oyster also be used to be processed into ostreae testa pulverata, adopted after typically oyster meat is beaten in addition to eating something rare and typically cooking
Obtained with being crushed after vacuum freeze drying, or dry acquisition after cooking liquor is concentrated in vacuo after oyster meat high pressure is boiled
, method is simple, oyster meat albuminous degeneration after shortening, and part nutriment is lost.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is a kind of method for preparing Chinese medicine composition of offer, and this method in process can
It is enough effectively to protect the active ingredient in raw material not to be destroyed, improve the utilization rate of Chinese medicine composition.
The second object of the present invention is to provide the Chinese medicine composition that a kind of above method is prepared from, the Chinese traditional medicine composition
In thing each component compatibility rationally, active ingredient preservation degree it is good, with splendid health-caring function.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of method for preparing Chinese medicine composition, it is characterised in that the described method comprises the following steps：
(A) abalone, raw oyster and Crassostrea rivularis, are handled in the following manner：A1, slurry will be broken into by pretreated raw material
And filter；A2, pre-freeze：By the thickness control of slurry in 5~10mm, at -50~-10 DEG C, 1~2h of pre-freeze；A3, distillation：Will
The thickness control of material is in 5~10mm after pre-freeze, is that 30~50Pa, temperature are under conditions of 65~75 DEG C, to dry 12 in pressure
~20 hours, produce freeze-dried powder；A4, freeze-dried powder is subjected to dispersion and fining, obtains homogeneous digested tankage；
(B) abalone powder, raw oyster powder and the Crassostrea rivularis powder for, obtaining step (A) are mixed.
The above-mentioned preparation method of the present invention takes the mode of vacuum freeze drying to add abalone, raw oyster and Crassostrea rivularis
Work.Vacuum freeze drying is under high vacuum state, using sublimation principle, to make in the material freezed in advance moisture without ice
Melt and be directly removed with the distillation of ice state for vapor, so as to reach the purpose of freeze-drying.Because material is low in low temperature
Drying is depressed, the loss of heat-sensitive substance and easy oxidation material can be greatly reduced, therefore, vacuum freeze drying can be most
Keep to limits the nutritional ingredient of food.A variety of nutriments are rich in abalone, raw oyster and Crassostrea rivularis, with splendid
Health-caring function, but amino acid therein, protein, vitamin easy deactivation in process.The present invention is used
Vacuum freeze-drying technique, above-mentioned raw materials can be solved well and dry the defect that active ingredient is easily inactivated in process.
During vacuum freeze-drying technique, material thickness, pre-freezing temperature, vacuum, heating-up temperature are to directly affect
Difference between the key process parameter of drying effect, different processing materials is big, the method for the invention particular for abalone,
The characteristic of raw oyster and Crassostrea rivularis itself, is optimized to above-mentioned parameter, and the processing method after optimization is to abalone, raw oyster and nearly river
Oyster has specificity and specific aim, and the active material in material can be retained to the maximum limit.
In some embodiments, methods described also includes after step (B)：(C), mixed freeze-dried powder is carried out
Crush, cross 70-90 mesh sieves, it is preferable that cross 80 mesh sieves.
The method of the invention also further combines superfine communication technique on the basis of vacuum freeze-drying technique, obtains
Product be ultra-micro powder, the particle of powder is small, and surface area is big, absorbs fast, using also more extensively, both can be directly as Chinese medicine
Medicine materical crude slice is eaten, and can also be expected as the first wife of other food, health products, medicine.
In some embodiments, the step a2 in methods described is specially：Pre-freeze：By the thickness control of each slurry 6
~9mm, at -50~-30 DEG C, 1.2~1.8h of pre-freeze；
The step a3 is specially：Distillation：By the thickness control of material after pre-freeze in 6~9mm, pressure be 35~
45Pa, temperature is under conditions of 70~75 DEG C, drying 15~20 hours produce freeze-dried powder.
In some embodiments, the step a2 is specially：Pre-freeze：By the thickness control of each slurry in 8mm, -50
At DEG C, pre-freeze 1.5h；
The step a3 is specially：Distillation：It is that 50Pa, temperature are in pressure by the thickness control of material after pre-freeze in 8mm
Under conditions of 70 DEG C, dry 15 hours, produce freeze-dried powder.
