CN107252110A - It is a kind of to strengthen the preparation method of body immunity and antidepression health food - Google Patents
It is a kind of to strengthen the preparation method of body immunity and antidepression health food Download PDFInfo
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- CN107252110A CN107252110A CN201710306375.4A CN201710306375A CN107252110A CN 107252110 A CN107252110 A CN 107252110A CN 201710306375 A CN201710306375 A CN 201710306375A CN 107252110 A CN107252110 A CN 107252110A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Strengthen the preparation method of body immunity and antidepression health food the invention discloses a kind of, solve that prior art preparation method is complicated and nonstandard problem.The present invention comprises the following steps：Prepare raw material by weight first, raw material and its weight proportion are：2~10 parts of ganoderma lucidum, 6~18 parts of wilsonii, 4~12 parts of pseudo-ginseng, 1~6 part of cape jasmine；Wilsonii, cape jasmine are added water to cook afterwards, decocting liquid filtration merges, and it is standby that filtrate decompression is concentrated to give clear cream；Ganoderma lucidum, pseudo-ginseng are pulverized and sieved followed by, fine powder is obtained standby；Then by gained clear cream it is dry dry extract；Subsequently gained dry extract is pulverized and sieved, dry extract is obtained；Subsequently gained fine powder is well mixed with gained dry extract, it is wetting agent softwood to add appropriate 85% ethanol；Finally step 6 gained softwood is sieved and pelletized, is dried, whole grain is encapsulated, packaging produces capsule.Specification of the present invention and simple to operate, safe and effective.
Description
Technical field
The present invention relates to field of health care food, more particularly to a kind of strengthens the preparation of body immunity and antidepression health food
Method.
Background technology
The immunologic function of human body is one of defence line, escorts health；It is that one kind gets rid of illness ability again, after people is ill
Rehabilitation can be promoted, this just turns into the disease-resistant basic place of human body salubrity.However, in daily life, thering are many factors to make human body
There is immunologic derangement in immunity degradation.Such as, meals are unreasonable, protein, vitamin, micro- insufficiency of intake；Life
It is irregular, sleep insufficiency；Lack exercise exercise, and the adaptability to environment is poor；Stress, it is overworked；Using hormone,
The adverse reaction of antibiotic etc, it is suppressed that immunity；Immunity is temporarily reduced when suffering from acute disease, it is then long when suffering from chronic diseases
Phase is in hypoimmunity state etc..If long-time hypoimmunity, the middle shape of health and disease just occurs in human body
State-sub-health state.And sub-health state is continually changing development, it can not such as be improved in time, it is more likely that to disease
Condition conversion.So, human autoimmune's function is improved, is the basic method that health is moved towards away from inferior health.
Substantial amounts of research has proven to the presence of interaction between the state of mind and immune system, i.e., cerebration can be adjusted and exempted from
Epidemic disease function, and the disorder of immune system can not only cause organism disease, also with psychology spirit, behavior, personality and the change of aging
It is relevant.The hypoimmunity of human body and depression are closely bound up.Depression can cause body immunity to decline, and immunity degradation is again
Further aggravate symptoms of depression.But enhancing body immunity at present safely, effectively, suitable for long-term taking and energy antidepression
Medicine still lack.
The content of the invention
The technical problem to be solved in the present invention is：The preparation of a kind of enhancing body immunity and antidepression health food is provided
Method, this preparation method is simple to operate, safe and effective, and the health food prepared in the method can effectively improve immunity of organism
Power, antidepression, safely and effectively.
To achieve the above object, the technical solution adopted by the present invention is as follows：
It is a kind of to strengthen the preparation method of body immunity and antidepression health food, comprise the following steps：
Step 1, prepare raw material by weight, the raw material and its weight proportion are：2~10 parts of ganoderma lucidum, wilsonii 6~
18 parts, 4~12 parts of pseudo-ginseng, 1~6 part of cape jasmine；
Step 2, wilsonii, cape jasmine added water to cook, decocting liquid filtration, merging filtrate, filtrate decompression is concentrated to give clear cream, standby
With；
Step 3, by ganoderma lucidum, pseudo-ginseng crush, sieving, obtain fine powder, it is standby；
Step 4, by step 2 gained clear cream it is dry dry extract；
Step 5, step 4 gained dry extract pulverized and sieved, obtain dry extract；
Step 6, step 3 gained fine powder is well mixed with step 5 gained dry extract, adds appropriate 85% ethanol to be wet
Moisten agent softwood；
Step 7, granulation that step 6 gained softwood sieves, obtain wet granular, wet granular is dried, and whole grain is encapsulated, packaging, i.e.,
Obtain capsule.
