CN107257793A - 抗蠕虫化合物、组合物及其使用方法 - Google Patents
抗蠕虫化合物、组合物及其使用方法 Download PDFInfo
- Publication number
- CN107257793A CN107257793A CN201680010899.2A CN201680010899A CN107257793A CN 107257793 A CN107257793 A CN 107257793A CN 201680010899 A CN201680010899 A CN 201680010899A CN 107257793 A CN107257793 A CN 107257793A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- haloalkyl
- membered
- amino
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC12C3C1C3*C2 Chemical compound CC12C3C1C3*C2 0.000 description 21
- GJEQDJXFWKFHKR-YVCMITCOSA-N C/C=C(\C(\C(F)(F)F)=C/CNC(CC1)CCC1Oc1nccc(Br)c1)/N=O Chemical compound C/C=C(\C(\C(F)(F)F)=C/CNC(CC1)CCC1Oc1nccc(Br)c1)/N=O GJEQDJXFWKFHKR-YVCMITCOSA-N 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N C1NCCNC1 Chemical compound C1NCCNC1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- OQYXKRUKQSNPIC-VWGJVVOMSA-N CC(/C=N\C(\C)=N/N)=[IH] Chemical compound CC(/C=N\C(\C)=N/N)=[IH] OQYXKRUKQSNPIC-VWGJVVOMSA-N 0.000 description 1
- MGZZRBAUDHVMRP-UHFFFAOYSA-N CC(C)c1c2nc[s]c2c(C)cc1 Chemical compound CC(C)c1c2nc[s]c2c(C)cc1 MGZZRBAUDHVMRP-UHFFFAOYSA-N 0.000 description 1
- PUEBJLVHAUEUKB-UHFFFAOYSA-N CC1(C)N=CC(C)=CN1 Chemical compound CC1(C)N=CC(C)=CN1 PUEBJLVHAUEUKB-UHFFFAOYSA-N 0.000 description 1
- NALMZNRUIUPVLP-UHFFFAOYSA-N CCCc1cc([s]nc2)c2c(C(C)C)c1 Chemical compound CCCc1cc([s]nc2)c2c(C(C)C)c1 NALMZNRUIUPVLP-UHFFFAOYSA-N 0.000 description 1
- BXUJNRJCVSGMKA-UHFFFAOYSA-N Cc(cc1)c2[o]ncc2c1I Chemical compound Cc(cc1)c2[o]ncc2c1I BXUJNRJCVSGMKA-UHFFFAOYSA-N 0.000 description 1
- NVNLHSSOPHPQIP-UHFFFAOYSA-N Cc1c2N[CH]Oc2c(C)cc1 Chemical compound Cc1c2N[CH]Oc2c(C)cc1 NVNLHSSOPHPQIP-UHFFFAOYSA-N 0.000 description 1
- KREQZPWIJCDEIK-UHFFFAOYSA-N Cc1cc(C)c(cn[o]2)c2c1 Chemical compound Cc1cc(C)c(cn[o]2)c2c1 KREQZPWIJCDEIK-UHFFFAOYSA-N 0.000 description 1
- BDHQVPWFPRIJQW-UHFFFAOYSA-N Cc1cc(C)c2[nH]cnc2c1 Chemical compound Cc1cc(C)c2[nH]cnc2c1 BDHQVPWFPRIJQW-UHFFFAOYSA-N 0.000 description 1
- VHRWRRDBAJITLR-UHFFFAOYSA-N Cc1cc(C)c2[nH]ncc2c1 Chemical compound Cc1cc(C)c2[nH]ncc2c1 VHRWRRDBAJITLR-UHFFFAOYSA-N 0.000 description 1
- XQJQKADNDFGUPY-UHFFFAOYSA-N Cc1cc(C)c2[o]cnc2c1 Chemical compound Cc1cc(C)c2[o]cnc2c1 XQJQKADNDFGUPY-UHFFFAOYSA-N 0.000 description 1
- NDUHYERSZLRFNL-UHFFFAOYSA-N Cc1cc(C)c2nc[o]c2c1 Chemical compound Cc1cc(C)c2nc[o]c2c1 NDUHYERSZLRFNL-UHFFFAOYSA-N 0.000 description 1
- TWGNOYAGHYUFFR-UHFFFAOYSA-N Cc1cncnc1 Chemical compound Cc1cncnc1 TWGNOYAGHYUFFR-UHFFFAOYSA-N 0.000 description 1
- LCZUOKDVTBMCMX-UHFFFAOYSA-N Cc1ncc(C)nc1 Chemical compound Cc1ncc(C)nc1 LCZUOKDVTBMCMX-UHFFFAOYSA-N 0.000 description 1
- PTPTZLXZHPPVKG-UHFFFAOYSA-N Fc1cc(Br)ccn1 Chemical compound Fc1cc(Br)ccn1 PTPTZLXZHPPVKG-UHFFFAOYSA-N 0.000 description 1
- XKTWPVGVBLSSJQ-UHFFFAOYSA-N N#Cc(cc1)c(C(F)(F)F)cc1NC1CCNCC1 Chemical compound N#Cc(cc1)c(C(F)(F)F)cc1NC1CCNCC1 XKTWPVGVBLSSJQ-UHFFFAOYSA-N 0.000 description 1
- QIQRWCCSCGGMLG-UHFFFAOYSA-N [O-][N+](c(c(C(F)(F)F)c1)ccc1NCC(CC1)CCC1O)=O Chemical compound [O-][N+](c(c(C(F)(F)F)c1)ccc1NCC(CC1)CCC1O)=O QIQRWCCSCGGMLG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105463P | 2015-01-20 | 2015-01-20 | |
| US62/105,463 | 2015-01-20 | ||
