CN107260689A - 用于鼻内递送的方法和组合物 - Google Patents

Info

Publication number

CN107260689A

CN107260689A CN201710415508.1A CN201710415508A CN107260689A CN 107260689 A CN107260689 A CN 107260689A CN 201710415508 A CN201710415508 A CN 201710415508A CN 107260689 A CN107260689 A CN 107260689A

Authority

CN

China

Prior art keywords

virus

microns

preparation

vaccine

powder

Prior art date

2010-04-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 157
• 239000000203 mixture Substances 0.000 title claims description 133
• 239000000843 powder Substances 0.000 claims abstract description 374
• 229960005486 vaccine Drugs 0.000 claims abstract description 327
• 238000002360 preparation method Methods 0.000 claims abstract description 269
• 210000004400 mucous membrane Anatomy 0.000 claims abstract description 22
• 238000004519 manufacturing process Methods 0.000 claims abstract description 6
• 241000700605 Viruses Species 0.000 claims description 299
• 102000036639 antigens Human genes 0.000 claims description 207
• 108091007433 antigens Proteins 0.000 claims description 207
• 239000000427 antigen Substances 0.000 claims description 197
• 239000007788 liquid Substances 0.000 claims description 107
• 206010022000 influenza Diseases 0.000 claims description 89
• 238000009472 formulation Methods 0.000 claims description 59
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 54
• 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 54
• 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 54
• 239000008108 microcrystalline cellulose Substances 0.000 claims description 52
• 229940016286 microcrystalline cellulose Drugs 0.000 claims description 52
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 43
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 43
• 201000010099 disease Diseases 0.000 claims description 38
• 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 38
• 235000019731 tricalcium phosphate Nutrition 0.000 claims description 38
• 230000003612 virological effect Effects 0.000 claims description 36
• 239000001506 calcium phosphate Substances 0.000 claims description 35
• 241000712461 unidentified influenza virus Species 0.000 claims description 35
• 229940078499 tricalcium phosphate Drugs 0.000 claims description 34
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 31
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 31
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 31
• 231100000614 poison Toxicity 0.000 claims description 31
• 239000002574 poison Substances 0.000 claims description 31
• 235000013339 cereals Nutrition 0.000 claims description 29
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 27
• 235000007164 Oryza sativa Nutrition 0.000 claims description 27
• 239000008101 lactose Substances 0.000 claims description 27
• 229910052757 nitrogen Inorganic materials 0.000 claims description 27
• 235000009566 rice Nutrition 0.000 claims description 27
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 26
• 229930195725 Mannitol Natural products 0.000 claims description 26
• 229960003983 diphtheria toxoid Drugs 0.000 claims description 26
• 230000002779 inactivation Effects 0.000 claims description 26
• 239000000594 mannitol Substances 0.000 claims description 26
• 235000010355 mannitol Nutrition 0.000 claims description 26
• 229960000814 tetanus toxoid Drugs 0.000 claims description 26
• 235000000346 sugar Nutrition 0.000 claims description 25
• 108090000623 proteins and genes Proteins 0.000 claims description 24
• 239000000872 buffer Substances 0.000 claims description 23
• 102000004169 proteins and genes Human genes 0.000 claims description 23
• 241000894006 Bacteria Species 0.000 claims description 20
• 239000002671 adjuvant Substances 0.000 claims description 15
• 230000002238 attenuated effect Effects 0.000 claims description 14
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 14
• 230000001580 bacterial effect Effects 0.000 claims description 13
• 108010052285 Membrane Proteins Proteins 0.000 claims description 12
• 102000018697 Membrane Proteins Human genes 0.000 claims description 12
• 239000007921 spray Substances 0.000 claims description 11
• 206010064097 avian influenza Diseases 0.000 claims description 10
• 230000004044 response Effects 0.000 claims description 10
• 210000002845 virion Anatomy 0.000 claims description 10
• 241001591005 Siga Species 0.000 claims description 9
• 230000009467 reduction Effects 0.000 claims description 8
• 206010069767 H1N1 influenza Diseases 0.000 claims description 7
• 238000000746 purification Methods 0.000 claims description 7
• 201000010740 swine influenza Diseases 0.000 claims description 7
• 229910019142 PO4 Inorganic materials 0.000 claims description 6
• 239000000969 carrier Substances 0.000 claims description 6
• 241000713196 Influenza B virus Species 0.000 claims description 5
• 230000002101 lytic effect Effects 0.000 claims description 4
• 239000003053 toxin Substances 0.000 claims description 4
• 231100000765 toxin Toxicity 0.000 claims description 4
• 206010043376 Tetanus Diseases 0.000 claims description 3
• 239000010452 phosphate Substances 0.000 claims description 3
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
• 230000000638 stimulation Effects 0.000 claims description 3
• 240000007594 Oryza sativa Species 0.000 claims 1
• 230000036039 immunity Effects 0.000 abstract description 7
• 210000001331 nose Anatomy 0.000 description 128
• 238000012360 testing method Methods 0.000 description 74
• 101710154606 Hemagglutinin Proteins 0.000 description 66
• 101710093908 Outer capsid protein VP4 Proteins 0.000 description 66
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 66
• 101710176177 Protein A56 Proteins 0.000 description 66
• 239000000185 hemagglutinin Substances 0.000 description 66
• 239000003381 stabilizer Substances 0.000 description 57
• 239000000523 sample Substances 0.000 description 54
• 229960003971 influenza vaccine Drugs 0.000 description 43
• 238000004108 freeze drying Methods 0.000 description 30
• 239000002245 particle Substances 0.000 description 30
• 230000000694 effects Effects 0.000 description 28
• 238000007710 freezing Methods 0.000 description 28
• 238000002474 experimental method Methods 0.000 description 27
• 229940074410 trehalose Drugs 0.000 description 27
• 241000209094 Oryza Species 0.000 description 26
• 210000002966 serum Anatomy 0.000 description 25
• 241001465754 Metazoa Species 0.000 description 24
• 230000028993 immune response Effects 0.000 description 23
• 229960001855 mannitol Drugs 0.000 description 23
• 239000000243 solution Substances 0.000 description 22
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 21
• 230000001717 pathogenic effect Effects 0.000 description 21
• 230000000890 antigenic effect Effects 0.000 description 20
• 239000003795 chemical substances by application Substances 0.000 description 19
• 238000001035 drying Methods 0.000 description 19
• 235000018102 proteins Nutrition 0.000 description 19
• 241000271566 Aves Species 0.000 description 18
• 244000052769 pathogen Species 0.000 description 18
• 238000011160 research Methods 0.000 description 18
• 230000008014 freezing Effects 0.000 description 17
• 238000002965 ELISA Methods 0.000 description 16
• 241000282414 Homo sapiens Species 0.000 description 16
• 210000004027 cell Anatomy 0.000 description 16
• 241000282693 Cercopithecidae Species 0.000 description 14
• 238000002156 mixing Methods 0.000 description 14
• 108010058846 Ovalbumin Proteins 0.000 description 13
• 229940092253 ovalbumin Drugs 0.000 description 13
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
• 241000283073 Equus caballus Species 0.000 description 12
• 239000012530 fluid Substances 0.000 description 11
• 102000004190 Enzymes Human genes 0.000 description 10
• 108090000790 Enzymes Proteins 0.000 description 10
• 241000699666 Mus <mouse, genus> Species 0.000 description 10
• 241001505332 Polyomavirus sp. Species 0.000 description 10
• 238000013461 design Methods 0.000 description 10
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 10