In the step 1, the raw material and its weight proportion are：3~8 parts of ganoderma lucidum, 7~15 parts of wilsonii, pseudo-ginseng 5~10
Part, 2~5 parts of cape jasmine.
In the step 1, the raw material and its weight proportion are：4 parts of ganoderma lucidum, 12 parts of wilsonii, 6 parts of pseudo-ginseng, cape jasmine 2
Part.
The ganoderma lucidum being previously mentioned in the present invention is On Polyporaceae red sesame Ganoderma lucidum (Leyss.
ExFr.) Karst. or purple sesame Ganoderma sinense Zhao, Xuet Zhang drying fructification.Whole year harvesting, is removed
Impurity, wipes out the lower end stem with rotten wood, silt or culture matrix, dry in the shade or Drying, i.e.,《Middle traditional Chinese medicines
Allusion quotation》The ganoderma lucidum that (version in 2015, one) is recorded.
The wilsonii being previously mentioned in the present invention is Araliaceae wilsonii Acanthopanax seuticosus
(Rupr.et Maxim.) Harms dry root and root ridge or lotus.Spring, the harvesting of season in autumn two, cleaning, drying, i.e.,《Chinese Pharmacopoeia》
The wilsonii that (version in 2015, one) is recorded.
The pseudo-ginseng being previously mentioned in the present invention is panax araliaceae plant Parmx notoginseng (Burk.) F. H.Chen
Dry root and rhizome.Excavated, clean before autumn, the flowers are in blossom, separate main root, branch root and rhizome, dry.Supporting root, which is practised, claims " rib ", root
Stem, which is practised, claims " clip ", i.e.,《Chinese Pharmacopoeia》The pseudo-ginseng that (version in 2015, one) is recorded.
The cape jasmine being previously mentioned in the present invention is the dry mature fruit that Juncao section plant grips sub- Ganiema Ellis.Month fruit maturation is harvested when being in reddish yellow, removes carpopodium and impurity, is steamed supreme gas or is put in boiling water and slightly scald, takes out, do
It is dry, i.e.,《Chinese Pharmacopoeia》The cape jasmine that (version in 2015, one) is recorded.
The pharmaceutically acceptable auxiliary material that the present invention is previously mentioned, including filler, disintegrant, lubricant, suspending agent, bonding
Agent, sweetener, flavouring, preservative, matrix etc..Filler includes：Starch, pregelatinized starch, lactose, mannitol, chitin,
Microcrystalline cellulose, sucrose etc.；Disintegrant includes：Starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, the poly- second of crosslinking
Alkene pyrrolidone, low-substituted hydroxypropyl cellulose, Ac-Di-Sol etc.；Lubricant includes：Magnesium stearate, dodecyl
Sodium sulphate, talcum powder, silica etc.；Suspending agent includes：Polyvinylpyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl
Ylmethyl cellulose etc.；Adhesive includes：Starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweetener bag
Include：Saccharin sodium, aspartame, sucrose, honey element, enoxolone etc.；Flavouring includes：Sweetener and various essence；Preservative
Including：Parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, the fixed, eucalyptus oil of acetic acid chloroethene etc.；Base
Matter includes：PEG6000, PEG4000, insect wax etc..
Ganoderma lucidum is sweet, mild-natured, the thoughts of returning home, lung, liver and kidney channel, with invigorating qi for tranquilization, relieving cough and asthma effect, for the mind not
Rather, insomnia palpitaition, deficiency syndrome of the lung cough and asthma, consumptive disease is losed heart, do not feel like eating.
Wilsonii is pungent, slight bitter, temperature, returns spleen, kidney, the heart channel of Hang-Shaoyin, with replenishing qi to invigorate the spleen, the effect tonified the kidney to relieve mental strain, for spleen and lung
The deficiency of vital energy, physically weak weak, poor appetite, deficiency of both the lung and kidney, chronic cough and dyspnea of deficiency type, kidney deficiency soreness of waist and knee joint, deficiency of both the heart and spleen, insomnia and dreamful sleep.
