CN107260748A - Traditional Chinese medicine oral liquid and preparation method thereof - Google Patents
Traditional Chinese medicine oral liquid and preparation method thereof Download PDFInfo
- Publication number
- CN107260748A CN107260748A CN201710446275.1A CN201710446275A CN107260748A CN 107260748 A CN107260748 A CN 107260748A CN 201710446275 A CN201710446275 A CN 201710446275A CN 107260748 A CN107260748 A CN 107260748A
- Authority
- CN
- China
- Prior art keywords
- consumption
- weight
- parts
- chinese medicine
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 35
- 239000003814 drug Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims abstract description 32
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims abstract description 32
- 238000002156 mixing Methods 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 18
- 239000002253 acid Substances 0.000 claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 14
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 12
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 12
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 11
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229940083466 soybean lecithin Drugs 0.000 claims abstract description 10
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 9
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 9
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 9
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 9
- 229940113088 dimethylacetamide Drugs 0.000 claims abstract description 9
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 8
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims abstract description 6
- 230000001954 sterilising effect Effects 0.000 claims abstract description 6
- -1 soybean lecithin acid Chemical class 0.000 claims abstract description 5
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 27
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 20
- 238000005119 centrifugation Methods 0.000 claims description 13
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 5
- 229910021529 ammonia Inorganic materials 0.000 claims description 3
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract description 7
- 238000010521 absorption reaction Methods 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 3
- 235000004400 serine Nutrition 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 244000068988 Glycine max Species 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- 235000004879 dioscorea Nutrition 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 150000003355 serines Chemical class 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 2
- 125000001095 phosphatidyl group Chemical group 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of traditional Chinese medicine oral liquid and preparation method thereof, this method includes heating after mixing serine, soybean lecithin acid and dimethyl acetamide, obtains mixture M；Extracted after the mixture M, extract and the first water are mixed, obtain phosphatidylserine；Decocted after the phosphatidylserine, Chinese yam, fructus alpiniae oxyphyllae, matrimony vine, Glucose Liquid and the second water are mixed, filtrate sterilizing is obtained into the traditional Chinese medicine oral liquid after filtering；Pass through the synergy between each raw material so that containing the higher phosphatidylserine of purity in obtained traditional Chinese medicine oral liquid, can more effectively promote absorption of the human body to phosphatidylserine.
Description
Technical field
The present invention relates to field of traditional Chinese, in particular it relates to traditional Chinese medicine oral liquid and preparation method thereof.
Background technology
Phosphatidylserine (Phosphatidylserine, PS) be mammalian cell membrane phosphatide important composition into
Point, especially in brain tissue, PS can successfully pass through blood-brain barrier, and a few minutes after being absorbed can enter intracerebral, its
It is closely related with the brain function such as cognition, mood, study, memory, it has been applied to improve Alzheimer disease, treatment at present depressed
In terms of disease, alleviation stress and physical fatigue.At present, phosphatidylserine is applied to the research of Chinese medicine preparation field also
It is fewer, therefore, how phosphatidylserine is applied in Chinese medicine preparation, more effectively to promote human body to phosphatidyl silk ammonia
The problem of absorption of acid is urgent need to resolve of the present invention.
The content of the invention
It is an object of the invention to provide a kind of traditional Chinese medicine oral liquid and preparation method thereof, the phosphatide in the traditional Chinese medicine oral liquid of preparation
Acyl serine is higher, can effectively facilitate absorption of the human body to phosphatidylserine.
To achieve these goals, the invention provides a kind of preparation method of traditional Chinese medicine oral liquid, the preparation method bag
Include：
(1) heated after mixing serine, soybean lecithin acid and dimethyl acetamide, obtain mixture M；
(2) extracted after mixing the mixture M, extract and the first water, obtain phosphatidylserine；
(3) decocted after mixing the phosphatidylserine, Chinese yam, fructus alpiniae oxyphyllae, matrimony vine, Glucose Liquid and the second water
Boil, filtrate sterilizing is obtained into the traditional Chinese medicine oral liquid after filtering.
Present invention also offers a kind of traditional Chinese medicine oral liquid, the traditional Chinese medicine oral liquid is made by above-mentioned preparation method.
