CN105687479B - A kind of jujube Qi spends Chinese medicine composition - Google Patents
A kind of jujube Qi spends Chinese medicine composition Download PDFInfo
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- CN105687479B CN105687479B CN201610091373.3A CN201610091373A CN105687479B CN 105687479 B CN105687479 B CN 105687479B CN 201610091373 A CN201610091373 A CN 201610091373A CN 105687479 B CN105687479 B CN 105687479B
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of jujube Qi spends compound compatibility Chinese medicine composition, the Chinese medicine composition to include the composition of following weight portion：70 100 parts of 11 15 parts of chrysanthemum, 1 12 parts of honeysuckle, 300 450 parts of date, 90 parts 150 parts of the sterculia seed, 10 parts 21 parts of lotus nut, 40 75 parts of matrimony vine and dried orange peel.The Chinese medicine composition of the present invention can improve the situation that hyperactivity of fire in young white collar is contained, internal heat toxin is stagnant or causes blurred vision because in poor health, listless for clearing liver-fire, removing toxic substances improving eyesight with good effect.Simultaneously, additionally it is possible to effectively improve physical function, remove middle-aged and old liver poison, in table, can prevent and treat middle-aged and old visual impairments affects the problem of normal life daily life for improving eyesight.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, more particularly to a kind of using date, matrimony vine, the sterculia seed as monarch drug in a prescription Chinese medicine
Composition components, are mainly used in clearing liver and improving vision, and treat hot illness in eye.
Background technology
The traditional Chinese medical science thinks that diet is irregular and is easily caused interior fire stasis, and yin-Yang is unbalance, and interior hyperactivity of fire is contained and can further make stomach
The accumulated heats such as intestines are damp and hot, and external manifestation is physically-draining, listless, blurred vision, it is difficult to concentrate one's energy.Along with society
Fast development, the rhythm of life of people are more and more faster, more and more young white collar because operating pressure is big, irregular eating,
The bad work and rest custom such as smoking and drinking, caused interior hyperactivity of fire are contained, and the weak phenomenon of physiological function is obvious.Young white collar generally needs face
To computer work up to 8 hours, adding evening stays up late overtime work, excess eye-using, and eyes are sour and astringent, and the undesirable condition such as distending pain is that year is bluish white
The usual impression of neck personage, because of excess eye-using even somebody's inflamed eyes, conjunctival congestion.
Meanwhile, because air ambient, the pollution of soil and water resources, substantial amounts of the elderly also occurs in that a large amount of healths are empty
Weak problem.Wherein serious with visual impairment, many middle-aged and old blurred visions are unclear, keep in dark place, and also have recently illness to enter
The younger trend of one step.
For above-mentioned city disease, the traditional Chinese medical science thinks that yin-Yang is unbalance, and it is to cause physically-draining mental status that interior hyperactivity of fire is contained
Not good main cause.Meanwhile, tcm health preserving theory is additionally considered that " liver opening at eye ", improves middle-aged and old eyesight status, in shield
Eye first has to protect liver simultaneously, and liver is bad, and eyes will be bad.So, need a kind of Chinese medicine composition for clearing liver and improving vision badly, clearing liver is rushed down
Fire, removing toxic substances improving eyesight, reach the purpose of the physical condition for improving people from modern metropolitan cities.
The main method of existing health care preventing and treating decline has：Increase rest recuperation scheme, reduce workload；Adjustment drink
Food, fasting plenty of meat and fish supplement the health foods such as cod-liver oil.Although these methods have certain effect, but are limited to people's
Working strength and working time limit, and long-time that can not be cmpletely executes, and cause final therapeutic effect micro- suddenly
Which is micro-.
Content of the invention
It is an object of the invention to it is more to overcome health preserving method in prior art to limit, lacking can be while improves white
Neck and city the elderly healths, realize clear liver and improve vision effect health medicine problem, there is provided a kind of Chinese traditional medicine composition
Thing, the Chinese medicine composition have good effect of clearing liver and improving vision, and can be effectively improved sufferer physiological situation, prevent and treat the shadow of city disease
Ring, the body heath for improving white collar, improve the quality of life of the elderly.