Pseudo-ginseng is sweet, slight bitter, warm-natured, Return liver, stomach.With dissipate stasis of blood hemostasis, the effect of detumescence ding-tong, for spitting blood, is told
Blood, Carp blood, has blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Cape jasmine bitter, cold in nature, the thoughts of returning home, lung, tri-jiao channel；With purging intense heat relieving restlessness, clearing heat and promoting diuresis, the effect of removing pattogenic heat from the blood and toxic material from the body is used
In Vexed, jaundice with damp-heat pathogen, the puckery pain of stranguria " blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles；Control bruise pain outside.
Compared with prior art, the invention has the advantages that：
(1) present invention selects ganoderma lucidum, wilsonii, pseudo-ginseng, cape jasmine as bulk drug, by scientific composition, by certain weight
Amount proportioning composition.Proved through animal experiment, with immune, antidepressant effect is strengthened, present invention process is simple, easy to operate,
Raw material sources are cheap and easy to get, last gained high yield rate, safely and effectively.
(2) medication of the present invention is exquisite, and compatibility is proper, and all medicines close medicine, can effectively strengthen immune and antidepression.Raw material of the present invention
In, the ganoderma lucidum thoughts of returning home, lung, liver and kidney channel, function focus on invigorating qi for tranquilization；Wilsonii returns spleen, kidney, the heart channel of Hang-Shaoyin, replenish qi to invigorate the spleen, and tonify the kidney to relieve mental strain；
Pseudo-ginseng Return liver, stomach, dissipate stasis of blood hemostasis, detumescence ding-tong；The cape jasmine thoughts of returning home, lung, tri-jiao channel, purging intense heat relieving restlessness.We using ganoderma lucidum as monarch drug in a prescription,
The effect of taking its invigorating qi for tranquilization, using wilsonii as ministerial drug, the effect for QI invigorating is played altogether, calming the nerves, assistant with pseudo-ginseng, cape jasmine, purging intense heat relieving restlessness,
Scattered stasis pain.Complete square compatibility side complements each other, and the Weiqi deficiency, liver depressionization caused by treatment disorder of weiqi are stagnant, exempt from so as to play enhancing
Epidemic disease power and antidepressant effect.
(3) bulk drug of the invention is conventional traditional Chinese medicine, it is easy to obtain genunie medicinal materials, and raw material sources are stable, matter
Amount is easily controllable.
(5) present invention in ganoderma lucidum and pseudo-ginseng it is un-extracted, be directly used as medicine with full powder, remain to greatest extent effectively into
Point, dosage is reduced, while being used as medicine with powder, the consumption of auxiliary material is reduced.The present invention uses scientific and rational preparation side
Method, prepares safely and effectively preparation so that the effect of regulation immunity of organisms is more stable, controllable.
(6) present invention employs oral formulations, conveniently produce, store, transport, carry and take.
Embodiment
With reference to embodiment, the invention will be further described, and mode of the invention includes but are not limited to following implementation
Example.
It is a kind of to strengthen the preparation method of body immunity and antidepression health food, comprise the following steps：
Step 1, prepare raw material by weight, the raw material and its weight proportion are：2~10 parts of ganoderma lucidum, wilsonii 6~
18 parts, 4~12 parts of pseudo-ginseng, 1~6 part of cape jasmine；
Step 2, wilsonii, cape jasmine added water to cook, decocting liquid filtration, merging filtrate, filtrate decompression is concentrated to give clear cream, standby
With；
Step 3, by ganoderma lucidum, pseudo-ginseng crush, sieving, obtain fine powder, it is standby；
Step 4, by step 2 gained clear cream it is dry dry extract；
Step 5, step 4 gained dry extract pulverized and sieved, obtain dry extract；
Step 6, step 3 gained fine powder is well mixed with step 5 gained dry extract, adds appropriate 85% ethanol to be wet
Moisten agent softwood；
Step 7, granulation that step 6 gained softwood sieves, obtain wet granular, wet granular is dried, and whole grain is encapsulated, packaging, i.e.,
Obtain capsule.
In the step 1, the raw material and its weight proportion are：3~8 parts of ganoderma lucidum, 7~15 parts of wilsonii, pseudo-ginseng 5~10
Part, 2~5 parts of cape jasmine.