By above-mentioned technical proposal, the invention provides a kind of traditional Chinese medicine oral liquid and preparation method thereof, this method includes will
Heated after serine, soybean lecithin acid and dimethyl acetamide mixing, obtain mixture M；By the mixture M, extract and
Extracted after the mixing of first water, obtain phosphatidylserine；By the phosphatidylserine, Chinese yam, fructus alpiniae oxyphyllae, matrimony vine, Portugal
Decocted after grape liquid glucose and the mixing of the second water, filtrate sterilizing is obtained into the traditional Chinese medicine oral liquid after filtering；By each raw material it
Between synergy so that containing the higher phosphatidylserine of purity in obtained traditional Chinese medicine oral liquid, can more effectively promote
Enter absorption of the human body to phosphatidylserine.
Other features and advantages of the present invention will be described in detail in subsequent embodiment part.
Embodiment
The embodiment to the present invention is described in detail below.It should be appreciated that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to limit the invention.
The end points and any value of disclosed scope are not limited to the accurate scope or value herein, these scopes or
Value should be understood to comprising the value close to these scopes or value.For number range, between the endpoint value of each scope, respectively
It can be combined with each other between the endpoint value of individual scope and single point value, and individually between point value and obtain one or more
New number range, these number ranges should be considered as specific open herein.
The invention provides a kind of preparation method of traditional Chinese medicine oral liquid, the preparation method includes：
(1) heated after mixing serine, soybean lecithin acid and dimethyl acetamide, obtain mixture M；(2) will be described
Extracted after mixture M, extract and the mixing of the first water, obtain phosphatidylserine；(3) by the phosphatidylserine,
Decocted after Chinese yam, fructus alpiniae oxyphyllae, matrimony vine, Glucose Liquid and the mixing of the second water, filtrate sterilizing is obtained into the Chinese medicine after filtering
Oral liquid.
The present invention it is a kind of preferred embodiment in, in order that also have purity higher in obtained traditional Chinese medicine oral liquid
Phosphatidylserine, further beneficial to the absorption of human body, relative to the dimethyl acetamide of 100 parts by weight, the serine
Consumption be 2-6 parts by weight, the consumption of soybean lecithin acid is 4-8 parts by weight, and the consumption of the extract weighs for 200-300
Part is measured, the consumption of first water is 80-120 parts by weight；
Relative to the Glucose Liquid of 100 parts by weight, the consumption of the phosphatidylserine is 2-5 parts by weight, the Chinese yam
Consumption be 20-40 parts by weight, the consumption of the fructus alpiniae oxyphyllae is 2-10 parts by weight, and the consumption of the matrimony vine is 0.5-1.5 weight
Part, the consumption of second water is 10-30 parts by weight.
The present invention it is a kind of preferred embodiment in, in order that serine and soybean lecithin acid between preferably send out
Raw reaction, the temperature of the heating is 80-90 DEG C, and the time of heating is 1-2h.
The present invention it is a kind of preferred embodiment in, in order to which the phosphatidylserine that purity is higher, the extraction is made
Liquid is taken to be made up of hexane and isopropanol, and the volume ratio of the hexane and the isopropanol is 1:2-4.
The present invention it is a kind of preferred embodiment in, in order that can preferably mix between raw material, step (3)
In mixing using centrifugation mixing by the way of, and centrifugation mixing speed be 800-1000rpm, centrifuge mixing time be 5-
10min。
Present invention also offers a kind of traditional Chinese medicine oral liquid, the traditional Chinese medicine oral liquid is made by above-mentioned preparation method.
The present invention will be described in detail by way of examples below.
Embodiment 1
Heated after 2g serines, 4g soybean lecithins acid and 100g dimethyl acetamides are mixed (temperature of heating is 80 DEG C,
The time of heating is 1h), obtain mixture M；The mixture M, 200g extracts (are made up of, and institute hexane and isopropanol
The volume ratio for stating hexane and the isopropanol is 1:2) and after the first water 80g mixing extracted, obtain phosphatidylserine；Will
Phosphatidylserine, 20g Chinese yams, 2g fructus alpiniae oxyphyllaes, 0.5g matrimony vines, 100g Glucose Liquids and the centrifugation mixing of the water of 10g second described in 2g
(speed of centrifugation mixing is 800rpm, and the time of centrifugation mixing is 5min) is decocted afterwards, obtains filtrate sterilizing after filtering
The traditional Chinese medicine oral liquid A1.
Embodiment 2
Heated after 6g serines, 8g soybean lecithins acid and 100g dimethyl acetamides are mixed (temperature of heating is 90 DEG C,
The time of heating is 2h), obtain mixture M；The mixture M, 300g extracts (are made up of, and institute hexane and isopropanol
The volume ratio for stating hexane and the isopropanol is 1:4) and after the mixing of the water of 120g first extracted, obtain phosphatidylserine；
Phosphatidylserine, 40g Chinese yams, 10g fructus alpiniae oxyphyllaes, 1.5g matrimony vines, 100g Glucose Liquids and the centrifugation of the water of 30g second described in 5g is mixed
Close (speed of centrifugation mixing is 1000rpm, and the time of centrifugation mixing is 10min) to be decocted afterwards, filtrate sterilizes after filtering
Obtain the traditional Chinese medicine oral liquid A2.