In order to realize foregoing invention purpose, the invention provides technical scheme below：
A kind of Chinese medicine composition, including the component of following weight portion：Chrysanthemum 11-15 parts, honeysuckle 1-12 parts, date 300-
450 parts, 90 parts -150 parts of the sterculia seed, 10 parts -21 parts of lotus nut, matrimony vine 40-75 parts, dried orange peel 70-100 parts.
The Chinese medicine composition of the present invention is the Chinese medicine that is especially selected meticulously according to traditional Chinese medical science pharmacology according to monarch prescription
Into for clearing liver-fire, removing toxic substances improving eyesight, with good effect.First, the Chinese medicine composition, can for city white collar
To improve young white collar because operating pressure is big, caused by irregular eating in hyperactivity of fire contain, internal heat toxin stagnates, in poor health,
Listless, the situation of blurred vision.Secondly, the Chinese medicine composition can reduce ring with detoxification and liver protection for the elderly
Caused by the pollution of border, toxin is piled up, and liver health is had one's ideas straightened out in mesh, and natural eyesight is also just recovered, for the body of the elderly
Situation improves with good effect.
In the Chinese medicine composition of the present invention, date, matrimony vine and the sterculia seed are monarch drug in a prescription altogether：Date is sweet, warm, returns spleen, stomach, the heart
Through, have functions that tonifying middle-Jiao and Qi, nourishing blood and tranquilization, for spleen eating less, weak loose stool, hysteria of womam.Matrimony vine (fruit of Chinese wolfberry),
Sweet, flat, return liver and kidney channel, have functions that nourishing liver and kidney, benefiting shrewd head, for consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus, sun
Impotence seminal emission, Heat Diabetes, blood deficiency chlorosis and blurred vision etc..The sterculia seed, sweet, cold, return lung, large intestine channel, with clearing heat and moistening lung, profit
Effect that pharynx is opened sound, relaxed bowel, for lung heat celostomia, dry cough without phlegm, pharyngodynia with dryness, thermojunction are just closed, hot eyes of having a headache.All medicines are altogether
With, mental-tranquilization, clear liver and improve vision, invigorate the spleen and benefit qi, entering Liver Channel, kidney channel, with mental-tranquilization, benefit the moon arrest sweating, calming the liver, clear liver
Improving eyesight, tonifying spleen and stopping diarrhea etc. are acted on, and for the internal equilibrium between yin and yang of city crowd, liver poison discharge is significant, in relieving liver
Dirty endotoxic while the effects such as naturally realizing vision restoration.
Be aided with ministerial drug chrysanthemum, honeysuckle, contribute to strengthening medicine for the therapeutic action that clears liver and improve vision, monarch drug in a prescription is reconciled to suffering from
Help that person is insufficiency of the spleen, takes into account the damp and hot simultaneous disease of other qi and bloods, strengthens therapeutic action.
Last using dried orange peel, lotus nut as adjutant, make medicine, it is to avoid monarch drug in a prescription for the non-excessive tune benefit effect for symptom,
Draw all medicines so that up to sick institute, the poison that clears liver is with strong curative effect.
Further, Chinese medicine composition of the invention is preferably only made up of mentioned component, no longer adds other compositions, it is to avoid
Impact of the other medicines composition to which.It is further preferred that the raw material dosage ratio of above-mentioned pharmaceutical compositions is preferably by upper
The ratio of stating is defined, if the usage ratio of each material composition changes, then the monarch in Chinese medicine composition
Relation can also change, for corresponding illness primary treatment and auxiliary adjustment situation can change, no longer may fit
Effect of clearing liver and improving vision for the purpose of the present invention, for the condition improvement result of inferior health personage can occur larger change
Change.
Further, preferably described Chinese medicine composition, including the component of following weight portion：Chrysanthemum 11-15 parts, honeysuckle 1-
12 parts, date 380-420 parts, 110 parts -130 parts of the sterculia seed, 10 parts -21 parts of lotus nut, matrimony vine 50-60 parts, dried orange peel 70-100
Part.On the basis of former Traditional Chinese medicine composition formula, optimize the consumption formula rate of monarch drug in a prescription in Chinese medicine composition, emphasis realizes monarch drug in a prescription
Between have coordinative role so that the therapeutic effect of the Chinese medicine composition for clearing liver and improving vision is obviously improved.
Further, preferably described Chinese medicine composition, including the component of following weight portion：Chrysanthemum 12-13 parts, honeysuckle 6-
8 parts, date 380-420 parts, 110 parts -130 parts of the sterculia seed, 10 parts -21 parts of lotus nut, matrimony vine 50-60 parts, dried orange peel 70-100 parts.
