CN107213445A - A kind of antiallergic composition and preparation method and application - Google Patents
A kind of antiallergic composition and preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The present invention relates to a kind of antiallergic composition and preparation method and application, the raw material of the antiallergic composition includes the component of following weight/mass percentage composition：Chamomile 15~25%, ginger 25~36%, radix glycyrrhizae 1~10%, centella 1~10%, polysorbas20 2~15%.Preparation method includes：The chamomile, ginger, radix glycyrrhizae, centella are dried, particle is ground into after mixing, alcohol extracting is separated afterwards, takes supernatant；Activated carbon is added into supernatant, places, centrifuges to obtain supernatant liquor；Gained supernatant liquor is distilled, and is dried, and is added the polysorbas20, is obtained antiallergic composition.The antiallergic composition of the present invention carries out the adjustment and replacement of component on the basis of CN102552076A, by synergy, more efficient antiallergic effect is obtained, the anti-allergy preparation is applied in skin care, bathing class cosmetics, the excitant of cosmetics is reduced, allergic reaction is reduced.
Description
Technical field
The present invention relates to field of fine chemical, and in particular to a kind of antiallergic composition and preparation method and application.
Background technology
Cosmetics be protection human body skin health, promote beauty articles for daily use, with cleaning skin, prevent and treat skin disease,
Anticracking, sun-proof, the effect of enhancing skin-nourishing.But a large amount of with cosmetics use, while cosmetics make one to become " beautiful ",
Also the problem of some are noticeable is brought, disease of skin also rolls up because of caused by cosmetics, allergic is exactly wherein
Extremely common one kind.Such as cosmetics cause that skin is red, swollen, hot, itched, pain, allergy of getting blister problem, not only can not find U.S.
Sensation, embarrassment but occur often.
The reason for cosmetics cause allergic is due to some of cosmetics composition, and stimulation is produced to Skin Cell,
Skin Cell is set to produce antibody, so as to cause allergy.Cosmetics sensitization source at most be spices, emulsifying agent, preservative, a huge sum of money
Category.In order that cosmetics have good smell, the outward appearance for attracting consumer's eyeball and prolonged shelf-life, the overwhelming majorityization
Cosmetic inevitably with the addition of spices, emulsifying agent and preservative, although these composition additions are less, result in skin
The generation of allergy.
At present, in order to avoid cosmetics cause allergic, formulator adds anti-sensitizer when deisgn product is formulated.But
Antiallergic composition in cosmetic formulations is a little chemical compositions mostly, and the chemicals of one-component can not have in cosmetic formulations
The allergy rate of effect reduction user.Some preparations can not produce a desired effect when usage amount is smaller, when increasing usage amount more
Skin is easily stimulated, allergy rate is improved.Even some producers ignore the requirement of regulation and made to obtain the effect got instant result
The safety of user, addition hormone is used as anti-sensitizer in product formula, although very short time can reach effect, but this method is only
It can cure the symptoms, not the disease, use for a long time, skin can be caused to develop immunity to drugs and dependence, over time, skin can be caused
Skin lesion.
At present, the problem of a kind of anti-sensitizer of highly effective and safe is in the urgent need to address in cosmetic industry, major ingredient companies
Also in full preparation antiallergic is carried out to plant extracts in terms of research, but there is not been reported, without breakthrough.
The method for preparing anti-sensitizer using the extract of chamomile, the leaf of bamboo, cactus, radix glycyrrhizae and ginger one of which has
Report, but by experiment, antiallergic effect is still unsatisfactory.
The content of the invention
In view of problems of the prior art, an object of the present invention is to provide a kind of antiallergic composition, it is described
The raw material of antiallergic composition includes the component of following weight/mass percentage composition：
Chamomile 15~25%, ginger 25~36%, radix glycyrrhizae 1~10%, centella 1~10%, Tween-20 2~15%.
For example, wherein the weight/mass percentage composition of chamomile be 15%, 18%, 20%, 21%, 22%, 23%, 24% or
25% etc., the weight/mass percentage composition of ginger is 25%, 28%, 30%, 31%, 32%, 33%, 34%, 35% or 36% etc., sweet
The weight/mass percentage composition of grass is 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% etc., the quality hundred of centella
It is 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% etc. to divide content, and the weight/mass percentage composition of Tween-20 is
2%th, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14% or 15% etc..
