CN107233490A - 一种益气养阴美容养颜的玛咖组合物 - Google Patents
一种益气养阴美容养颜的玛咖组合物 Download PDFInfo
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Abstract
本发明公开了一种益气养阴美容养颜的玛咖组合物,由包括如下重量份数的原料经提取制备得到:玛咖36~42份,山药7~10份,白芷15~18份,桑椹7~9份,无花果4~6份,玉竹2~10份,百合4~6份,葛根4~6份,罗汉果1~5份,金银花2~4份。本发明按照上述配方合理配伍,具有温性调理、促进血液循环、平衡女性内分泌、养阴润肺、消炎止痛、清心安神、益气养颜的功效;并且,所述玛咖组合物的制备方法简便易行,生产成本低,便于工业化生产;可根据需要制成多种剂型,服用方便,药性温和,原料均为天然食材,无毒副作用。
Description
技术领域
本发明属于保健品技术领域,更具体地,涉及一种益气养阴美容养颜的玛咖组合物。
背景技术
玛咖(Lepedium meyenii Walp),原产于海拔4000米以上的秘鲁安第斯山区,属十字花科独行菜属。玛咖是一种药食两用植物,可食用部分为其根部。玛咖营养丰富,含有蛋白质、脂肪、多糖、生物碱、芥子油苷及微量元素等多种营养成分,其独有的生物碱类成分玛咖酰胺和玛咖烯对平衡人体荷尔蒙分泌有显著的效果。食用者食用一定量的玛咖后,可以调整及平衡人体内分泌,激发人体内源激素,促进荷尔蒙代谢及平衡荷尔蒙分泌;能够清除自由基、坚固免疫系统,改善亚健康状况,是可以预防多种疾病的新资源食品。
由于环境、社会、生活等等诸多方面的压力,许多女性由于内分泌紊乱,导致月经不调、痛经、不孕不育、皮肤色素沉着等等亚健康问题,有些人通过运动来调理,有些人通过饮食调理,都不失为一个好方法,但是都很难在较短时间内达到预期的效果,如果长时间日积月累,容易诱发各种难以治愈的妇科疾病,严重影响女性的身体健康。
目前,市面上也出现了一些具有益气养阴、美容养颜功效的玛咖组合物保健品,但是它们大多疗效不明显,见效缓慢,一方面是由于其配方优化不够,另一方面是由于玛咖中的一些功能性成分在提取过程中被破坏,失去功效;玛咖的功效性成分既有水溶性成分,也有脂溶性成分,单一溶媒对功效成分提取不完全,现有的玛咖提取方法不能对其活性成分有效提取,造成资源的浪费。
发明内容
针对上述现有技术中的不足,本发明提供了一种益气养阴美容养颜的玛咖组合物,制备工艺简单,疗效好,安全无副作用。
本发明的上述目的是通过以下技术方案予以实现的。
一种益气养阴美容养颜的玛咖组合物,由包括如下重量份数的原料经提取制备得到:玛咖36~42份,山药7~10份,白芷15~18份,桑椹7~9份,无花果4~6份,玉竹2~10份,百合4~6份,葛根4~6份,罗汉果1~5份,金银花2~4份。
本发明基于我国传统医学对女性身体调理的理论,参考现代药理研究,通过各组分之间的协同复配,获得了一种能够有效益气养阴、美容养颜的玛咖组合物,该组合物对于内伤劳倦或病久虚羸导致的气短懒言、面色苍白、神疲无力、肌肉消瘦等症有效缓解,还可以调理女性内分泌,清除体内代谢淤积,平衡女性气血,使内分泌系统恢复正常运行,对于痛经、手脚冰凉、宫寒怕冷、乳房肿痛、心悸气短、神疲乏力、睡眠质量差、神经衰弱、记忆力减退、面色无华、雀斑、身体劳累等症状功效明显。发明人发现,只有将上述各组分按照本发明所述重量百分比进行合理复配,才能使其达到相互协同增效的目的。
