CN107242556A - A kind of dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge and preparation method thereof - Google Patents
A kind of dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge and preparation method thereof Download PDFInfo
- Publication number
- CN107242556A CN107242556A CN201710378885.2A CN201710378885A CN107242556A CN 107242556 A CN107242556 A CN 107242556A CN 201710378885 A CN201710378885 A CN 201710378885A CN 107242556 A CN107242556 A CN 107242556A
- Authority
- CN
- China
- Prior art keywords
- haizhou
- china
- flos chrysanthemi
- chrysanthemi alba
- lozenge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000628997 Flos Species 0.000 title claims abstract description 77
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 title claims abstract description 77
- 239000007937 lozenge Substances 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 21
- 239000000843 powder Substances 0.000 claims abstract description 21
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 16
- 235000019477 peppermint oil Nutrition 0.000 claims abstract description 16
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 15
- 239000007884 disintegrant Substances 0.000 claims abstract description 15
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 12
- 239000008101 lactose Substances 0.000 claims abstract description 12
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 11
- 229930195725 Mannitol Natural products 0.000 claims abstract description 11
- 239000000594 mannitol Substances 0.000 claims abstract description 11
- 235000010355 mannitol Nutrition 0.000 claims abstract description 11
- 235000010447 xylitol Nutrition 0.000 claims abstract description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 9
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 7
- 239000000945 filler Substances 0.000 claims abstract description 7
- 238000005469 granulation Methods 0.000 claims abstract description 7
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- 102000011759 adducin Human genes 0.000 claims abstract 2
- 108010076723 adducin Proteins 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims description 29
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- 238000002156 mixing Methods 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 2
- 235000007516 Chrysanthemum Nutrition 0.000 abstract description 18
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract description 18
- 239000003814 drug Substances 0.000 abstract description 12
- 235000019640 taste Nutrition 0.000 abstract description 7
- 235000013305 food Nutrition 0.000 abstract description 5
- 238000009472 formulation Methods 0.000 abstract description 3
- 239000002304 perfume Substances 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 31
- 239000002994 raw material Substances 0.000 description 19
- 239000003826 tablet Substances 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 15
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- 239000003765 sweetening agent Substances 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 8
- 238000013461 design Methods 0.000 description 8
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 8
- 239000000811 xylitol Substances 0.000 description 8
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 8
- 229960002675 xylitol Drugs 0.000 description 8
- 230000001953 sensory effect Effects 0.000 description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- 244000269722 Thea sinensis Species 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
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- 235000013616 tea Nutrition 0.000 description 6
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- 239000000796 flavoring agent Substances 0.000 description 5
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- 210000003800 pharynx Anatomy 0.000 description 5
- 239000003507 refrigerant Substances 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 244000246386 Mentha pulegium Species 0.000 description 4
- 235000016257 Mentha pulegium Nutrition 0.000 description 4
- 235000004357 Mentha x piperita Nutrition 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 235000019658 bitter taste Nutrition 0.000 description 4
- 235000001050 hortel pimenta Nutrition 0.000 description 4
- 238000005457 optimization Methods 0.000 description 4
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- 239000002585 base Substances 0.000 description 3
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- 239000002245 particle Substances 0.000 description 3
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- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
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- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 241000205585 Aquilegia canadensis Species 0.000 description 2
- 240000005250 Chrysanthemum indicum Species 0.000 description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010013789 Dry throat Diseases 0.000 description 2
- 241001347978 Major minor Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 229940046011 buccal tablet Drugs 0.000 description 2
- 239000006189 buccal tablet Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
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- 206010025482 malaise Diseases 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000000697 sensory organ Anatomy 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 240000001592 Amaranthus caudatus Species 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 235000019224 Camellia sinensis var Qingmao Nutrition 0.000 description 1
- 241000131317 Capitulum Species 0.000 description 1
- 235000009604 Chrysanthemum X morifolium Nutrition 0.000 description 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 description 1
- 241001016310 Epimedium grandiflorum Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
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- 206010019233 Headaches Diseases 0.000 description 1
- 206010025280 Lymphocytosis Diseases 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 206010028665 Myxoedema Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 244000226566 Psoralea corylifolia Species 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