| PCT/US2016/014148 WO2016118638A1 (en) | 2015-01-20 | 2016-01-20 | Anthelmintic compounds, compositions and method of using thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107257793A true CN107257793A (zh) | 2017-10-17 |
Family
ID=55299781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680010899.2A Pending CN107257793A (zh) | 2015-01-20 | 2016-01-20 | 抗蠕虫化合物、组合物及其使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10597364B2 (enExample) |
| EP (1) | EP3247701B1 (enExample) |
| JP (1) | JP6771469B2 (enExample) |
| CN (1) | CN107257793A (enExample) |
| AU (3) | AU2016209321B2 (enExample) |
| BR (1) | BR112017015273A2 (enExample) |
| CA (1) | CA2973873A1 (enExample) |
| ES (1) | ES2907461T3 (enExample) |
| MX (1) | MX379304B (enExample) |
| NZ (1) | NZ734082A (enExample) |
| WO (1) | WO2016118638A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113194937A (zh) * | 2018-10-04 | 2021-07-30 | 礼蓝动物健康股份公司 | 蠕虫治疗的增强 |
| CN113474007A (zh) * | 2018-12-18 | 2021-10-01 | 特兰斯丰特控股有限公司 | 缀合物 |
Families Citing this family (33)
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| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| CA2968836C (en) | 2016-06-13 | 2025-09-02 | Gilead Sciences, Inc. | FXR MODULATING COMPOUNDS (NR1H4) |
| ES2921432T3 (es) | 2016-06-13 | 2022-08-25 | Gilead Sciences Inc | Derivados de azetidina como moduladores de FXR (NR1H4) |
| US10710980B2 (en) | 2016-07-20 | 2020-07-14 | Novartis Ag | Aminopyridine derivatives and their use as selective ALK-2 inhibitors |
| EP4424364B1 (en) | 2017-03-28 | 2026-01-21 | Gilead Sciences, Inc. | Combinations for use in the treatment of cirrhosis and liver fibrosis |
| RU2020105929A (ru) | 2017-08-04 | 2021-09-06 | Скайхоук Терапьютикс, Инк. | Способы и композиции для модулирования сплайсинга |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| BR122022012697B1 (pt) | 2018-07-10 | 2023-04-04 | Novartis Ag | Usos de derivados de 3-(5-hidróxi-1-oxoisoindolin-2-il)piperidina-2,6- diona, e kit |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| PE20211907A1 (es) | 2019-01-15 | 2021-09-28 | Gilead Sciences Inc | Compuestos moduladores de fxr (nr1h4) |
| RS66416B1 (sr) | 2019-01-18 | 2025-02-28 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluorometoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i metode njegove primene |
| EP3911640A4 (en) | 2019-01-18 | 2022-10-26 | Astrazeneca AB | PCSK9 INHIBITORS AND METHODS OF USE THEREOF |
| EP3920926A4 (en) | 2019-02-05 | 2022-10-19 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP7603592B2 (ja) | 2019-02-05 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| WO2020163544A1 (en) | 2019-02-06 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| CN119638696A (zh) | 2019-02-06 | 2025-03-18 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| KR102725082B1 (ko) | 2019-02-19 | 2024-11-04 | 길리애드 사이언시즈, 인코포레이티드 | Fxr 효능제의 고체 형태 |
| BR112021018631A2 (pt) * | 2019-03-19 | 2021-11-23 | Boehringer Ingelheim Animal Health Usa Inc | Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano |
| UY38687A (es) | 2019-05-17 | 2023-05-15 | Novartis Ag | Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso |
| US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
| JP7558267B2 (ja) | 2019-10-25 | 2024-09-30 | ギリアード サイエンシーズ， インコーポレイテッド | Ｇｌｐ－１ｒ調節化合物 |
| JP7717065B2 (ja) | 2019-11-22 | 2025-08-01 | インサイト コーポレーション | Ａｌｋ２阻害剤及びｊａｋ２阻害剤を含む併用療法 |
| CN120518596A (zh) | 2020-01-29 | 2025-08-22 | 吉利德科学公司 | Glp-1r调节化合物 |
| IL297128A (en) | 2020-04-07 | 2022-12-01 | Mitobridge Inc | Cd38 inhibitors |
| BR112022023199A2 (pt) | 2020-05-15 | 2023-04-04 | Algen Biotechnologies Inc | Certas composições químicas e métodos de uso das mesmas |
| AU2021292484A1 (en) | 2020-06-16 | 2023-01-19 | Incyte Corporation | ALK2 inhibitors for the treatment of anemia |
| US11851419B2 (en) | 2020-11-20 | 2023-12-26 | Gilead Sciences, Inc. | GLP-1R modulating compounds |
| EP4304712A1 (en) | 2021-03-11 | 2024-01-17 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| US12091404B2 (en) | 2021-03-11 | 2024-09-17 | Gilead Sciences, Inc. | GLP-1R modulating compounds |
| US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
| IL306110A (en) | 2021-04-21 | 2023-11-01 | Gilead Sciences Inc | Carboxy-benzimidazole glp-1r modulating compounds |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050277640A1 (en) * | 2003-10-10 | 2005-12-15 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives for treatment of hyperproliferative disorders |
| US20060009453A1 (en) * | 2004-05-07 | 2006-01-12 | Geuns-Meyer Stephanie D | Protein kinase modulators and method of use |
| WO2014023723A1 (en) * | 2012-08-08 | 2014-02-13 | Novartis Ag | Subtituted azines as pesticides |
| US20140142114A1 (en) * | 2012-11-20 | 2014-05-22 | Merial Limited | Anthelmintic compounds and compositions and method of using thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4208254A1 (de) | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
| AU1631699A (en) | 1997-12-18 | 1999-07-05 | E.I. Du Pont De Nemours And Company | Cyclohexylamine arthropodicides and fungicides |
| US20010049373A1 (en) | 2000-01-28 | 2001-12-06 | Chalquest Richard R. | Materials and methods for killing nematodes and nematode eggs |
| US7199147B2 (en) | 2001-06-12 | 2007-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Rho kinase inhibitors |
| DE102005032838A1 (de) * | 2005-07-14 | 2007-02-08 | Merck Patent Gmbh | Mischung von Onium-Alkylsulfonaten und Onium-Alkylsulfiten |
| WO2007063839A1 (ja) * | 2005-11-30 | 2007-06-07 | Shionogi & Co., Ltd. | シクロヘキサン誘導体 |
| TW200938203A (en) | 2007-12-17 | 2009-09-16 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201041868A (en) | 2009-03-20 | 2010-12-01 | Intervet Int Bv | Anthelmintic agents and their use |
| TW201111358A (en) | 2009-06-18 | 2011-04-01 | Intervet Int Bv | Anthelmintic agents and their use |
| AU2010303780B2 (en) | 2009-10-09 | 2014-02-20 | Irm Llc | Compounds and compositions as modulators of GPR119 activity |
| US8952037B2 (en) * | 2010-05-13 | 2015-02-10 | Amgen Inc. | Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors |
| US8497265B2 (en) * | 2010-05-13 | 2013-07-30 | Amgen Inc. | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors |
| EP2468096A1 (en) | 2010-12-21 | 2012-06-27 | Intervet International BV | Anthelmintic combinations |
