CN115590910A - Preparation method of radix paeoniae alba decoction pieces based on biological enzymolysis - Google Patents
Preparation method of radix paeoniae alba decoction pieces based on biological enzymolysis Download PDFInfo
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- CN115590910A CN115590910A CN202211382208.5A CN202211382208A CN115590910A CN 115590910 A CN115590910 A CN 115590910A CN 202211382208 A CN202211382208 A CN 202211382208A CN 115590910 A CN115590910 A CN 115590910A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
Radix Paeoniae alba has effects of nourishing blood, regulating menstruation, protecting liver and benefiting spleen. The preparation method of the radix paeoniae alba decoction pieces based on biological enzymolysis solves the problems of backward processing level and the like of the traditional technology, reduces the irritation of the decoction pieces, retains the nutrient components of the radix paeoniae alba to the maximum extent, has high leaching rate, is easy to absorb and is convenient to take.
Description
Technical Field
The invention relates to a preparation method of radix paeoniae alba decoction pieces based on biological enzymolysis.
Background
White peony root, a traditional Chinese medicine in China, is the dry root of the plant white peony root. Picking, cleaning, removing head and tail, decocting, removing skin, decocting, and drying in sunlight. Has effects in nourishing blood, regulating menstruation, astringing yin, arresting sweating, nourishing liver, relieving pain, and suppressing liver yang. The white peony root decoction pieces are prepared by a traditional white peony root processing method, wherein white peony root is cleaned, moistened in a container of 36918after being cut into slices and dried. The traditional processing level is backward, the utilization rate is low, active substances are seriously damaged, and the like, and the traditional processing method is generally used for soaking wine and cooking, can cause the damage of nutrient components after long-time soaking and high-temperature cooking, and has irregular and uneven sizes and shapes of decoction pieces.
Disclosure of Invention
The invention aims to provide a preparation method of white peony root decoction pieces.
The present invention adopts the following technical solutions to achieve the above objects.
(1) Pretreatment of raw materials: selecting fresh white peony root, cleaning, drying at 50 ℃, cutting the dried white peony root into small pieces, and carrying out superfine grinding to obtain white peony root powder with the particle size of 1000-2000 meshes:
(2) Adding water into radix Paeoniae alba, adjusting pH to 4.8-5.0, adding acid enzyme, and stirring at 50 deg.C; adjusting pH of the enzymolysis solution to 8.0-9.0, adding alkaline enzyme, and performing enzymolysis reaction at 60 deg.C for 1.5 hr;
(3) Separation: centrifuging the enzymolysis liquid prepared in the step (2), removing precipitates, and collecting supernatant;
(4) And (3) drying: spray drying the enzymolysis supernatant prepared in the step (3);
(5) Tabletting: and (5) crushing and uniformly mixing the extract prepared in the step (4), sieving the mixture to obtain a powder with the particle size of 100 meshes, and tabletting the powder by using a tabletting machine to form the tablet.
The granularity of the crushed raw materials in the step (1) is 1000-2000 meshes.
The acid enzyme in the step (2) is two or three of cellulase (0.5-1.5%), hemicellulase (0.2-0.5%) and pectinase (0.3-0.8%); the alkaline enzyme is two or three of cellulase (0.5-1.5%), protease (0.2-0.4%) and pectinase (0.3-0.8%);
the extract in the step (5) is crushed to have the particle size of 100 meshes.
The present invention will be further illustrated by the following examples, but the scope of the present invention is not limited to the following examples.
Drawings
FIG. 1: extract content (%) obtained for each group.
Detailed Description
Example 1: (1) pretreatment of raw materials: selecting fresh white peony root, cleaning, drying at 50 deg.C, cutting dried white peony root into small pieces, and ultramicro-pulverizing to obtain powder with particle size of 1000-2000 meshes.
(2) Biological enzymolysis: adding water into radix Paeoniae alba, adjusting pH to 4.8-5.0, adding acidic cellulase 1.5%, acidic hemicellulase 0.5% and acidic pectinase 0.8%, and stirring at 50 deg.C for 1.5 hr; adjusting pH of the enzymolysis solution to 8.0-9.0, adding alkaline cellulase 1.5%, alkaline protease 0.5% and alkaline pectinase 0.8%, and performing enzymolysis reaction at 60 deg.C for 1.5 hr;
(3) Separation: centrifuging the enzymolysis liquid prepared in the step (2), removing precipitates, and collecting supernatant;
(4) And (3) drying: spray drying the enzymolysis supernatant prepared in the step (3);
(5) Tabletting: and (4) crushing and uniformly mixing the extract prepared in the step (4), sieving the mixture to obtain a powder with the particle size of 100 meshes, and tabletting the powder by using a tabletting machine to form the tablet.
Example 2: raw material pretreatment: selecting fresh white peony root, cleaning, drying at 50 deg.C, cutting the dried white peony root into small pieces, and ultramicro-pulverizing to obtain the invented product whose grain size is 1000-2000 meshes.