In the step 1, the raw material and its weight proportion are：4 parts of ganoderma lucidum, 12 parts of wilsonii, 6 parts of pseudo-ginseng, cape jasmine 2
Part.
The present invention is in preparation process, and the health food is, using ganoderma lucidum, wilsonii, pseudo-ginseng, cape jasmine as bulk drug, to add
The preparation that pharmaceutically acceptable auxiliary material is conventionally prepared from；The preparation is by wilsonii, cape jasmine conventional method
Extraction is prepared into extract, and ganoderma lucidum, pseudo-ginseng are prepared into fine powder and be made；The extract is decocting thing, and the preparation is oral system
Any one in granule, tablet or capsule can be made in agent, the oral formulations.
In order that those skilled in the art of the present technique more fully understand the marrow of the present invention, spy provides following embodiment and is subject to
Explanation.
Embodiment 1
1. ganoderma lucidum disintegrating process is investigated
Method：3 parts of the net medicinal material of ganoderma lucidum is weighed, each 50g in after 60 DEG C of low temperature dryings, being ground into fine powder, crosses 100 mesh sieves, claimed
Amount, calculates flour extraction, the results are shown in Table 1.
The pulverizing medicinal materials technique of table 1 investigates result
Result of the test shows that the average flour extraction that ganoderma lucidum is crushed is 96.28%.
2. pseudo-ginseng disintegrating process is investigated
Method：3 parts of the net medicinal material of pseudo-ginseng is weighed, each 50g in after 60 DEG C of low temperature dryings, being ground into fine powder, crosses 100 mesh sieves, claimed
Amount, calculates flour extraction, the results are shown in Table 1.
The pulverizing medicinal materials technique of table 1 investigates result
Result of the test shows that the average flour extraction that ganoderma lucidum is crushed is 95.61%.
Embodiment 2
Composition：Ganoderma lucidum 40g, wilsonii 120g, pseudo-ginseng 60g, cape jasmine 20g, magnesium stearate 3g.
Preparation method：Raw material is weighed by weight；Wilsonii, cape jasmine are added water to cook, decocting liquid filtration, merging filtrate,
Filtrate decompression is concentrated to give clear cream, dries, obtains dry extract；Ganoderma lucidum, pseudo-ginseng are crushed, sieving obtains fine powder, mixed with dry extract
Even, it is wetting agent softwood to add appropriate 85% ethanol, and sieving granulation obtains wet granular, dried, and adds magnesium stearate, whole grain, dress
Capsule, packaging, produces capsule.
Embodiment 3
Composition：Ganoderma lucidum 10g, wilsonii 40g, pseudo-ginseng 20g, cape jasmine 20g, microcrystalline cellulose 10g, magnesium stearate 2g.
Preparation method：Raw material is weighed by weight；Wilsonii, cape jasmine are added water to cook, decocting liquid filtration, merging filtrate,
Filtrate decompression is concentrated to give clear cream, dries, obtains dry extract；By ganoderma lucidum, pseudo-ginseng crush, sieving, obtain fine powder, with to crystalline cellulose,
Dry extract is well mixed, and it is wetting agent softwood to add appropriate 85% ethanol, and sieving granulation obtains wet granular, dried, adds stearic
Sour magnesium, whole grain, tabletting, packaging produces tablet.
Embodiment 4
Composition：Ganoderma lucidum 50g, wilsonii 100g, pseudo-ginseng 100g, cape jasmine 80g, magnesium stearate 5g.
Preparation method：Raw material is weighed by weight；Wilsonii, cape jasmine are added water to cook, decocting liquid filtration, merging filtrate,
Filtrate decompression is concentrated to give clear cream, dries, obtains dry extract；Ganoderma lucidum, pseudo-ginseng are crushed, sieving obtains fine powder, mixed with dry extract
Even, it is wetting agent softwood to add appropriate 85% ethanol, and sieving granulation obtains wet granular, dried, and adds magnesium stearate, whole grain, dress
Capsule, packaging, produces capsule.
Embodiment 5
Composition：Ganoderma lucidum 60g, wilsonii 120g, pseudo-ginseng 150g, cape jasmine 10g, microcrystalline cellulose 15g, magnesium stearate 3g.