The raw material of the antiallergic composition preferably includes the component of following weight/mass percentage composition：
Chamomile 17~20%, ginger 30~32%, radix glycyrrhizae 3~5%, centella 3~5%, Tween-20 3~5%.
The second object of the present invention is to provide the preparation method of the antiallergic composition as described in the first purpose, including following step
Suddenly：
The chamomile, ginger, radix glycyrrhizae, centella are dried, particle is ground into after mixing, alcohol extracting is separated, taken afterwards
Clear liquid；Activated carbon is added into supernatant, places, centrifuges to obtain supernatant liquor；Gained supernatant liquor is distilled, and is dried, and is added
The Tween-20, obtains antiallergic composition.
The alcohol of the alcohol drawings preferably include concentration be 50~90wt% ethanol, for example concentration be 50wt%, 52wt%,
55wt%, 58wt%, 60wt%, 63wt%, 66wt%, 69wt%, 70wt%, 72wt%, 75wt%, 78wt%, 80wt%,
82wt%, 85wt%, 88wt% or 90wt% ethanol.
Preferably, the mass/volume of the particle and the alcohol of the alcohol drawings is 1:(5~25), such as 1:5、1:8、1:
10、1:12、1:15、1:16、1:17、1:18、1:20、1:22、1:24 or 1:25 etc., preferably 1:(16~18).
Preferably, the activated carbon account for the supernatant volumn concentration be 10~50%, such as 10%, 12%,
15%th, 18%, 20%, 23%, 26%, 30%, 35%, 38%, 40%, 43%, 47% or 50% etc..
The third object of the present invention is to provide the application of the antiallergic composition as described in the first purpose.
A kind of antiallergic frost, its raw material includes the material of following mass percent：
Stearyl alcohol 3.0~7.0%, Dormant oils 2.0~6.0%, octanoic acid or Triglyceride DDD 2.0~6.0%, olive oil
5.0~10.0%, antiallergic composition 0.05~3.0% described in the first purpose, PEG-100 stearic acid and tristerin 1.0
~5.0%, glycerine 4.0~10.0%, spices 0.05~0.2%, preservative 0.1~0.4%, surplus is deionized water.
For example stearyl alcohol 3.0%, 3.2%, 3.5%, 3.8%, 4.0%, 4.2%, 4.3%, 4.5%, 4.8%,
5.0%th, 5.3%, 5.6%, 6.0%, 6.3%, 6.7% or 7.0% etc., Dormant oils 2.0%, 2.2%, 2.5%, 2.8%,
3.0%th, 3.2%, 3.5%, 3.8%, 4.0%, 4.2%, 4.3%, 4.5%, 4.8%, 5.0%, 5.3%, 5.6% or
6.0% etc., octanoic acid or Triglyceride DDD 2.0%, 2.2%, 2.5%, 2.8%, 3.0%, 3.2%, 3.5%, 3.8%,
4.0%th, 4.2%, 4.3%, 4.5%, 4.8%, 5.0%, 5.3%, 5.6% or 6.0% etc., olive oil 5.0%, 5.3%,
5.6%th, 6.0%, 6.3%, 6.7%, 7.0%, 7.5%, 8%, 8.5%, 9%, 9.5% or 10% etc., described in the first purpose
Antiallergic composition 0.05%, 0.1%, 0.2%, 0.5%, 0.8%, 1%, 1.5%, 2%, 2.3%, 2.8% or 3.0% etc.,
PEG-100 stearic acid and tristerin 1.0%, 1.5%, 2%, 2.5%, 3.0%, 3.2%, 3.5%, 3.8%,
4.0%th, 4.2%, 4.3%, 4.5%, 4.8% or 5.0% etc., the wherein ratio of PEG-100 stearic acid and tristerin
Do not limit.Glycerine 4.0%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 8%, 9% or 10.0% etc., spices 0.05%,
0.08%th, 0.1%, 0.12%, 0.15%, 0.18% or 0.2% etc., preservative 0.1%0.2%0.3% or 0.4% etc..
