CN107212414B - Medicinal and edible composition and application thereof, plant beverage and preparation method thereof - Google Patents
Medicinal and edible composition and application thereof, plant beverage and preparation method thereof Download PDFInfo
- Publication number
- CN107212414B CN107212414B CN201710617528.7A CN201710617528A CN107212414B CN 107212414 B CN107212414 B CN 107212414B CN 201710617528 A CN201710617528 A CN 201710617528A CN 107212414 B CN107212414 B CN 107212414B
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- water extraction
- mint
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 235000013361 beverage Nutrition 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 50
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 50
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 50
- 241000196324 Embryophyta Species 0.000 claims abstract description 37
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 33
- 235000012907 honey Nutrition 0.000 claims abstract description 33
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 30
- 229940041616 menthol Drugs 0.000 claims abstract description 30
- 239000002994 raw material Substances 0.000 claims abstract description 29
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 27
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 27
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 27
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 27
- 244000197580 Poria cocos Species 0.000 claims abstract description 27
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 27
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 27
- 235000011477 liquorice Nutrition 0.000 claims abstract description 27
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 26
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 26
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 26
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 26
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 26
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 26
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 26
- 240000000171 Crataegus monogyna Species 0.000 claims abstract description 26
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 26
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 26
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 26
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 26
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 26
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 26
- 244000274050 Platycodon grandiflorum Species 0.000 claims abstract description 26
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 26
- 235000008397 ginger Nutrition 0.000 claims abstract description 26
- 235000021282 Sterculia Nutrition 0.000 claims abstract description 22
- 229940059107 sterculia Drugs 0.000 claims abstract description 22
- 230000000694 effects Effects 0.000 claims abstract description 20
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 12
- 244000273928 Zingiber officinale Species 0.000 claims abstract 7
- 238000003809 water extraction Methods 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- 239000000706 filtrate Substances 0.000 claims description 23
- 241000628997 Flos Species 0.000 claims description 20
- 244000046146 Pueraria lobata Species 0.000 claims description 20
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 20
- 210000000582 semen Anatomy 0.000 claims description 20
- 235000006751 Platycodon Nutrition 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 229930189914 platycodon Natural products 0.000 claims description 14
- 235000021552 granulated sugar Nutrition 0.000 claims description 12
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 11
- 239000004376 Sucralose Substances 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 235000019408 sucralose Nutrition 0.000 claims description 11
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 11
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 10
- 235000021096 natural sweeteners Nutrition 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 claims description 5
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical group O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229930189775 mogroside Natural products 0.000 claims description 4
- 229940013618 stevioside Drugs 0.000 claims description 4
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019202 steviosides Nutrition 0.000 claims description 4
- 241000723353 Chrysanthemum Species 0.000 claims 6
- 241000934878 Sterculia Species 0.000 claims 6
- 235000013402 health food Nutrition 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 abstract description 21
- 201000007100 Pharyngitis Diseases 0.000 abstract description 19
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract description 18
- 240000001058 Sterculia urens Species 0.000 abstract description 16
- 235000013305 food Nutrition 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 description 26
- 210000003800 pharynx Anatomy 0.000 description 21
- 241000234314 Zingiber Species 0.000 description 19
- 238000012360 testing method Methods 0.000 description 18
- 238000004140 cleaning Methods 0.000 description 12
- 235000008216 herbs Nutrition 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 238000005520 cutting process Methods 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000002893 slag Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 238000011049 filling Methods 0.000 description 5
- 230000001684 chronic effect Effects 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- 239000006188 syrup Substances 0.000 description 4
- 235000013616 tea Nutrition 0.000 description 4
- 241001571446 Scaphium scaphigerum Species 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000005034 decoration Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- 206010001076 Acute sinusitis Diseases 0.000 description 1
- 241001529821 Agastache Species 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010014020 Ear pain Diseases 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000334160 Isatis Species 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 208000001705 Mouth breathing Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000935974 Paralichthys dentatus Species 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241001162994 Rugosus Species 0.000 description 1
- 241001412228 Scaphium lychnophorum Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 206010057040 Temperature intolerance Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 201000004427 acute laryngopharyngitis Diseases 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 235000005300 cardamomo Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229940067866 dandelion extract Drugs 0.000 description 1
- 235000020691 dandelion extract Nutrition 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 208000007176 earache Diseases 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229940105902 mint extract Drugs 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000001845 taraxacum officinale leaf extract Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
- A23L21/25—Honey; Honey substitutes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Insects & Arthropods (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
The invention relates to the technical field of food and beverage, and particularly relates to a medicinal and edible composition and application thereof, a plant beverage and a preparation method thereof. The medicinal and edible composition is prepared from, by weight, 0.1-30 parts of honey, 0.3-0.5 part of liquorice, 2-3 parts of boat-fruited sterculia seed, 0.1-3 parts of lotus seed, 0.3-0.5 part of hawthorn, 0.1-0.2 part of dried orange peel, 0.05-0.2 part of platycodon grandiflorum, 0.1-0.2 part of poria cocos, 0.1-0.2 part of dried ginger, 1-3 parts of chrysanthemum, 8-10 parts of mint, 0.1-0.2 part of honeysuckle, 0.05-0.2 part of radix puerariae and 0.01-0.15 part of menthol. The medicinal and edible composition and the plant beverage have obvious effects of clearing and moistening the throat, use medicinal and edible natural herbaceous plants as main raw materials, are sugar-free and low-energy beverages, have small weight burden, and are suitable for most consumers to drink, particularly patients with sore throat.