• 238000011081 inoculation Methods 0.000 description 10
• 239000002953 phosphate buffered saline Substances 0.000 description 10
• 238000003860 storage Methods 0.000 description 10
• 241001529453 unidentified herpesvirus Species 0.000 description 10
• 208000006454 hepatitis Diseases 0.000 description 9
• 231100000283 hepatitis Toxicity 0.000 description 9
• 208000015181 infectious disease Diseases 0.000 description 9
• -1 pasteurization Substances 0.000 description 9
• 230000004224 protection Effects 0.000 description 9
• 238000007792 addition Methods 0.000 description 8
• 238000005516 engineering process Methods 0.000 description 8
• 230000008569 process Effects 0.000 description 8
• 241001430294 unidentified retrovirus Species 0.000 description 8
• 241000125945 Protoparvovirus Species 0.000 description 7
• 241000282898 Sus scrofa Species 0.000 description 7
• 210000004369 blood Anatomy 0.000 description 7
• 239000008280 blood Substances 0.000 description 7
• 238000009826 distribution Methods 0.000 description 7
• 235000013601 eggs Nutrition 0.000 description 7
• 239000000463 material Substances 0.000 description 7
• 238000005259 measurement Methods 0.000 description 7
• 238000011282 treatment Methods 0.000 description 7
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
• 239000009493 Hova Substances 0.000 description 6
• 241000371980 Influenza B virus (B/Shanghai/361/2002) Species 0.000 description 6
• 241000589902 Leptospira Species 0.000 description 6
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
• 241000702263 Reovirus sp. Species 0.000 description 6
• 210000001744 T-lymphocyte Anatomy 0.000 description 6
• 230000023555 blood coagulation Effects 0.000 description 6
• 201000002491 encephalomyelitis Diseases 0.000 description 6
• 238000012216 screening Methods 0.000 description 6
• 230000003248 secreting effect Effects 0.000 description 6
• 238000005406 washing Methods 0.000 description 6
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
• 241000282326 Felis catus Species 0.000 description 5
• 241000699729 Muridae Species 0.000 description 5
• 206010028980 Neoplasm Diseases 0.000 description 5
• 208000002606 Paramyxoviridae Infections Diseases 0.000 description 5
• 241001494479 Pecora Species 0.000 description 5
• 241000701062 Saimiriine gammaherpesvirus 2 Species 0.000 description 5
• 230000008901 benefit Effects 0.000 description 5
• 239000011575 calcium Substances 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• 229940035032 monophosphoryl lipid a Drugs 0.000 description 5
• 229920000642 polymer Polymers 0.000 description 5
• 108090000765 processed proteins & peptides Proteins 0.000 description 5
• 238000012545 processing Methods 0.000 description 5
• 230000006641 stabilisation Effects 0.000 description 5
• 238000011105 stabilization Methods 0.000 description 5
• 150000003625 trehaloses Chemical class 0.000 description 5
• 241000701161 unidentified adenovirus Species 0.000 description 5
• 241000193830 Bacillus <bacterium> Species 0.000 description 4
• 241000589562 Brucella Species 0.000 description 4
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
• 241001466953 Echovirus Species 0.000 description 4
• 241000709661 Enterovirus Species 0.000 description 4
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 206010061192 Haemorrhagic fever Diseases 0.000 description 4
• 241000175212 Herpesvirales Species 0.000 description 4
• 241000725303 Human immunodeficiency virus Species 0.000 description 4
• 241000712431 Influenza A virus Species 0.000 description 4
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
• 241000712079 Measles morbillivirus Species 0.000 description 4
• 241000714177 Murine leukemia virus Species 0.000 description 4
• 206010035664 Pneumonia Diseases 0.000 description 4
• 206010039491 Sarcoma Diseases 0.000 description 4
• 208000000389 T-cell leukemia Diseases 0.000 description 4
• 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 4
• 241000700618 Vaccinia virus Species 0.000 description 4
• 238000002835 absorbance Methods 0.000 description 4
• 230000001133 acceleration Effects 0.000 description 4
• 210000003484 anatomy Anatomy 0.000 description 4
• 238000013459 approach Methods 0.000 description 4
• 230000015572 biosynthetic process Effects 0.000 description 4
• 210000000234 capsid Anatomy 0.000 description 4
• 235000011089 carbon dioxide Nutrition 0.000 description 4
• 150000001875 compounds Chemical class 0.000 description 4
• 239000003599 detergent Substances 0.000 description 4
• 239000010419 fine particle Substances 0.000 description 4
• 239000007789 gas Substances 0.000 description 4
• 239000011521 glass Substances 0.000 description 4
• 208000002672 hepatitis B Diseases 0.000 description 4
• 238000002347 injection Methods 0.000 description 4
• 239000007924 injection Substances 0.000 description 4
• 238000003780 insertion Methods 0.000 description 4
• 230000037431 insertion Effects 0.000 description 4
• 208000032839 leukemia Diseases 0.000 description 4
• 210000004877 mucosa Anatomy 0.000 description 4
• 229920001223 polyethylene glycol Polymers 0.000 description 4
• 229920001184 polypeptide Polymers 0.000 description 4
• 102000004196 processed proteins & peptides Human genes 0.000 description 4
• VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 4
• QZTKDVCDBIDYMD-UHFFFAOYSA-N 2,2'-[(2-amino-2-oxoethyl)imino]diacetic acid Chemical compound NC(=O)CN(CC(O)=O)CC(O)=O QZTKDVCDBIDYMD-UHFFFAOYSA-N 0.000 description 3
• 239000007988 ADA buffer Substances 0.000 description 3
• 241000272525 Anas platyrhynchos Species 0.000 description 3
• 241000713826 Avian leukosis virus Species 0.000 description 3
• 241000145903 Bombyx mori cypovirus 1 Species 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 241000283707 Capra Species 0.000 description 3
• 241000701022 Cytomegalovirus Species 0.000 description 3
• 241000712471 Dhori virus Species 0.000 description 3
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
• 208000010201 Exanthema Diseases 0.000 description 3
• 241000282324 Felis Species 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• 241000150562 Hantaan orthohantavirus Species 0.000 description 3
• 241000709715 Hepatovirus Species 0.000 description 3
• 241000238631 Hexapoda Species 0.000 description 3
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 3
• 241000598436 Human T-cell lymphotropic virus Species 0.000 description 3
• 241000701024 Human betaherpesvirus 5 Species 0.000 description 3
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• 241000701029 Murid betaherpesvirus 1 Species 0.000 description 3
• 241000702244 Orthoreovirus Species 0.000 description 3
• 206010037660 Pyrexia Diseases 0.000 description 3
• 241000710799 Rubella virus Species 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
• 241000700647 Variola virus Species 0.000 description 3
• 241000711975 Vesicular stomatitis virus Species 0.000 description 3
• 238000010521 absorption reaction Methods 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 229940024606 amino acid Drugs 0.000 description 3
• 235000001014 amino acid Nutrition 0.000 description 3
• 150000001413 amino acids Chemical class 0.000 description 3
• 210000003719 b-lymphocyte Anatomy 0.000 description 3
• 210000004556 brain Anatomy 0.000 description 3
• 239000003153 chemical reaction reagent Substances 0.000 description 3
• 230000002596 correlated effect Effects 0.000 description 3
• 238000010790 dilution Methods 0.000 description 3
• 239000012895 dilution Substances 0.000 description 3
• 206010013023 diphtheria Diseases 0.000 description 3
• 210000001163 endosome Anatomy 0.000 description 3
• 210000002919 epithelial cell Anatomy 0.000 description 3
• 201000005884 exanthem Diseases 0.000 description 3
• 150000004676 glycans Chemical class 0.000 description 3
• 238000000227 grinding Methods 0.000 description 3
• 230000001976 improved effect Effects 0.000 description 3
• 230000006698 induction Effects 0.000 description 3
• 210000003563 lymphoid tissue Anatomy 0.000 description 3
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