玛咖,味辛、微辣,性温热,归肺、肾经,具有益气、益精血等功效,富含人体所需的各种氨基酸、活性酶、矿物质、微量元素及生理活性的次生代谢产物,可调节人体的阴阳平衡,促进血液循环,达到益气养阴、美容养颜的功效。在传统上,玛咖用于提高生育力、抗疲劳增强体力、改善性功能、调节内分泌系统、平衡荷尔蒙、抗贫血症、缓解女性更年期综合症、抗风湿性关节炎等。
山药,性味甘、平,归脾、肺、肾经,具有补脾养胃、生津益肺、补肾涩精、助五脏、强筋骨、长志安神、延缓衰老的功效;主治脾胃虚弱、倦怠无力、食欲不振、肺气虚燥、痰喘咳嗽、肾气亏耗、腰膝酸软、下肢痿弱、带下白浊、皮肤赤肿、肥胖等病症。近年来研究表明,山药具有诱导产生干扰素,增强人体免疫功能的作用。
白芷味辛,性温,归肺、脾、胃经,具有祛风止痛、燥湿止带、消肿排脓、祛风止痒的功效;对女性头昏及面部头痛有较好的疗效,对肠胃、子宫也具有一定的解痉作用。
桑椹性味甘寒,营养丰富,桑椹中的脂肪酸具有分解脂肪、降低血脂,防止血管硬化等作用;有改善皮肤(包括头皮)血液供应,营养肌肤,使皮肤白嫩及乌发等作用,并能延缓衰老;桑椹主入肝肾,善滋阴养血、生津润燥,常食桑椹,能够促进人体免疫、补血养颜,缓解肝肾阴血不足及津亏消渴、肠燥等症。
无花果味甘,性凉,入肺、胃、大肠经,具有清热生津、健脾开胃、解毒消肿之功效;主治咽喉肿痛、乳汁稀少、肠热便秘、食欲不振、消化不良等。
玉竹,味甘性平,归肺、胃经。功能主治:滋阴润肺,养胃生津,用于燥咳、劳嗽,热病阴液耗伤之咽干口渴,内热消渴,阴虚外感,头昏眩晕,筋脉挛痛。
百合味甘,性寒,归心、肺经;具有养阴润肺,清心安神的功效;主治阴虚燥咳、劳嗽咳血、虚烦惊悸、失眠多梦、精神恍惚,具有一定的镇静、抗疲劳作用。
葛根味甘、辛,性凉,归肺、胃经;具有解肌退热、透疹、生津止渴、升阳止泻的功效;主治表证发热,项背强痛,阴虚消渴,热泻热痢,脾虚泄泻。
罗汉果味甘,性凉;营养价值高,含有丰富的维生素C,有抗衰老、抗癌、养阴益肤、瘦体美容的作用,主治肺热燥咳,咽痛失音,肠燥便秘。罗汉果对支气管炎、高血压等疾病有显著疗效,对肠管运动机能有双向调节作用。
金银花味甘,性寒,含有绿原酸、木犀草素苷等药理活性成分,对溶血性链球菌、金黄葡萄球菌等多种致病菌及上呼吸道感染致病病毒等有较强的抑制力;善清解血毒,用于各种热性病,另外还可增强免疫力、补虚疗风的功效。
优选地,所述玛咖的重量份数为39~40份。
优选地,由如下重量份数的原料经提取制备得到:玛咖40份,山药8份,白芷15份,桑椹8份,无花果6份,玉竹5份,百合5份,葛根5份,罗汉果4份,金银花4份。
优选地,原料中所述玛咖的提取步骤包括:
S1. 将玛咖干根切片后粉碎成5~20目的粗粉,然后进行亚临界的浸出处理,压力为0.5~3Mpa,温度25~40℃,通入丁烷,浸润2~6h;再进行萃取处理,萃取时间30~60min,萃取1~3次,将萃取液的环境减压至常压,20℃~30℃蒸发溶剂,得玛咖脂溶性浸膏;
S2. 将玛咖亚临界萃取后的剩余物料高温灭酶,以料液比1:5~1:10加水,40~60℃提取2次,合并提取液减压浓缩至60℃时比重为1.10~1.20,得玛咖浓缩液;
S3. 将步骤S1中得到的玛咖脂溶性浸膏加热至50~70℃,然后与步骤S2得到的玛咖浓缩液混合,经高压均质乳化成200~400nm的纳米乳化溶液,均质压力40~60MPa;
S4. 将步骤S3得到的乳化溶液喷雾干燥,进料温度60~70℃,进风温度170~190℃,出风温度70~80℃,制得玛咖提取物。