Description
Technical Field
The invention relates to the technical field of food and beverage, and particularly relates to a medicinal and edible composition and application thereof, a plant beverage and a preparation method thereof.
Background
Cough and throat discomfort can be caused by cold, excessive use of throat, smoking, haze and the like, and sphagitis is caused. Pharyngolaryngitis is a disease caused by bacteria, and is divided into acute pharyngolaryngitis and chronic pharyngolaryngitis. Acute pharyngolaryngitis is often caused by virus or bacteria, is most common in winter and spring, and is mostly secondary to acute rhinitis, acute sinusitis and acute tonsillitis. Chronic pharyngolaryngitis is mainly caused by recurrent attacks due to incomplete treatment of acute pharyngolaryngitis, chronic pharyngolaryngitis, or irritation to the pharynx due to obstruction of nasal orifices, long-term mouth breathing, physical and chemical factors, neck radiotherapy, etc. Clinical manifestations of acute laryngopharyngitis: adult mainly takes pharyngeal symptoms as main symptoms, throat is dry, itchy, scorching and gradually painful at the beginning of diseases, the swallowing becomes worse, saliva is increased, and the pharyngeal paranasal cable is involved, so that obvious earache is caused; the symptoms of pharyngolaryngitis of weak adults or children are marked, and the symptoms of the whole body include fever, cold intolerance, headache, inappetence, soreness of limbs and the like. Clinical manifestations of chronic pharyngolaryngitis: the throat is uncomfortable, dry, itchy and swollen, the secretion is much and burning pain, the throat is easy to dry and dislike, the throat is not fluke, the throat can not be swallowed, the symptoms are aggravated after the throat is fed with irritant food, fatigue or weather change, and the throat and the swallow are smooth.
People in daily life often prefer throat-soothing products for relief of discomfort. At present, throat-moistening products are mostly in the form of syrup or hard candy, for example, the invention patent with publication/publication number of CN104041649A discloses a breath-refreshing throat-moistening candy containing traditional Chinese medicine plant extracts and a preparation method thereof, wherein the throat-moistening candy is prepared from reed rhizome, tuckahoe, cardamom, agastache rugosus, angelica dahurica, dried orange peel, liquorice, clove, isomaltitol, menthol, acesulfame potassium, eucalyptus oil, edible essence and green tea powder; also, for example, the invention patent with publication/publication number CN102550782A discloses a herbal cool throat-moistening candy, which is prepared by processing the following raw materials: 4-5 parts of Hangzhou white chrysanthemum extract, 4-5 parts of licorice extract, 4-5 parts of isatis root extract, 4-5 parts of honeysuckle extract, 1-2 parts of mint extract, 1-2 parts of mulberry leaf extract, 3-5 parts of fructus momordicae extract, 1-2 parts of dandelion extract, 40-60 parts of starch syrup and 50-70 parts of white granulated sugar.
However, the existing throat moistening product has higher sweetness and slow relieving effect, and cannot meet the requirements of consumers. Thus, there is a need to provide a throat-moistening product that has a better and faster throat-moistening effect.
