CN107233316A - A kind of nanoscale extract wall breaking technology - Google Patents
A kind of nanoscale extract wall breaking technology Download PDFInfo
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- CN107233316A CN107233316A CN201710552916.1A CN201710552916A CN107233316A CN 107233316 A CN107233316 A CN 107233316A CN 201710552916 A CN201710552916 A CN 201710552916A CN 107233316 A CN107233316 A CN 107233316A
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- China
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- nanoscale
- wall breaking
- breaking technology
- technology according
- extract wall
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
Abstract
The invention discloses a kind of nanoscale extract wall breaking technology for being directed to the more plant medicine material of fiber content, by being dried, roughly grinding to Chinese medicine, sieve, secondary drying, fine grinding, mixing and superfine grinding obtain the Chinese traditional powder that D90 is 400 800nm.The diameter of particle that the inventive method grinding is obtained is uniform, and narrow particle size distribution, sporoderm-broken rate is high, and active principle stripping quantity is high, dissolution rate is fast, and with appropriate hygroscopicity and adsorptivity, storage is convenient.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of nanoscale extract for being directed to string class Chinese medicine
Wall breaking technology.
Technical background
The active ingredient of plant medicine material is distributed mainly in intracellular and cytoplasm, and based on intracellular, because
This, in order to improve in the release rate and absorptivity of active ingredient, the development process of underway medicine preparation, generally enters to Chinese medicine
Row is crushed, grinding, to improve the sporoderm-broken rate of cell so that active ingredient is not required to just can be quick, big by cell membrane and cell membrane
Amount release, so as to improve the utilization rate of medicinal material, increases curative effect.
However, for the more plant medicine material of fiber, its toughness is stronger, is easily produced by after external mechanical force
The shape that changes without fractureing easily, and its stronger cohesive force can offset portion of external mechanical force, can also increase
The difficulty of crushing；And then cause when carrying out attrition grinding to the species Chinese medicine, shearing force is too small fully to be crushed, shearing
Power is excessive to damage larger to plant equipment, therefore attrition grinding parameter is difficult to determine.In addition, Chinese medicine water content before attrition grinding
Control directly determines the quality of grinding distribution, and humidity is excessive non-breakable, and particle diameter is uneven, the too small easy reunion of humidity, is difficult point
Dissipate；It would therefore be highly desirable to design a kind of sporoderm-broken rate height, uniform nanoscale extract wall breaking technology is crushed.
The content of the invention
In view of the above-mentioned problems, the present invention provides a kind of nanoscale extract wall breaking technology, the plant more to fiber content
Class Chinese medicine gradually grind and dry, it is ensured that grinding is abundant, uniform particle sizes.
A kind of nanoscale extract wall breaking technology, it is characterised in that comprise the following steps：
(1) string class Chinese medicine is dried or dried naturally, holding water content is 4-5%；
(2) dry Chinese medicine is placed in grinder and roughly ground, the D50 of medicinal powder is less than after 2mm, corase grind and cross 10 mesh
Sieve；
(3) medicinal powder for crossing 10 mesh sieves in step (2) is subjected to fine grinding, the D90 of medicinal powder is less than 0.1mm；
(4) secondary drying is carried out to the fiber grain for not crossing 10 mesh sieves in step (2), holding water content is 2-3%；Drying
After carry out fine grinding, make fiber grain D90 be less than 0.1mm；
(5) step (3) is well mixed with medicinal powder obtained by step (4), is placed in superfine grinder and grinds, make medicinal powder
D90 is 400-800nm.
Further, drying temperature is 50-60 DEG C in the step (1).
Further, corase grind rotating speed is 1000-1500r/min in the step (2).
Further, corase grind repeatedly grinds for the short time in the step (2), and each milling time is no more than 1min；And
And feeding quantity is the 1/3-1/2 of total capacity.
Further, fine grinding rotating speed is 1000-1500r/min in the step (3).
Further, fine grinding rotating speed is 1200-1500r/min in the step (3).
Further, drying temperature is 50-60 DEG C in the step (4).
Further, fine grinding rotating speed is 1500-2000r/min in the step (4).
Further, fine grinding rotating speed is 1600-1800r/min in the step (4).
Further, grinding rotating speed is 15000-28000r/min in the step (5).
Further, grinding rotating speed is 18000-23000r/min in the step (5).
Further, the D90 of powder is 500-600nm obtained in the step (5).