| US8530461B2 (en) * | 2011-12-29 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
| SMT202100687T1 (it) | 2013-03-12 | 2022-01-10 | Vertex Pharma | Inibitori della dna-pk |
| CA2926700C (en) | 2013-11-18 | 2018-03-20 | Novartis Tiergesundheit Ag | Pyridyl, pyrimidinyl and phenyl compounds and their use in the control of parasites |
| US10045979B2 (en) | 2014-05-19 | 2018-08-14 | Merial Inc. | Anthelmintic compounds |
-
2016
- 2016-01-20 ES ES16702865T patent/ES2907461T3/es active Active
- 2016-01-20 US US15/544,837 patent/US10597364B2/en active Active
- 2016-01-20 JP JP2017538327A patent/JP6771469B2/ja not_active Expired - Fee Related
- 2016-01-20 MX MX2017009408A patent/MX379304B/es unknown
- 2016-01-20 CA CA2973873A patent/CA2973873A1/en not_active Abandoned
- 2016-01-20 NZ NZ734082A patent/NZ734082A/en not_active IP Right Cessation
- 2016-01-20 AU AU2016209321A patent/AU2016209321B2/en not_active Ceased
- 2016-01-20 EP EP16702865.3A patent/EP3247701B1/en active Active
- 2016-01-20 CN CN201680010899.2A patent/CN107257793A/zh active Pending
- 2016-01-20 BR BR112017015273-8A patent/BR112017015273A2/pt active Search and Examination
- 2016-01-20 WO PCT/US2016/014148 patent/WO2016118638A1/en not_active Ceased
-
2019
- 2019-04-18 AU AU2019202773A patent/AU2019202773B2/en not_active Ceased
-
2020
- 2020-06-30 AU AU2020204400A patent/AU2020204400A1/en not_active Abandoned
Patent Citations (4)
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| US20050277640A1 (en) * | 2003-10-10 | 2005-12-15 | Bayer Pharmaceuticals Corporation | Pyrimidine derivatives for treatment of hyperproliferative disorders |
| US20060009453A1 (en) * | 2004-05-07 | 2006-01-12 | Geuns-Meyer Stephanie D | Protein kinase modulators and method of use |
| WO2014023723A1 (en) * | 2012-08-08 | 2014-02-13 | Novartis Ag | Subtituted azines as pesticides |
| US20140142114A1 (en) * | 2012-11-20 | 2014-05-22 | Merial Limited | Anthelmintic compounds and compositions and method of using thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113194937A (zh) * | 2018-10-04 | 2021-07-30 | 礼蓝动物健康股份公司 | 蠕虫治疗的增强 |
| CN113474007A (zh) * | 2018-12-18 | 2021-10-01 | 特兰斯丰特控股有限公司 | 缀合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6771469B2 (ja) | 2020-10-21 |
| MX2017009408A (es) | 2017-10-02 |
| US10597364B2 (en) | 2020-03-24 |
| WO2016118638A1 (en) | 2016-07-28 |
| US20180009754A1 (en) | 2018-01-11 |
| AU2019202773A1 (en) | 2019-05-16 |
| CA2973873A1 (en) | 2016-07-28 |
| AU2019202773B2 (en) | 2020-07-02 |
| JP2018502877A (ja) | 2018-02-01 |
| EP3247701A1 (en) | 2017-11-29 |
| MX379304B (es) | 2025-03-11 |
| ES2907461T3 (es) | 2022-04-25 |
| NZ734082A (en) | 2019-01-25 |
| EP3247701B1 (en) | 2021-09-22 |
| AU2020204400A1 (en) | 2020-07-30 |
| AU2016209321A1 (en) | 2017-08-17 |
| AU2016209321B2 (en) | 2019-05-09 |
| BR112017015273A2 (pt) | 2018-01-09 |
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Effective date of registration: 20190712 Address after: Georgia Applicant after: Bollinger Ingham Animal Health USA Address before: Georgia Applicant before: Cimmeria limited-liability company |
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Application publication date: 20171017 |