Disclosure of Invention
In view of the above, the invention provides a medicinal and edible composition and application thereof, a plant beverage and a preparation method thereof. The plant beverage has effects of clearing heat from throat and moistening throat, and has low weight burden and good stability.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a medicine-food homologous composition which is prepared from, by weight, 0.1-30 parts of honey, 0.3-0.5 part of liquorice, 2-3 parts of sterculia lychnophora, 0.1-3 parts of lotus seeds, 0.3-0.5 part of hawthorn, 0.1-0.2 part of dried orange peel, 0.05-0.2 part of platycodon grandiflorum, 0.1-0.2 part of poria cocos, 0.1-0.2 part of dried ginger, 1-3 parts of chrysanthemum, 8-10 parts of mint, 0.1-0.2 part of honeysuckle, 0.05-0.2 part of radix puerariae and 0.01-0.15 part of menthol.
Preferably, the medicinal and edible composition is prepared from 0.1 part by weight of honey, 0.4 part by weight of liquorice, 2 parts by weight of boat-fruited sterculia seed, 0.1 part by weight of lotus seed, 0.4 part by weight of hawthorn, 0.1 part by weight of dried orange peel, 0.1 part by weight of platycodon root, 0.1 part by weight of poria cocos, 0.1 part by weight of dried ginger, 3 parts by weight of chrysanthemum, 10 parts by weight of mint, 0.1 part by weight of honeysuckle, 0.1 part by weight of kudzu root and 0.05 part by weight of menthol.
In an embodiment provided by the invention, the medicinal and edible composition is prepared from 30 parts by weight of honey, 0.4 part by weight of liquorice, 2 parts by weight of boat-fruited sterculia seed, 2 parts by weight of lotus seed, 0.4 part by weight of hawthorn, 0.1 part by weight of dried orange peel, 0.1 part by weight of platycodon root, 0.1 part by weight of poria cocos, 0.1 part by weight of dried ginger, 3 parts by weight of chrysanthemum, 10 parts by weight of mint, 0.1 part by weight of honeysuckle, 0.1 part by weight of kudzu root and 0.05 part by weight of menthol.
In another embodiment provided by the invention, the medicinal and edible composition is prepared from 20 parts by weight of honey, 0.3 part by weight of liquorice, 2.5 parts by weight of boat-fruited sterculia seed, 3 parts by weight of lotus seed, 0.5 part by weight of hawthorn, 0.15 part by weight of dried orange peel, 0.2 part by weight of platycodon root, 0.15 part by weight of poria cocos, 0.2 part by weight of dried ginger, 1 part by weight of chrysanthemum, 9 parts by weight of mint, 0.15 part by weight of honeysuckle, 0.2 part by weight of kudzu root and 0.01 part by weight of menthol.
In another embodiment provided by the invention, the medicinal and edible composition is prepared from, by weight, 0.1 part of honey, 0.5 part of liquorice, 3 parts of scaphium scaphigerum, 0.1 part of lotus seed, 0.3 part of hawthorn, 0.2 part of dried orange peel, 0.05 part of platycodon grandiflorum, 0.2 part of poria cocos, 0.15 part of dried ginger, 2 parts of chrysanthemum, 8 parts of mint, 0.2 part of honeysuckle, 0.05 part of radix puerariae and 0.15 part of menthol.
Preferably, the preparation method of the medicinal and edible composition comprises the following steps:
step 1: extracting Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae, and radix Puerariae with water;
step 2: adding mint into the water extract obtained in the step 1 for water extraction to obtain a filtrate;
and step 3: mixing the filtrate with Mel and Mentholum.
Preferably, the step 1 aqueous extraction is: adding water which is 20-40 times of the weight of the raw materials for water extraction, wherein the water extraction temperature is 90-95 ℃, and the water extraction time is 18-22 min.
Preferably, the step 1 aqueous extraction is: adding water 30 times the weight of the raw materials, and extracting with water at 95 deg.C for 20 min.
Preferably, the step 2 aqueous extraction is: adding water 30 times the weight of herba Menthae, and extracting with water at 95 deg.C for 20 min.
The invention also provides application of the medicinal and edible composition in preparation of medicines or health-care foods with the effects of clearing and moistening throat.