In some embodiments, the step a2 is specially：Pre-freeze：By the thickness control of each slurry in 9mm, -40
At DEG C, pre-freeze 2h；
The step a3 is specially：Distillation：It is that 40Pa, temperature are in pressure by the thickness control of material after pre-freeze in 9mm
Under conditions of 75 DEG C, dry 12 hours, produce freeze-dried powder.
In some embodiments, the step a2 is specially：Pre-freeze：By the thickness control of each slurry in 10mm, -30
At DEG C, pre-freeze 2h；
The step a3 is specially：Distillation：It is 30Pa, temperature in pressure by the thickness control of material after pre-freeze in 10mm
Under conditions of 65 DEG C, dry 20 hours, produce freeze-dried powder.
In some embodiments, the raw material is pre-processed in the following manner：Fresh raw material is taken to go intestines to shell, clearly
Wash clean, and broken obtain cube meat.
In some embodiments, the mode filtered described in step a1 is specially：The slurry of acquisition is crossed into 100~150 mesh
Mesh screen, it is preferable that cross 120 mesh sieves.
The present invention also provides the Chinese medicine composition being prepared from by the above method.On the one hand, by the above method, composition
The active ingredient of middle abalone, raw oyster and Crassostrea rivularis is intact, powder particle is small, and surface area is big, beneficial to absorption, the opposing party
Face, the abalone, raw oyster and Crassostrea rivularis compatibility are reasonable, cooperative compensating, with raising immunity, menstruation regulating ease constipation, anti-aging, guarantor
Liver cholagogic, establishing-Yang and antitoxic heart-soothing and sedative etc. are acted on.
In some embodiments, by weight, the composition includes：1~80 part of abalone powder, raw oyster powder 5~60
5~60 parts of part and Crassostrea rivularis powder.
In some embodiments, by weight, the composition includes：Abalone powder 10~80, raw oyster powder 10~50,
Crassostrea rivularis powder 10~50.
In some embodiments, the Chinese medicine composition is pulvis, capsule, granule, tablet and pill；It is preferred that
Ground, the Chinese medicine composition is pulvis or capsule, and the capsule is preferably snap fit capsule.
Compared with prior art, beneficial effects of the present invention are：
1), the method for the invention processes abalone, Crassostrea rivularis and raw oyster, Neng Goubao by the way of vacuum freeze drying
Active ingredient and nutritional ingredient in full above-mentioned raw materials are not destroyed, and rehydration is good, is widely used.
2), the method for the invention is directed to the material characteristic of abalone, Crassostrea rivularis and raw oyster to vacuum freeze drying process
In key parameter optimize, its active ingredient can be saved from damage to greatest extent.
3), the method for the invention uses Vacuum Freezing ＆ Drying Technology combination superfine communication technique, and the product of acquisition is super
Micropowder, powder particle is small, and surface area is big, absorbs faster, purposes is more extensive.
4) Chinese medicine composition of the present invention is compounded to abalone, Crassostrea rivularis and raw oyster, and compatibility is closed between each composition
Reason, cooperative compensating, are acted on immunity, menstruation regulating ease constipation, anti-aging, hepatic cholagogic, establishing-Yang and antitoxic heart-soothing and sedative etc. is improved.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, be
The conventional products that can be obtained by commercially available purchase.
Embodiment 1
1st, a kind of Chinese medicine freezes the preparation method of powder raw material, comprises the following steps：
(1) medicinal material is checked and accepted：The abalone of examination is from Zhanjiang City East Sea Naozhou Island of Zhanjiang abalone culture, and the raw oyster of examination is from Zhan
Jiang Zhongji Sheng Hao plants, the Crassostrea rivularis of examination comes from Zhanjiang City port owned by the government Oyashio oyster bed.
(2) cleaning is slaughtered：Fresh medicinal material is gone after intestines shell, to be cleaned up with circulating water.
(3) rub：Through bone and flesh pulverizer crush respectively and obtain cube meat.
(4) it is beaten：Step (3) cube meat is beaten and levigate respectively, the slurries that grain diameter is less than 10 μm are obtained.
(5) filter：Starched with meat of the 120 eye mesh screen filtration steps (4) after levigate, to go the removal of impurity and cube meat.
(6) freeze, first pre-freeze：50 DEG C of control material thickness 8mm, temperature ﹣, 1.5 hours time.Distil again：Control material
Thickness 8mm, pressure 50Pa when drying, 70 DEG C of temperature of heating plate, are obtained 15 hours time to material moisture control within 5%
Digested tankage.
(7) crush：Digested tankage after will be lyophilized carries out dispersion and fining, crosses 80 mesh sieves, obtains the homogeneous powdered digested tankage of quality.