玛咖含有丰富的蛋白质、氨基酸、还原糖、矿物质、不饱和脂肪酸,尤其是牛磺酸、矿物质锌、支链氨基酸 (亮氨酸,缬氨酸,异亮氨酸)等抗疲劳营养物质,它们在消除运动中枢疲劳和机体疲劳中有重要作用。此外,玛咖的次生代谢物质主要有玛咖酰胺、玛咖烯、芥子油苷、甾醇和生物碱等,其中,玛咖酰胺和玛咖烯是玛咖中的特有成分,是实现玛咖抗疲劳功效的核心物质。以往的玛咖提取方法对玛咖脂溶性成分提取不够,并且损失大量的营养成分;而上述方法获得的玛咖提取物富含玛咖脂溶性及水溶性活性成分,其中玛咖酰胺种类齐全,各种玛咖酰胺比例与天然玛咖原料相近,玛咖总玛咖酰胺含量达5~10%。
优选地,按所述重量份数比例取山药、白芷、桑椹、无花果、玉竹、百合、葛根、罗汉果、金银花,混匀,加水煎煮两次,过滤,合并滤液,浓缩至60℃时比重为1.10~1.20,加入95%乙醇,使乙醇浓度达70%,静置醇沉,过滤,滤液浓缩至60℃时比重为1.20~1.30,再喷雾干燥得复方提取物;将所述复方提取物与制得的玛咖提取物混合,即得所述的玛咖组合物。
优选地,所述组合物的剂型为口服液体制剂、颗粒剂、粉剂、散剂、片剂、丸剂或胶囊剂中的任意一种;添加适当的辅剂并配合常规的制备工艺即得。
与现有技术相比,本发明有益效果在于:(1)本发明提供的玛咖组合物进行组方优化配比,具有温性调理、促进血液循环、平衡女性内分泌、养阴润肺、消炎止痛、清心安神、益气养颜的功效。(2)本发明组合物的制备方法简单易行,获得的玛咖提取物富含玛咖脂溶性及水溶性活性成分,各种玛咖酰胺比例与天然玛咖原料相近,玛咖总玛咖酰胺含量5~10%,同时,在25℃水中的溶解度达90%以上,可用于制备多种剂型的组合物产品。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。除非特别说明,本发明采用的试剂、方法和设备为本技术领域常规试剂、方法和设备。
具体实施方式中的玛咖组合物可制成口服液体制剂、颗粒剂、粉剂、散剂、片剂、丸剂或胶囊剂等。
下述实施例1~4的玛咖组合物经原料筛选,粉碎为粒径小于100目的细粉,经传统的水提醇沉法提取,然后添加常规的固体制剂辅料,制成片剂。实施例5~6玛咖组合物的制备方法在具体实施例中说明。
所述水提醇沉法包括如下步骤:按所述重量份数比例取玛咖、山药、白芷、桑椹、无花果、玉竹、百合、葛根、罗汉果、金银花,混匀,加水煎煮两次,过滤,合并滤液,浓缩,加入95%乙醇,使乙醇浓度达70%,静置醇沉,过滤,滤液浓缩,再喷雾干燥得复方提取物。
以下以具体实施条件为例对本发明方法进行进一步说明。
实施例1
一种益气养阴美容养颜的玛咖组合物,由如下重量份数的原料经提取制备得到:玛咖40份,山药8份,白芷15份,桑椹8份,无花果6份,玉竹5份,百合5份,葛根5份,罗汉果4份,金银花4份。
实施例2
一种益气养阴美容养颜的玛咖组合物,由如下重量份数的原料经提取制备得到:玛咖39份,山药7份,白芷18份,桑椹7份,无花果4份,玉竹10份,百合4份,葛根4份,罗汉果3份,金银花4份。
实施例3
一种益气养阴美容养颜的玛咖组合物,由如下重量份数的原料经提取制备得到:玛咖42份,山药10份,白芷17份,桑椹9份,无花果5份,玉竹2份,百合6份,葛根6份,罗汉果1份,金银花2份。
实施例4
一种益气养阴美容养颜的玛咖组合物,由如下重量份数的原料经提取制备得到:玛咖36份,山药9份,白芷16份,桑椹8份,无花果5份,玉竹8份,百合5份,葛根5份,罗汉果5份,金银花3份。
实施例5
本实施例配方与实施例1相同,不同之处在于原料中玛咖的提取步骤包括:
S1. 将玛咖干根切片后粉碎成5目的粗粉,然后进行亚临界的浸出处理,压力为0.5~3Mpa,温度25~40℃,通入丁烷,浸润6h;再进行萃取处理,萃取时间30min,萃取3次,将萃取液的环境减压至常压,20℃~30℃蒸发溶剂,得玛咖脂溶性浸膏;
S2. 将玛咖亚临界萃取后的剩余物料高温灭酶,以料液比1:5加水,40~60℃提取2次,合并提取液减压浓缩至60℃时比重为1.10~1.20,得玛咖浓缩液;