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- 235000008081 Rheum officinale Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 235000002912 Salvia officinalis Nutrition 0.000 description 1
- 241001515806 Stictis Species 0.000 description 1
- 244000185386 Thladiantha grosvenorii Species 0.000 description 1
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- 235000015063 acidophilus milk Nutrition 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
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- 238000004821 distillation Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000018905 epimedium Nutrition 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
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- 231100000869 headache Toxicity 0.000 description 1
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- 235000012907 honey Nutrition 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000003786 myxedema Diseases 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000020339 pu-erh tea Nutrition 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
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- -1 sucrose Sugar alcohol Chemical class 0.000 description 1
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- 239000011573 trace mineral Substances 0.000 description 1
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- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of preparation method of dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge, it comprises the following steps：(1) by weight, 6~18 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower Ultramicro-powders, 35~39 parts of xylitols, 10~13 parts of polyethylene glycol, 12~18 portions of disintegrants and 20~29 parts of fillers are mixed；The disintegrant is by citric acid and sodium acid carbonate by weight 7:10 compositions, the filler is by lactose and mannitol by weight 8:1 composition；(2) 2~4 μ l/g are pressed ● the ratio of step (1) gains, adds peppermint oil to step (1) gains and mix；Add 95% edible ethanol, softwood processed, mix；(3) it is dried, sieves and tabletting granulation, produces the lozenge.Gained lozenge disintegration rate of the invention is fast, different from conventional effervescent formulation, and present invention gained lozenge occurs without effervesce state in dissolving；Gained lozenge of the invention has the light chrysanthemum perfume of the FLOS CHRYSANTHEMI ALBA from Haizhou of China of typicalness, and cool taste, sour-sweet degree are suitable, suitable for food and medicament dual-purpose.
Description
Technical field
The invention belongs to FLOS CHRYSANTHEMI ALBA from Haizhou of China manufacture field, and in particular to a kind of dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge and preparation method thereof.
Background technology
FLOS CHRYSANTHEMI ALBA from Haizhou of China (Chrysanthemum morifoLium) is the dry capitulum of feverfew chrysanthemum, also name little Tang
Yellow, feverfew, is listed as Chinese four big chrysanthemums with chu chrysanthemum, Bo chrysanthemum, tribute chrysanthemum, abounds with Zhejiang Province Tongxiang City, be " eight Zhe's " it
One.Cultivated area about 3333hm2, annual production up to 5 × 106kg, account for the whole nation drink 9/10ths of chrysanthemum total amount, its process product
Find a good sale in the countries and regions such as domestic market, Hong Kong, Macao and Taiwan, Southeast Asia.FLOS CHRYSANTHEMI ALBA from Haizhou of China is the integration of drinking and medicinal herbs of first approval of health ministry
One of genunie medicinal materials, not only with very high nutritive value, and with very strong medicinal efficacy.Traditional Chinese medical theory is recognized
Have for, chrysanthemum and dissipate wind heat-clearing, flat liver improving eyesight, clearing heat and detoxicating effect, available for anemopyretic cold, dizziness of having a headache, hot eyes it is dim-sighted,
Furuncle swelling toxin.Also can clear away heart-fire, kidney tonifying, strengthening the spleen and stomach, wet one's whistle, promote the production of body fluid, adjusting blood fat etc..Modern pharmacology research shows, chrysanthemum
With anti-oxidant, antibacterial, anti-infective, antiviral, reducing blood lipid, vasodilator and antitumor isoreactivity.FLOS CHRYSANTHEMI ALBA from Haizhou of China contains a variety of functions
Property composition, such as volatile oil, flavonoids, Polyphenols, polysaccharide, amino acid, aliphatic acid and trace element, also given birth to containing abundant dimension
Plain A, B, C, E etc..
At present, multinomial research has proven to FLOS CHRYSANTHEMI ALBA from Haizhou of China and contains a variety of functional components with special physiological function, but its
Develop very limited.Investigation shows, the consumption of FLOS CHRYSANTHEMI ALBA from Haizhou of China currently is concentrated mainly on medicinal material and tea product the two aspects, main
It is tea bag and chrysanthemum composite beverage to want form, and processing mode is only simply to dry or dry, and occupation mode is also limited to
Wherein water miscible active ingredient is dissolved with water, such as chrysanthemum Instant Drinks or the dispensing of chrysanthemum beverage.As FLOS CHRYSANTHEMI ALBA from Haizhou of China consumes city
The continuous expansion of field and the further investigation of active ingredient, increasing deep processed product are continued to bring out, except FLOS CHRYSANTHEMI ALBA from Haizhou of China drink
Material and tea bag, other kinds of deep processed product also are continuously developed out.Mainly have at present：FLOS CHRYSANTHEMI ALBA from Haizhou of China Pu'er tea Compound-acid
Milk, FLOS CHRYSANTHEMI ALBA from Haizhou of China honey acidophilus milk, chrysanthemum milk tea, chrysanthemum beer, FLOS CHRYSANTHEMI ALBA from Haizhou of China volatile oil buccal tablet etc..Many functions in FLOS CHRYSANTHEMI ALBA from Haizhou of China into
Divide and lose more in process, and Land use systems are single, and main component is not utilized well, causes resource
Significant wastage.