• 108020004707 nucleic acids Proteins 0.000 description 3
• 102000039446 nucleic acids Human genes 0.000 description 3
• 150000007523 nucleic acids Chemical class 0.000 description 3
• 229920001282 polysaccharide Polymers 0.000 description 3
• 239000005017 polysaccharide Substances 0.000 description 3
• 239000002243 precursor Substances 0.000 description 3
• 238000004321 preservation Methods 0.000 description 3
• 206010037844 rash Diseases 0.000 description 3
• 210000002345 respiratory system Anatomy 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• 230000028327 secretion Effects 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• 239000003643 water by type Substances 0.000 description 3
• 208000002874 Acne Vulgaris Diseases 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• 241000282465 Canis Species 0.000 description 2
• 241000700664 Capripoxvirus Species 0.000 description 2
• SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
• 101710088194 Dehydrogenase Proteins 0.000 description 2
• 241000702421 Dependoparvovirus Species 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• 241000710945 Eastern equine encephalitis virus Species 0.000 description 2
• 241000725630 Ectromelia virus Species 0.000 description 2
• 208000004232 Enteritis Diseases 0.000 description 2
• 241000701081 Equid alphaherpesvirus 1 Species 0.000 description 2
• 241000701915 Feline panleukopenia virus Species 0.000 description 2
• 241000287828 Gallus gallus Species 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 108090000288 Glycoproteins Proteins 0.000 description 2
• 102000003886 Glycoproteins Human genes 0.000 description 2
• 241000893570 Hendra henipavirus Species 0.000 description 2
• 241000709721 Hepatovirus A Species 0.000 description 2
• 208000009889 Herpes Simplex Diseases 0.000 description 2
• 241000701085 Human alphaherpesvirus 3 Species 0.000 description 2
• 241000702617 Human parvovirus B19 Species 0.000 description 2
• 241000714192 Human spumaretrovirus Species 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• 208000002979 Influenza in Birds Diseases 0.000 description 2
• 241001500350 Influenzavirus B Species 0.000 description 2
• 241001500343 Influenzavirus C Species 0.000 description 2
• 229920001202 Inulin Polymers 0.000 description 2
• 241000701646 Kappapapillomavirus 2 Species 0.000 description 2
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
• 241000712898 Machupo mammarenavirus Species 0.000 description 2
• 241001529936 Murinae Species 0.000 description 2
• 241000711466 Murine hepatitis virus Species 0.000 description 2
• 241000699670 Mus sp. Species 0.000 description 2
• SEQKRHFRPICQDD-UHFFFAOYSA-N N-tris(hydroxymethyl)methylglycine Chemical compound OCC(CO)(CO)[NH2+]CC([O-])=O SEQKRHFRPICQDD-UHFFFAOYSA-N 0.000 description 2
• 206010028740 Nasal dryness Diseases 0.000 description 2
• 241000588650 Neisseria meningitidis Species 0.000 description 2
• 102000005348 Neuraminidase Human genes 0.000 description 2
• 108010006232 Neuraminidase Proteins 0.000 description 2
• 241000526636 Nipah henipavirus Species 0.000 description 2
• 241001631646 Papillomaviridae Species 0.000 description 2
• OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 208000000474 Poliomyelitis Diseases 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• 239000004743 Polypropylene Substances 0.000 description 2
• 241000700564 Rabbit fibroma virus Species 0.000 description 2
• 241000712909 Reticuloendotheliosis virus Species 0.000 description 2
• 241000702670 Rotavirus Species 0.000 description 2
• 241000714474 Rous sarcoma virus Species 0.000 description 2
• 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 2
• 241000700584 Simplexvirus Species 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 201000005010 Streptococcus pneumonia Diseases 0.000 description 2
• 241000193998 Streptococcus pneumoniae Species 0.000 description 2
• 229930006000 Sucrose Natural products 0.000 description 2
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
• 206010042971 T-cell lymphoma Diseases 0.000 description 2
• YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 2
• 241000710959 Venezuelan equine encephalitis virus Species 0.000 description 2
• 206010000496 acne Diseases 0.000 description 2
• 230000002776 aggregation Effects 0.000 description 2
• 238000004220 aggregation Methods 0.000 description 2
• 239000003443 antiviral agent Substances 0.000 description 2
• 238000003556 assay Methods 0.000 description 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
• VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 2
• OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 2
• 208000002352 blister Diseases 0.000 description 2
• 230000000903 blocking effect Effects 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• 238000004925 denaturation Methods 0.000 description 2
• 230000036425 denaturation Effects 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 239000000539 dimer Substances 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• 238000002651 drug therapy Methods 0.000 description 2
• 230000003028 elevating effect Effects 0.000 description 2
• 206010014599 encephalitis Diseases 0.000 description 2
• 239000000945 filler Substances 0.000 description 2
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
• 229910052737 gold Inorganic materials 0.000 description 2
• 239000010931 gold Substances 0.000 description 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
• 102000057593 human F8 Human genes 0.000 description 2
• 238000002649 immunization Methods 0.000 description 2
• 230000005847 immunogenicity Effects 0.000 description 2
• 230000003308 immunostimulating effect Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 230000002458 infectious effect Effects 0.000 description 2
• 230000002757 inflammatory effect Effects 0.000 description 2
• 238000010255 intramuscular injection Methods 0.000 description 2
• 239000007927 intramuscular injection Substances 0.000 description 2
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 2
• 229940029339 inulin Drugs 0.000 description 2
• 229960001375 lactose Drugs 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 150000002632 lipids Chemical class 0.000 description 2
• 239000002502 liposome Substances 0.000 description 2
• 230000007108 local immune response Effects 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 210000002751 lymph Anatomy 0.000 description 2
• 210000001161 mammalian embryo Anatomy 0.000 description 2
• 239000011159 matrix material Substances 0.000 description 2
• 239000000178 monomer Substances 0.000 description 2
• 229940037525 nasal preparations Drugs 0.000 description 2
• JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 2
• 239000001301 oxygen Substances 0.000 description 2
• 229910052760 oxygen Inorganic materials 0.000 description 2
• 239000006174 pH buffer Substances 0.000 description 2
• 239000003182 parenteral nutrition solution Substances 0.000 description 2
• 238000009928 pasteurization Methods 0.000 description 2
• 235000021317 phosphate Nutrition 0.000 description 2
• 230000035479 physiological effects, processes and functions Effects 0.000 description 2
• 210000004180 plasmocyte Anatomy 0.000 description 2
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
• 229920001155 polypropylene Polymers 0.000 description 2
• 229920000053 polysorbate 80 Polymers 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 229960000380 propiolactone Drugs 0.000 description 2
• 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
• 229940047431 recombinate Drugs 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 238000005057 refrigeration Methods 0.000 description 2
• 239000004576 sand Substances 0.000 description 2
• 229930182490 saponin Natural products 0.000 description 2
• 150000007949 saponins Chemical class 0.000 description 2
• 230000001932 seasonal effect Effects 0.000 description 2
• 238000013207 serial dilution Methods 0.000 description 2
• 238000007873 sieving Methods 0.000 description 2