S3. 将步骤S1中得到的玛咖脂溶性浸膏加热至50~70℃,然后与步骤S2得到的玛咖浓缩液混合,经高压均质乳化成200~400nm的纳米乳化溶液,均质压力40~60MPa;
S4. 将步骤S3得到的乳化溶液喷雾干燥,进料温度60~70℃,进风温度170~190℃,出风温度70~80℃,制得玛咖提取物。
将制得玛咖提取物过100目筛,与粉碎为粒径小于100目细粉的其他组分混匀,再添加常规的固体制剂辅料,制成片剂。
所述玛咖提取物经过分光光度计法和高速液相色谱法检测,按质量分数主要包括8.7%的总玛咖酰胺、11.0%的芳香族芥子油苷、4.1%的总皂苷、2.8%的腺苷,1.7%的甾醇,其中总玛咖酰胺中N-苄基亚油酰胺含量占总玛咖酰胺含量的38.5%。还包含未检测的其它非活性成分。
实施例6
本实施例配方与实施例1相同,不同之处在于玛咖组合物的制备方法不同,具体包括以下步骤:
S1. 将玛咖干根切片后粉碎成20目的粗粉,然后进行亚临界的浸出处理,压力为0.5~3Mpa,温度25~40℃,通入丁烷,浸润2h;再进行萃取处理,萃取时间60min,萃取1次,将萃取液的环境减压至常压,20℃~30℃蒸发溶剂,得玛咖脂溶性浸膏;
S2. 将玛咖亚临界萃取后的剩余物料高温灭酶,以料液比1:10加水,40~60℃提取2次,合并提取液减压浓缩至60℃时比重为1.10~1.20,得玛咖浓缩液;
S3. 将步骤S1中得到的玛咖脂溶性浸膏加热至50~70℃,然后与步骤S2得到的玛咖浓缩液混合,经高压均质乳化成200~400nm的纳米乳化溶液,均质压力40~60MPa;
S4. 将步骤S3得到的乳化溶液喷雾干燥,进料温度60~70℃,进风温度170~190℃,出风温度70~80℃,制得玛咖提取物。
S5. 按所述重量份数比例取山药、白芷、桑椹、无花果、玉竹、百合、葛根、罗汉果、金银花,混匀,加水煎煮两次,过滤,合并滤液,浓缩至60℃时比重为1.10~1.20,加入95%乙醇,使乙醇浓度达70%,静置醇沉,过滤,滤液浓缩至60℃时比重为1.20~1.30,再喷雾干燥得复方提取物;将所述复方提取物与步骤S4制得的玛咖提取物混合,添加常规的固体制剂辅料,制成玛咖组合物片剂。
所述玛咖提取物经过分光光度计法和高速液相色谱法检测,按质量分数主要包括8.9%的总玛咖酰胺、11.9%的芳香族芥子油苷、4.0%的总皂苷、1.6%的腺苷,1.4%的甾醇,其中总玛咖酰胺中N-苄基亚油酰胺含量占总玛咖酰胺含量的40.5%。还包含未检测的其它非活性成分。
对比例1
本对比例与实施例6玛咖组合物的配方不同,具体为由包括如下重量份数的原料经提取制备得到:玛咖40份,山药8份,白芷10份,桑椹14份,无花果6份,玉竹5份,百合2份,葛根3份,罗汉果6份,金银花6份。
对比例2
本对比例与实施例6的制备方法不同,具体为:
S1. 将玛咖干根切片后粉碎成20目的粗粉,装入亚临界萃取釜,以脱氧去离子水为溶剂,以体积百分比为20~30%的乙醇为夹带剂,压力为3Mpa,温度100℃,萃取时间60min,进行玛咖的亚临界水提取,萃取2次;
S2.将上述萃取混合物通过减压冷却釜进行分离,得滤渣和清液,将所述清液在60℃低温浓缩得浓缩液;
S3.将步骤S2得到的浓缩液经高压均质乳化成200~400nm的纳米乳化溶液,均质压力40~60MPa;
S4. 将步骤S3得到的乳化溶液喷雾干燥,进料温度60~70℃,进风温度170~190℃,出风温度70~80℃,制得玛咖提取物。