Then, on the basis of former Traditional Chinese medicine composition formula, optimize ministerial drug usage ratio scope in Chinese medicine composition so that the monarch and his subjects are main
Synergy between composition strengthens so that Chinese medicine composition is further lifted for the effect that clears liver and improve vision, and therapeutic effect is more
Plus prominent, and the injury of toxic and side effect can be eliminated.
Further, preferably described Chinese medicine composition, including the component of following weight portion：Chrysanthemum 12-13 parts, honeysuckle 6-
8 parts, date 380-420 parts, 110 parts -130 parts of the sterculia seed, 10 parts -21 parts of lotus nut, matrimony vine 50-60 parts, dried orange peel 80-90 parts.
On the basis of former Traditional Chinese medicine composition formula, in optimum organization thing, the consumption of adjutant dried orange peel makes the use of the middle adjutant of pharmaceutical composition
Amount control more precisely, can more adjust the performance of drug effect.
Further, preferably described Chinese medicine composition, including the component of following weight portion：Chrysanthemum 12-13 parts, honeysuckle 6-
8 parts, date 380-420 parts, 110 parts -130 parts of the sterculia seed, 13 parts -16 parts of lotus nut, matrimony vine 50-60 parts, dried orange peel 80-90 parts.
In terms of the Chinese medicine composition of the present invention can apply to health food (health products), food or drink, that is, preparing
Apply in health products, food or drink.Wherein described drink includes tea, such as loose tea, tea in bag etc..The Chinese traditional medicine composition of the present invention
The selection of thing composition is more based on health-related, is processed and is prepared into health food or tea drink use, with prominent convenience,
Can be convenient for people to use, ensure that Chinese medicine composition is easy during prolonged application well, particularly tea in bag.
The Chinese medicine composition of the present invention can be processed the medicine system for being prepared into modern medicine accreditation using following methods
Agent, health products or drink, such as tablet, capsule, tea etc..
As an example or preferably, Chinese medicine composition of the invention can be prepared processing using following methods：Preparation side
Method, comprises the following steps：(1) date, matrimony vine, lotus nut, chrysanthemum, honeysuckle, the sterculia seed and dried orange peel is taken, is added water, decoct 1-5
Secondary, merge decoction liquor, be concentrated to give decocting liquid.(2) by decocting liquid, it is processed further making pharmaceutically acceptable formulation,
Or it is processed into health products or food.
The above-mentioned formulation or health products for being further processed into pharmaceutically giving and accepting is referred to：Decocting liquid is directly prepared into pharmacy
Upper acceptable packaging, obtains decoction.Or decocting liquid is concentrated to dryness, add pharmaceutical formulations auxiliary material, such as filler, figuration
In agent, disintegrant, starch, cellulose, lactose, polyvinylpyrrolidone etc., one or more, prepare piece agent, pill, capsule
Pharmaceutically acceptable formulation or the health products such as agent.The formulation of health products can be pharmaceutically pharmaceutical dosage form, such as tablet, ball
Agent, capsule.
Further, preparation method is comprised the following steps：(1) following weight portion is pressed：Chrysanthemum 11-15 parts, honeysuckle 1-12 parts,
Date 300-450 parts, 90 parts -150 parts of the sterculia seed, 10 parts -21 parts of lotus nut, matrimony vine 40-75 parts, dried orange peel 70-100 parts, weigh
Traditional Chinese medicinal material raw materials, mixing.Add 0.5-10 times of water to be decocted, decoct 1-5 time, merge decoction liquor, be concentrated to give decocting liquid.
(2) decocting liquid is distributed into parcel, obtains final product traditional Chinese herbal decoction.Or decocting liquid is concentrated to dryness, concentrate preferably under protective atmosphere
To dry and appropriate auxiliary material mixing, the pharmaceutical preparations such as capsule, tablet, pill are made.Preferably, the protective atmosphere is nitrogen
The inert atmosphere such as gas or argon gas, easily obtains, and for the inertia of Chinese medicine extract is high, protected effect is good.