• 239000002002 slurry Substances 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• 239000002689 soil Substances 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• 230000004936 stimulating effect Effects 0.000 description 2
• 210000002784 stomach Anatomy 0.000 description 2
• 208000003265 stomatitis Diseases 0.000 description 2
• 239000005720 sucrose Substances 0.000 description 2
• 229960004793 sucrose Drugs 0.000 description 2
• 238000013268 sustained release Methods 0.000 description 2
• 239000012730 sustained-release form Substances 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• 238000003786 synthesis reaction Methods 0.000 description 2
• 238000010998 test method Methods 0.000 description 2
• 210000001519 tissue Anatomy 0.000 description 2
• 238000004448 titration Methods 0.000 description 2
• 229940031572 toxoid vaccine Drugs 0.000 description 2
• 230000001960 triggered effect Effects 0.000 description 2
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
• 201000008827 tuberculosis Diseases 0.000 description 2
• 244000052613 viral pathogen Species 0.000 description 2
• NFKMCDNOKFCLOJ-UHFFFAOYSA-N (2-chloro-1H-indol-3-yl) dihydrogen phosphate Chemical class C1=CC=C2C(OP(O)(=O)O)=C(Cl)NC2=C1 NFKMCDNOKFCLOJ-UHFFFAOYSA-N 0.000 description 1
• XMQUEQJCYRFIQS-YFKPBYRVSA-N (2s)-2-amino-5-ethoxy-5-oxopentanoic acid Chemical compound CCOC(=O)CC[C@H](N)C(O)=O XMQUEQJCYRFIQS-YFKPBYRVSA-N 0.000 description 1
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
• OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
• KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 description 1
• IHPYMWDTONKSCO-UHFFFAOYSA-N 2,2'-piperazine-1,4-diylbisethanesulfonic acid Chemical compound OS(=O)(=O)CCN1CCN(CCS(O)(=O)=O)CC1 IHPYMWDTONKSCO-UHFFFAOYSA-N 0.000 description 1
• MIJDSYMOBYNHOT-UHFFFAOYSA-N 2-(ethylamino)ethanol Chemical compound CCNCCO MIJDSYMOBYNHOT-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• AJTVSSFTXWNIRG-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanesulfonic acid Chemical compound OCC[NH+](CCO)CCS([O-])(=O)=O AJTVSSFTXWNIRG-UHFFFAOYSA-N 0.000 description 1
• 229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 description 1
• UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical class OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
• WKNMKGVLOWGGOU-UHFFFAOYSA-N 2-aminoacetamide;hydron;chloride Chemical class Cl.NCC(N)=O WKNMKGVLOWGGOU-UHFFFAOYSA-N 0.000 description 1
• ACERFIHBIWMFOR-UHFFFAOYSA-N 2-hydroxy-3-[(1-hydroxy-2-methylpropan-2-yl)azaniumyl]propane-1-sulfonate Chemical compound OCC(C)(C)NCC(O)CS(O)(=O)=O ACERFIHBIWMFOR-UHFFFAOYSA-N 0.000 description 1
• HOMYIYLRRDTKAA-UHFFFAOYSA-N 2-hydroxy-N-[3-hydroxy-1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]hexadecanamide Chemical compound CCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=CCCCCCCCCC)COC1OC(CO)C(O)C(O)C1O HOMYIYLRRDTKAA-UHFFFAOYSA-N 0.000 description 1
• DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 1
• INEWUCPYEUEQTN-UHFFFAOYSA-N 3-(cyclohexylamino)-2-hydroxy-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(O)CNC1CCCCC1 INEWUCPYEUEQTN-UHFFFAOYSA-N 0.000 description 1
• NUFBIAUZAMHTSP-UHFFFAOYSA-N 3-(n-morpholino)-2-hydroxypropanesulfonic acid Chemical compound OS(=O)(=O)CC(O)CN1CCOCC1 NUFBIAUZAMHTSP-UHFFFAOYSA-N 0.000 description 1
• RZQXOGQSPBYUKH-UHFFFAOYSA-N 3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCC(CO)(CO)NCC(O)CS(O)(=O)=O RZQXOGQSPBYUKH-UHFFFAOYSA-N 0.000 description 1
• XCBLFURAFHFFJF-UHFFFAOYSA-N 3-[bis(2-hydroxyethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound OCCN(CCO)CC(O)CS(O)(=O)=O XCBLFURAFHFFJF-UHFFFAOYSA-N 0.000 description 1
• QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
• QRXMUCSWCMTJGU-UHFFFAOYSA-N 5-bromo-4-chloro-3-indolyl phosphate Chemical compound C1=C(Br)C(Cl)=C2C(OP(O)(=O)O)=CNC2=C1 QRXMUCSWCMTJGU-UHFFFAOYSA-N 0.000 description 1
• ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
• 239000007991 ACES buffer Substances 0.000 description 1
• 241001519451 Abramis brama Species 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 241000120516 African horse sickness virus Species 0.000 description 1
• 241000701386 African swine fever virus Species 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 241000282981 Alces alces alces Species 0.000 description 1
• 241000710929 Alphavirus Species 0.000 description 1
• 241000702419 Ambidensovirus Species 0.000 description 1
• 208000003829 American Hemorrhagic Fever Diseases 0.000 description 1
• ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
• 208000035013 Ape disease Diseases 0.000 description 1
• 241000702652 Aquareovirus Species 0.000 description 1
• 241000239290 Araneae Species 0.000 description 1
• 241000712891 Arenavirus Species 0.000 description 1
• 108700016232 Arg(2)-Sar(4)- dermorphin (1-4) Proteins 0.000 description 1
• 201000009695 Argentine hemorrhagic fever Diseases 0.000 description 1
• 240000003291 Armoracia rusticana Species 0.000 description 1
• 235000011330 Armoracia rusticana Nutrition 0.000 description 1
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
• 241000228197 Aspergillus flavus Species 0.000 description 1
• 241001225321 Aspergillus fumigatus Species 0.000 description 1
• 241000972773 Aulopiformes Species 0.000 description 1
• 241000178568 Aura virus Species 0.000 description 1
• 241000711404 Avian avulavirus 1 Species 0.000 description 1
• 241000713842 Avian sarcoma virus Species 0.000 description 1
• 239000007989 BIS-Tris Propane buffer Substances 0.000 description 1
• 241000231314 Babanki virus Species 0.000 description 1
• 241000193738 Bacillus anthracis Species 0.000 description 1
• 241000405758 Betapartitivirus Species 0.000 description 1
• 241000150523 Black Creek Canal orthohantavirus Species 0.000 description 1
• 241001446316 Bohle iridovirus Species 0.000 description 1
• 241001118702 Border disease virus Species 0.000 description 1
• 241000589968 Borrelia Species 0.000 description 1
• 241000829192 Bos taurus polyomavirus 1 Species 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• 241000701083 Bovine alphaherpesvirus 1 Species 0.000 description 1
• 241000711443 Bovine coronavirus Species 0.000 description 1
• 241001227615 Bovine foamy virus Species 0.000 description 1
• 241000714266 Bovine leukemia virus Species 0.000 description 1
• 241000701822 Bovine papillomavirus Species 0.000 description 1
• 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 1
• 206010006187 Breast cancer Diseases 0.000 description 1
• 208000026310 Breast neoplasm Diseases 0.000 description 1
• 208000011691 Burkitt lymphomas Diseases 0.000 description 1
• 239000008000 CHES buffer Substances 0.000 description 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
• 241001137864 Camelpox virus Species 0.000 description 1
• 241000589875 Campylobacter jejuni Species 0.000 description 1
• 241000178270 Canarypox virus Species 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 241000711506 Canine coronavirus Species 0.000 description 1
• 241000701931 Canine parvovirus Species 0.000 description 1
• 241000150506 Cano Delgadito orthohantavirus Species 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 241000710190 Cardiovirus Species 0.000 description 1
• 206010062746 Carditis Diseases 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 241001502567 Chikungunya virus Species 0.000 description 1
• 241001647378 Chlamydia psittaci Species 0.000 description 1
• 241000606153 Chlamydia trachomatis Species 0.000 description 1
• 102000009016 Cholera Toxin Human genes 0.000 description 1
• 108010049048 Cholera Toxin Proteins 0.000 description 1
• 229920001287 Chondroitin sulfate Polymers 0.000 description 1
• 241000710777 Classical swine fever virus Species 0.000 description 1
• 241000193163 Clostridioides difficile Species 0.000 description 1
• 241000193468 Clostridium perfringens Species 0.000 description 1
• 241000193449 Clostridium tetani Species 0.000 description 1
• 102100026735 Coagulation factor VIII Human genes 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 241000306271 Colombian datura virus Species 0.000 description 1