(8) pack:Carry out package encapsulation in time to the digested tankage after refinement, and be put in storage preservation.
2nd, a kind of Chinese medicine freezes compound powder and preparation method thereof, and the Chinese medicine freezes compound powder by following raw material by weight
Proportioning is made (1000g)：
Abalone powder 600g
Raw oyster powder 300g
Crassostrea rivularis powder 100g
(1) raw material abalone powder, raw oyster powder, Crassostrea rivularis powder are placed in three-dimensional mixer, are sufficiently mixed, incorporation time
30min, is made mixed material.
(2) mixed raw material powder loads snap fit capsule, and capsule 500 is made.
Embodiment 2
1st, a kind of Chinese medicine freezes the preparation method of powder raw material, comprises the following steps：
(1) medicinal material is checked and accepted：The abalone of examination is from Zhanjiang City East Sea Naozhou Island of Zhanjiang abalone culture, and the raw oyster of examination is from Zhan
Jiang Zhongji Sheng Hao plants, the Crassostrea rivularis of examination comes from Zhanjiang City port owned by the government Oyashio oyster bed.
(2) cleaning is slaughtered：Fresh medicinal material is gone after intestines shell, to be cleaned up with circulating water.
(3) rub：Through bone and flesh pulverizer crush respectively and obtain cube meat.
(4) it is beaten:Step (3) cube meat is beaten and levigate respectively, the slurries that grain diameter is less than 10 μm are obtained.
(5) filter:Starched with meat of the 120 eye mesh screen filtration steps (4) after levigate, to go the removal of impurity and cube meat；
(6) freeze, first pre-freeze：40 DEG C of control material thickness 9mm, temperature ﹣, time 2 h.Distil again：Control material is thick
9mm is spent, pressure 40Pa when drying, 75 DEG C of temperature of heating plate, meat is obtained to material moisture control at 12 hours time within 5%
Powder；
(7) crush：Digested tankage after will be lyophilized carries out dispersion and fining, crosses 80 mesh sieves, obtains the homogeneous powdered digested tankage of quality.
(8) pack:Carry out package encapsulation in time to the digested tankage after refinement, and be put in storage preservation.
2nd, a kind of Chinese medicine freezes compound powder and preparation method thereof, and the Chinese medicine freezes compound powder by following raw material by weight
Proportioning is made (1000g)：
Abalone powder 500g
Raw oyster powder 400g
Crassostrea rivularis powder 100g
(1) raw material abalone powder, raw oyster powder, Crassostrea rivularis powder are placed in three-dimensional mixer, are sufficiently mixed, incorporation time
25min, is made mixed material.
(2) mixed raw material powder loads snap fit capsule, and capsule 500 is made.
Embodiment 3
1st, a kind of Chinese medicine freezes the preparation method of powder raw material, comprises the following steps：
(1) medicinal material is checked and accepted：The abalone of examination is from Zhanjiang City East Sea Naozhou Island of Zhanjiang abalone culture, and the raw oyster of examination is from Zhan
Jiang Zhongji Sheng Hao plants, the Crassostrea rivularis of examination comes from Zhanjiang City port owned by the government Oyashio oyster bed.
(2) cleaning is slaughtered：Fresh medicinal material is gone after intestines shell, to be cleaned up with circulating water.
(3) rub：Through bone and flesh pulverizer crush respectively and obtain cube meat.
(4) it is beaten:Step (3) cube meat is beaten and levigate respectively, the slurries that grain diameter is less than 10 μm are obtained.
(5) filter:Starched with meat of the 120 eye mesh screen filtration steps (4) after levigate, to go the removal of impurity and cube meat.
(6) freeze, first pre-freeze：Control material thickness 10mm, -30 DEG C of temperature, time 2 h.Distil again：Control material is thick
10mm is spent, pressure 30Pa when drying, 65 DEG C of temperature of heating plate, meat is obtained to material moisture control at 20 hours time within 5%
Powder；
(7) crush：Digested tankage after will be lyophilized carries out dispersion and fining, crosses 80 mesh sieves, obtains the homogeneous powdered digested tankage of quality.
(8) pack:Carry out package encapsulation in time to the digested tankage after refinement, and be put in storage preservation.