Preferably, above-mentioned prepare Chinese medicine composition parts by weight of raw materials composition proportion be：Chrysanthemum 12-13 parts, honeysuckle 6-8
Part, date 380-420 parts, 110 parts -130 parts of the sterculia seed, 13 parts -16 parts of lotus nut, matrimony vine 50-60 parts, dried orange peel 80-90 parts.Main
To include above raw material, other raw materials of interpolation a small amount of (less than 10wt%) that can also be appropriate.
The Chinese medicine composition of the present invention can be processed using following methods and be prepared into health food or drink.
A kind of method for preparing drink using Chinese medicine composition of the present invention, comprises the following steps：(1) date, Chinese holly are taken
Qi, lotus nut, chrysanthemum, honeysuckle, the sterculia seed and dried orange peel, dry, standby.(2) by drying after raw material, chip is packetized into 1-
The tea in bag of 10g.Chip is that medicinal material is cut into chip, and the length of chip is less, but more than general medicinal powder.It is preferred that
, the length of the medicinal material for obtaining is cut during chip less than 1-8mm, is packaged in the packaging bag in tea in bag, drink of both conveniently having made tea
With will not run out from packaging bag, have influence on and drink again.
Chip of the present invention is referred to medicinal material cutting machine stripping and slicing, into bits shape, the length control after medicinal material cutting
In 1-8mm, greatly increase the specific surface area of medicinal material, can be packed with pouch again, facilitate boiling water immersion and be unlikely to
Medicinal material flows out.It is preferred that length of chip is controlled between 0.2-3mm.Length of chip control effectively can change between 0.2-3mm
Kind medicinal material is distributed into during parcel tea in bag for the control requirement of packaging, improves the sealing effectiveness of packaging, it is to avoid is crossed and is
Tiny chip spills the color and luster for affecting tea-drinking, it is ensured that compliance when tea-drinking is taken.Simultaneously, it is ensured that the surface face of chip raw material
Product is larger, being capable of more preferable dissolution beneficiating ingredient therein when infusion beverage.
Compared with prior art, beneficial effects of the present invention：
1. the Chinese medicine composition of the present invention with date, matrimony vine and the sterculia seed altogether as monarch drug in a prescription, minister with chrysanthemum, honeysuckle, with old
Skin, lotus nut are made for assistant, and all medicines are shared, and for clearing liver-fire, removing toxic substances improving eyesight, with good effect, can improve year bluish white
In neck, hyperactivity of fire is contained, and internal heat toxin stagnates, in poor health, listless, the situation of blurred vision.
2. the Chinese medicine composition of the present invention, due to the synergy of a variety of Chinese medicine composition (dietotherapy material), particularly each
The consumption of component meets：Chrysanthemum 12-13 parts, honeysuckle 6-8 parts, date 380-420 parts, 110 parts -130 parts of the sterculia seed, lotus nut
13 parts -16 parts, matrimony vine 50-60 parts, dried orange peel 80-90 parts when, can effectively improve physical function, it is possible to reduce environment is dirty
The caused toxin of dye is piled up, and removes middle-aged and old livers poison, detoxification and liver protection, and improving eyesight is in table, preventing and treating the elderly's visual impairment shadow
Ring the problem of normal life daily life.
3. date is reused in the full side of the Chinese medicine composition of the present invention, and date is reused big as a kind of fruit of nutritive value
Jujube can realize food and medicine consangunity, improve the characteristics of taking the good patient compliance of the present composition.And date, sweet, temperature.Return
Spleen, stomach, for person in poor health can play tonifying middle-Jiao and Qi, effect of nourishing blood and tranquilization, for auxiliary realization is clear liver and improved vision, is solved
Toxic material and nourishing life is significant, even if the Chinese medicine composition that healthy population takes the present invention can also play good health care
The effect of.
4. the Chinese medicine composition of the present invention is a kind of Chinese prescription through allocating meticulously, and medicament is all any of which simply
Through allocated meticulously, obvious synergy between ingredients can lift the same of therapeutic effect maximized
When avoid medicine for the toxic and side effect of body.
Specific embodiment
With reference to test example and specific embodiment, the present invention is described in further detail.But this should not be understood
Scope for above-mentioned theme of the invention is only limitted to below example, and all technology that is realized based on present invention belong to this
The scope of invention.