• 241000204955 Colorado tick fever virus Species 0.000 description 1
• 241000702669 Coltivirus Species 0.000 description 1
• 206010010741 Conjunctivitis Diseases 0.000 description 1
• 241000711573 Coronaviridae Species 0.000 description 1
• 241000186227 Corynebacterium diphtheriae Species 0.000 description 1
• 241000709687 Coxsackievirus Species 0.000 description 1
• 241000710127 Cricket paralysis virus Species 0.000 description 1
• 241000150230 Crimean-Congo hemorrhagic fever orthonairovirus Species 0.000 description 1
• 206010011416 Croup infectious Diseases 0.000 description 1
• 201000007336 Cryptococcosis Diseases 0.000 description 1
• 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
• 241000221204 Cryptococcus neoformans Species 0.000 description 1
• 241000195493 Cryptophyta Species 0.000 description 1
• 241000223935 Cryptosporidium Species 0.000 description 1
• 241000702662 Cypovirus Species 0.000 description 1
• 241000252233 Cyprinus carpio Species 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
• WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
• QWIZNVHXZXRPDR-UHFFFAOYSA-N D-melezitose Natural products O1C(CO)C(O)C(O)C(O)C1OC1C(O)C(CO)OC1(CO)OC1OC(CO)C(O)C(O)C1O QWIZNVHXZXRPDR-UHFFFAOYSA-N 0.000 description 1
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
• YTBSYETUWUMLBZ-QWWZWVQMSA-N D-threose Chemical compound OC[C@@H](O)[C@H](O)C=O YTBSYETUWUMLBZ-QWWZWVQMSA-N 0.000 description 1
• YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 1
• 206010011841 Dacryoadenitis acquired Diseases 0.000 description 1
• 241001506928 Deformed wing virus Species 0.000 description 1
• 241000701808 Deltapapillomavirus 2 Species 0.000 description 1
• 208000001490 Dengue Diseases 0.000 description 1
• 206010012310 Dengue fever Diseases 0.000 description 1
• 201000004624 Dermatitis Diseases 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
• 208000000655 Distemper Diseases 0.000 description 1
• 241000907524 Drosophila C virus Species 0.000 description 1
• 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 description 1
• 241001115402 Ebolavirus Species 0.000 description 1
• 108010000912 Egg Proteins Proteins 0.000 description 1
• 102000002322 Egg Proteins Human genes 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• 241000710188 Encephalomyocarditis virus Species 0.000 description 1
• 241000194032 Enterococcus faecalis Species 0.000 description 1
• 241000710803 Equine arteritis virus Species 0.000 description 1
• 239000004386 Erythritol Substances 0.000 description 1
• UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
• 241000588724 Escherichia coli Species 0.000 description 1
• 241000465885 Everglades virus Species 0.000 description 1
• 241000877986 Eyach virus Species 0.000 description 1
• 208000004729 Feline Leukemia Diseases 0.000 description 1
• 241000714201 Feline calicivirus Species 0.000 description 1
• 241000519954 Feline foamy virus Species 0.000 description 1
• 241000713800 Feline immunodeficiency virus Species 0.000 description 1
• 201000008808 Fibrosarcoma Diseases 0.000 description 1
• 241000711950 Filoviridae Species 0.000 description 1
• 241001470863 Flanders hapavirus Species 0.000 description 1
• 241000710831 Flavivirus Species 0.000 description 1
• 229930091371 Fructose Natural products 0.000 description 1
• 239000005715 Fructose Substances 0.000 description 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 241001663880 Gammaretrovirus Species 0.000 description 1
• 206010017711 Gangrene Diseases 0.000 description 1
• 208000005577 Gastroenteritis Diseases 0.000 description 1
• 241000608297 Getah virus Species 0.000 description 1
• 241000713813 Gibbon ape leukemia virus Species 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 241001631709 Gonometa Species 0.000 description 1
• 206010018612 Gonorrhoea Diseases 0.000 description 1
• 241001517118 Goose parvovirus Species 0.000 description 1
• 239000007995 HEPES buffer Substances 0.000 description 1
• OWXMKDGYPWMGEB-UHFFFAOYSA-N HEPPS Chemical compound OCCN1CCN(CCCS(O)(=O)=O)CC1 OWXMKDGYPWMGEB-UHFFFAOYSA-N 0.000 description 1
• 239000007996 HEPPS buffer Substances 0.000 description 1
• GIZQLVPDAOBAFN-UHFFFAOYSA-N HEPPSO Chemical compound OCCN1CCN(CC(O)CS(O)(=O)=O)CC1 GIZQLVPDAOBAFN-UHFFFAOYSA-N 0.000 description 1
• 241000606768 Haemophilus influenzae Species 0.000 description 1
• 241000711549 Hepacivirus C Species 0.000 description 1
• 241000724709 Hepatitis delta virus Species 0.000 description 1
• 208000029433 Herpesviridae infectious disease Diseases 0.000 description 1
• 241000228404 Histoplasma capsulatum Species 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
• 208000012860 Horse disease Diseases 0.000 description 1
• 241000700588 Human alphaherpesvirus 1 Species 0.000 description 1
• 241001502974 Human gammaherpesvirus 8 Species 0.000 description 1
• 241000829111 Human polyomavirus 1 Species 0.000 description 1
• 101710091977 Hydrophobin Proteins 0.000 description 1
• WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
• 241000252234 Hypophthalmichthys nobilis Species 0.000 description 1
• 241001371826 Ichneumon suspiciosus Species 0.000 description 1
• 241000700723 Ictalurid herpesvirus 1 Species 0.000 description 1
• 206010061598 Immunodeficiency Diseases 0.000 description 1
• 208000029462 Immunodeficiency disease Diseases 0.000 description 1
• 241000711450 Infectious bronchitis virus Species 0.000 description 1
• 241000710921 Infectious pancreatic necrosis virus Species 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 206010022004 Influenza like illness Diseases 0.000 description 1
• 241001500351 Influenzavirus A Species 0.000 description 1
• 241000401052 Influenzavirus D Species 0.000 description 1
• 241000701372 Iridovirus Species 0.000 description 1
• 241001661732 Isavirus Species 0.000 description 1
• 241000710842 Japanese encephalitis virus Species 0.000 description 1
• 241000712890 Junin mammarenavirus Species 0.000 description 1
• 241000120527 Kemerovo virus Species 0.000 description 1
• FAIXYKHYOGVFKA-UHFFFAOYSA-N Kinetin Natural products N=1C=NC=2N=CNC=2C=1N(C)C1=CC=CO1 FAIXYKHYOGVFKA-UHFFFAOYSA-N 0.000 description 1
• 241000897510 Klamath virus Species 0.000 description 1
• 241000479166 Kolongo virus Species 0.000 description 1
• 241000231318 Kyzylagach virus Species 0.000 description 1
• LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
• RGHNJXZEOKUKBD-KLVWXMOXSA-N L-gluconic acid Chemical class OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)C(O)=O RGHNJXZEOKUKBD-KLVWXMOXSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
• PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
• 241000713102 La Crosse virus Species 0.000 description 1
• 241001520693 Lagos bat lyssavirus Species 0.000 description 1
• 206010023927 Lassa fever Diseases 0.000 description 1
• 241000712902 Lassa mammarenavirus Species 0.000 description 1
• 241000589248 Legionella Species 0.000 description 1
• 208000007764 Legionnaires' Disease Diseases 0.000 description 1
• 241000270322 Lepidosauria Species 0.000 description 1
• 241001148628 Leptospira kirschneri Species 0.000 description 1
• 241001135196 Leptospira noguchii Species 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 241000186781 Listeria Species 0.000 description 1
• 241000609846 Lumpy skin disease virus Species 0.000 description 1
• 208000016604 Lyme disease Diseases 0.000 description 1
• 208000008771 Lymphadenopathy Diseases 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 239000007993 MOPS buffer Substances 0.000 description 1
• 101000599943 Macaca mulatta Interferon gamma Proteins 0.000 description 1
• 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
• GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
• 241001559177 Mapuera rubulavirus Species 0.000 description 1
• 241001115401 Marburgvirus Species 0.000 description 1
• 241000283923 Marmota monax Species 0.000 description 1
• 241000608292 Mayaro virus Species 0.000 description 1
