CN107255584B - 用于预处理包埋的生物样本的不混溶两相系统 - Google Patents

用于预处理包埋的生物样本的不混溶两相系统 Download PDF

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CN107255584B
CN107255584B CN201710343058.XA CN201710343058A CN107255584B CN 107255584 B CN107255584 B CN 107255584B CN 201710343058 A CN201710343058 A CN 201710343058A CN 107255584 B CN107255584 B CN 107255584B
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solvent
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embedding medium
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CN107255584A (zh
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S·H·马蒂森
S·尼尔森
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Agilent Technologies Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G01N2001/366—Moulds; Demoulding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201710343058.XA 2011-02-28 2012-02-28 用于预处理包埋的生物样本的不混溶两相系统 Active CN107255584B (zh)

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US201161447364P 2011-02-28 2011-02-28
US61/447,364 2011-02-28
CN201280010677.2A CN103930761B (zh) 2011-02-28 2012-02-28 用于预处理包埋的生物样本的不混溶两相系统

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AU (3) AU2012222963B2 (enExample)
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2285979B2 (en) 2008-05-27 2020-02-19 Dako Denmark A/S Hybridization compositions and methods
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
EP3252173A1 (en) * 2011-10-21 2017-12-06 Dako Denmark A/S Hybridization compositions and methods
US8701980B2 (en) 2011-10-27 2014-04-22 Veltek Associates, Inc. Air sample tracking system and method
DE102013204646B4 (de) 2013-03-15 2018-04-05 Leica Biosystems Nussloch Gmbh Gerät zum Bearbeiten von histologischen Proben
US10839509B2 (en) 2015-07-10 2020-11-17 3Scan Inc. Spatial multiplexing of histological stains
US10281374B2 (en) * 2015-11-04 2019-05-07 Diagnostic Biosystems Method of pretreatment of biological samples for an analyte-staining assay method
JP6220101B1 (ja) * 2016-01-29 2017-10-25 シスメックス株式会社 標本染色装置、塗抹標本作製装置および標本染色方法
WO2018081693A1 (en) 2016-10-31 2018-05-03 Agilent Technologies, Inc. Deparaffinization of tissue by electric field generation and ionization
US10379015B2 (en) 2017-06-04 2019-08-13 Diagnostic Biosystems Method for labeling concentration density differentials of an analyte in a biological sample
CN107828862A (zh) * 2017-12-15 2018-03-23 郑州大学第附属医院 淋巴瘤组织石蜡包埋切片荧光原位杂交检测的预处理方法
WO2019195677A1 (en) * 2018-04-05 2019-10-10 Instapath, Inc. Disposable biopsy staining kit and related methods and systems
US11525759B2 (en) 2018-04-24 2022-12-13 Agilent Technologies, Inc. Deparaffinization of tissue utilizing electric field
CN109142012A (zh) * 2018-08-17 2019-01-04 上海迈景纳米科技有限公司 一种ffpe样本快速脱蜡装置及其使用方法
EP3969876B1 (en) * 2019-05-14 2025-08-20 Ventana Medical Systems, Inc. System including a biological sample treatment chamber and use
CN110132673B (zh) * 2019-05-22 2021-06-15 上海市农业科学院 一种制备金针菇子实体组织切片的方法
CN112113822A (zh) * 2019-06-21 2020-12-22 深圳迈瑞生物医疗电子股份有限公司 生物样本染色装置、推片染色机及生物样本染色方法
CN111238912A (zh) * 2020-03-12 2020-06-05 河南农业大学 一种叶片切片包埋的方法和叶片制片方法
JP7623471B2 (ja) * 2020-08-10 2025-01-28 ライカ ビオズュステムス ヌスロッホ ゲーエムベーハー キシレンフリーの組織処理装置及び組織を処理するための方法
US12496582B2 (en) 2020-09-10 2025-12-16 Instapath, Inc. Systems for delivery of a liquid to and removal of a liquid from a sample
CN113092219B (zh) * 2021-03-24 2025-07-18 迪帕微(上海)生物科技有限公司 一种硬组织切片防脱预处理装置及防脱预处理方法
US20230392196A1 (en) * 2022-06-06 2023-12-07 Applied Materials, Inc. RNA retrieval process for preparing formalin-fixed, paraffin-embedded (FFPE) tissue samples for in situ hybridization