The invention also provides a plant beverage, wherein each 10000 parts of the plant beverage comprise, by weight, 0.1-20 parts of honey, 0.3-0.5 part of liquorice, 2-3 parts of boat-fruited sterculia seed, 0.1-3 parts of lotus seed, 0.3-0.5 part of hawthorn, 0.1-0.2 part of dried orange peel, 0.05-0.2 part of platycodon root, 0.1-0.2 part of poria cocos, 0.1-0.2 part of dried ginger, 1-3 parts of chrysanthemum, 8-10 parts of mint, 0.1-0.2 part of honeysuckle, 0.05-0.2 part of kudzu root, 0.01-0.15 part of menthol, 0.1-0.4 part of natural sweetener, 15-40 parts of white granulated sugar and 0.05-0.1 part of sucralose.
Preferably, per 10000 parts of the plant beverage by weight, the raw materials comprise 0.1 part of honey, 0.4 part of liquorice, 2 parts of boat-fruited sterculia seed, 0.1 part of lotus seed, 0.4 part of hawthorn, 0.1 part of dried orange peel, 0.1 part of platycodon root, 0.1 part of tuckahoe, 0.1 part of dried ginger, 3 parts of chrysanthemum, 10 parts of mint, 0.1 part of honeysuckle, 0.1 part of kudzu root, 0.05 part of menthol, 0.2 part of natural sweetener, 40 parts of white granulated sugar and 0.05 part of sucralose.
In an embodiment provided by the invention, in each 10000 parts by weight of the plant beverage, the raw materials comprise 30 parts by weight of honey, 0.4 part by weight of liquorice, 2 parts by weight of scaphium scaphigerum, 2 parts by weight of lotus seed, 0.4 part by weight of hawthorn, 0.1 part by weight of dried orange peel, 0.1 part by weight of platycodon grandiflorum, 0.1 part by weight of poria cocos, 0.1 part by weight of dried ginger, 3 parts by weight of chrysanthemum, 10 parts by weight of mint, 0.1 part by weight of honeysuckle, 0.1 part by weight of kudzu root, 0.05 part by weight of menthol, 0.2 part by weight of natural sweetener, 15.
In another embodiment provided by the invention, the raw materials comprise, by weight, 30 parts of honey, 0.4 part of liquorice, 2 parts of scaphium scaphigerum, 2 parts of lotus seeds, 0.4 part of hawthorn, 0.1 part of dried orange peel, 0.1 part of platycodon grandiflorum, 0.1 part of poria cocos, 0.1 part of dried ginger, 3 parts of chrysanthemum, 10 parts of mint, 0.1 part of honeysuckle, 0.1 part of radix puerariae, 0.05 part of menthol, 0.2 part of natural sweetener, 15 parts of white granulated sugar and 0.05 part of sucralose per 10000 parts of the plant beverage.
Preferably, the natural sweetener is stevioside and/or mogroside.
The invention also provides a preparation method of the plant beverage, which comprises the following steps:
step 1: extracting Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae, and radix Puerariae with water;
step 2: adding mint into the water extract obtained in the step 1 for water extraction to obtain a filtrate;
and step 3: mixing the filtrate with white sugar, Mel, Mentholum, natural sweetener, and sucralose, standing, centrifuging, diluting to desired volume, and sterilizing to obtain plant beverage.
Preferably, the step 1 aqueous extraction is: adding water which is 20-40 times of the weight of the raw materials for water extraction, wherein the water extraction temperature is 90-95 ℃, and the water extraction time is 18-22 min.
Preferably, the step 1 aqueous extraction is: adding water 30 times the weight of the raw materials, and extracting with water at 95 deg.C for 20 min.
Preferably, the step 2 aqueous extraction is: adding water with the weight 20-40 times that of the mint for water extraction, wherein the water extraction temperature is 90-95 ℃, and the water extraction time is 18-22 min.
Preferably, the step 2 aqueous extraction is: adding water 30 times the weight of herba Menthae, and extracting with water at 95 deg.C for 20 min.
Preferably, a standing step is further included between the water extraction and the filtrate obtaining in the step 2, the standing temperature is 80-85 ℃, and the standing time is 30-40 min.
Preferably, a standing step is further included between the water extraction and the filtrate obtaining in the step 2, the standing temperature is 80 ℃, and the standing time is 40 min.
Preferably, the standing temperature in the step 3 is 80-85 ℃, and the standing time is 30-40 min.
Preferably, the temperature of the standing in the step 3 is 80 ℃, and the time of the standing is 40 min.
Preferably, the method further comprises a filling step after the sterilization.
Preferably, the filling temperature is 20-25 ℃.
Preferably, the water used in the tea beverage preparation method is alkaline ionized water.