Beneficial effect：The present invention provides a kind of nanoscale extract for being directed to the more plant medicine material of fiber content
Wall breaking technology, Chinese medicine is dried before grinding, it is ensured that the appropriate humidity of Chinese medicine, is avoided while increase fiber weakness
It is uneven that degree dries the powder reuniting caused, particle；Cross 10 mesh sieves after corase grind to sift out the broken fiber of hardly possible, to prevent secondary drying
Cause the powder reuniting that particle diameter is small；Secondary drying is carried out to the fiber grain sifted out, further the fragility of increase fiber grain, drop
The broken difficulty of self raising flour；The fiber grain of the medicinal powder and secondary drying to crossing 10 mesh sieves carries out fine grinding respectively, facilitates the control of abrasive parameters
System so that grind more uniform, narrow particle size distribution；The well mixed superfine that carries out of medicinal powder and fiber grain after fine grinding is ground
Mill, and the medicinal powder D90 controls that grinding is obtained are in 400-800nm, improve sporoderm-broken rate, active principle stripping quantity, dissolution rate it is same
When, it is ensured that appropriate hygroscopicity and adsorptivity, facilitate the storage of medicinal powder.
Brief description of the drawings
Fig. 1 show the ginsenoside dissolution experimental result of experimental group ginseng pulverate in the embodiment of the present invention 1；
Fig. 2 show the ginsenoside dissolution experimental result of control group ginseng pulverate in the embodiment of the present invention 1.
Embodiment
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of nanoscale extract wall breaking technology, comprises the following steps：
(1) ginseng is dried or 50 DEG C of drying naturally, it is 5% to keep water content；Water content mistake after drying in this step
Height is unfavorable for the crushing of ginseng, and water content is too low to cause the small ginseng pulverate of particle diameter to reunite, and reduce the dispersiveness of powder.
(2) dried ginseng is placed in grinder in being roughly ground under 1000r/min, is less than the D50 of ginseng pulverate
10 mesh sieves are crossed after 2mm, corase grind, the small powder screening of ginseng fiber particle and particle diameter are opened, in order to the secondary baking of fiber grain
It is dry.
(3) make the D90 of ginseng pulverate low in carrying out fine grinding under 1000r/min the ginseng pulverate for crossing 10 mesh sieves in step (2)
In 0.1mm.
(4) secondary drying is carried out to the fiber grain for not crossing 10 mesh sieves in step (2), drying temperature is 50 DEG C, keeps containing
Water is 3%；Drying makes the D90 of fiber grain be less than 0.1mm after carrying out fine grinding under 1500r/min.
(5) step (3) is well mixed with ginseng pulverate obtained by step (4), be placed in superfine grinder in 15000r/
It is ground under min, the D90 for making ginseng pulverate is 800nm；Ginseng pulverate's particle diameter is too small in this step can increase the hygroscopicity of powder
And adsorptivity, increase the difficulty of storage；Ginseng pulverate's particle diameter crosses conference reduction active principle stripping quantity and dissolution rate.
Further, corase grind repeatedly grinds for the short time in step (2), and each milling time is no more than 1min, to prevent
The long damage to milling apparatus of milling time；Feeding quantity is the 1/3-1/2 of total capacity, it is ensured that grinding is fully, uniformly.
The dissolution experiment of ginsenoside is carried out to the ginseng pulverate obtained in the present embodiment, ginseng pulverate, shake are soaked using methanol
High performance liquid chromatography detection is carried out after swinging mixing 10min, testing result is as shown in Figure 1.Not carry out screening and secondary drying step
Suddenly it is control group, directly to grind obtained ginseng pulverate, and high performance liquid chromatography detection is carried out after extracting 20min using methanol concussion,
Testing result is as shown in Figure 2.
47min goes out peak area, the screened ginseng pulverate's ginsenoside dissolution rate obtained with secondary drying, dissolution in such as figure
Amount is significantly better than that control group, it is seen then that the shell-broken effect of nanoscale extract wall breaking technology of the present invention is good.
Embodiment 2
A kind of nanoscale extract wall breaking technology, comprises the following steps：
(1) root of kudzu vine is dried or 60 DEG C of drying naturally, it is 4% to keep water content；Water content mistake after drying in this step
Height is unfavorable for the crushing of the root of kudzu vine, and water content is too low to cause the small kudzu-vine root powder powder ball of particle diameter to gather, and reduce the dispersiveness of powder.