At present, the product research such as the effervescent tablet, the lozenge that are made by raw material of FLOS CHRYSANTHEMI ALBA from Haizhou of China are extremely limited, and wherein most is sent out
It is bright to be mainly using FLOS CHRYSANTHEMI ALBA from Haizhou of China as a kind of auxiliary material, coordinate the raw materials such as honeysuckle, fig, tealeaves to be produced.This kind of product is very
Effect value as main component has been played well, but it is extremely limited for the utilization of food ingredient FLOS CHRYSANTHEMI ALBA from Haizhou of China.
Chinese patent CN102526475A discloses a kind of cigarette clear throat buccal tablet and preparation method and application, category
In food and medicine field.By radix polygonati officinalis, radix glycyrrhizae, barrenwort, rheum officinale, psoralea corylifolia, Momordica grosvenori, peppermint, FLOS CHRYSANTHEMI ALBA from Haizhou of China and dark plum composition.With
In the oral cavity malaise symptoms caused by smoking.If the invention can be eliminated effectively, the dry throat caused by smoking is intended to cough, thing is choked larynx, sound
The oral cavity malaise symptoms such as mute mouth is puckery.The preparation method is simple, steady quality, and is the formula of medicine and food raw materials, uses safety.
But the main product is used for medicine field, adds more Chinese medicine, and FLOS CHRYSANTHEMI ALBA from Haizhou of China does not play its feature.
Chinese patent CN1565519A discloses a kind of pharyngitis, tonsillitis Traditional Chinese medicine lozenge and this Traditional Chinese medicine lozenge for the treatment of
Preparation method, the raw material that the Traditional Chinese medicine lozenge is matched by following weight：98~118g of FLOS CHRYSANTHEMI ALBA from Haizhou of China, 98~118g of honeysuckle, peppermint 62
~82g, 98~118g of olive, 26~46g of tealeaves, and auxiliary material is added, obtained through decoction, concentration, granulation, full wafer, tabletting, to pharynx
Bitterly, pharynx itch, the cardinal symptom such as dry throat, dry cough, foreign body sensation and congestion of throat, myxedema, pharynx rear wall lymphocytosis, secretion
The main physical signs such as thing attachment have improvement result.Though the invention make use of significant percentage of FLOS CHRYSANTHEMI ALBA from Haizhou of China, still it is suitable for Chinese medicine
Field, it is unsuitable popular edible.
Chinese patent CN103989802A discloses a kind of preparation method of spina date seed fig effervescent tablet, the product be by
The raw material of following weight parts is made：Fig 100-120, spina date seed 15-20, wooden fish stone powder 1-2, mushroom powder 4-5, zein
Powder 1-2, sodium bicarbonate 2-3, FLOS CHRYSANTHEMI ALBA from Haizhou of China 4-5, Common Sage Herb 2-3, wintergreen 1-2, prepared rhizome of rehmannia 3-4, elscholtiza 1-2, fruits of elm 2-3, ear water
Amaranth 1-2, sour powder are appropriate, convenient to take, and addition spina date seed, mushroom powder and Chinese medicine material make that effervescent tablet is nutritious, fragrance is unique,
With good health-care efficacy.But the invention is mainly used on the nutritive value of fig and spina date seed, stricti jurise not
It is the functional product exploitation of FLOS CHRYSANTHEMI ALBA from Haizhou of China.
Therefore, using FLOS CHRYSANTHEMI ALBA from Haizhou of China as major ingredient, exploring the method and deep development of its functional component separating-purifying has its function
The product of composition is the emphasis of current FLOS CHRYSANTHEMI ALBA from Haizhou of China application study.