Preferably, the pH of the basic ionized water: the pH value is more than 7 and less than or equal to 8.5.
The invention provides a medicinal and edible composition and application thereof, a plant beverage and a preparation method thereof. The medicinal and edible composition is prepared from, by weight, 0.1-30 parts of honey, 0.3-0.5 part of liquorice, 2-3 parts of boat-fruited sterculia seed, 0.1-3 parts of lotus seed, 0.3-0.5 part of hawthorn, 0.1-0.2 part of dried orange peel, 0.05-0.2 part of platycodon grandiflorum, 0.1-0.2 part of poria cocos, 0.1-0.2 part of dried ginger, 1-3 parts of chrysanthemum, 8-10 parts of mint, 0.1-0.2 part of honeysuckle, 0.05-0.2 part of radix puerariae and 0.01-0.15 part of menthol. The invention has at least one of the following advantages:
(1) the medicinal and edible composition has the obvious effects of clearing and moistening throat.
(2) The plant beverage has the obvious effects of clearing and moistening the throat, the natural herbaceous plants with homology of medicine and food are used as main raw materials, the product is a sugar-free low-energy beverage, the burden on the weight is small, and the plant beverage is suitable for most consumers to drink, particularly patients with sore throat.
(3) The invention uses the aseptic cold filling technology, ensures the flavor and taste of the product, and simultaneously ensures the product to be easy to store and the quality of the product.
(4) The preparation method is simple and convenient and is suitable for industrial production.
Detailed Description
The invention discloses a medicinal and edible composition and application thereof, a plant beverage and a preparation method thereof, and can be realized by appropriately improving process parameters by referring to the contents. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The medicinal and edible composition and the application thereof, the plant beverage and the raw material medicines or auxiliary materials used in the preparation method thereof can be purchased from the market.
The invention is further illustrated by the following examples:
example 1
The medicinal and edible composition mainly comprises the following raw materials in parts by weight:
0.1g of honey, 0.4g of liquorice, 2g of boat-fruited sterculia seed, 0.1g of lotus seed, 0.4g of hawthorn, 0.1g of dried orange peel, 0.1g of platycodon root, 0.1g of tuckahoe, 0.1g of dried ginger, 3g of chrysanthemum, 10g of mint, 0.1g of honeysuckle, 0.1g of kudzuvine root and 0.05g of menthol;
the manufacturing process comprises the following steps:
the first step is as follows: weighing the raw materials according to the composition proportion for later use;
the second step is that: cleaning Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae and radix Puerariae, cutting herba Menthae into 4-5cm segments, and cleaning;
the third step: carrying out primary 95-DEG C hot water extraction on the washed herbs except the mint in the alkaline ionized water with the PH of 8.0 which is 30 times of that of the herbs for 20min, adding the mint, adding the alkaline ionized water with the PH of 8.0 which is 30 times of that of the mint for secondary water extraction at the water extraction temperature of 95 ℃ for 20min, and filtering, standing, centrifuging and removing slag to obtain filtrate for later use; standing at 80 deg.C for 40 min.
The fourth step: adding honey and menthol into the filtrate obtained in the third step, uniformly stirring, standing and centrifuging to obtain the medicinal and edible composition.
Example 2
The medicinal and edible composition mainly comprises the following raw materials in parts by weight:
30g of honey, 0.4g of liquorice, 2g of boat-fruited sterculia seed, 2g of lotus seed, 0.4g of hawthorn, 0.1g of dried orange peel, 0.1g of platycodon root, 0.1g of tuckahoe, 0.1g of dried ginger, 3g of chrysanthemum, 10g of mint, 0.1g of honeysuckle, 0.1g of kudzu root and 0.05g of menthol;
the manufacturing process comprises the following steps:
the first step is as follows: weighing the raw materials according to the composition proportion for later use;
the second step is that: cleaning Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae and radix Puerariae, cutting herba Menthae into 4-5cm segments, and cleaning;
the third step: carrying out primary 95-DEG C hot water extraction on the washed herbs except the mint in the alkaline ionized water with the PH of 8.0 which is 30 times of that of the herbs for 20min, adding the mint, adding the alkaline ionized water with the PH of 8.0 which is 30 times of that of the mint for secondary water extraction at the water extraction temperature of 95 ℃ for 20min, and filtering, standing, centrifuging and removing slag to obtain filtrate for later use; standing at 80 deg.C for 40 min.