• 241000710949 Middelburg virus Species 0.000 description 1
• 241000713862 Moloney murine sarcoma virus Species 0.000 description 1
• 241000700627 Monkeypox virus Species 0.000 description 1
• 241000868135 Mucambo virus Species 0.000 description 1
• 241000711386 Mumps virus Species 0.000 description 1
• 241000711408 Murine respirovirus Species 0.000 description 1
• 201000005805 Murray valley encephalitis Diseases 0.000 description 1
• 241000829388 Mus musculus polyomavirus 1 Species 0.000 description 1
• 241000186359 Mycobacterium Species 0.000 description 1
• 241000186362 Mycobacterium leprae Species 0.000 description 1
• 241000187481 Mycobacterium phlei Species 0.000 description 1
• 241000187917 Mycobacterium ulcerans Species 0.000 description 1
• 241000202934 Mycoplasma pneumoniae Species 0.000 description 1
• 208000009525 Myocarditis Diseases 0.000 description 1
• 102000003505 Myosin Human genes 0.000 description 1
• 108060008487 Myosin Proteins 0.000 description 1
• 241000700562 Myxoma virus Species 0.000 description 1
• NMOJAXCSURVGEY-UHFFFAOYSA-N N#CC#N.[S] Chemical compound N#CC#N.[S] NMOJAXCSURVGEY-UHFFFAOYSA-N 0.000 description 1
• FSVCELGFZIQNCK-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)glycine Chemical compound OCCN(CCO)CC(O)=O FSVCELGFZIQNCK-UHFFFAOYSA-N 0.000 description 1
• DBXNUXBLKRLWFA-UHFFFAOYSA-N N-(2-acetamido)-2-aminoethanesulfonic acid Chemical compound NC(=O)CNCCS(O)(=O)=O DBXNUXBLKRLWFA-UHFFFAOYSA-N 0.000 description 1
• MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 description 1
• 241001457453 Nairobi sheep disease virus Species 0.000 description 1
• 241000264424 Nariva virus Species 0.000 description 1
• 241000238847 Nelson Bay orthoreovirus Species 0.000 description 1
• 241000772415 Neovison vison Species 0.000 description 1
• 241000411132 Nola virus Species 0.000 description 1
• 241000714209 Norwalk virus Species 0.000 description 1
• 241001428748 Ockelbo virus Species 0.000 description 1
• 241000353345 Odontesthes regia Species 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 241000702259 Orbivirus Species 0.000 description 1
• 241000250439 Oropouche virus Species 0.000 description 1
• 241000713112 Orthobunyavirus Species 0.000 description 1
• 241000712464 Orthomyxoviridae Species 0.000 description 1
• 241000150218 Orthonairovirus Species 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 241000123724 Ovine papillomavirus Species 0.000 description 1
• 239000007990 PIPES buffer Substances 0.000 description 1
• 241000120518 Palyam virus Species 0.000 description 1
• 241000282577 Pan troglodytes Species 0.000 description 1
• 206010034038 Parotitis Diseases 0.000 description 1
• 241000287127 Passeridae Species 0.000 description 1
• 201000005702 Pertussis Diseases 0.000 description 1
• 241000710778 Pestivirus Species 0.000 description 1
• 201000000239 Phlebotomus fever Diseases 0.000 description 1
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
• 241000709664 Picornaviridae Species 0.000 description 1
• 241000868134 Pixuna virus Species 0.000 description 1
• 241000223960 Plasmodium falciparum Species 0.000 description 1
• 241000269908 Platichthys flesus Species 0.000 description 1
• 241000142787 Pneumocystis jirovecii Species 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 241001135549 Porcine epidemic diarrhea virus Species 0.000 description 1
• 208000005585 Poxviridae Infections Diseases 0.000 description 1
• 108010007288 PrPSc Proteins Proteins 0.000 description 1
• 241000621172 Pseudocowpox virus Species 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 241000569181 Quailpox virus Species 0.000 description 1
• 241001096097 Rabbit kidney vacuolating virus Species 0.000 description 1
• 241001455645 Rabbitpox virus Species 0.000 description 1
• 241000711798 Rabies lyssavirus Species 0.000 description 1
• 241000700638 Raccoonpox virus Species 0.000 description 1
• 206010037888 Rash pustular Diseases 0.000 description 1
• 206010057190 Respiratory tract infections Diseases 0.000 description 1
• 241000189140 Rhizidiomyces Species 0.000 description 1
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
• 241000606695 Rickettsia rickettsii Species 0.000 description 1
• 241000713124 Rift Valley fever virus Species 0.000 description 1
• 241000711897 Rinderpest morbillivirus Species 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 241000315672 SARS coronavirus Species 0.000 description 1
• 241000192617 Sabia mammarenavirus Species 0.000 description 1
• 241000608282 Sagiyama virus Species 0.000 description 1
• 241000607142 Salmonella Species 0.000 description 1
• 241000479163 Sandjimba virus Species 0.000 description 1
• 241001123657 Seal parapoxvirus Species 0.000 description 1
• 241000150278 Seoul orthohantavirus Species 0.000 description 1
• 206010040047 Sepsis Diseases 0.000 description 1
• 241000700665 Sheeppox virus Species 0.000 description 1
• 241000607764 Shigella dysenteriae Species 0.000 description 1
• 241000607760 Shigella sonnei Species 0.000 description 1
• 241000713311 Simian immunodeficiency virus Species 0.000 description 1
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
• 244000258044 Solanum gilo Species 0.000 description 1
• 235000018650 Solanum gilo Nutrition 0.000 description 1
• 241001476589 Squirrel fibroma virus Species 0.000 description 1
• 241000713820 Squirrel monkey retrovirus Species 0.000 description 1
• 241001279364 Stachybotrys chartarum Species 0.000 description 1
• UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
• 241000191967 Staphylococcus aureus Species 0.000 description 1
• 241001147691 Staphylococcus saprophyticus Species 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 241000193985 Streptococcus agalactiae Species 0.000 description 1
• 241000193996 Streptococcus pyogenes Species 0.000 description 1
• 241000702287 Sugarcane streak virus Species 0.000 description 1
• 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• 239000005864 Sulphur Substances 0.000 description 1
• UZMAPBJVXOGOFT-UHFFFAOYSA-N Syringetin Natural products COC1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UZMAPBJVXOGOFT-UHFFFAOYSA-N 0.000 description 1
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
• 241000712908 Tacaribe mammarenavirus Species 0.000 description 1
• 241001137863 Taterapox virus Species 0.000 description 1
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
• 210000004241 Th2 cell Anatomy 0.000 description 1
• 240000001068 Thogoto virus Species 0.000 description 1
• 208000004006 Tick-borne encephalitis Diseases 0.000 description 1
• 241000710771 Tick-borne encephalitis virus Species 0.000 description 1
• 241001125862 Tinca tinca Species 0.000 description 1
• 241000723848 Tobamovirus Species 0.000 description 1
• 241000711517 Torovirus Species 0.000 description 1
• 241000530410 Trachypithecus Species 0.000 description 1
• 239000007997 Tricine buffer Substances 0.000 description 1
• GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
• 206010044684 Trismus Diseases 0.000 description 1
• 241000288667 Tupaia glis Species 0.000 description 1
• 241000385708 Turkeypox virus Species 0.000 description 1
• 208000034953 Twin anemia-polycythemia sequence Diseases 0.000 description 1
• 241000608278 Una virus Species 0.000 description 1
• 241000202921 Ureaplasma urealyticum Species 0.000 description 1
• 206010046865 Vaccinia virus infection Diseases 0.000 description 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
• 241000711970 Vesiculovirus Species 0.000 description 1
• 241000725110 Vilyuisk human encephalomyelitis virus Species 0.000 description 1
• 241001442055 Vipera berus Species 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• 241000120535 Wallal virus Species 0.000 description 1
• 241000120524 Warrego virus Species 0.000 description 1
• 241000710886 West Nile virus Species 0.000 description 1
• 241000710951 Western equine encephalitis virus Species 0.000 description 1
• 241000231320 Whataroa virus Species 0.000 description 1
• 241000702661 Wound tumor virus Species 0.000 description 1
• 208000027418 Wounds and injury Diseases 0.000 description 1
• TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
• 241001536558 Yaba monkey tumor virus Species 0.000 description 1
• 241000710772 Yellow fever virus Species 0.000 description 1
• 241000607479 Yersinia pestis Species 0.000 description 1
• 241001481505 Yug Bogdanovac vesiculovirus Species 0.000 description 1
• LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 238000009825 accumulation Methods 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 230000006978 adaptation Effects 0.000 description 1
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 230000000240 adjuvant effect Effects 0.000 description 1
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
• SRBFZHDQGSBBOR-QMKXCQHVSA-N alpha-L-arabinopyranose Chemical compound O[C@H]1CO[C@@H](O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-QMKXCQHVSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
• 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 1
• 229910021529 ammonia Inorganic materials 0.000 description 1
• 208000007502 anemia Diseases 0.000 description 1
• 239000000730 antalgic agent Substances 0.000 description 1
• 230000005875 antibody response Effects 0.000 description 1
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
• 238000003491 array Methods 0.000 description 1
• 206010003230 arteritis Diseases 0.000 description 1
• 206010003246 arthritis Diseases 0.000 description 1
• 229960001230 asparagine Drugs 0.000 description 1
• 235000009582 asparagine Nutrition 0.000 description 1
• 229940091771 aspergillus fumigatus Drugs 0.000 description 1
• 244000309743 astrovirus Species 0.000 description 1
• 229940065181 bacillus anthracis Drugs 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
• SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
• GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
• 239000007998 bicine buffer Substances 0.000 description 1
• 230000000035 biogenic effect Effects 0.000 description 1
• 230000006287 biotinylation Effects 0.000 description 1
• 238000007413 biotinylation Methods 0.000 description 1
• HHKZCCWKTZRCCL-UHFFFAOYSA-N bis-tris propane Chemical compound OCC(CO)(CO)NCCCNC(CO)(CO)CO HHKZCCWKTZRCCL-UHFFFAOYSA-N 0.000 description 1
• 229920001400 block copolymer Polymers 0.000 description 1
• 208000003836 bluetongue Diseases 0.000 description 1
• 210000001124 body fluid Anatomy 0.000 description 1
• 239000010839 body fluid Substances 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 229940098773 bovine serum albumin Drugs 0.000 description 1
• 206010006451 bronchitis Diseases 0.000 description 1
• 239000007975 buffered saline Substances 0.000 description 1
• 239000001110 calcium chloride Substances 0.000 description 1
• 229910001628 calcium chloride Inorganic materials 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 229940095731 candida albicans Drugs 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 239000000679 carrageenan Substances 0.000 description 1
• 235000010418 carrageenan Nutrition 0.000 description 1
• 229920001525 carrageenan Polymers 0.000 description 1
• 229940113118 carrageenan Drugs 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 210000003850 cellular structure Anatomy 0.000 description 1
• 235000010980 cellulose Nutrition 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 238000002144 chemical decomposition reaction Methods 0.000 description 1
• 229940038705 chlamydia trachomatis Drugs 0.000 description 1
• 229940059329 chondroitin sulfate Drugs 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 230000001113 coital effect Effects 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 229960005188 collagen Drugs 0.000 description 1
• 239000002131 composite material Substances 0.000 description 1
• 235000009508 confectionery Nutrition 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 201000010549 croup Diseases 0.000 description 1
• LXWYCLOUQZZDBD-LIYNQYRNSA-N csfv Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C1=CC=C(O)C=C1 LXWYCLOUQZZDBD-LIYNQYRNSA-N 0.000 description 1
• 238000005520 cutting process Methods 0.000 description 1
• 201000004400 dacryoadenitis Diseases 0.000 description 1
• 238000000354 decomposition reaction Methods 0.000 description 1
• 239000000850 decongestant Substances 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 208000025729 dengue disease Diseases 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• KCFYHBSOLOXZIF-UHFFFAOYSA-N dihydrochrysin Natural products COC1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 KCFYHBSOLOXZIF-UHFFFAOYSA-N 0.000 description 1
• 210000001840 diploid cell Anatomy 0.000 description 1
• 150000002016 disaccharides Chemical class 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 241001493065 dsRNA viruses Species 0.000 description 1
• 102000013035 dynein heavy chain Human genes 0.000 description 1
• 108060002430 dynein heavy chain Proteins 0.000 description 1
• 235000014103 egg white Nutrition 0.000 description 1
• 210000000969 egg white Anatomy 0.000 description 1
• 230000008030 elimination Effects 0.000 description 1
• 238000003379 elimination reaction Methods 0.000 description 1
• 210000004696 endometrium Anatomy 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 229940032049 enterococcus faecalis Drugs 0.000 description 1
• 230000000688 enterotoxigenic effect Effects 0.000 description 1
• 230000007613 environmental effect Effects 0.000 description 1
• UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
• 235000019414 erythritol Nutrition 0.000 description 1
• 229940009714 erythritol Drugs 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 239000003172 expectorant agent Substances 0.000 description 1
• 230000003419 expectorant effect Effects 0.000 description 1
• 230000001605 fetal effect Effects 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 206010016629 fibroma Diseases 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 239000012520 frozen sample Substances 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 238000010353 genetic engineering Methods 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• 235000011187 glycerol Nutrition 0.000 description 1
• 229930182470 glycoside Natural products 0.000 description 1
• 230000001492 haemagglutinating effect Effects 0.000 description 1
• 229940047650 haemophilus influenzae Drugs 0.000 description 1
• 230000003394 haemopoietic effect Effects 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 210000002443 helper t lymphocyte Anatomy 0.000 description 1
• 208000031169 hemorrhagic disease Diseases 0.000 description 1
• 235000014304 histidine Nutrition 0.000 description 1
• 230000028996 humoral immune response Effects 0.000 description 1
• 230000008348 humoral response Effects 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 230000003301 hydrolyzing effect Effects 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 230000002631 hypothermal effect Effects 0.000 description 1
• 150000002460 imidazoles Chemical class 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 230000007813 immunodeficiency Effects 0.000 description 1
• 239000002955 immunomodulating agent Substances 0.000 description 1
• 230000002584 immunomodulator Effects 0.000 description 1
• 229940121354 immunomodulator Drugs 0.000 description 1
• 239000003547 immunosorbent Substances 0.000 description 1
• 229960001438 immunostimulant agent Drugs 0.000 description 1
• 239000003022 immunostimulating agent Substances 0.000 description 1
• 230000001506 immunosuppresive effect Effects 0.000 description 1
• 230000000415 inactivating effect Effects 0.000 description 1
• 210000003000 inclusion body Anatomy 0.000 description 1
• 238000011534 incubation Methods 0.000 description 1
• 208000037951 infantile gastroenteritis Diseases 0.000 description 1
• 201000006747 infectious mononucleosis Diseases 0.000 description 1
• 230000001524 infective effect Effects 0.000 description 1