Although CN101125103A provides a kind of Indian chrysanthemum effervescent and preparation method thereof, the patent is only system
A kind of standby pharmaceutical preparation, the edible flavor of gained preparation is not considered.Because the characteristic and chrysanthemum indicum of FLOS CHRYSANTHEMI ALBA from Haizhou of China have bigger difference,
And with very outstanding health care effect, how to be prepared into that taste is good and preparation of instant, it is this area
Technical problem urgently to be resolved hurrily.
The content of the invention
In view of the shortcomings of the prior art, an object of the present invention is to provide a kind of preparation side of dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge
Method, " dual-purpose " of the present invention is " edible and medicinal dual-purpose ".The preparation method of the present invention comprises the following steps：
(1) by weight, by 6~18 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower Ultramicro-powders, 35~39 parts of xylitols, 10~13 parts of poly- second two
Alcohol, 12~18 portions of disintegrants and 20~29 parts of filler mixing；The disintegrant is by citric acid and sodium acid carbonate by weight 7:
10 compositions, the filler is by lactose and mannitol by weight 8:1 composition；
(2) 2~4 μ l/g are pressed ● the ratio of step (1) gains, adds peppermint oil to step (1) gains and mix；Again
The edible ethanol of addition 95%, softwood processed is mixed；
(3) step (2) gains are dried, sieved and tabletting granulation, produce the lozenge.
The molecular weight of the polyethylene glycol is 6000.
The FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower Ultramicro-powder is obtained by the following method：By FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower carry out ultramicro grinding, cross 100 mesh or
120 mesh sieves, are produced.
The addition of described 95% edible ethanol is 0.02ml/g ● step (1) gains.
It is preferred that, in step (3), when carrying out described dry, 1~2h is dried in 45~55 DEG C of baking ovens.
It is preferred that, in step (3), when carrying out the sieving, the material after drying is sufficiently stirred for, 100 mesh sieves are crossed.
Another object of the present invention is to provide the dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge prepared by above-mentioned preparation method.
Unlike the prior art, the present invention is effective processing and utilization using FLOS CHRYSANTHEMI ALBA from Haizhou of China as the leisure food of major ingredient, breaks biography
The medicinal material and tea product edible way of system, had both developed for FLOS CHRYSANTHEMI ALBA from Haizhou of China and have provided a new field, and also solved FLOS CHRYSANTHEMI ALBA from Haizhou of China and exist
Cause the problem of functional components are wasted as auxiliary material in effervescent tablet, lozenge, its utilization rate and nutritive value is reached maximum
Change.
Meanwhile, if directly using FLOS CHRYSANTHEMI ALBA from Haizhou of China as unique major ingredient, products obtained therefrom mouthfeel is more stimulated, bitterness.In order to ensure mouthfeel,
Present invention addition xylitol is as sweetener, while have the auxiliary material such as citric acid and lactose, mannitol, and it is soft using peppermint oil system
Material, can add peppermint fragrance, and pained and sweet sense of discomfort, prominent refrigerant sense are relaxed but also as flavor enhancement.Pass through experiment
Formula is continued to optimize, is prepared with the suitable lozenge of light chrysanthemum taste, refrigerant, sour-sweet degree：It is placed in water after disintegration, solution color
It is yellowish limpid and have strong chrysanthemum-flavored.Meanwhile, present invention gained lozenge is different from conventional effervescent tablet, although dissolution velocity
It hurry up, but occur without effervesce state, more conducively eat.
The present invention first passes through preliminary experiment and prepares lozenge, then carries out the single factor experiments of main and supplementary materials and determine substantially charge ratio,
The ratio of disintegrant consumption and citric acid and sodium acid carbonate is adjusted according to disintegration time limited, finally using subjective appreciation as index, is passed through
Mixture experiment design tests to obtain optimization formula.Final products disintegration time limited is controlled in 48-163s (60 DEG C of water temperature), and average piece weight is
0.7024g, tablet weight variation meets the tablet weight variation as piece weight >=0.3g and cannot be greater than 5% between+0.021 to -0.010
Regulation, the tablet hardness of the obtained FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge of experiment is 5kg-9kg.Meanwhile, preparation technology of the present invention is simple, it is easy to grasp
Make, equipment requirement is low, energy effectively save time and production cost, feasibility are high, and access threshold is low, be adapted to medium-sized and small enterprises operation life
Production, also disclosure satisfy that extensive, industrialization, the demand of batch production, with preferable application prospect.