A kind of antiallergic nourishing and moisturizing emulsion, its raw material includes the material of following mass percent：
Stearyl alcohol 0.5~3.0%, stearic acid 1.0~4.0%, isopropyl palmitate 3.0~6.0%, polydimethylsiloxanes
Alkane 0.5~4.0%, PEG-20 methyls sesquistearate 1.0~3.0%, methyl glucoside sesquistearate 0.5
~2.5%, antiallergic composition 0.05~3.0% described in the first purpose, glycerine 4.0~8.0%, spices 0.05~0.15% is prevented
Rotten agent 0.1~0.4%, surplus is deionized water.
For example, wherein stearyl alcohol 0.5%, 0.8%, 1%, 1.5%, 2%, 2.3%, 2.8% or 3.0% etc., stearic acid
1%th, 1.5%, 2%, 2.3%, 2.8%, 3.0%, 3.2%, 3.5%, 3.8% or 4.0% etc., isopropyl palmitate 3.0%,
3.2%th, 3.5%, 3.8%, 4.0%, 4.2%, 4.3%, 4.5%, 4.8%, 5%, 5.5% or 6% etc., polydimethylsiloxanes
Alkane 0.5%, 0.8%, 1%, 1.5%, 2%, 2.3%, 2.8%, 3.0%, 3.2%, 3.5%, 3.8% or 4.0% etc., PEG-
20 methyl sesquistearates 1%, 1.5%, 2%, 2.3%, 2.8% or 3.0% etc., methyl glucoside times semi-solid fat
Acid esters 0.5%, 0.8%, 1%, 1.5%, 2%, 2.3% or 2.5% etc., antiallergic composition 0.05% described in the first purpose,
0.1%th, 0.2%, 0.5%, 0.8%, 1%, 1.5%, 2%, 2.3%, 2.8% or 3.0% etc., glycerine 4.0%, 4.2%,
4.3%th, 4.5%, 4.8%, 5%, 5.5%, 6%, 6.5%, 7% or 8% etc., spices 0.05%, 0.08%, 0.1%,
0.12% or 0.15% etc., preservative 0.1%, 0.2%, 0.3% or 0.4% etc..
A kind of antiallergic anti-ageing face mask, its raw material includes the material of following mass percent：
Cetostearyl alcohol 1.0~4.0%, olive oil 2.0~5.0%, dimethyl silicone polymer 1.0~4.0%, octanoic acid/
Triglyceride DDD 2.0~5.0%, tocopherol acetate 0.2~2.0%, shea butter 0.5~3.0%, PEG-100 is stearic
Acid and stearine 0.5~2.0%, jojoba oil 1.0~4.0%, antiallergic composition 0.05 described in the first purpose~
3.0%, glycerine 3.0~7.0%, hyaluronic acid 0.01~0.2%, spices 0.05~0.15%, preservative 0.1~0.4% is remaining
Measure as deionized water.
A kind of Gel miles of antiallergic whitening and skin-protecting, its raw material includes the material of following mass percent：
Glycerine 4.0~10.0%, hyaluronic acid 0.01~0.2%, acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters is handed over
Linked polymer 0.2~2.0%, VC0.3~2.0%, antiallergic composition 0.05~3.0% described in the first purpose, triethanolamine 0.3
~1.5%, spices 0.05~0.15%, preservative 0.1~0.4%, surplus is deionized water.
A kind of antiallergic mildy wash, its raw material includes the material of following mass percent：
Laureth sodium sulfovinate 10.0~30.0%, stearyl alcohol 2.0~6.0%, Cocoamidopropyl betaine 5.0
~10.0%, lauryl glucoside 2.0~5.0%, ethylene glycol monostearate 0.5~2.5%, EGDS
0.5~2.5%, antiallergic composition 0.05~3.0% described in the first purpose, glycerine 3.0~8.0%, spices 0.05~0.15%,
Preservative 0.1~0.4%, surplus is deionized water.
A kind of antiallergic shower cream, its raw material includes the material of following mass percent：Potassium laurate 5.0~15.0%, the moon
Osmanthus amido propyl betaine 3.0~9.0%, coconut oleoyl amine DEA2.0~6.0%, laureth sodium sulfovinate 5.0~
10.0%, olive oil 1.0~4.0%, PEG-6000 2.0~5.0%, EDTA0.05~0.5%, described in the first purpose
Antiallergic composition 0.05~3.0%, spices 0.05~0.15%, preservative 0.1~0.4%, surplus is deionized water.