S5. 按所述重量份数比例取山药、白芷、桑椹、无花果、玉竹、百合、葛根、罗汉果、金银花,混匀,加水煎煮两次,过滤,合并滤液,浓缩至60℃时比重为1.10~1.20,加入95%乙醇,使乙醇浓度达70%,静置醇沉,过滤,滤液浓缩至60℃时比重为1.20~1.30,再喷雾干燥得复方提取物;将所述复方提取物与步骤S4制得的玛咖提取物混合,添加常规的固体制剂辅料,制成玛咖组合物片剂。
所述玛咖提取物经过分光光度计法和高速液相色谱法检测,按质量分数主要包括2.5%的总玛咖酰胺、1.3%的芳香族芥子油苷、1.6%的总皂苷、1.5%的腺苷,0.9%的甾醇,其中总玛咖酰胺中N-苄基亚油酰胺含量占总玛咖酰胺含量的28.9%。还包含未检测的其它非活性成分。
应用例1
实验动物:大鼠162只,体重200g±5g,约3月龄,全雌,未经交配,随机平分18笼饲养,分别为空白组、造模组、试验1~6低/高剂量组和对比1~2低/高剂量组(分别对应实施例1~6和对比例1~2获得的八种玛咖组合物),各组在整个实验过程中均给予全价颗粒饲料、饮自来水,室温25℃,自由摄食,自然光照,每日清洁。
给药剂量:本发明的玛咖组合物适用于口服,故本实验采用大鼠灌胃给药。
空白组:9只,每日灌胃一次,每只灌服蒸馏水10ml/kg体重,连续21天。
造模组:9只,每日灌胃一次,每只灌服蒸馏水10ml/kg体重,连续21天。
试验1~6、对比1~2低剂量组:每组9只,每日灌胃一次,每只灌服0.6g/kg体重,连续21天。
试验1~6、对比1~2高剂量组:每组9只,每日灌胃一次,每只灌服2.4g/kg体重,连续21天。
所有大鼠每日定时灌胃,容量相同。
除空白组外,其余17组静注氢化可的松注射液,剂量6.25mg/kg体重,连续5天;造模后第6天开始按上述各分组给药,连续8天。观察指标:1) 对阴虚大鼠体重的影响:给药前和给药8天后,称动物体重。2) 对阴虚大鼠自主活动次数的影响:给药第8天,用光电计数仪记录10min内的大鼠活动次数;将大鼠放入自主活动仪内,前3min为适应期,后10min由计数仪统计大鼠自主活动次数。 3) 对阴虚大鼠游泳存活时间的影响:给药第8天,将大鼠放入水温为15±1℃的水中;记录其入水至力竭的游泳存活时间,力竭标准:游泳动作明显失调,不能再坚持或沉入水底超过3秒不能重回水面。出现上述情况,及时捞起,并注意保暖。
表1 玛咖组合物对肾阴虚大鼠自主活动、体重、力竭游泳时间的影响()
注 :与空白组比较 :*0.01<P<0.05,**P<0.01;与造模组比较:# 0.01<P<0.05,##P<0.01。
由表1结果可知:经氢化可的松造模后,与空白组比较,各组动物体重显著下降,证明肾阴虚造模成功。与造模组比较本发明玛咖组合物低/高剂量可改善氢化可的松造模造成的体重下降,具有显著性差异。与空白组比较,造模组、本发明组合物低/高剂量动物自主活动次数增加,具有显著性差异,与造模组比较本发明玛咖组合物可减少氢化可的松造模造成的自主活动次数增加,具有显著性差异。与空白组比较,造模组动物的力竭游泳的时间缩短,具有显著性差异,与造模组比较本发明玛咖组合物低/高剂量可显著延长大鼠力竭游泳的时间。经比较发现,本发明玛咖组合物中实施例6优于实施例5优于实施例1优于实施例2优于实施例3~4优于对比例1~2;经大量实验分析验证,发现只有对本发明各组分以优化比例配伍、优化制备工艺才能达到所述的益气养阴功效。
应用例2
临床选取经专业医生诊断为阴虚体质的女性患者500例,年龄在20~55岁,随机分成5组,每组100例。诊断标准包括:1)、血小板减少,阴虚内热,气血双亏,气不摄血,心慌,腰痛尿频,面色萎黄,毛发、肌肤缺少光泽,皮肤粗糙,口唇无泽,舌淡,脉虚弱无力;2)、头痛头昏,手足心热,或潮热汗出,舌淡红少苔,脉弦细或细涩;3)、痛经,月经不调,体虚宫寒,贫血,小腹胀痛,心烦易怒,精神抑郁;4)、胸闷,倦怠,食积不消、不思饮食,中气不省,呕恶,带下量多色白等。