To sum up, beneficial effects of the present invention can be summarized as：
1st, present invention gained lozenge disintegration rate is fast, and different from conventional effervescent formulation, present invention gained lozenge is in dissolving
When occur without effervesce state；
2nd, present invention gained lozenge has the light chrysanthemum perfume of the FLOS CHRYSANTHEMI ALBA from Haizhou of China of typicalness, and cool taste, sour-sweet degree are suitable, are suitable to
Food and medicament dual-purpose.
Embodiment
The present invention is specifically described below by embodiment, it is necessary to it is pointed out here that be following examples be use
It is further detailed in the present invention, it is impossible to be interpreted as limiting the scope of the invention, the field is skilled in technique
Some nonessential modifications and adaptations that personnel are made according to foregoing invention content, still fall within protection scope of the present invention.
Embodiment 1
(1) prepared by FLOS CHRYSANTHEMI ALBA from Haizhou of China powder
FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower is subjected to ultramicro grinding, the FLOS CHRYSANTHEMI ALBA from Haizhou of China powder for crossing 120 mesh sieves is used as raw material for standby.
(2) raw material is mixed
Other raw materials such as the FLOS CHRYSANTHEMI ALBA from Haizhou of China powder that step (1) is obtained and citric acid are proportionally mixed.Using total amount 10g as base
Standard, adds FLOS CHRYSANTHEMI ALBA from Haizhou of China 1.479g, citric acid/sodium acid carbonate (07：1) 1.200g, xylitol 3.825g, lactose/mannitol (8：1)
2.296g, polyethylene glycol 1.000g.
(3) softwood processed
40ug peppermint oils are added into mixed raw material, using 95% edible ethanol as wetting agent softwood, addition is
0.2mL, is mixed, standby.
(4) dry
The raw material of mixing is placed in 45 DEG C of baking ovens and dries 1.5h.
(5) sieve
Raw material after drying is sufficiently stirred for, and crosses 100 mesh sieves, standby.
(6) tabletting is pelletized
Tabletting machine is pelletized, and is produced.
(7) pack
The pure and fresh lozenge finished product of FLOS CHRYSANTHEMI ALBA from Haizhou of China is subjected to pack packaging.
Embodiment 2
(1) prepared by FLOS CHRYSANTHEMI ALBA from Haizhou of China powder
FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower is subjected to ultramicro grinding, the FLOS CHRYSANTHEMI ALBA from Haizhou of China powder for crossing 120 mesh sieves is used as raw material for standby.
(2) raw material is mixed
Other raw materials such as the FLOS CHRYSANTHEMI ALBA from Haizhou of China powder that step (1) is obtained and citric acid are proportionally mixed.Using total amount 10g as base
Standard, adds FLOS CHRYSANTHEMI ALBA from Haizhou of China 0.600g, citric acid/sodium acid carbonate (07：1) 1.709g, xylitol 3.629g, lactose/mannitol (8：1)
2.862g, polyethylene glycol 1.000g.
(3) softwood processed
40ug peppermint oils are added into mixed raw material, using 95% edible ethanol as wetting agent softwood, addition is
0.2mL, is mixed, standby.
(4) dry
The raw material of mixing is placed in 45 DEG C of baking ovens and dries 1.5h.
(5) sieve
Raw material after drying is sufficiently stirred for, and crosses 100 mesh sieves, standby.
(6) tabletting is pelletized
Tabletting machine is pelletized, and is produced.
(7) pack
The pure and fresh lozenge finished product of FLOS CHRYSANTHEMI ALBA from Haizhou of China is subjected to pack packaging.
Experimental example
2. the determination of basic ingredients
The processing of 2.1 FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flowers
2.1.1 powder is prepared
FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower is passed through into ultramicro grinding, 120 mesh sieves is crossed, produces FLOS CHRYSANTHEMI ALBA from Haizhou of China powder stock.2.1.2 medicinal extract is prepared
The size-reduced machine of FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower is crushed, through extraction, ultrasonic wave extraction, filtering, ethanol distillation, lyophilized, crushing etc.
Step, obtains FLOS CHRYSANTHEMI ALBA from Haizhou of China raw material.
The determination of 2.2 sweeteners
Design three kinds of experimental programs：(1) with lactose/mannitol 1:1 is sweetener；(2) it is sweetener (3) with wood using sucrose
Sugar alcohol is sweetener, and optimal sweetener is determined according to organoleptic analysis and quality analysis.