The fourth step: adding honey and menthol into the filtrate obtained in the third step, uniformly stirring, standing and centrifuging to obtain the medicinal and edible composition.
Example 3
The medicinal and edible composition mainly comprises the following raw materials in parts by weight:
20g of honey, 0.3g of liquorice, 2.5g of boat-fruited sterculia seed, 3g of lotus seed, 0.5g of hawthorn, 0.15g of dried orange peel, 0.2g of platycodon root, 0.15g of tuckahoe, 0.2g of dried ginger, 1g of chrysanthemum, 9g of mint, 0.15g of honeysuckle, 0.2g of kudzuvine root and 0.01g of menthol;
the manufacturing process comprises the following steps:
the first step is as follows: weighing the raw materials according to the composition proportion for later use;
the second step is that: cleaning Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae and radix Puerariae, cutting herba Menthae into 4-5cm segments, and cleaning;
the third step: carrying out primary 95-DEG C hot water extraction on the washed herbs except the mint in the alkaline ionized water with the PH of 8.0 which is 30 times of that of the herbs for 20min, adding the mint, adding the alkaline ionized water with the PH of 8.0 which is 30 times of that of the mint for secondary water extraction at the water extraction temperature of 95 ℃ for 20min, and filtering, standing, centrifuging and removing slag to obtain filtrate for later use; standing at 80 deg.C for 40 min.
The fourth step: adding honey and menthol into the filtrate obtained in the third step, uniformly stirring, standing and centrifuging to obtain the medicinal and edible composition.
Example 4
The medicinal and edible composition mainly comprises the following raw materials in parts by weight:
0.1g of honey, 0.5g of liquorice, 3g of boat-fruited sterculia seed, 0.1g of lotus seed, 0.3g of hawthorn, 0.2g of dried orange peel, 0.05g of platycodon root, 0.2g of tuckahoe, 0.15g of dried ginger, 2g of chrysanthemum, 8g of mint, 0.2g of honeysuckle, 0.05g of kudzuvine root and 0.15g of menthol;
the manufacturing process comprises the following steps:
the first step is as follows: weighing the raw materials according to the composition proportion for later use;
the second step is that: cleaning Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae and radix Puerariae, cutting herba Menthae into 4-5cm segments, and cleaning;
the third step: carrying out primary 95-DEG C hot water extraction on the washed herbs except the mint in the alkaline ionized water with the PH of 8.0 which is 30 times of that of the herbs for 20min, adding the mint, adding the alkaline ionized water with the PH of 8.0 which is 30 times of that of the mint for secondary water extraction at the water extraction temperature of 95 ℃ for 20min, and filtering, standing, centrifuging and removing slag to obtain filtrate for later use; standing at 80 deg.C for 40 min.
The fourth step: adding honey and menthol into the filtrate obtained in the third step, uniformly stirring, standing and centrifuging to obtain the medicinal and edible composition.
Comparative example 1
The comparative example medicinal and edible composition mainly comprises the following raw materials by weight (compared with example 1, the boat-fruited sterculia seed is lacked):
0.1g of honey, 0.4g of liquorice, 0.1g of lotus seed, 0.4g of hawthorn, 0.1g of dried orange peel, 0.1g of platycodon grandiflorum, 0.1g of poria cocos, 0.1g of dried ginger, 3g of chrysanthemum, 10g of mint, 0.1g of honeysuckle, 0.1g of radix puerariae and 0.05g of menthol;
the procedure was the same as in example 1.
Comparative example 2
The comparative medicinal and edible composition mainly comprises the following raw materials by weight (compared with the example 1, the mint is absent):
0.1g of honey, 0.4g of liquorice, 2g of boat-fruited sterculia seed, 0.1g of lotus seed, 0.4g of hawthorn, 0.1g of dried orange peel, 0.1g of platycodon root, 0.1g of tuckahoe, 0.1g of dried ginger, 3g of chrysanthemum, 0.1g of honeysuckle, 0.1g of kudzu root and 0.05g of menthol;
the procedure was the same as in example 1.
Comparative example 3
The comparative example medicinal and edible composition mainly comprises the following raw materials by weight (compared with example 1, chrysanthemum is absent):
0.1g of honey, 0.4g of liquorice, 2g of boat-fruited sterculia seed, 0.1g of lotus seed, 0.4g of hawthorn, 0.1g of dried orange peel, 0.1g of platycodon root, 0.1g of tuckahoe, 0.1g of dried ginger, 10g of mint, 0.1g of honeysuckle, 0.1g of kudzu root and 0.05g of menthol;
the procedure was the same as in example 1.