Preparation method：Raw material is weighed by weight；Wilsonii, cape jasmine are added water to cook, decocting liquid filtration, merging filtrate,
Filtrate decompression is concentrated to give clear cream, dries, obtains dry extract；By ganoderma lucidum, pseudo-ginseng crush, sieving, obtain fine powder, with to crystalline cellulose,
Dry extract is well mixed, and it is wetting agent softwood to add appropriate 85% ethanol, and sieving granulation obtains wet granular, dried, adds stearic
Sour magnesium, whole grain, tabletting, packaging produces tablet.
Embodiment 6
Composition：Ganoderma lucidum 40g, wilsonii 50g, pseudo-ginseng 70g, cape jasmine 30g, magnesium stearate 4g.
Preparation method：Raw material is weighed by weight；Wilsonii, cape jasmine are added water to cook, decocting liquid filtration, merging filtrate,
Filtrate decompression is concentrated to give clear cream, dries, obtains dry extract；Ganoderma lucidum, pseudo-ginseng are crushed, sieving obtains fine powder, mixed with dry extract
Even, it is wetting agent softwood to add appropriate 85% ethanol, and sieving granulation obtains wet granular, dried, and adds magnesium stearate, whole
Grain, encapsulated, packaging, produces capsule.
Embodiment 7
Composition：Ganoderma lucidum 30g, wilsonii 80g, pseudo-ginseng 40g, cape jasmine 60g, magnesium stearate 2g.
Preparation method：Raw material is weighed by weight；Wilsonii, cape jasmine are added water to cook, decocting liquid filtration, merging filtrate,
Filtrate decompression is concentrated to give clear cream, dries, obtains dry extract；Ganoderma lucidum, pseudo-ginseng are crushed, sieving obtains fine powder, mixed with dry extract
Even, it is wetting agent softwood to add appropriate 85% ethanol, and sieving granulation obtains wet granular, dried, and adds magnesium stearate, whole
Grain, encapsulated, packaging, produces capsule.
Embodiment 8
Strengthen immunity is tested
(1) by reagent
Invention formulation 1：Capsule is prepared into by embodiment 2, adds water and suspension is made.
Invention formulation 2：Tablet is prepared into by embodiment 2, adds water and suspension is made.
Negative control：Distilled water.
(2) experimental animal：Female ICR mice, body weight 18-22g, by institute of lab animals of Sichuan Academy of Medical Sciences
There is provided.
(3) test data is handled using SPSS 10.0forWindows software kits.
(4) test method and result
According to《Health food is examined and assessment technique specification》(version in 2003) is operated.
1st, to the influence of mouse cell immunologic function
The influence of 1.1 pairs of mouse delayed allergies (DTH)
1.1.1 test method：Delayed allergy (DTH) (ear swelling method)
According to《Health food is examined and assessment technique specification》(version in 2003) is operated.After gavage 30 days, to mouse web portion
Skin depilatory, about 3cm × 3cm, sensitization is uniformly smeared with the μ l of DNFB solution 50.After 5 days, mouse is applied to the μ l of DNFB solution 10
Auris dextra (two sides) is attacked.Put to death mouse within 24 hours after attack, cut left and right auricular concha, diameter 8mm ear is removed with card punch
Piece, weighs.
1.1.2 result of the test following table.
Influence of the table 1 to mouse delayed allergy (DTH)
From table 1, continuous gavage is after 30 days, ear swelling and the feminine gender of the middle and high dosage group animal of invention formulation
Control group, which is compared, more significant difference (P<0.05).
The influence of the mouse lymphocyte conversion test of 1.2 pairs of ConA inductions
1.2.1 test method：The mouse lymphocyte conversion test (mtt assay) of ConA inductions
It is sterile to take spleen, it is placed in the plate for filling appropriate sterile Hank's liquid, cell suspension is made, through 200 eye mesh screen mistakes
Filter.Washed with Hank's liquid 2 times, l0min (1000r/min) is centrifuged every time.Then cell is suspended in 1mL complete culture solutions,
Living cell counting number, it is 3*10 to adjust cell concentration with RPMI1640 nutrient solutions6Individual/mL..Cell suspension point holes is added again
In 24 well culture plates, per hole 1mL, a hole adds 75uL ConA liquid (equivalent to 7.5uL/mL) wherein, and another hole is as right
According to putting 5%CO2, 72h is cultivated in 37 DEG C of carbon dioxide incubators.4h gently sucks supernatant 0.7mL before culture terminates, and adds
0.7mL is free of the RPMI1640 nutrient solutions of calf serum, while adding MTT (5mg/mL) 50uL/ holes, continues to cultivate 4h.Culture
After end, 1mL acid isopropyl alcohol is added per hole, piping and druming mixes, is completely dissolved purple crystal, is then dispensed into 96 well culture plates
In, 3 parallel holes are made in each hole, and with ELIASA, OD value is determined with 570nm wavelength.The multiplication capacity of lymphocyte, which is used, to be added
The OD value in ConA holes, which is subtracted, to be not added with the OD value in ConA holes and represents.