(2) the dry root of kudzu vine is placed in grinder in being roughly ground under 1500r/min, is less than the D50 of kudzu-vine root powder
10 mesh sieves are crossed after 2mm, corase grind, the small powder screening of root of kudzu vine fiber grain and particle diameter are opened, in order to the secondary baking of fiber grain
It is dry.
(3) make the D90 of kudzu-vine root powder low in carrying out fine grinding under 1500r/min the kudzu-vine root powder for crossing 10 mesh sieves in step (2)
In 0.1mm.
(4) secondary drying is carried out to the fiber grain for not crossing 10 mesh sieves in step (2), drying temperature is 60 DEG C, keeps containing
Water is 2%；Drying makes the D90 of fiber grain be less than 0.1mm after carrying out fine grinding under 2000r/min.
(5) step (3) is well mixed with medicinal powder obtained by step (4), be placed in superfine grinder in 28000r/min
Under be ground, make kudzu-vine root powder D90 be 400nm；In this step the too small hygroscopicity that can increase powder of kudzu-vine root powder particle diameter and
Adsorptivity, increases the difficulty of storage；Kudzu-vine root powder particle diameter crosses conference reduction active principle stripping quantity and dissolution rate.
Further, corase grind repeatedly grinds for the short time in step (2), and each milling time is no more than 1min, to prevent
The long damage to milling apparatus of milling time；Feeding quantity is the 1/3-1/2 of total capacity, it is ensured that grinding is fully, uniformly.
Embodiment 3
A kind of nanoscale extract wall breaking technology, comprises the following steps：
(1) radix glycyrrhizae is dried or 55 DEG C of drying naturally, it is 4.5% to keep water content；Water content after drying in this step
The too high crushing for being unfavorable for medicinal material, water content is too low to cause the small licorice powder of particle diameter to be reunited, and reduce the dispersiveness of powder.
(2) dry radix glycyrrhizae is placed in grinder in being roughly ground under 1200r/min, is less than the D50 of licorice powder
10 mesh sieves are crossed after 2mm, corase grind, the small powder screening of radix glycyrrhizae fiber grain and particle diameter are opened, in order to the secondary baking of fiber grain
It is dry.
(3) make the D90 of licorice powder low in carrying out fine grinding under 1200r/min the licorice powder for crossing 10 mesh sieves in step (2)
In 0.1mm.
(4) secondary drying is carried out to the fiber grain for not crossing 10 mesh sieves in step (2), drying temperature is 55 DEG C, keeps containing
Water is 2.5%；Drying makes the D90 of fiber grain be less than 0.1mm after carrying out fine grinding under 1600r/min.
(5) step (3) is well mixed with licorice powder obtained by step (4), be placed in superfine grinder in 18000r/
It is ground under min, the D90 for making licorice powder is 600nm；Licorice powder particle diameter is too small in this step can increase the hygroscopicity of powder
And adsorptivity, increase the difficulty of storage；Licorice powder particle diameter crosses conference reduction active principle stripping quantity and dissolution rate.
Further, corase grind repeatedly grinds for the short time in step (2), and each milling time is no more than 1min, to prevent
The long damage to milling apparatus of milling time；Feeding quantity is the 1/3-1/2 of total capacity, it is ensured that grinding is fully, uniformly.
Embodiment 4
A kind of nanoscale extract wall breaking technology, comprises the following steps：
(1) golden cypress is dried or 52 DEG C of drying naturally, it is 4.8% to keep water content；Water content after drying in this step
The too high crushing for being unfavorable for golden cypress, water content is too low to cause the small golden cypress powder ball of particle diameter to gather, and reduce the dispersiveness of powder.
(2) dry golden cypress is placed in grinder in being roughly ground under 1400r/min, is less than the D50 of golden cypress powder
10 mesh sieves are crossed after 2mm, corase grind, the small powder screening of golden cypress fiber grain and particle diameter are opened, in order to the secondary baking of fiber grain
It is dry.
(3) make the D90 of golden cypress powder low in carrying out fine grinding under 1400r/min in the golden cypress powder for crossing 10 mesh sieves in step (2)
In 0.1mm.
(4) secondary drying is carried out to the fiber grain for not crossing 10 mesh sieves in step (2), drying temperature is 52 DEG C, keeps containing
Water is 2.8%；Drying makes the D90 of fiber grain be less than 0.1mm after carrying out fine grinding under 1800r/min.
(5) step (3) is well mixed with golden cypress powder obtained by step (4), be placed in superfine grinder in 23000r/
It is ground under min, the D90 for making medicinal powder is 500nm；In this step the too small hygroscopicity that can increase powder in golden cypress powder footpath and
Adsorptivity, increases the difficulty of storage；Conference reduction active principle stripping quantity and dissolution rate are crossed in golden cypress powder footpath.