Test example 1:
clinical treatment research is carried out on patients with throat discomfort, and the effectiveness of the product is determined.
1. Case selection: 400 patients suffering from pharyngolaryngitis and having throat discomfort with peculiar smell are observed, and are divided into 8 groups by double blindness at random, and each group comprises 50 patients.
2. The treatment method comprises the following steps:
test groups 1-4 take the medicinal and edible composition prepared in examples 1-4 2 times a day, 250mL each time.
Control groups 1-3: the medicinal and edible composition prepared in the comparative examples 1-3 is taken for 2 times a day, and 250mL is taken each time.
Control group 4: no throat-moistening medicine was taken.
3. Evaluation criteria:
the effect is shown: after the traditional Chinese medicine composition is taken for three days, the symptoms are obviously improved, and the symptoms basically disappear after one week.
The method has the following advantages: the symptoms improved after three days of administration, and most of the symptoms were relieved or disappeared after one week.
And (4) invalidation: the symptoms are not obviously changed or improved after the medicine is taken.
4. The results are shown in table 1:
TABLE 1 evaluation results of throat-moistening efficacy of test group and control group
The experimental results show that the tested population does not have obvious uncomfortable symptoms during taking the medicinal and edible composition provided by the invention, throat uncomfortable symptoms can be effectively improved, the total effective rate is obviously different from that of a control group, and the results show that the medicinal and edible composition provided by the invention has the effect of obviously relieving throat discomfort.
Example 5:
1kg of plant beverage, which mainly comprises the following raw materials by weight:
15g of white granulated sugar, 30g of honey, 0.4g of liquorice, 2g of boat-fruited sterculia seed, 2g of lotus seed, 0.4g of hawthorn, 0.1g of dried orange peel, 0.1g of platycodon root, 0.1g of tuckahoe, 0.1g of dried ginger, 3g of chrysanthemum, 10g of mint, 0.1g of honeysuckle, 0.1g of kudzuvine root, 0.05g of menthol, 0.05g of sucralose and 0.2g of stevioside;
the manufacturing process comprises the following steps:
the first step is as follows: weighing the raw materials according to the composition proportion for later use;
the second step is that: cleaning Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae, and radix Puerariae, cutting herba Menthae into 4-5cm segments, and cleaning;
the third step: carrying out primary 95-DEG C hot water extraction on the washed herbs except the mint in the alkaline ionized water with the PH of 8.0 which is 30 times of that of the herbs for 20min, adding the mint, adding the alkaline ionized water with the PH of 8.0 which is 30 times of that of the mint for secondary water extraction at the water extraction temperature of 95 ℃ for 20min, and filtering, standing, centrifuging and removing slag to obtain filtrate for later use;
the fourth step: adding white granulated sugar, honey, menthol, stevioside and sucralose into the filtrate obtained in the third step, uniformly stirring, standing, centrifuging, fixing the volume, sterilizing, and finally filling at 20-25 ℃;
the standing temperature in the third step and the fourth step is 80 ℃ for 40 min.
Example 6:
1kg of plant beverage, which mainly comprises the following raw materials by weight:
15g of white granulated sugar, 30g of honey, 0.4g of liquorice, 2g of boat-fruited sterculia seed, 2g of lotus seed, 0.4g of hawthorn, 0.1g of dried orange peel, 0.1g of platycodon root, 0.1g of tuckahoe, 0.1g of dried ginger, 3g of chrysanthemum, 10g of mint, 0.1g of honeysuckle, 0.1g of kudzuvine root, 0.05g of menthol, 0.05g of sucralose and 0.2g of mogroside;
the manufacturing process comprises the following steps:
the first step is as follows: weighing the raw materials according to the composition proportion for later use;
the second step is that: cleaning Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae, radix Puerariae and fructus Siraitiae Grosvenorii, cutting herba Menthae into 4-5cm segments, and cleaning;
the third step: carrying out primary 95-DEG C hot water extraction on the washed herbs except the mint in the alkaline ionized water with the PH of 8.0 which is 30 times of that of the herbs for 20min, adding the mint, adding the alkaline ionized water with the PH of 8.0 which is 30 times of that of the mint for secondary water extraction at the water extraction temperature of 95 ℃ for 20min, and filtering, standing, centrifuging and removing slag to obtain filtrate for later use;
the fourth step: adding white granulated sugar, honey, menthol, sucralose and mogroside into the filtrate obtained in the third step, stirring uniformly, standing, centrifuging, fixing the volume, sterilizing, and finally filling at 20-25 ℃;
the standing temperature in the third step and the fourth step is 80 ℃ for 40 min.