1.2.2 result of the test following table.
Influence of the table 2 to the ConA mouse lymphocyte conversion tests induced
From table 2, the middle high dose group of invention formulation 1,2 it is continuous to mouse stomach 30 days after, the lymph of mouse is thin
Born of the same parents' multiplication capacity more has significant difference (P compared with negative control group<0.05).
1.3 conclusion
Shown by the result of table 1, table 2, the present invention is positive to the test for celluar immunity result of mouse.
The influence of 2 pairs of NK cells in mice activity
2.1 test method：NK cytoactive detections (lactate dehydrogenase L DH determination methods)
Cervical dislocation puts to death animal, takes out spleen, tears up, and crosses after 200 eye mesh screens, washes 3 times with Hank ' s liquid, every time
1000r/min centrifuges 10min, takes cytoplasm, and aqua sterilisa splitting erythrocyte, platform phenol orchid dyeing counting (should be more than 95%) is used
Complete 1640 culture medium is made into 2x107Individual/ml cell suspensions.By the cell suspension of each mouse take 300 μ l be placed in 96 holes training
Support in plate, per the μ l of hole 100, add target cell (YAC-1 cells, 4x10 per hole5Individual/m) 100 μ l, while doing target cell Spontaneous release
Hole (target cell 100 μ l, μ l of nutrient solution 100) and maximum release aperture (μ l of 100 μ+2.5%Triton of target cell 100) each 3 hole,
37 DEG C of 5%CO2Culture 4 hours, takes out 1500r/min centrifugations 5min.Each μ l of hole supernatant 100 are placed in another culture plate,
100 μ l matrix are added per hole, 1mol/LHCL30 μ l terminating reactions are added after 10 minutes, OD values are determined at 490nm, NK are calculated thin
Cytoactive rate.
2.2 result of the tests, are shown in Table 3.
Influence of the table 3 to NK cells in mice activity
From table 3, the middle high dose group of invention formulation 1,2 it is continuous to mouse stomach 30 days after, NK cells in mice is lived
Property is statistically analyzed compared with negative control group, there is significant difference (P<0.05).
2.3 conclusion
The result of table 3 shows that the present invention is positive to NK cells in mice activity test result.
To sum up, the present invention is positive to mouse cell immunity test result, is in sun to NK cells in mice activity test result
Property.The present invention has the effect of strengthen immunity.
Embodiment 9
Antidepressant effect is tested
(1) by reagent
Invention formulation 1：Capsule is prepared into by embodiment 2, adds water and suspension is made.
Invention formulation 2：Tablet is prepared into by embodiment 2, adds water and suspension is made.
Negative control：Distilled water.
(2) experimental animal：Male ICR mouse, body weight 20-24g, by institute of lab animals of Sichuan Academy of Medical Sciences
There is provided.
(3) test data is handled using SPSS 10.0for Windows software kits.
(4) test method and result
1 animal and packet
Healthy male mice in kunming, weight 20-24g, cleaning grade animal.After animal was fed through 3 days adaptability, at random
Packet, freely ingests and drinks water, and maintains room temperature (22 ± 2) DEG C, relative humidity (55 ± 5) %, per 5, cage.Behaviors survey
Carry out in quiet warm environment, each experimental group is parallel.
2 tail-suspention tests
Take 70 male mices, after laboratory is adapted to 3 days, carry out tail-suspention test screening, reject the dead time less than 20s or
Mouse more than 160s, chooses 50, negative control group, test group, every group 10 is randomly divided into by dead time length；Daily
Be administered in the morning on time, continuous 7 days, and water is can't help in 1h fasting before administration every time.1h carries out tail-suspention test after 3rd time and the 7th time administration.