Embodiment 1
Take 125 grams of chrysanthemum, 70 grams of honeysuckle, 4000 grams of date, 1200 grams of the sterculia seed, 145 grams of lotus nut, 550 grams of matrimony vine,
850 grams of dried orange peel, mixing add 3 times of water to be decocted (the corresponding 1kg medicinal materials of 1L water), decoct 2 hours, filter.Medicinal material after filtration
3 times of water are added, is decocted 2 hours again, filtered.After filtration, medicine adds 2 times of water, decocts 2 hours, filters, and filter residue is discarded, and merges
Decoction liquor, reduced pressure concentration, to the corresponding 2L medicinal raw materials of 1L decocting liquids, obtain final product jujube Qi flower compound decoction.
Embodiment 2
Jujube Qi flower compound decoction, the following Table A institute of the raw material that preparation process is adopted are prepared using method same as Example 1
Show.
Raw material part proportion relation (unit of decoction is prepared in Table A embodiment 2：Gram)
The raw material condition of proportioning different proportion in the present embodiment 2, decocts the decoction for preparing different ratios of raw materials, as
Follow-up animal experiment research is used.
Embodiment 3
Jujube Qi flower compound decoction, the raw material such as following table B institute that preparation process is adopted are prepared using method same as Example 1
Show.
Raw material part proportion relation (unit of decoction is prepared in table B embodiment 3：Gram)
The raw material condition of proportioning different proportion in the present embodiment 3, decocts the decoction for preparing different ratios of raw materials.Implement
Example 3-6 to 3-8 mainly prepares the formula for subtracting taste Chinese medicine material for having lacked adjutant, having made medicine, the Chinese medicine with full side's group of the present invention
Composition decoction is contrasted.
Embodiment 5
Decoction prepared by Example 2-4, be evaporated to dry, by the dry powder doses for preparing add suitable auxiliary material into
Point, it is well mixed, is prepared into capsule.
Embodiment 6
Take chrysanthemum 12-13g, honeysuckle 6-8g, date 380-420g, sterculia seed 110g-130g, lotus nut 13g-16g, Chinese holly
Qi 50-60g, dried orange peel 80-90g, dry.Raw material after by drying, chip of the chip into 0.2-5mm, is distributed into the bubble of 3g/ bags
Tea.The elderly can drink this bag of ditch tea 2 and wrap/day, reach the effect that clears liver and improve vision, and improve middle-aged and old blurred visions, solution
Certainly live inconvenience problem.
Comparative example 1
Jujube Qi flower compound decoction, the raw material such as following table C institute that preparation process is adopted are prepared using method same as Example 1
Show.
Raw material part proportion relation (unit of decoction is prepared in table C comparative examples 1：Gram)
The raw material condition of proportioning different proportion in this comparative example 1, decocts the decoction for preparing different ratios of raw materials.Wherein
The extra Chinese medicine that selects has selfheal and ginseng.Selfheal, pungent, bitter, tremble with fear.Return liver, gallbladder channel.Clearing liver-fire, improving eyesight, dissipating bind disappear
Swollen.For red eye, swell pain, mesh pearl nyctalgia, dizziness of having a headache, scrofula, goiter and tumor, acute mastitis, newborn addiction, swollen breasts.The main function of ginseng is
Reinforce vital energy, invigorating the spleen Feng Xi, intelligence development of allaying excitement.As a comparison, the present invention studies other Chinese medicines for the impact of therapeutic effect.
The experimental study jujube Qi flower each compatibility group of compound is clear liver and improved vision pharmacodynamic experiment research
1 material
1.1 trial drug jujube Qis flower compound (be made up of date, matrimony vine, lotus nut, chrysanthemum, honeysuckle, the sterculia seed, dried orange peel-
Quan Fang, hereinafter referred to as " ZQH ") decocting liquid, carbon tetrachloride, Jining Hua Kai resin Co., Ltd；Paracetamol, Mike group.