• 208000021646 inflammation of heart layer Diseases 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 230000000977 initiatory effect Effects 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 210000004347 intestinal mucosa Anatomy 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• QANMHLXAZMSUEX-UHFFFAOYSA-N kinetin Chemical compound N=1C=NC=2N=CNC=2C=1NCC1=CC=CO1 QANMHLXAZMSUEX-UHFFFAOYSA-N 0.000 description 1
• 229960001669 kinetin Drugs 0.000 description 1
• 230000006651 lactation Effects 0.000 description 1
• 230000002045 lasting effect Effects 0.000 description 1
• 239000010410 layer Substances 0.000 description 1
• 230000021633 leukocyte mediated immunity Effects 0.000 description 1
• GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical class O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 208000019423 liver disease Diseases 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 230000001926 lymphatic effect Effects 0.000 description 1
• 208000018555 lymphatic system disease Diseases 0.000 description 1
• 230000001589 lymphoproliferative effect Effects 0.000 description 1
• 206010025482 malaise Diseases 0.000 description 1
• 201000004792 malaria Diseases 0.000 description 1
• 235000013372 meat Nutrition 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• QWIZNVHXZXRPDR-WSCXOGSTSA-N melezitose Chemical compound O([C@@]1(O[C@@H]([C@H]([C@@H]1O[C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)CO)CO)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QWIZNVHXZXRPDR-WSCXOGSTSA-N 0.000 description 1
• HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1
• 235000010981 methylcellulose Nutrition 0.000 description 1
• 230000000813 microbial effect Effects 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 208000027889 monkey disease Diseases 0.000 description 1
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
• 235000019796 monopotassium phosphate Nutrition 0.000 description 1
• 150000002772 monosaccharides Chemical class 0.000 description 1
• 208000030194 mouth disease Diseases 0.000 description 1
• 230000016379 mucosal immune response Effects 0.000 description 1
• 238000002703 mutagenesis Methods 0.000 description 1
• 231100000350 mutagenesis Toxicity 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 210000003928 nasal cavity Anatomy 0.000 description 1
• 210000001989 nasopharynx Anatomy 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 210000005036 nerve Anatomy 0.000 description 1
• CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 1
• 210000002445 nipple Anatomy 0.000 description 1
• 231100000252 nontoxic Toxicity 0.000 description 1
• 230000003000 nontoxic effect Effects 0.000 description 1
• 231100000956 nontoxicity Toxicity 0.000 description 1
• 230000000474 nursing effect Effects 0.000 description 1
• 229920002113 octoxynol Polymers 0.000 description 1
• 210000001706 olfactory mucosa Anatomy 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 208000003154 papilloma Diseases 0.000 description 1
• 208000029211 papillomatosis Diseases 0.000 description 1
• 210000003899 penis Anatomy 0.000 description 1
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 206010034674 peritonitis Diseases 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
• 210000002706 plastid Anatomy 0.000 description 1
• 231100000572 poisoning Toxicity 0.000 description 1
• 230000000607 poisoning effect Effects 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1
• 229920000747 poly(lactic acid) Polymers 0.000 description 1
• 238000006116 polymerization reaction Methods 0.000 description 1
• 229920001451 polypropylene glycol Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 229910000160 potassium phosphate Inorganic materials 0.000 description 1
• 235000011009 potassium phosphates Nutrition 0.000 description 1
• 244000144977 poultry Species 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 230000000644 propagated effect Effects 0.000 description 1
• 230000001681 protective effect Effects 0.000 description 1
• 239000011241 protective layer Substances 0.000 description 1
• 238000010926 purge Methods 0.000 description 1
• 208000029561 pustule Diseases 0.000 description 1
• 210000001187 pylorus Anatomy 0.000 description 1
• MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 230000000241 respiratory effect Effects 0.000 description 1
• 230000029058 respiratory gaseous exchange Effects 0.000 description 1
• 230000001177 retroviral effect Effects 0.000 description 1
• 238000010839 reverse transcription Methods 0.000 description 1
• 206010039083 rhinitis Diseases 0.000 description 1
• 229940075118 rickettsia rickettsii Drugs 0.000 description 1
• 230000000630 rising effect Effects 0.000 description 1
• 229920002477 rna polymer Polymers 0.000 description 1
• 210000001581 salivary duct Anatomy 0.000 description 1
• 235000019515 salmon Nutrition 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 208000013223 septicemia Diseases 0.000 description 1
• 235000015170 shellfish Nutrition 0.000 description 1
• 229940007046 shigella dysenteriae Drugs 0.000 description 1
• 229940115939 shigella sonnei Drugs 0.000 description 1
• SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
• 125000005629 sialic acid group Chemical group 0.000 description 1
• 238000004088 simulation Methods 0.000 description 1
• 238000004513 sizing Methods 0.000 description 1
• 239000001632 sodium acetate Substances 0.000 description 1
• 235000017281 sodium acetate Nutrition 0.000 description 1
• 239000011780 sodium chloride Substances 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 235000011121 sodium hydroxide Nutrition 0.000 description 1
• 239000001488 sodium phosphate Substances 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• 229940074404 sodium succinate Drugs 0.000 description 1
• ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
• UASJMJKAMKICKL-UHFFFAOYSA-M sodium;3-[bis(2-hydroxyethyl)amino]-2-hydroxypropane-1-sulfonate Chemical compound [Na+].OCCN(CCO)CC(O)CS([O-])(=O)=O UASJMJKAMKICKL-UHFFFAOYSA-M 0.000 description 1
• 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 238000001179 sorption measurement Methods 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 229940031439 squalene Drugs 0.000 description 1
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
• UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
• 235000000891 standard diet Nutrition 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 229940030998 streptococcus agalactiae Drugs 0.000 description 1
• 230000001629 suppression Effects 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 239000000725 suspension Substances 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 150000003536 tetrazoles Chemical class 0.000 description 1
• 231100000331 toxic Toxicity 0.000 description 1
• 230000002588 toxic effect Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 238000012549 training Methods 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
• 241000701451 unidentified granulovirus Species 0.000 description 1
• 241000007181 unidentified human coronavirus Species 0.000 description 1
• 239000002691 unilamellar liposome Substances 0.000 description 1
• 210000004291 uterus Anatomy 0.000 description 1
• 238000002255 vaccination Methods 0.000 description 1
• 208000007089 vaccinia Diseases 0.000 description 1
• 230000002477 vacuolizing effect Effects 0.000 description 1
• 210000001215 vagina Anatomy 0.000 description 1
• 239000004474 valine Substances 0.000 description 1
• 229960004854 viral vaccine Drugs 0.000 description 1
• 230000008673 vomiting Effects 0.000 description 1
• 239000007762 w/o emulsion Substances 0.000 description 1
• 238000005303 weighing Methods 0.000 description 1
• 210000004885 white matter Anatomy 0.000 description 1
• 238000004804 winding Methods 0.000 description 1
• 229920001285 xanthan gum Polymers 0.000 description 1
• 239000000811 xylitol Substances 0.000 description 1
• 235000010447 xylitol Nutrition 0.000 description 1
• 229960002675 xylitol Drugs 0.000 description 1
• HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1
• 229940051021 yellow-fever virus Drugs 0.000 description 1
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1