Relative to prior art, the present invention at least has the advantages that：
The antiallergic composition of the present invention carries out the adjustment and replacement of component on the basis of CN102552076A, is made by cooperateing with
With the anti-allergy preparation is applied in skin care, bathing class cosmetics, reduces cosmetics by the more efficient antiallergic effect of acquirement
Excitant, reduce allergic reaction.
Embodiment
Technical scheme is further illustrated below by embodiment.
For the present invention is better described, technical scheme is readily appreciated, it is as follows that the present invention enumerates embodiment.Ability
Understanding is of the invention it will be clearly understood that the embodiment is only to aid in by field technique personnel, is not construed as the concrete restriction to the present invention.
In following embodiments unless otherwise specified, the % is weight/mass percentage composition.
Embodiment 1
Antiallergic composition A, is prepared by the following method：
15% chamomile, 36% ginger, 1% radix glycyrrhizae, 10% centella are dried, little particle is ground into, with 50% second
Alcohol solution extracts 8h, and solid-to-liquid ratio is 1: 5 (mass/volume), and extraction terminates, and is centrifuged, and takes supernatant, then up clear liquid
It is middle to add the activated carbon that volumn concentration is 25%, place after 8h, centrifuge to obtain supernatant, vacuum distillation is carried out to supernatant,
Recycling design ethanol, yellow paste in cucurbit is dried in vacuo, and is added 2% Tween-20, is produced antiallergic composition A.
Embodiment 2
Antiallergic composition B, is prepared by the following method：
25% chamomile, 25% ginger, 10% radix glycyrrhizae, 1% centella are dried, little particle is ground into, with 75% second
Alcoholic solution extracts 4h, and solid-to-liquid ratio is 1: 15 (mass/volume), and extraction terminates, and is centrifuged, and takes supernatant, then by supernatant
It is middle to add the activated carbon that volumn concentration is 10%, place after 12h, centrifuge to obtain supernatant, vacuum distillation is carried out to supernatant,
Recycling design ethanol, yellow paste in cucurbit is dried in vacuo, and is added 15% Tween-20, is produced antiallergic composition
B。
Embodiment 3
Antiallergic composition C, is prepared by the following method：
17% chamomile, 32% ginger, 3% radix glycyrrhizae, 5% centella are dried, little particle is ground into, with 90% ethanol
Solution extracts 1h, and solid-to-liquid ratio is 1: 25 (mass/volume), and extraction terminates, and is centrifuged, and takes supernatant, then by supernatant
The activated carbon that volumn concentration is 50% is added, places after 15h, centrifuges to obtain supernatant, vacuum distillation is carried out to supernatant, is returned
Etoh solvent is received, yellow paste in cucurbit is dried in vacuo, 3% Tween-20 is added, produces antiallergic composition C.
Embodiment 4
Antiallergic frost, is made up of following raw material：
5.0% stearyl alcohol, 6.0% Dormant oils, 2.0% glycerol decanoate, 8.0% olive oil, the antiallergic of 3.0% embodiment 2
Composition B, 3.0%PEG-100 stearic acid and tristerin, 10.0% glycerine, 0.05% spices, 0.25%GPL anti-corrosions
Agent, 62.7% deionized water.
Comparative example 1
With differing only in for embodiment 4：Substituted and implemented with the antiallergic composition (B) in CN102552076A embodiments 1
The antiallergic composition B of example 4.
Embodiment 5
Nourishing and moisturizing emulsion, is made up of following raw material：
0.5% stearyl alcohol, 2.5% stearic acid, 6.0% isopropyl palmitate, 4.0% dimethyl siloxane, 2.0% methyl
The ether sesquistearate of glucoside ethylene glycol -20,0.5% methyl glucoside sesquistearate, 0.05% embodiment 1
Antiallergic composition A, 6.0% glycerine, 0.15% spices, 0.1%GPL preservatives, 79.2% deionized water.
Comparative example 2
With differing only in for embodiment 5：Substituted and implemented with the antiallergic composition (A) in CN102552076A embodiments 1
The antiallergic composition A of example 5.