The determination of 2.3 disintegrants
Design two kinds of experimental programs：(1) using sodium carboxymethyl starch as disintegrant；(2) constituted with citric acid and sodium acid carbonate
Disintegrant.Sodium acid carbonate is added on the basis of original formulation and is used as alkali source, and citric acid (1:1 ratio) disintegrant is constituted, it is added without
Sodium carboxymethyl starch, pelletizing press sheet determines optimal disintegrant according to organoleptic analysis and quality analysis.
3. the determination of main and supplementary materials content
, it is necessary to further investigate FLOS CHRYSANTHEMI ALBA from Haizhou of China addition, soda acid on the basis of the main and supplementary materials that preliminary experiment is determined are matched substantially
Than, the main and supplementary materials factor such as sweetener addition, lubricant addition, filler addition.Using single factor experiment, commented with sense organ
Valency comprehensive grading is index, it is determined that optimal dispensing mode.
3.1 soda acids are designed than the single factor experiment of investigation
According to disintegration effect, the proportioning of citric acid and sodium acid carbonate is investigated, as shown in table 1.
The citric acid of table 1 allocates the single factor experiment of ratio with sodium acid carbonate
The single factor experiment design of 3.2 other main and supplementary materials
3.2.1 the single factor experiment of auxiliary material content
Major ingredient content is determined, changes polyethylene glycol and lactose/mannitol 8:1 content, as shown in table 2.
The auxiliary material content of table 2 determines experiment
3.2.2 the single factor experiment of wetting agent (ethanol)
Concentration of alcohol and ethanol addition are determined according to granulating efficiency, as shown in table 3-3.
The single factor experiment of the ethanol of table 3
3.2.3 the single factor experiment of major ingredient content
On the basis of auxiliary material content single factor experiment, auxiliary material content is determined, changes FLOS CHRYSANTHEMI ALBA from Haizhou of China and sweet tea
Taste agent (xylitol) content, optimum formula is determined according to subjective appreciation.As shown in table 4.
The major ingredient content of table 4 determines experiment
4. design mixture expirement determines optimization formula
To try to achieve the optimization formula of main and supplementary materials, on the basis of single factor experiment, tested using mixture experiment design, with integrated sensory
Evaluation fraction is index, with FLOS CHRYSANTHEMI ALBA from Haizhou of China, citric acid (citric acid/sodium acid carbonate 1:1), xylitol, lactose (lactose/mannitol 1:
1), polyethyleneglycol content is factor, designs mixture expirement.Such as table 5.
The mixture experiment design of table 5 tests table
5. result and analysis
The determination of 5.1 basic ingredients
5.1.1 the processing of FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower
(1) Hang Zhou chrysanthemum flower extract:Hygroscopicity is extremely strong, and granulation situation is poor；
(2) FLOS CHRYSANTHEMI ALBA from Haizhou of China powder：Hygroscopicity is smaller, pelletizes all right.
Medicinal extract is water-soluble to be preferably fully dissolved in water, and un-extracted powder has a water insoluble ingredients, but due to
Medicinal extract hygroscopicity causes to be difficult to good tabletting granulation by force, therefore is finally used as raw material using the FLOS CHRYSANTHEMI ALBA from Haizhou of China powder through ultramicro grinding.
5.1.2 the determination of disintegrant
(1) sodium carboxymethyl starch：Disintegration rate is slow.
(2) citric acid/sodium acid carbonate 1:1：Disintegration rate is very fast.
Two kinds of disintegrants pelletize the sensory properties such as its structural state, local flavor, mouthfeel, color and luster and before difference less, and
The latter is containing, without obvious bubble sense, hardness is bigger when changing；The latter's disintegration rate is considerably more rapid.
5.1.3 the determination of sweetener
(1) lactose, mannitol：Local flavor is bitter, without obvious sweet taste；
(2) sucrose：Sour-sweet degree is suitable；
(3) xylitol：Sour-sweet degree is suitable, there is refrigerant sense；
Pelletized using sucrose by sweetener, its bitter taste weakens, sour-sweet degree is suitable, mouthfeel with taste is better；But sucrose heat
Amount is too high, therefore selection does not easily cause the xylitol replacement sucrose of carious tooth as sweetener.
5.1.4 basic ingredients than determination
By the determination of preliminary experiment disintegrant and sweetener, the basic ingredients of preliminary experiment are than result such as table 6 below.