1.2 animal health adult strain Kunming mouses, SD rats are tested by People's Hospital, Sichuan Prov. of Sichuan Academy of Medical Sciences
Institute of Botany is provided, production licence number：SCXK (river) 2015-23.Male and female half and half, 18～22g of body weight, according to monarch, minister,
Help, make (monarch drug in a prescription date, matrimony vine, the sterculia seed；Ministerial drug is chrysanthemum, honeysuckle；Adjutant is dried orange peel；It is lotus nut to make medicine), random point
For 15 groups：Peanut oil (control) group, carbon tetrachloride (paracetamol) group, low dose (3.2g.kg-1), middle dosage (6.4g.kg-1)
With heavy dose (12.8g.kg-1) jujube Qi spends full side's group, (monarch drug in a prescription heavy dose group (12.8g.kg-1), ministerial drug heavy dose group
(12.8g.kg-1), adjutant heavy dose group (12.8g.kg-1), make medicine heavy dose group (12.8g.kg-1), monarch drug in a prescription+ministerial drug heavy dose of
Group (12.8g.kg-1), monarch drug in a prescription+adjutant heavy dose group (12.8g.kg-1), monarch drug in a prescription+make medicine heavy dose group (12.8g.kg-1), ministerial drug
+ adjutant heavy dose group (12.8g.kg-1), ministerial drug+make medicine heavy dose group (12.8g.kg-1), adjutant+make medicine heavy dose group
(12.8g.kg-1).Above-described corresponding Chinese medicine part bulk formulation is tested using compound decoction prepared by embodiment 2
Research, the dosage for distinguishing heavy dose of, middle dosage and low dose is calculated based on crude drug amount.
1.3 instrument, 7060 type full automatic biochemical apparatus (Japan produces Hitachi).
2 methods and result
2.1 each compatibility group decocting liquids cause the impact mouse 200 of mouse liver injury to carbon tetrachloride, are randomly divided into 20 groups：
Ig. (gavage) 3.2,6.4,12.8g (crude drug amount) .kg-1.d-1ZQH or the physiological saline of same volume, continuous l0d, last dose
1h afterwards, administration group and carbon tetrachloride group press 10ml.kg-1Ip 0.1%CCL4Peanut oil solution, control group ip. (lumbar injection) are same
The peanut oil solution of volume, after fasting 16h, takes blood system from serum, determines the activity of serum and AST.As a result visible full side's group is right
CCL4Mouse liver injury is caused to determine the activity rising of glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminease (AST) in serum, with obvious
Antagonism.Liver index has significant difference at high doses.It is shown in Table 1.
1 each compatibility group decocting liquid of table causes the impact of mouse liver injury to tetrahydro carbon
Note：Compare with carbon tetrachloride group,*P 0.05,**P 0.01
Remarks：In table 1, monarch drug in a prescription group, ministerial drug group, minister assistant group etc. represent the selection of corresponding traditional Chinese medicine ingredients, its weight portion respectively
Proportioning presses 12.5 parts of chrysanthemum, 7 parts of honeysuckle, 400 parts of date, 120 parts of the sterculia seed, 14.5 parts of lotus nut, 55 parts of matrimony vine, dried orange peel 85
The ratio of part is taken.Monarch drug in a prescription：Date, matrimony vine and the sterculia seed.Ministerial drug：Chrysanthemum, honeysuckle.Adjutant：Dried orange peel.Make medicine：Lotus nut.Lift
Under for example, monarch drug in a prescription group then only selects date, matrimony vine and the sterculia seed, and ratio is taken according to the above ratio, the total amount that takes
For the dosage in table 1, such as 12.8g.Illustrate again, then according to the above ratio from whole Chinese medicine compositions, overall control is for full side
12.8g, 6.4g, 3.2 etc..The test group of remaining each several part medication takes mode ibid.Take in test example 2.2-2.4 below
The scheme of corresponding fractions taken by such scheme.Compile in the corresponding corresponding embodiment such as numbering 4-2 in table 1
Number little set product, concrete numbering see Table A, B, C etc..
The Chinese medicine composition for clearing liver and improving vision that as seen from the above table prepared by the present invention, for the damage for treating or improving mouse liver
Wound has good help, by the analysis result of rating unit medicine group, ALT and AST two in the mice serum of full side's group
Item index is significantly better than that other parts medicine group, corresponding mouse liver index are in ideal level.The present invention's
Full side's group can play good effect in protection liver is badly damaged, for the poisoning removing toxic substances of liver has prominent tribute
Offer, under protection extreme case, liver toxicity damages and there is prominent effect.
Comparative example 4-1 to 4-5 is visible for comparative analysis, although comparative example 4-1 employs identical and just organizes full traditional Chinese medicine ingredients, but
When being the amount ranges that wherein specific amounts of components is not on the present invention, drug effect general performance is not still good, in high dose
The too late currently preferred full side's group of two indexes of ALT and AST in mice serum in the case of application.It can be seen that, the present invention is right
Particularly significant into component selections and parts by weight ratio in Chinese medicine composition, the ratio that any of which is is not good all possible
The serious composition that reduces is for the protective effect of liver.