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1277156A (zh) * 2000-08-08 2000-12-20 杨传芳 溶氧法污水处理工艺及装置
CN1726386A (zh) * 2002-12-20 2006-01-25 达可斯通(丹麦)公司 生物样品预处理方法和装置
EP1793218A1 (en) * 2005-11-30 2007-06-06 Dako Denmark A/S Removal of embedding medium
CN101693156A (zh) * 2009-10-23 2010-04-14 张子楠 发电厂凝汽器内多功能净化装置
CN201605875U (zh) * 2010-03-08 2010-10-13 河北和拓嘉实环境工程有限公司 防风抑尘网
CN101929927A (zh) * 2009-06-19 2010-12-29 莱卡生物系统努斯洛赫有限责任公司 在组织处理器中自动处理组织样品的方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2137549A (en) 1935-05-10 1938-11-22 Union Oil Co Method for dewaxing oils
US3769934A (en) 1973-01-26 1973-11-06 Dow Chemical Co Sample preparing apparatus
DE2753710C2 (de) * 1977-12-02 1980-01-03 Thomas, Carlos, Prof. Dr., 7808 Waldkirch Verfahren zur Entwässerung von Gewebeproben o.dgl. und Vorrichtung zur Durchführung des Verfahrens
DE2915248C3 (de) 1979-04-14 1982-01-14 Gise, Frhr. von, Hardo, Dr.med., 7400 Tübingen Einrichtung zum automatischen wahlweisen u. exakten Behandeln von Präparaten
US4379525A (en) * 1981-08-06 1983-04-12 Owens-Illinois, Inc. Process for recycling plastic container scrap
JPS60131442A (ja) * 1983-12-21 1985-07-13 Chiyoda Seisakusho:Kk 包埋装置におけるパラフイン障害除去装置
US5023187A (en) * 1985-09-13 1991-06-11 Fisher Scientific Company Method and device for accelerated treatment of thin sample on surface
JP2693450B2 (ja) 1987-09-16 1997-12-24 株式会社東芝 磁気ヘッド
JPH0725669Y2 (ja) * 1989-06-26 1995-06-07 株式会社千代田製作所 一槽式標本処理装置に於ける気泡混入防止装置
US5273905A (en) * 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
ATE165917T1 (de) * 1993-02-03 1998-05-15 Histaggen Inc Automatisiertes histo-zytochemisches gerät und einkapselungssystem zum behandeln von biologischem material
US5344637A (en) 1993-06-01 1994-09-06 Camiener Gerald W Use of saturated, ring-containing compounds as clearing solvents in histologic procedures
US6451551B1 (en) * 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
US6632598B1 (en) 1994-03-11 2003-10-14 Biogenex Laboratories Deparaffinization compositions and methods for their use
EP0729021A1 (de) * 1995-02-25 1996-08-28 Roche Diagnostics GmbH Vorrichtung zur Bearbeitung von Proben auf Objektträgern
JP2901521B2 (ja) * 1995-07-31 1999-06-07 アロカ株式会社 生物組織の処理装置
JPH1019749A (ja) * 1996-06-28 1998-01-23 Aloka Co Ltd 生物組織処理装置
US5948359A (en) 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
US8137619B2 (en) 1997-08-11 2012-03-20 Ventana Medical Systems, Inc. Memory management method and apparatus for automated biological reaction system
US6855559B1 (en) * 1998-09-03 2005-02-15 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6183693B1 (en) * 1998-02-27 2001-02-06 Cytologix Corporation Random access slide stainer with independent slide heating regulation
JP3847559B2 (ja) 1998-02-27 2006-11-22 ベンタナ・メデイカル・システムズ・インコーポレーテツド 独立スライド加熱器を有する自動化分子病理学装置
JP4082782B2 (ja) * 1998-04-30 2008-04-30 雪印乳業株式会社 歯周病予防及び改善剤
US7410753B2 (en) * 1998-09-03 2008-08-12 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
CN100389314C (zh) * 1998-09-03 2008-05-21 文塔纳医疗系统公司 在自动染色仪上除去生物学标本包埋介质并调节细胞状态