2nd, a kind of Chinese medicine freezes compound powder and preparation method thereof, and the Chinese medicine freezes compound powder by following raw material by weight
Proportioning is made (1000g)：
Abalone powder 400g
Raw oyster powder 400g
Crassostrea rivularis powder 200g
(1) raw material abalone powder, raw oyster powder, Crassostrea rivularis powder are placed in three-dimensional mixer, are sufficiently mixed, incorporation time
30min, is made mixed material.
(2) mixed raw material powder loads snap fit capsule, and capsule 500 is made.
Comparative example 1
1st, a kind of Chinese medicine freezes the preparation method of powder raw material, comprises the following steps：
(1) medicinal material is checked and accepted：The abalone of examination is from Zhanjiang City East Sea Naozhou Island of Zhanjiang abalone culture, and the raw oyster of examination is from Zhan
Jiang Zhongji Sheng Hao plants, the Crassostrea rivularis of examination comes from Zhanjiang City port owned by the government Oyashio oyster bed.
(2) cleaning is slaughtered：Fresh medicinal material is gone after intestines shell, to be cleaned up with circulating water.
(3) rub：Through bone pulverizer crush respectively and obtain cube meat.
(4) it is beaten：Step (3) cube meat is beaten and levigate respectively, the slurries that grain diameter is less than 10 μm are obtained.
(5) filter：Starched with meat of the 120 eye mesh screen filtration steps (4) after levigate, to go the removal of impurity and cube meat.
(6) freeze, first pre-freeze：Control material thickness 15mm, -20 DEG C of temperature, 3 hours time.Distil again：Control material is thick
15mm is spent, pressure 50Pa when drying, 70 DEG C of temperature of heating plate, meat is obtained to material moisture control at 20 hours time within 5%
Powder.
(7) crush：Digested tankage after will be lyophilized carries out dispersion and fining, crosses 80 mesh sieves, obtains the homogeneous powdered digested tankage of quality.
(8) pack:Carry out package encapsulation in time to the digested tankage after refinement, and be put in storage preservation.
2nd, a kind of Chinese medicine freezes compound powder and preparation method thereof, and the Chinese medicine freezes compound powder by following raw material by weight
Proportioning is made (1000g)：
Abalone powder 600g
Raw oyster powder 300g
Crassostrea rivularis powder 100g
(1) raw material abalone powder, raw oyster powder, Crassostrea rivularis powder are placed in three-dimensional mixer, are sufficiently mixed, incorporation time
30min, is made mixed material.
(2) mixed raw material powder loads snap fit capsule, and capsule 500 is made.
Comparative example 2
1st, a kind of Chinese medicine freezes the preparation method of powder raw material, comprises the following steps：
(1) medicinal material is checked and accepted：The abalone of examination is from Zhanjiang City East Sea Naozhou Island of Zhanjiang abalone culture, and the raw oyster of examination is from Zhan
Jiang Zhongji Sheng Hao plants, the Crassostrea rivularis of examination comes from Zhanjiang City port owned by the government Oyashio oyster bed.
(2) cleaning is slaughtered：Fresh medicinal material is gone after intestines shell, to be cleaned up with circulating water.
(3) rub：Through bone pulverizer crush respectively and obtain cube meat.
(4) it is beaten：Step (3) cube meat is beaten and levigate respectively, the slurries that grain diameter is less than 10 μm are obtained.
(5) filter：Starched with meat of the 120 eye mesh screen filtration steps (4) after levigate, to go the removal of impurity and cube meat.
(6) freeze, first pre-freeze：50 DEG C of control material thickness 8mm, temperature ﹣, 1.5 hours time.Distil again：Control material
Thickness 8mm, pressure 100Pa when drying, 45 DEG C of temperature of heating plate, are obtained 15 hours time to material moisture control within 5%
Digested tankage.
(7) crush：Digested tankage after will be lyophilized carries out dispersion and fining, crosses 80 mesh sieves, obtains the homogeneous powdered digested tankage of quality.
(8) pack:Carry out package encapsulation in time to the digested tankage after refinement, and be put in storage preservation.
2nd, a kind of Chinese medicine freezes compound powder and preparation method thereof, and the Chinese medicine freezes compound powder by following raw material by weight
Proportioning is made (1000g)：
Abalone powder 600g
Raw oyster powder 300g
Crassostrea rivularis powder 100g
(1) raw material abalone powder, raw oyster powder, Crassostrea rivularis powder are placed in three-dimensional mixer, are sufficiently mixed, incorporation time
30min, is made mixed material.
(2) mixed raw material powder loads snap fit capsule, and capsule 500 is made.