(2) Biological enzymolysis: adding water into radix Paeoniae alba, adjusting pH to 4.8-5.0, adding acidic cellulase 1%, acidic hemicellulase 0.3% and acidic pectinase 0.5%, and stirring at 50 deg.C for 1 hr; adjusting pH of the enzymolysis solution to 8.0-9.0, adding 1% of alkaline cellulase, 0.3% of alkaline protease and 0.5% of alkaline pectinase, and performing enzymolysis reaction at 60 deg.C for 1 hr;
(3) Separation: centrifuging the enzymolysis liquid prepared in the step (2), removing precipitates, and collecting supernatant;
(4) And (3) drying: spray drying the enzymolysis supernate prepared in the step (3);
(5) Tabletting: and (5) crushing and uniformly mixing the extract prepared in the step (4), sieving the mixture to obtain a powder with the particle size of 100 meshes, and tabletting the powder by using a tabletting machine to form the tablet.
Example 3: raw material pretreatment: selecting fresh white peony root, cleaning, drying at 50 deg.C, cutting dried white peony root into small pieces, and ultramicro-pulverizing to obtain powder with particle size of 1000-2000 meshes.
(2) Biological enzymolysis: adding water into radix Paeoniae alba, adjusting pH to 4.8-5.0, adding acidic cellulase 1%, acidic hemicellulase 0.3% and acidic pectinase 0.5%, and stirring at 50 deg.C for 1.5 hr; adjusting pH of the enzymolysis solution to 8.0-9.0, adding 1% of alkaline cellulase, 0.3% of alkaline protease and 0.5% of alkaline pectinase, and performing enzymolysis reaction at 60 deg.C for 1.5 hr;
(3) Separation: centrifuging the enzymolysis liquid prepared in the step (2), removing precipitates, and collecting supernatant;
(4) And (3) drying: spray drying the enzymolysis supernatant prepared in the step (3);
(5) Tabletting: and (5) crushing and uniformly mixing the extract prepared in the step (4), sieving the mixture to obtain a powder with the particle size of 100 meshes, and tabletting the powder by using a tabletting machine to form the tablet.
Comparative example: weighing 10g of the prepared white paeony root decoction pieces and three commercially available white paeony root decoction pieces 1, 2 and 3 respectively, decocting for 20min by using water, centrifuging to remove precipitates, drying and weighing, calculating extract content (%) according to the reduced amount of the precipitates, and comparing the extract contents of the prepared white paeony root decoction pieces and the three commercially available products.
As can be seen from figure 1, the radix paeoniae alba decoction pieces prepared by the method can obviously improve the leaching rate of active ingredients compared with the commercially available products.
Claims (4)
1. The invention relates to a preparation method of radix paeoniae alba decoction pieces based on biological enzymolysis, which mainly solves the problems of backward processing level, low utilization rate, serious active substance damage and the like in the prior art and is characterized by comprising the following steps:
(1) Pretreatment of raw materials: selecting fresh white peony root, cleaning, drying at 50 ℃, cutting the dried white peony root into small pieces, and carrying out superfine grinding;
(2) Biological enzymolysis: adding water into radix Paeoniae alba, adjusting pH to 4.8-5.0, adding acid enzyme, and stirring at 50 deg.C; adjusting pH of the enzymolysis solution to 8.0-9.0, adding alkaline enzyme, and performing enzymolysis reaction at 60 deg.C for 1.5 hr;
(3) Separation: centrifuging the enzymolysis liquid prepared in the step (2), removing precipitates, and collecting supernatant;
(4) And (3) drying: spray drying the enzymolysis supernatant prepared in the step (3);
(5) Tabletting: and (4) crushing and uniformly mixing the extract prepared in the step (4), sieving, and tabletting by using a tabletting machine.
2. The method for preparing radix paeoniae alba decoction pieces based on biological enzymolysis as claimed in claim 1, wherein the particle size of the crushed raw materials in step (1) is 1000-2000 meshes.
3. The method for preparing radix paeoniae alba decoction pieces based on biological enzymolysis according to claim 1, wherein the acid enzyme in step (2) is two or three of cellulase (0.5-1.5%), hemicellulase (0.2-0.5%) and pectinase (0.3-0.8%); the alkaline enzyme is two or three of cellulase (0.5-1.5%), protease (0.2-0.4%) and pectinase (0.3-0.8%).
4. The method for preparing radix paeoniae alba decoction pieces based on biological enzymolysis as claimed in claim 1, wherein the extract in the step (5) is ground into particles with a size of 100 meshes.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211382208.5A CN115590910A (en) | 2022-11-07 | 2022-11-07 | Preparation method of radix paeoniae alba decoction pieces based on biological enzymolysis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211382208.5A CN115590910A (en) | 2022-11-07 | 2022-11-07 | Preparation method of radix paeoniae alba decoction pieces based on biological enzymolysis |
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| CN115590910A true CN115590910A (en) | 2023-01-13 |
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| CN202211382208.5A Pending CN115590910A (en) | 2022-11-07 | 2022-11-07 | Preparation method of radix paeoniae alba decoction pieces based on biological enzymolysis |
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- 2022-11-07 CN CN202211382208.5A patent/CN115590910A/en active Pending
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