Further, corase grind repeatedly grinds for the short time in step (2), and each milling time is no more than 1min, to prevent
The long damage to milling apparatus of milling time；Feeding quantity is the 1/3-1/2 of total capacity, it is ensured that grinding is fully, uniformly.
It the above is only the preferred embodiment of the present invention, protection scope of the present invention is not limited to reality shown in this article
Example is applied, all technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that being led for this technology
For the those of ordinary skill in domain, some modifications and retouching without departing from the principles of the present invention also should be regarded as the present invention's
Protection domain.
Claims (8)
1. a kind of nanoscale extract wall breaking technology, it is characterised in that comprise the following steps：
(1) string class Chinese medicine is dried or dried naturally, holding water content is 4-5%；
(2) dry Chinese medicine is placed in grinder and roughly ground, the D50 of medicinal powder is less than after 2mm, corase grind and cross 10 mesh sieves；
(3) medicinal powder for crossing 10 mesh sieves in step (2) is subjected to fine grinding, the D90 of medicinal powder is less than 0.1mm；
(4) secondary drying is carried out to the fiber grain for not crossing 10 mesh sieves in step (2), holding water content is 2-3%；Drying is laggard
Row fine grinding, makes the D90 of fiber grain be less than 0.1mm；
(5) step (3) is well mixed with medicinal powder obtained by step (4), is placed in superfine grinder and grinds, make the D90 of medicinal powder
For 400-800nm.
2. a kind of nanoscale extract wall breaking technology according to claim 1, it is characterised in that：Dried in the step (1)
Dry temperature is 50-60 DEG C.
3. a kind of nanoscale extract wall breaking technology according to claim 1, it is characterised in that：It is thick in the step (2)
Mill rotating speed is 1000-1500r/min.
4. a kind of nanoscale extract wall breaking technology according to claim 1, it is characterised in that：It is thick in the step (2)
Grind and repeatedly ground for the short time, each milling time is no more than 1min；And feeding quantity is the 1/3-1/2 of total capacity.
5. a kind of nanoscale extract wall breaking technology according to claim 1, it is characterised in that：It is thin in the step (3)
Mill rotating speed is 1000-1500r/min.
6. a kind of nanoscale extract wall breaking technology according to claim 1, it is characterised in that：Dried in the step (4)
Dry temperature is 50-60 DEG C.
7. a kind of nanoscale extract wall breaking technology according to claim 1, it is characterised in that：It is thin in the step (4)
Mill rotating speed is 1500-2000r/min.
8. a kind of nanoscale extract wall breaking technology according to claim 1, it is characterised in that：Ground in the step (5)
Mill rotating speed is 15000-28000r/min.
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| CN201710552916.1A CN107233316A (en) | 2017-07-07 | 2017-07-07 | A kind of nanoscale extract wall breaking technology |
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| CN201710552916.1A CN107233316A (en) | 2017-07-07 | 2017-07-07 | A kind of nanoscale extract wall breaking technology |
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Citations (4)
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|---|---|---|---|---|
| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN101147746B (en) * | 2006-09-18 | 2011-02-16 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
| CN102085224A (en) * | 2009-12-02 | 2011-06-08 | 周亚强 | Method for preparing nano-level notoginseng root powder |
| CN104644694A (en) * | 2015-02-09 | 2015-05-27 | 江苏海王健康生物科技有限公司 | Preparation method of ultramicro spirulina powder as well as preparation and application thereof |
-
2017
- 2017-07-07 CN CN201710552916.1A patent/CN107233316A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362059A (en) * | 2001-01-05 | 2002-08-07 | 唐山王清任制药有限公司 | Nano Chinese medicine piece and its prepn |
| CN101147746B (en) * | 2006-09-18 | 2011-02-16 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
| CN102085224A (en) * | 2009-12-02 | 2011-06-08 | 周亚强 | Method for preparing nano-level notoginseng root powder |
| CN104644694A (en) * | 2015-02-09 | 2015-05-27 | 江苏海王健康生物科技有限公司 | Preparation method of ultramicro spirulina powder as well as preparation and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张晶 等: ""超微粉碎对人参中皂苷测定量的影响"", 《食品科学》 * |
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| 黎冬明: "超微百合全粉的制备及其物化特性研究", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
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Application publication date: 20171010 |