Experimental example 1
The HPLC detections being related in experimental example of the present invention use following detection method：
Chromatographic condition：
Chromatographic column：Agilent-C18 (250mm × 4.6mm, 5 μm)
Mobile phase：Sodium acetate-methanol (58：42, pH=5.5)
Flow velocity：1.0mL/min
Column temperature：25.0℃
Detection wavelength：330nm
Theoretical cam curve is no less than 3000.
It is prepared by reference substance solution：Precision weighs 80 DEG C of dryings to the taurine standard items (Sigma Co., USA) of constant weight
0.100g, is dissolved with ultra-pure water and is settled to 100mL, obtain 1mg/ml storing solution.1ml storing solutions are taken to 100ml volumetric flasks, plus
Ultra-pure water is diluted to scale, obtains 10ug/ml taurine reference substance solution.
It is prepared by need testing solution：
Sample 1g accurately is weighed, 100mL is settled to ultra-pure water, the solution that concentration is 10mg/mL is obtained.Precision is measured
10mg/mL solution 5mL, with ultra-pure water precise volume setting to 100mL, obtains 500ug/mL sample solution after mixing.Then again
Precision measures in 500ug/mL samples 5ml to 50ml volumetric flask and is settled to scale with ultra-pure water, obtains 10ug/mL samples molten
Liquid.
Determination method：
With ultra-pure water as blank, liquid chromatograph is injected, detection sensitivity is adjusted, the peak height for making principal component chromatographic peak is
The 25% of full scale, then precision measure taurine reference substance solution and each 20 μ l of sample solution, are injected separately into liquid chromatograph, note
Chromatogram is recorded to 2 times of principal component peak retention time.The content of taurine in sample is calculated using peak area method for normalizing.
Detect in lyophilized powder raw material prepared by embodiment 1-3 and comparative example 1-2 methods describeds (abalone powder, raw oyster powder and
Crassostrea rivularis powder) taurine content, it is as shown in the table 1 for specific testing result.
Table 1 freezes the content detection of taurine in powder raw material
Experimental example 2
The therapeutic effect of Chinese medicine composition of the present invention can be confirmed by the observation of following clinical cases：
Following patient is convened, the Chinese medicinal composition capsules of the preparation of embodiment 1 is taken, each taking 2, takes daily 3 times,
Continuously take 1 month, specifically take effect as follows：
1st, patient, man, 45 years old, symptom：Whole body is tired powerless, heartbeat, and shortness of breath is uncomfortable in chest, sleeps bad, often insomnia, often
It is dizzy.Diagnosis：Coronary heart disease, neurasthenia, apocamnosis.Therapeutic effect：After treatment end, sb.'s illness took a favorable turn, and very well, whole body is or not spirit
Feel tired, turn round and feel brisk, work is also unconsciously tired, and strength increases.
2nd, patient, female, 14 years old, symptom：Giddy, anaemia, menstruation are few, abnormal, upper class hour is dizzy, sleepy, memory not
It is good, vexed, without spirit, general weakness, tired.Diagnosis：Anaemia, apocamnosis.Therapeutic effect：After treatment end, menstruation recovery
Normally, can normally it listen to the teacher, giddy is got better, memory is than preceding increase, and body is tired to be mitigated, and spirit is very well.
3rd, patient, female, 62 years old, symptom：Often ache all over, hand can not extract weight, One's spirits are drooping, fatigue and weak, food
It is intended to reduce.Diagnosis：Hypoimmunity.Therapeutic effect：After treatment end,
4th, patient, man, 39 years old, symptom：Constipation history 3 years, it is especially even more serious with autumn and winter, often take defaecation spirit etc.
Treatment.Diagnosis：Habitual constipation.Therapeutic effect：After treatment end, free movement of the bowels recovers normal, half a year is paid a return visit without recurrence.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, but it will be understood by those within the art that：Its
The technical scheme described in foregoing embodiments can still be modified, or to which part or all technical characteristic
Carry out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention skill
The scope of art scheme.
Claims (10)
1. a kind of method for preparing Chinese medicine composition, it is characterised in that the described method comprises the following steps：
(A) abalone, raw oyster and Crassostrea rivularis, are handled in the following manner：A1, slurry and mistake will be broken into by pretreated raw material
Filter；A2, pre-freeze：By the thickness control of slurry in 5~10mm, at -50~-10 DEG C, 1~2h of pre-freeze；A3, distillation：By pre-freeze
The thickness control of material is in 5~10mm afterwards, is that 30~50Pa, temperature are under conditions of 65~75 DEG C, to dry 12~20 in pressure
Hour, produce freeze-dried powder；A4, freeze-dried powder is subjected to dispersion and fining, obtains homogeneous digested tankage；
(B) abalone powder, raw oyster powder and the Crassostrea rivularis powder for, obtaining step (A) are mixed.