US6544798B1 (en) 1999-02-26 2003-04-08 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6248535B1 (en) * 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
WO2001073399A2 (en) 2000-03-24 2001-10-04 Biogenex Laboratories, Inc. Device and methods for automated specimen processing
JP4596501B2 (ja) * 2000-04-10 2010-12-08 サクラ精機株式会社 顕微鏡標本のカバーガラス貼着装置
JP2004515752A (ja) 2000-09-15 2004-05-27 バイオジェネックス ラボラトリーズ ｉｎｓｉｔｕハイブリダイゼーションの向上
US7468161B2 (en) * 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
JP4299150B2 (ja) 2002-04-15 2009-07-22 ベンタナ・メデイカル・システムズ・インコーポレーテツド 大容量のスライドを自動染色するシステム
US7438940B2 (en) 2002-04-19 2008-10-21 E. I. Du Pont De Nemours And Company Film and film structures having improved oxygen transmission, forming, and puncture resistances
WO2004057308A1 (en) 2002-12-20 2004-07-08 Dakocytomation Denmark A/S An automated sample processing apparatus and a method of automated treating of samples and use of such apparatus
US7767152B2 (en) * 2003-08-11 2010-08-03 Sakura Finetek U.S.A., Inc. Reagent container and slide reaction retaining tray, and method of operation
US20070248924A1 (en) 2003-12-10 2007-10-25 Torstein Ljungmann Apparatus for treatment of tissue specimens
EP1771730B1 (en) * 2004-07-23 2014-08-20 Ventana Medical Systems, Inc. Method and apparatus for applying fluids to a biological sample
US8236255B2 (en) * 2004-12-02 2012-08-07 Lab Vision Corporation Slide treatment apparatus and methods for use
CA2764294C (en) * 2004-12-17 2013-12-24 Ventana Medical Systems, Inc. Methods and compositions for a microemulsion-based tissue treatment
WO2009127350A1 (en) * 2008-04-15 2009-10-22 Universität Bern Method for optimized isolation of rna from fixed tissue
US8158061B2 (en) 2008-12-10 2012-04-17 Rushabh Instruments, Llc Automated slide staining apparatus
DE202009018981U1 (de) * 2009-07-01 2015-03-11 Axagarius Gmbh & Co. Kg Verwendung eines Kits für die Isolierung von Biomolekülen aus biologischen Proben sowie Kit dafür
CN201607343U (zh) * 2009-12-17 2010-10-13 巨石集团有限公司 液体取样装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1277156A (zh) * 2000-08-08 2000-12-20 杨传芳 溶氧法污水处理工艺及装置
CN1726386A (zh) * 2002-12-20 2006-01-25 达可斯通(丹麦)公司 生物样品预处理方法和装置
EP1793218A1 (en) * 2005-11-30 2007-06-06 Dako Denmark A/S Removal of embedding medium
CN101929927A (zh) * 2009-06-19 2010-12-29 莱卡生物系统努斯洛赫有限责任公司 在组织处理器中自动处理组织样品的方法
CN101693156A (zh) * 2009-10-23 2010-04-14 张子楠 发电厂凝汽器内多功能净化装置
CN201605875U (zh) * 2010-03-08 2010-10-13 河北和拓嘉实环境工程有限公司 防风抑尘网

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US20140051118A1 (en) 2014-02-20
CN103930761B (zh) 2017-06-13
AU2012222963A1 (en) 2013-08-22
AU2018250513A1 (en) 2018-11-15
AU2016222358A1 (en) 2016-09-22
EP2686662B1 (en) 2022-01-19
CA2826056A1 (en) 2012-09-07
CA2826056C (en) 2021-01-26
AU2012222963B2 (en) 2016-09-22
US10295442B2 (en) 2019-05-21
AU2018250513B2 (en) 2020-05-21
EP2686662A2 (en) 2014-01-22
CN103930761A (zh) 2014-07-16
WO2012117294A2 (en) 2012-09-07
EP2686662A4 (en) 2017-07-26
JP2014523514A (ja) 2014-09-11
WO2012117294A3 (en) 2016-07-28
CN107255584A (zh) 2017-10-17
JP6013376B2 (ja) 2016-10-25

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