Embodiment 6
Anti-ageing face mask, is made up of following raw material：
4.0% cetostearyl alcohol, 2.0% olive oil, 2.5% dimethicone, 5.0% caprylic/capric glyceride,
0.2% tocopherol acetate, 2.0% shea butter, 0.5%PEG-100 stearic acid and tristerin, 4.0% Jojoba
Oil, the antiallergic composition C of 1.5% embodiment 3,5.0% glycerine, 0.2% hyaluronic acid, 0.05% spices, 0.4%GPL anti-corrosions
Agent, 72.65% deionized water.
Comparative example 3
With differing only in for embodiment 6：Substituted and implemented with the antiallergic composition (C) in CN102552076A embodiments 1
The antiallergic composition C of example 6.
Embodiment 7
Whitening and skin-protecting is seen mile, is made up of following raw material：
7.0% glycerine, 0.2% hyaluronic acid, 0.2%C10-30 alkylol acrylamide acid esters cross-linked polymers, 0.3% embodiment
2 antiallergic composition B, 0.05%VC, 1.5% triethanolamine, 0.1% spices, 0.1%GPL preservatives, 90.55% deionization
Water.
Comparative example 4
With differing only in for embodiment 7：Substituted and implemented with the antiallergic composition (B) in CN102552076A embodiments 1
The antiallergic composition B of example 7.
Embodiment 8
Mildy wash, is made up of following raw material：
20.0% laureth sodium sulfovinate, 6.0% stearyl alcohol, 5.0% Cocoamidopropyl betaine, 2.0% month
Osmanthus base glucoside, 5.0% EGDS, the antiallergic composition B of 1.5% embodiment 2,5.0% glycerine, 0.15% is fragrant
Material, 0.1%GPL preservatives, 55.25% deionized water.
Comparative example 5
With differing only in for embodiment 8：Substituted and implemented with the antiallergic composition (B) in CN102552076A embodiments 1
The antiallergic composition B of example 8.
Embodiment 9
Shower cream, is made up of following raw material：
10.0% potassium laurate, 6.0% lauroylamidopropyl betaine, 4.0% coconut oleoyl amine DEA, 10% laruyl alcohol gathers
Ether sodium sulfovinate, 1.0% olive oil, 2.0% PEG-6000,0.5%EDTA, the antiallergic composition of 1.5% embodiment 2
B, 0.1% spices, 0.1%GPL preservatives, 64.8% deionized water.
Comparative example 6
With differing only in for embodiment 9：Substituted and implemented with the antiallergic composition (B) in CN102552076A embodiments 1
The antiallergic composition B of example 9.
The clinic of the antiallergic product of other extracts of embodiment 4-9 and comparative example 1-6 antiallergic product and addition equal amount
Effect test：
Human experimentation, test population is constituted by particular experiment crowd, and test subject uses cosmetics (and cosmetics work(
Effect composition) before and after cause the possibility of human body skin adverse reaction.
Spot tries device：The production of Beijing North doctor's management of investment Co., Ltd, circular, diameter 12mm.
Spot tries thing：Embodiment 4-9 and comparative example 1-6 product, chamomile frost, ginger frost, licorice spray, centella are white and right
According to frost.
Subject amounts to 30 people, and specific sex composition and age composition determine (to meet at random《Cosmetics contact dermatitis is examined
Disconnected standard and treatment principle》Include, exclusion standard).
Test the time started：On May 27th, 2016
Experimental method
(1) subject is selected by subject enrollment standard, number is 100.
(2) qualified patch material is selected, is put into after sample is infiltrated with filter paper in spot examination device, control wells are blank control
(not putting any material).The bent side of forearm that sample and blank control are affixed on into subject, is gently pressed with palm and is allowed to equably paste
Spread on skin, continue 24h.
(3) 30min is spaced after removing patch device, dermoreaction is observed after impression disappears.
(4) 24h and 48h are observed once again respectively after patch test, observe dermoreaction.
(5) result judges：
Reactionless recipient site is (0), and it is (1) that light red spot, which occurs, in skin, and skin erythema, infiltration or papule occurs for (2),
There is edematous erythema, papule for (3) in skin, and significantly red and swollen, companion's papule occurs in skin or bleb is (4).
The number for occurring 2 grades of skin adverse reactions in 100 is more than 5, or any 13 grades or more than 3 grades skins occurs
During adverse reaction, judge that tested material has adverse reaction to human body.
Test result is arranged in table 1.