Embodiment 3
Heated after 4g serines, 6g soybean lecithins acid and 100g dimethyl acetamides are mixed (temperature of heating is 85 DEG C,
The time of heating is 1.5h), obtain mixture M；By the mixture M, 250g extracts (be made up of hexane and isopropanol, and
The volume ratio of the hexane and the isopropanol is 1:3) and after the mixing of the water of 100g first extracted, obtain phosphatidyl silk ammonia
Acid；Phosphatidylserine, 30g Chinese yams, 6g fructus alpiniae oxyphyllaes, 1g matrimony vines, 100g Glucose Liquids and the centrifugation of the water of 20g second described in 3g is mixed
Close (speed of centrifugation mixing is 900rpm, and the time of centrifugation mixing is 8min) to be decocted afterwards, filtrate sterilizes after filtering
To the traditional Chinese medicine oral liquid A3.
Comparative example 1
Carried out according to the method for embodiment 3, unlike, the dimethyl acetamide relative to 100g, the serine
Consumption is 1g, and the consumption of the soybean lecithin acid is 3g, and the consumption of the extract is 150g, and the consumption of first water is
70g；Glucose Liquid relative to 100g, the consumption of the phosphatidylserine is 1g, and the consumption of the Chinese yam is 15g, described
The consumption of fructus alpiniae oxyphyllae is 1g, and the consumption of the matrimony vine is 0.3g, and the consumption of second water is 8g, obtains the traditional Chinese medicine oral liquid
D1。
Comparative example 2
Carried out according to the method for embodiment 3, unlike, the dimethyl acetamide relative to 100g, the serine
Consumption is 7g, and the consumption of the soybean lecithin acid is 10g, and the consumption of the extract is 350g, and the consumption of first water is
130g；Glucose Liquid relative to 100g, the consumption of the phosphatidylserine is 6g, and the consumption of the Chinese yam is 45g, described
The consumption of fructus alpiniae oxyphyllae is 15g, and the consumption of the matrimony vine is 1.8g, and the consumption of second water is 35g, obtains the extract oral
Liquid D2.
Table 1
Obtained traditional Chinese medicine oral liquid within the scope of the invention is can be seen that by above table data, it contains higher
The phosphatidylserine of purity, and be conducive to the absorption of human body, and outside the scope of the invention obtained traditional Chinese medicine oral liquid, it contains
Phosphatidylserine purity it is relatively low, assimilation effect is relatively poor.
The preferred embodiment of the present invention described in detail above, still, the present invention are not limited in above-mentioned embodiment
Detail, in the range of the technology design of the present invention, a variety of simple variants can be carried out to technical scheme, this
A little simple variants belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (6)
1. a kind of preparation method of traditional Chinese medicine oral liquid, it is characterised in that the preparation method includes：
(1) heated after mixing serine, soybean lecithin acid and dimethyl acetamide, obtain mixture M；
(2) extracted after mixing the mixture M, extract and the first water, obtain phosphatidylserine；
(3) decocted after mixing the phosphatidylserine, Chinese yam, fructus alpiniae oxyphyllae, matrimony vine, Glucose Liquid and the second water, mistake
Filtrate sterilizing is obtained into the traditional Chinese medicine oral liquid after filter.
2. preparation method according to claim 1, wherein, relative to the dimethyl acetamide of 100 parts by weight, the silk ammonia
The consumption of acid is 2-6 parts by weight, and the consumption of the soybean lecithin acid is 4-8 parts by weight, and the consumption of the extract is 200-300
Parts by weight, the consumption of first water is 80-120 parts by weight；
Relative to the Glucose Liquid of 100 parts by weight, the consumption of the phosphatidylserine is 2-5 parts by weight, the use of the Chinese yam
Measure as 20-40 parts by weight, the consumption of the fructus alpiniae oxyphyllae is 2-10 parts by weight, and the consumption of the matrimony vine is 0.5-1.5 parts by weight, institute
The consumption for stating the second water is 10-30 parts by weight.
3. preparation method according to claim 1 or 2, wherein, the temperature of the heating is 80-90 DEG C, the time of heating
For 1-2h.