2. according to the method described in claim 1, it is characterised in that methods described also includes after step (B)：(C), will be mixed
Freeze-dried powder after conjunction is crushed, and crosses 70-90 mesh sieves, it is preferable that cross 80 mesh sieves.
3. according to the method described in claim 1, it is characterised in that the step a2 is specially：Pre-freeze：By the thickness of each slurry
Control is in 6~9mm, at -50~-30 DEG C, 1.2~1.8h of pre-freeze；
The step a3 is specially：Distillation：It is 35~45Pa, temperature in pressure by the thickness control of material after pre-freeze in 6~9mm
Spend under conditions of 70~75 DEG C, to dry 15~20 hours, produce freeze-dried powder.
4. according to the method described in claim 1, it is characterised in that the step a2 is specially：Pre-freeze：By the thickness of each slurry
Control is in 8mm, at -50 DEG C, pre-freeze 1.5h；
The step a3 is specially：Distillation：It is that 50Pa, temperature are 70 DEG C in pressure by the thickness control of material after pre-freeze in 8mm
Under conditions of, dry 15 hours, produce freeze-dried powder.
5. according to the method described in claim 1, it is characterised in that the raw material is pre-processed in the following manner：Take fresh
Raw material go intestines to shell, clean up, and broken obtain cube meat.
6. according to the method described in claim 1, it is characterised in that the mode filtered described in step a1 is specially：By acquisition
Slurry crosses 100~150 mesh mesh screens, it is preferable that cross 120 mesh sieves.
7. the Chinese medicine composition that any one of claim 1-6 methods described is prepared from.
8. Chinese medicine composition according to claim 7, it is characterised in that by weight, the composition includes：Abalone powder
5~60 parts of 1~80 part, 5~60 parts of raw oyster powder and Crassostrea rivularis powder.
9. Chinese medicine composition according to claim 7, it is characterised in that by weight, the composition includes：Abalone
Powder 10~80, raw oyster powder 10~50, Crassostrea rivularis powder 10~50.
10. Chinese medicine composition according to claim 9, it is characterised in that the Chinese medicine composition be pulvis, capsule,
Granule, tablet and pill；Preferably, the Chinese medicine composition is pulvis or capsule, and the capsule is preferably that gelatin is hard
Capsule.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586312A (en) * | 2004-08-27 | 2005-03-02 | 宁波大学 | Method for producing oyster biological active substance and its product |
| CN1666778A (en) * | 2004-11-02 | 2005-09-14 | 大连轻工业学院 | Anti-oxidation, anti-senium oyster product and its preparation method |
| CN1706490A (en) * | 2005-05-26 | 2005-12-14 | 大连轻工业学院 | Natural Yin-nourishing and Yang-strengthening health food capsule and its prepn process |
| CN104783234A (en) * | 2015-05-06 | 2015-07-22 | 北海市银海区蓝海牧场贝类养殖农民专业合作社 | Preparation method for oyster powder |
| CN106692703A (en) * | 2017-03-17 | 2017-05-24 | 贵州健瑞安药业有限公司 | Preparation method of dendrobium freeze-dried powder |
-
2017
- 2017-06-29 CN CN201710515443.8A patent/CN107281225A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586312A (en) * | 2004-08-27 | 2005-03-02 | 宁波大学 | Method for producing oyster biological active substance and its product |
| CN1666778A (en) * | 2004-11-02 | 2005-09-14 | 大连轻工业学院 | Anti-oxidation, anti-senium oyster product and its preparation method |
| CN1706490A (en) * | 2005-05-26 | 2005-12-14 | 大连轻工业学院 | Natural Yin-nourishing and Yang-strengthening health food capsule and its prepn process |
| CN104783234A (en) * | 2015-05-06 | 2015-07-22 | 北海市银海区蓝海牧场贝类养殖农民专业合作社 | Preparation method for oyster powder |
| CN106692703A (en) * | 2017-03-17 | 2017-05-24 | 贵州健瑞安药业有限公司 | Preparation method of dendrobium freeze-dried powder |
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