Table 1
| Embodiment | (0) | (1) | (2) | (3) | (4) | Comparative example | (0) | (1) | (2) | (3) | (4) |
| Embodiment 4 | 100 | 0 | 0 | 0 | 0 | Comparative example 1 | 98 | 2 | 0 | 0 | 0 |
| Embodiment 5 | 100 | 0 | 0 | 0 | 0 | Comparative example 2 | 98 | 1 | 1 | 0 | 0 |
| Embodiment 6 | 100 | 0 | 0 | 0 | 0 | Comparative example 3 | 97 | 3 | 0 | 0 | 0 |
| Embodiment 7 | 100 | 0 | 0 | 0 | 0 | Comparative example 4 | 97 | 2 | 1 | 0 | 0 |
| Embodiment 8 | 100 | 0 | 0 | 0 | 0 | Comparative example 5 | 98 | 1 | 1 | 0 | 0 |
| Embodiment 9 | 100 | 0 | 0 | 0 | 0 | Comparative example 6 | 92 | 4 | 2 | 0 | 0 |
| Licorice spray | 85 | 11 | 4 | 0 | 0 | Chamomile frost | 83 | 15 | 2 | 0 | 0 |
| Ginger frost | 84 | 12 | 4 | 0 | 0 | Centella frost | 85 | 9 | 6 | 0 | 0 |
| Control frost | 75 | 13 | 7 | 5 | 0 | Plum blossom frost | 83 | 15 | 2 | 0 | 0 |
As it can be seen from table 1 the above results show the white effect of antiallergic substantially, better than control sample and add that equal amount is single to be carried
Take the frost of thing.The antiallergic composition of the present invention carries out the adjustment and replacement of component on the basis of CN102552076A, passes through collaboration
Effect, obtains more efficient antiallergic effect, and the anti-allergy preparation is applied in skin care, bathing class cosmetics, cosmetic is reduced
The excitant of product, reduces allergic reaction.
The preferred embodiment of the present invention described in detail above, but the present invention is not limited in above-mentioned embodiment
Detail, in the range of the technology design of the present invention, can carry out a variety of simple variants to technical scheme, these
Simple variant belongs to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to it is various can
The combination of energy no longer separately illustrates.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should equally be considered as content disclosed in this invention.
Claims (10)
1. a kind of antiallergic composition, it is characterised in that the raw material of the antiallergic composition includes the group of following weight/mass percentage composition
Point：
Chamomile 15~25%, ginger 25~36%, radix glycyrrhizae 1~10%, radix scutellariae 1~10%, Tween-20 2~15%.
2. antiallergic composition as claimed in claim 1, it is characterised in that the raw material of the antiallergic composition includes following quality
The component of percentage composition：
Chamomile 17~20%, ginger 30~32%, radix glycyrrhizae 3~5%, centella 3~5%, Tween-20 3~5%.
3. the preparation method of antiallergic composition as claimed in claim 1 or 2, it is characterised in that comprise the following steps：
The chamomile, ginger, radix glycyrrhizae, centella are dried, particle is ground into after mixing, alcohol extracting is separated afterwards, takes supernatant
Liquid；Activated carbon is added into supernatant, places, centrifuges to obtain supernatant liquor；Gained supernatant liquor is distilled, and is dried, and adds institute
Tween-20 is stated, antiallergic composition is obtained.
4. preparation method as claimed in claim 3, it is characterised in that it is 50~90wt% that the alcohol of the alcohol drawings, which includes concentration,
Ethanol；
Preferably, the mass/volume of the particle and the alcohol of the alcohol drawings is 1:(5~25), preferably 1:(16~18)；
Preferably, the volumn concentration that the activated carbon accounts for the supernatant is 10~50%.
5. a kind of antiallergic frost, it is characterised in that its raw material includes the material of following mass percent：
Stearyl alcohol 3.0~7.0%, Dormant oils 2.0~6.0%, octanoic acid or Triglyceride DDD 2.0~6.0%, olive oil 5.0~
10.0%, antiallergic composition 0.05~3.0% described in claim 1 or 2, PEG-100 stearic acid and tristerin 1.0~
5.0%, glycerine 4.0~10.0%, spices 0.05~0.2%, preservative 0.1~0.4%, surplus is deionized water.