The basic ingredients ratio of table 6
The determination of 5.2 main and supplementary materials contents
5.2.1 soda acid compares result
Single factor experiment by 3.1 soda acids than investigation is designed, and draws experiment of single factor result of the soda acid of table 7 than investigation, is selected
Select sour-sweet degree suitable, disintegration time limited is formulated faster, finally determines citric acid：Sodium acid carbonate is 0.7:1 is optimal proportion.
Experiment of single factor result of the soda acid of table 7 than investigation
5.2.2 major ingredient and accessory formula result
Designed by the single factor experiment of 3.2 other main and supplementary materials, table 8, the main and supplementary materials formulation analysis of table 9 are drawn, by analysis result
Consider, it is determined that experiment three is more excellent major-minor material formula.I.e. by the single factor experiment of main and supplementary materials, in the formula for determining product
Major ingredient FLOS CHRYSANTHEMI ALBA from Haizhou of China 15%, xylitol 36%；Auxiliary material lactose：Mannitol (8:1) 20%, polyethylene glycol 13%.
The single factor experiment of table 8 determines basic ingredients ratio
The major-minor material formula organoleptic analysis of table 9
The determination (mixture expirement result) of 5.3 optimization formulas
5.4 quality analysis
5.4.1 texture is analyzed
Every group takes 4 tablets of FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenges, is sequentially placed into the sample cell of the intelligent tablet hardness instruments of YD-2B, and manual tabletting is read
Take and record maximum pressure when tablet is crushed, the results are shown in Table 10.5.4.2 quality testing
(1) tablet weight variation
Every group takes 5 tablets of FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenges, claims its gross weight and calculates average piece weight, weighs respectively, records every piece weight, count
Tablet weight variation is calculated, 10 are the results are shown in Table.
10 weights of table, tablet hardness testing result
During granulation, the poor fluidity of particle, the thickness of particle differs greatly too big, and the feeding quantity in loading hopper is excessive or mistake
The factor such as few can cause tablet weight variation to exceed defined scope, therefore can be by detecting tablet weight variation come really during tablet manufacturing
Whether fixed output quota product are qualified and whether detection mobility of particle quality, granular size are homogeneous.Every group of 5 tablets of FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge distinguishes gross weight
For 14.0479g, average piece weight is 0.7024g, and tablet weight variation meets between+0.021 to -0.010 and works as piece as defined in medicine
Tablet weight variation cannot be greater than 5% during weight >=0.3g, and the tablet hardness of the obtained FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge of experiment is from 5kg -9kg or so.
(2) disintegration time limited
Every group takes 3 tablets of FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenges, be sequentially placed into 60 DEG C, 50 DEG C, in the water of 40 DEG C of equivalent milliliter, record from
The time being disintegrated completely is put into, 11 are the results are shown in Table.
Table 11 disintegration time limited testing result
Disintegration time of the gained lozenge in water as seen from the above table, different and different, base is formulated from 50s to 4min with temperature
This meets requirement of the effervescent tablet to disintegration time.
6 addition peppermint oils are contrasted to the sense organ of product
On the basis of formula is determined, influence of the peppermint oil addition to product sensory is investigated.As shown in table 12.
The different peppermint oil addition sensory results of table 12
To sum up, the improvement that a certain amount of peppermint oil (20-40ul/10g) is conducive to product special flavour is added, on the one hand covered
The effect of FLOS CHRYSANTHEMI ALBA from Haizhou of China itself bitter taste, makes sour-sweet degree and hardship degree suitable, is big well-established, on the other hand assigns product salubrious thin
Lotus delicate fragrance, and with pleasant refrigerant sense.In addition, the refrigerant effect wet one's whistle that also clears away heart-fire with FLOS CHRYSANTHEMI ALBA from Haizhou of China of peppermint in itself is mutually obtained
Benefit is evident.But the excessive peppermint oil of addition, can not only aggravate the bitter taste of product, and the taste stimulation that heavier mint flavored is brought is also difficult
With by big well-established.
Therefore, according to the experiment for investigating peppermint oil addition, using subjective appreciation as index, through analysis, 20-40ul is most suitable
Suitable addition.Results of sensory evaluation such as table 13 below.