4. preparation method according to claim 3, wherein, the extract is made up of hexane and isopropanol, and it is described oneself
The volume ratio of alkane and the isopropanol is 1:2-4.
5. preparation method according to claim 4, wherein, mixing by the way of centrifugation mixing in step (3), and from
The speed of heart mixing is 800-1000rpm, and the time of centrifugation mixing is 5-10min.
6. a kind of traditional Chinese medicine oral liquid, it is characterised in that the traditional Chinese medicine oral liquid is as the system described in any one in claim 1-5
Preparation Method is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710446275.1A CN107260748A (en) | 2017-06-14 | 2017-06-14 | Traditional Chinese medicine oral liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710446275.1A CN107260748A (en) | 2017-06-14 | 2017-06-14 | Traditional Chinese medicine oral liquid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107260748A true CN107260748A (en) | 2017-10-20 |
Family
ID=60066188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710446275.1A Pending CN107260748A (en) | 2017-06-14 | 2017-06-14 | Traditional Chinese medicine oral liquid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107260748A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116391876A (en) * | 2023-05-22 | 2023-07-07 | 陕西中科通大生命科学技术有限公司 | Preparation method of modified phosphatidylserine oral preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104327114A (en) * | 2014-11-06 | 2015-02-04 | 江南大学 | Preparation method of phosphatidyl serine |
-
2017
- 2017-06-14 CN CN201710446275.1A patent/CN107260748A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104327114A (en) * | 2014-11-06 | 2015-02-04 | 江南大学 | Preparation method of phosphatidyl serine |
Non-Patent Citations (4)
| Title |
|---|
| 吴复苍等主编: "《常见病遣方用药规律》", 31 October 2015, 人民军医出版社 * |
| 孙明波等: "磷脂酰丝氨酸制备的研究进展", 《微生物学杂志》 * |
| 薛立英等: "药食同源中药抗衰老研究进展", 《食品科学》 * |
| 金苹等: "磷脂酰丝氨酸／茯苓组合对快速老化模型小鼠学习记忆能力的作用及其机制", 《解剖学研究》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116391876A (en) * | 2023-05-22 | 2023-07-07 | 陕西中科通大生命科学技术有限公司 | Preparation method of modified phosphatidylserine oral preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104857030A (en) | Wall breaking method for ganoderma lucidum spore powder and product obtained with same | |
| CN107343892A (en) | Traditional Chinese medicine oral liquid and preparation method thereof | |
| CN103585400B (en) | Have and strengthen immunologic function and the compositions alleviating fatigue effect and preparation method thereof | |
| CN102450352A (en) | Rose tea | |
| CN107260748A (en) | Traditional Chinese medicine oral liquid and preparation method thereof | |
| CN103504037A (en) | Beautifying five-flower tea | |
| CN103919818B (en) | A kind of preparation method of nanoscale Cordycepses microcapsule | |
| CN107334773A (en) | Traditional Chinese medicine oral liquid and preparation method thereof | |
| CN107938333A (en) | A kind of wrinkle resistant antibacterial cotton fabric finishing agent and preparation method thereof | |
| CN101240232B (en) | Fatigue resisting wine | |
| CN107149146A (en) | Lozenge containing phosphatidylserine and preparation method thereof | |
| CN105341261A (en) | Ginkgo leaf and pseudo-ginseng flower tea | |
| CN105995985A (en) | Walnut oil oral liquid | |
| CN106857971A (en) | A kind of preparation method for protecting the chrysanthemum tea of optic nerve and retina | |
| CN109043040A (en) | A kind of processing method of jasmine tea | |
| CN104758582A (en) | Traditional Chinese medicine composition for treating arrhythmia in the type of fire excess from yin deficiency | |
| CN107156296A (en) | Yoghourt containing phosphatidylserine and preparation method thereof | |
| CN109907245A (en) | Rhizoma polygonati beans sauce and preparation method thereof | |
| CN106189352B (en) | A kind of extracting method of carthamin yellow | |
| CN103859086A (en) | Beautifying tea | |
| CN105219578A (en) | The manufacture method of a kind of red rice, safflower crude drug wine | |
| CN108504512A (en) | A kind of Chinese caterpillar fungus health medicinal liquor and preparation method thereof | |
| CN102888323A (en) | Sweet fermented-rice wine | |
| CN106924298A (en) | A kind of Cordyceps militaris extract and its preparation method and application | |
| CN107260722A (en) | Syrup containing anthocyanidin and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171020 |
|
| RJ01 | Rejection of invention patent application after publication |