And in comparative example 4-2 and 4-3, using the traditional Chinese medicine ingredients of full side's group, and it is withered additionally to the addition of the summer of clearing liver-fire
Grass, in mice serum, two indexes of ALT and AST have certain fluctuation, but on the whole mouse liver index is to be weaker than the present invention
Full side's group.Illustrate that the Chinese medicine composition of full side's group of the present invention is larger for the holistic health level for improving mouse liver has
Help, and in Chinese medicine composition each component usage ratio require higher, arbitrarily should not adjust.For other clearing liver-fires
Chinese medicine composition, might not further promote the lifting of drug effect after adding, and part may be caused on the contrary
Reducing occurs in index.
2.2 each compatibility group decocting liquids cause the impact mouse 150 of mouse liver injury to paracetamol (AAP), are randomly divided into
15 groups：Ig.3.2,6.4,12.8g (crude drug amount) .kg-1.d-1ZQH or the physiological saline of same volume, continuous l0d, last dose
After 24h, administration group and paracetamol group press 150mg.kg-1Ip.AAP solution, the normal saline solution of control group ip same volumes are prohibited
After food 16h, blood system is taken from serum, determine the activity of Serum ALT and AST.As a result visible full side's group can obviously reduce AAP and cause mouse
The activity of serum of hepatic injury ALT and AST.Compared with control group, there was no significant difference at high doses for liver index.It is shown in Table 2.
2 each compatibility group decocting liquid of table causes the impact of mouse liver injury to paracetamol
Note：Compare with paracetamol group,*P 0.05,**P 0.01
From table 2, the Chinese medicine composition of full side's group of the present invention is in the infringement for protecting generally conventional chemicals
Preferably effect is played, while a certain degree of liver protection effect is also shown with other parts medicine group in process of the test,
But various pieces medicine group integrally on from the point of view of not what rule, performance generally slightly weak, part compared with full side's group
Medicine group gap is less, may be relevant for drug effect plays key core effect with main a few taste medicinal ingredients.Can also recognize
For being that the detoxication that is likely to be breached is not fully relevant under the effect of less liver damage.
Impact of the 2.3 each compatibility group decocting liquids to immune function of mice：150 mouse are randomly divided into 15 groups, per group 10
Only, ig.3.2,6.4,12.8g (crude drug amount) .kg-1.d-1Full side's group or the physiological saline of same volume, positive drug levamisol group
(50mg/kg)；Administration group continuous gavage is administered, and dosage is 0.2ml/g, and model control group gives equivalent distilled water；After administration 2d,
The equal lumbar injection 5 of 15 groups of mouse：3(V：V the sheep red blood cell (SRBC) suspension 0.2ml/ for) diluting only, carries out immunity.15 groups of continuation administrations
5d, after last dose 1h, plucks eyeball respectively and takes blood, separate serum, determine haemolysis cellulose content.As a result visible, full side's group hemolysin
Content has significant difference, is shown in Table 3.
Impact of the 3 each compatibility group decocting liquid of table to mice serum haemolysis cellulose content
Note：Compare with model control group,*P 0.05
From table 2, the Chinese medicine composition of full side's group of the present invention can significantly improve mouse blood in mouse test
The content of hemolysin in liquid is substantially suitable with positive controls (levamisol).And the situation of other parts drug control group is then
According to the difference comprising traditional Chinese medicine ingredients there is larger difference, be especially the absence of monarch-minister drug composition tears group overall drug effect performance open
Poor.Show that full side's group medicine of the present invention, for the immunologic function for strengthening mouse has obvious action, effectively can be carried
High immunity.
2.4 each compatibility group decocting liquid rats are to ocular tissue and the measure of blood superoxide dismutase (SOD)：From healthy SD
Rat, male and female half and half, 180～210g of body weight are randomly divided into 15 groups, 10 per group, ig.3.2,6.4,12.8g (crude drug amount)
.kg-1.d-1Full side's group or the physiological saline of same volume, daily gavage 1 time, continuous 15 days, the won rat eye for l5 days, low
Be homogenized under temperature, centrifuging and taking supernatant, SOD values are determined with radioimmunoassay (use-calculating instrument determines CPM)；Blood is taken simultaneously,
Centrifuging and taking serum, surveys SOD values in blood.The heavy dose of combination middle dose group of jujube Qi flower compound can significantly improve ocular tissue's SOD values, with life
Reason salt solution group compares P<0.05, though there are certain raising trend to blood SOD values, no significant difference.Other compatibilities
There was no significant difference for group, is shown in Table 4.