The peppermint oil addition sensory evaluation scores table of table 13
Analyzed with Fuzzy Comprehensive Evaluation method, after the comprehensive evaluation result for calculating four groups of samples, according to
Weighted average principle is to result P-adic valuation P (V1=3；V2=2；V3=1) average again, concrete outcome such as table 14 below.
The peppermint oil Comprehensive Assessment result of table 14
As seen from table, when peppermint oil addition is 40ul, sensory evaluation scores highest scoring, it is thus determined that on the basis of 10g
Lozenge peppermint oil addition is 40ul.
Claims (7)
1. a kind of preparation method of dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge, it is characterised in that the preparation method comprises the following steps：
(1) by weight, by 6~18 parts of FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower Ultramicro-powders, 35~39 parts of xylitols, 10~13 parts of polyethylene glycol,
12~18 portions of disintegrants and 20~29 parts of filler mixing；The disintegrant is by citric acid and sodium acid carbonate by weight 7:10 groups
Into the filler is by lactose and mannitol by weight 8:1 composition；
(2) 2~4 μ l/g are pressed ● the ratio of step (1) gains, adds peppermint oil to step (1) gains and mix；Add
95% edible ethanol, softwood processed is mixed；
(3) step (2) gains are dried, sieved and tabletting granulation, produce the lozenge.
2. preparation method according to claim 1, it is characterised in that the molecular weight of the polyethylene glycol is 6000.
3. preparation method according to claim 1, it is characterised in that the FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower Ultramicro-powder is obtained by the following method
：FLOS CHRYSANTHEMI ALBA from Haizhou of China dried flower is subjected to ultramicro grinding, 100 mesh or 120 mesh sieves is crossed, produces.
4. preparation method according to claim 1, it is characterised in that the addition of described 95% edible ethanol is
0.02ml/g ● step (1) gains.
5. preparation method according to claim 1, it is characterised in that in step (3), when carrying out described dry, in 45~
1~2h is dried in 55 DEG C of baking ovens.
6. preparation method according to claim 1, it is characterised in that in step (3), when carrying out the sieving, will be dried
Material afterwards is sufficiently stirred for, and crosses 100 mesh sieves.
7. the dual-purpose FLOS CHRYSANTHEMI ALBA from Haizhou of China lozenge prepared by any one of claim 1~6 preparation method.
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| CN1565519A (en) * | 2003-06-16 | 2005-01-19 | 浙江可立思安制药有限公司 | Chinese medicine buccal tablet and its preparing process |
| CN101112408A (en) * | 2007-08-31 | 2008-01-30 | 山东轻工业学院 | Sustained-release ji chrysanthemum tablet and method for preparing the same |
| CN101125130A (en) * | 2006-08-14 | 2008-02-20 | 北京四环科宝制药有限公司 | Indian chrysanthemum effervescent preparation and preparation method thereof |
| CN101669643A (en) * | 2009-09-23 | 2010-03-17 | 上海应用技术学院 | Chrysanthemum tea effervescent tablets and preparation method thereof |
| CN102441019A (en) * | 2011-11-30 | 2012-05-09 | 中山市中智药业集团有限公司 | Chinese medicinal chrysanthemum buccal tablet |
| CN102727556A (en) * | 2012-07-16 | 2012-10-17 | 西南大学 | Throat-clearing traditional Chinese medicine buccal tablet and preparation method thereof |
-
2017
- 2017-05-25 CN CN201710378885.2A patent/CN107242556B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565519A (en) * | 2003-06-16 | 2005-01-19 | 浙江可立思安制药有限公司 | Chinese medicine buccal tablet and its preparing process |
| CN101125130A (en) * | 2006-08-14 | 2008-02-20 | 北京四环科宝制药有限公司 | Indian chrysanthemum effervescent preparation and preparation method thereof |
| CN101112408A (en) * | 2007-08-31 | 2008-01-30 | 山东轻工业学院 | Sustained-release ji chrysanthemum tablet and method for preparing the same |
| CN101669643A (en) * | 2009-09-23 | 2010-03-17 | 上海应用技术学院 | Chrysanthemum tea effervescent tablets and preparation method thereof |
| CN102441019A (en) * | 2011-11-30 | 2012-05-09 | 中山市中智药业集团有限公司 | Chinese medicinal chrysanthemum buccal tablet |
| CN102727556A (en) * | 2012-07-16 | 2012-10-17 | 西南大学 | Throat-clearing traditional Chinese medicine buccal tablet and preparation method thereof |
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