治疗方法:5组病患分别口服本发明实施例1、3、6及对比例1、2的组合物制剂,白天饭前30~60min用蜂蜜水送服,每日2次,摄入量<5 g,服用该药3个疗程,10天为一个疗程。
疗效判定标准:①痊愈:全身症状完全消失,并持续两个月以上未反复者。②好转:全身症状明显减轻,并持续减轻至两个月以上者。③无效:全身症状无明显减轻者。
治疗结果:如表2所示,本发明实施例1、3、6的玛咖组合物配方在改善女性阴虚方面效果显著,治疗的有效率达100%;而对比例1、2的组合物治疗女性气血不足时虽有一定疗效,但其有效率明显低于本发明实施例。说明本发明玛咖组合物通过各组分之间的协同复配,能够显著改善女性阴虚的体质。
表2 不同玛咖组合物配方在改善女性阳虚体寒方面的效果
经临床调查发现,经优化工艺的提取,本发明玛咖组合物口感好、吸收效果好,能够更好地发挥各营养成分之间相互协同的药理作用。
以上详细描述了本发明的实施,但是,本发明并不限于上述实施方式中的具体细节,在本发明的技术构思范围内,可以对本发明的技术方案进行多种简单变型,这些简单变型均属于本发明的保护范围。
Claims (6)
1.一种益气养阴美容养颜的玛咖组合物,其特征在于,由包括如下重量份数的原料经提取制备得到:玛咖36~42份,山药7~10份,白芷15~18份,桑椹7~9份,无花果4~6份,玉竹2~10份,百合4~6份,葛根4~6份,罗汉果1~5份,金银花2~4份。
2.根据权利要求1所述的玛咖组合物,其特征在于,所述玛咖的重量份数为39~40份。
3.根据权利要求2所述的玛咖组合物,其特征在于,由如下重量份数的原料经提取制备得到:玛咖40份,山药8份,白芷15份,桑椹8份,无花果6份,玉竹5份,百合5份,葛根5份,罗汉果4份,金银花4份。
4.根据权利要求1~3任一项所述的玛咖组合物,其特征在于,原料中所述玛咖的提取步骤包括:
S1. 将玛咖干根切片后粉碎成5~20目的粗粉,然后进行亚临界的浸出处理,压力为0.5~3Mpa,温度25~40℃,通入丁烷,浸润2~6h;再进行萃取处理,萃取时间30~60min,萃取1~3次,将萃取液的环境减压至常压,20℃~30℃蒸发溶剂,得玛咖脂溶性浸膏;
S2. 将玛咖亚临界萃取后的剩余物料高温灭酶,以料液比1:5~1:10加水,40~60℃提取2次,合并提取液减压浓缩至60℃时比重为1.10~1.20,得玛咖浓缩液;
S3. 将步骤S1中得到的玛咖脂溶性浸膏加热至50~70℃,然后与步骤S2得到的玛咖浓缩液混合,经高压均质乳化成200~400nm的纳米乳化溶液,均质压力40~60MPa;
S4. 将步骤S3得到的乳化溶液喷雾干燥,进料温度60~70℃,进风温度170~190℃,出风温度70~80℃,制得玛咖提取物。
5.根据权利要求4所述的玛咖组合物,其特征在于,按所述重量份数比例取山药、白芷、桑椹、无花果、玉竹、百合、葛根、罗汉果、金银花,混匀,加水煎煮两次,过滤,合并滤液,浓缩至60℃时比重为1.10~1.20,加入95%乙醇,使乙醇浓度达70%,静置醇沉,过滤,滤液浓缩至60℃时比重为1.20~1.30,再喷雾干燥得复方提取物;将所述复方提取物与制得的玛咖提取物混合,即得所述的玛咖组合物。
6.根据权利要求1~3任一项所述的玛咖组合物,其特征在于,所述组合物的剂型为口服液体制剂、颗粒剂、粉剂、散剂、片剂、丸剂或胶囊剂中的任意一种。
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