Impact of the 4 each compatibility group decocting liquid of table to ocular tissue and blood SOD values
Note：Qiju Dihuang Wan used in which is manufactured for Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory
Qiju Dihuang Wan.
From the data of table 4, full side's group pharmaceutical compositions of the present invention are for super oxygen discrimination in raising mouse body
Change enzyme level and there is remarkable effect, the ability that organism resists aging can be improved so that organism keeps more healthy for a long time
State.And comparatively, the performance of some drugs group is then poor, compare with physiological saline group basic without effect.In addition, this
The Chinese medicine composition of invention is mainly characterized by the SOD values of ocular tissue being had to good improvement result, and survey in blood
Test result then shows that each test group situation in blood is substantially suitable.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that by the component of following weight portion：Chrysanthemum 11-15 parts, honeysuckle 1-12 parts,
Date 300-450 parts, 90 parts -150 parts of the sterculia seed, 10 parts -21 parts of lotus nut, matrimony vine 40-75 parts and dried orange peel 70-100 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that in the Chinese medicine composition：The consumption proportion of date
For 380-420 parts, the consumption proportion of the sterculia seed is 110 parts -130 parts, and the consumption proportion of matrimony vine is 50-60 parts.
3. Chinese medicine composition according to claim 1, it is characterised in that in the Chinese medicine composition：The consumption proportion of chrysanthemum
Consumption proportion for 12-13 parts, honeysuckle is 6-8 parts.
4. Chinese medicine composition according to claim 1, it is characterised in that in the Chinese medicine composition：The consumption proportion of dried orange peel
For 80-90 parts.
5. application of the Chinese medicine composition as claimed in claim 1 in terms of health food or drink.
6. the method for preparing medicine or health products of Chinese medicine composition described in a kind of utilization claim 1, it is characterised in that include
Following steps：
（1）Take chrysanthemum 11-15 parts, honeysuckle 1-12 parts, date 300-450 parts, 90 parts -150 parts of the sterculia seed, 10 parts of lotus nut -
21 parts, matrimony vine 40-75 parts and dried orange peel 70-100 parts, add water, and decoct 1-5 time, merge decoction liquor, are concentrated to give decocting liquid；
（2）Decocting liquid is processed further to make the formulation for pharmaceutically receiving, or is further processed into health products.
7. the method for preparing medicine or health products of Chinese medicine composition according to claim 6, it is characterised in that the weight of raw material
Amount part proportioning is as follows：Chrysanthemum 11-15 parts, honeysuckle 1-12 parts, date 380-420 parts, 110 parts -130 parts of the sterculia seed, lotus nut
10 parts -21 parts, matrimony vine 50-60 parts, dried orange peel 70-100 parts.
8. the method for preparing medicine or health products of Chinese medicine composition according to claim 6, it is characterised in that the weight of raw material
Amount part proportioning is as follows：Chrysanthemum 12-13 parts, honeysuckle 6-8 parts, date 380-420 parts, 110 parts -130 parts of the sterculia seed, lotus nut 10
- 21 parts of part, matrimony vine 50-60 parts, dried orange peel 70-100 parts.
9. the method for preparing medicine or health products of Chinese medicine composition according to claim 7, it is characterised in that step（2）
In, concentration is carried out under protective atmosphere.
10. the method that Chinese medicine composition described in a kind of utilization claim 1 prepares drink, comprises the following steps：
（1）Take chrysanthemum 11-15 parts, honeysuckle 1-12 parts, date 300-450 parts, 90 parts -150 parts of the sterculia seed, 10 parts of lotus nut -
21 parts, matrimony vine 40-75 parts and dried orange peel 70-100 parts, dry, standby；
（2）Raw material after by drying, chip are packetized into the tea in bag of 1-10g/ bags.
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| CN103141906B (en) * | 2013-02-28 | 2014-11-19 | 康美药业股份有限公司 | Extract capable of clearing heat and relieving sore throat, and preparation method and application thereof |
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