Animal is overcomes abnormal position and struggle activity, but after movable a period of time, and it is motionless discontinuity occur, the disappointed state of display.
Observe the accumulative dead time in 5min after 6min, record.
Result of the test is shown in Table 4.
The Tail suspension test result table of table 4
From table 4, the middle high dose group of invention formulation 1,2 reduces dead time and feminine gender in Tail suspension test
Control group is compared, and is statistically analyzed, and has significant difference (P<0.05).
3 forced swim tests
Take 70 male mices, after laboratory is adapted to 3 days, carry out tail-suspention test screening, reject the dead time less than 20s or
Mouse more than 160s, chooses 50, negative control group, test group, every group 10 is randomly divided into by dead time length；3rd
1h carries out forced swim test after secondary and the 7th administration.Mouse is respectively placed in a transparent glass container went swimming 6min, added up
Mouse stops struggling or in floating state in water in 4min afterwards, and only small limb motion is to keep what head kept afloat to hold
The continuous time (i.e. dead time).Every animal changes a water.
Result of the test, is shown in Table 5.
The forced swim test result table of table 5
From table 5, the basic, normal, high dosage group of invention formulation 1,2 reduce dead time in forced swim test with
Negative control group is compared, and is statistically analyzed, and has significant difference (P<0.05).
To sum up, the present invention can reduce the dead time in Tail suspension test and forced swim test.The present invention has anti-
Depressed effect.
Above-described embodiment is only one of the preferred embodiment of the present invention, should not be taken to limit the protection model of the present invention
Enclose, as long as the present invention body design thought and mentally make have no the change of essential meaning or polishing, it is solved
Technical problem it is still consistent with the present invention, should be included in protection scope of the present invention within.
Claims (3)
1. a kind of strengthen the preparation method of body immunity and antidepression health food, it is characterised in that comprises the following steps：
Step 1, prepare raw material by weight, the raw material and its weight proportion are：2~10 parts of ganoderma lucidum, wilsonii 6~18
Part, 4~12 parts of pseudo-ginseng, 1~6 part of cape jasmine；
Step 2, wilsonii, cape jasmine added water to cook, decocting liquid filtration, merging filtrate, filtrate decompression is concentrated to give clear cream, standby；
Step 3, by ganoderma lucidum, pseudo-ginseng crush, sieving, obtain fine powder, it is standby；
Step 4, by step 2 gained clear cream it is dry dry extract；
Step 5, step 4 gained dry extract pulverized and sieved, obtain dry extract；
Step 6, step 3 gained fine powder is well mixed with step 5 gained dry extract, it is wetting agent to add appropriate 85% ethanol
Softwood processed；
Step 7, granulation that step 6 gained softwood sieves, obtain wet granular, wet granular is dried, and whole grain is encapsulated, packaging produces glue
Wafer.
2. the preparation method of a kind of enhancing body immunity according to claim 1 and antidepression health food, its feature
It is, in the step 1, the raw material and its weight proportion are：3~8 parts of ganoderma lucidum, 7~15 parts of wilsonii, 5~10 parts of pseudo-ginseng,
2~5 parts of cape jasmine.
3. the preparation method of a kind of enhancing body immunity according to claim 2 and antidepression health food, its feature
It is, in the step 1, the raw material and its weight proportion are：4 parts of ganoderma lucidum, 12 parts of wilsonii, 6 parts of pseudo-ginseng, 2 parts of cape jasmine.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569642A (en) * | 2008-04-30 | 2009-11-04 | 北京卓越同创药物研究院 | Medicament composition for accelerating sleeping as well as preparation method and application thereof |
| CN106214844A (en) * | 2016-08-26 | 2016-12-14 | 成都润馨堂药业有限公司 | A kind of compositions with fat-reducing and immunoregulation effect and preparation method thereof |
-
2017
- 2017-05-04 CN CN201710306375.4A patent/CN107252110A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569642A (en) * | 2008-04-30 | 2009-11-04 | 北京卓越同创药物研究院 | Medicament composition for accelerating sleeping as well as preparation method and application thereof |
| CN106214844A (en) * | 2016-08-26 | 2016-12-14 | 成都润馨堂药业有限公司 | A kind of compositions with fat-reducing and immunoregulation effect and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄世敬主编: "《抗抑郁中药良方》", 28 February 2016, 金盾出版社 * |
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Application publication date: 20171017 |