6. a kind of antiallergic nourishing and moisturizing emulsion, it is characterised in that its raw material includes the material of following mass percent：
Stearyl alcohol 0.5~3.0%, stearic acid 1.0~4.0%, isopropyl palmitate 3.0~6.0%, dimethyl silicone polymer
0.5~4.0%, PEG-20 methyl sesquistearate 1.0~3.0%, methyl glucoside sesquistearate 0.5~
2.5%, antiallergic composition 0.05~3.0% described in claim 1 or 2, glycerine 4.0~8.0%, spices 0.05~0.15%,
Preservative 0.1~0.4%, surplus is deionized water.
7. a kind of antiallergic anti-ageing face mask, it is characterised in that its raw material includes the material of following mass percent：
Cetostearyl alcohol 1.0~4.0%, olive oil 2.0~5.0%, dimethyl silicone polymer 1.0~4.0%, caprylic/capric
Triglycerides 2.0~5.0%, tocopherol acetate 0.2~2.0%, shea butter 0.5~3.0%, PEG-100 stearic acid and
Stearine 0.5~2.0%, jojoba oil 1.0~4.0%, antiallergic composition 0.05 described in claim 1 or 2~
3.0%, glycerine 3.0~7.0%, hyaluronic acid 0.01~0.2%, spices 0.05~0.15%, preservative 0.1~0.4% is remaining
Measure as deionized water.
8. a kind of Gel miles of antiallergic whitening and skin-protecting, it is characterised in that its raw material includes the material of following mass percent：
Glycerine 4.0~10.0%, hyaluronic acid 0.01~0.2%, acrylic acid (ester) class or the crosslinking of C10-30 alkylol acrylamides acid esters
Polymer 0.2~2.0%, VC0.3~2.0%, antiallergic composition 0.05~3.0%, triethanolamine described in claim 1 or 2
0.3~1.5%, spices 0.05~0.15%, preservative 0.1~0.4%, surplus is deionized water.
9. a kind of antiallergic mildy wash, it is characterised in that its raw material includes the material of following mass percent：
Laureth sodium sulfovinate 10.0~30.0%, stearyl alcohol 2.0~6.0%, Cocoamidopropyl betaine 5.0~
10.0%, lauryl glucoside 2.0~5.0%, ethylene glycol monostearate 0.5~2.5%, EGDS 0.5
~2.5%, antiallergic composition 0.05~3.0% described in claim 1 or 2, glycerine 3.0~8.0%, spices 0.05~
0.15%, preservative 0.1~0.4%, surplus is deionized water.
10. a kind of antiallergic shower cream, it is characterised in that its raw material includes the material of following mass percent：Potassium laurate 5.0~
15.0%, lauroylamidopropyl betaine 3.0~9.0%, coconut oleoyl amine DEA2.0~6.0%, laureth sodium sulfovinate
5.0~10.0%, olive oil 1.0~4.0%, PEG-6000 2.0~5.0%, EDTA0.05~0.5%, right will
Seek antiallergic composition 0.05~3.0% described in 1 or 2, spices 0.05~0.15%, preservative 0.1~0.4%, surplus for go from
Sub- water.
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| CN201710507498.4A CN107213445A (en) | 2017-06-28 | 2017-06-28 | A kind of antiallergic composition and preparation method and application |
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| CN201710507498.4A CN107213445A (en) | 2017-06-28 | 2017-06-28 | A kind of antiallergic composition and preparation method and application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302245A (en) * | 2019-08-22 | 2019-10-08 | 广州环亚化妆品科技有限公司 | A kind of Chinese medicine composition and its preparation method and application having effects that antiallergic is repaired |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
| CN105708757A (en) * | 2016-02-17 | 2016-06-29 | 佛山市芊茹化妆品有限公司 | Antiallergic microemulsion |
-
2017
- 2017-06-28 CN CN201710507498.4A patent/CN107213445A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552076A (en) * | 2010-12-13 | 2012-07-11 | 烟台新时代健康产业日化有限公司 | Anti-allergy preparation and preparation method and application thereof |
| CN105708757A (en) * | 2016-02-17 | 2016-06-29 | 佛山市芊茹化妆品有限公司 | Antiallergic microemulsion |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302245A (en) * | 2019-08-22 | 2019-10-08 | 广州环亚化妆品科技有限公司 | A kind of Chinese medicine composition and its preparation method and application having effects that antiallergic is repaired |
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