Test example 2 evaluation test of taste of throat-moistening plant drink
The throat-moistening plant beverages of examples 5 and 6 are assigned to people with swollen and sore throat in Shanghai for tasting, the number of people is 30 in total, and the test subjects generally believe that the throat-moistening plant beverage has good sweetness, is cool after entering the mouth and has traditional Chinese medicine taste, compared with throat-moistening products such as throat-moistening sugar and syrup eaten by the test subjects before, 90% of the test subjects believe that the throat-moistening plant beverage has better mouthfeel and is more convenient to eat, and 10% of the test subjects believe that the difference is not large. Of these, 80% of the subjects considered better acceptance in example 5.
Test example 3 throat-moistening effect test
Subject: mainly aiming at patients with swollen and sore throat, the patients are divided into A, B groups and 15 patients respectively.
Group A: the throat-moistening plant beverage of the embodiment 5 of the invention is dispatched to the patient with the symptoms, and the administration method comprises the following steps: 2 bottles are taken one day, and 250mL is taken in 1 bottle, and the drink is ready to drink.
Group B: 15 patients with the above symptoms did not take the throat-moistening beverage described in example 5, but only take the placebo herbal flavored water added with the same white granulated sugar, and the taking method is the same as that of group A.
The throat-moistening curative effect is investigated after taking for 3, 7 and 10 days, and the test results are shown in tables 2 and 3:
TABLE 2 throat-moistening efficacy survey of the test population drinking the beverage of example 5
TABLE 3 throat-moistening efficacy survey of test population drinking placebo herbal flavored water
Group A: the experimental result shows that 12 people show that a certain symptom which shows the sore throat is relieved after the medicine is taken for 3 days, 3 people show that the effect is not obvious, 11 people show that the symptom of the sore throat is better and better after the medicine is taken for 7 days, 2 people show that the symptom of the sore throat is relieved, and 2 people show that the effect is not obvious; after 10 days of taking, 9 people show that the symptoms of the sore throat are obviously improved, 4 people show that the symptoms of the sore throat are improved, 1 person shows that the symptoms of the sore throat are relieved, and 1 person shows that the effect is not obvious. Only one person of the above test population showed a slight weight gain (1% rise).
Group B: the experimental result shows that after 3 days of taking, 2 people show that a certain symptom of swollen sore throat is relieved, 13 people show that the effect is not obvious, 1 person shows that the symptom of swollen sore throat is improved after 7 days of taking, 4 people show that the symptom of swollen sore throat is relieved, and 10 people show that the effect is not obvious; after 10 days of taking, 4 people show that the symptoms of the sore throat are obviously improved, 5 people show that the symptoms of the sore throat are improved, 4 people show that the symptoms of the sore throat are relieved, and 2 people show that the effect is not obvious. In 3 of the above test populations, a slight weight gain (1-5% rise) occurred.
The test result shows that the throat-moistening plant beverage disclosed in the specific example 5 has an obvious effect of relieving sore throat, and meanwhile, the low-sugar beverage has little influence on the body weight of a patient and does not increase burden on body metabolism.
Similar experiments are carried out on the bitter tea beverage described in the specific example 6, and the results are similar to those of the specific example 5, which show that the bitter tea beverage has obvious effect of relieving sore throat and has little influence on body weight after drinking the bitter tea beverage.
Discussion: from the experimental results, the low-sugar throat-moistening plant beverage provided by the invention provides better cooling, moderate sweetness and good taste of traditional Chinese medicines than similar products such as throat-moistening sugar, throat-moistening syrup and the like, and has a good health-care function of clearing and benefiting throat. The burden of energy intake of modern people can be relieved through low sugar, low energy and other requirements, and the weight cannot be obviously influenced.
Test example 4 low-sugar throat-moistening plant beverage stability test:
the low-sugar throat-moistening plant beverages of examples 5 and 6 were stored in 37 ℃ incubators at the same time, and the amount of precipitates were measured after 0, 4, 8, and 12 weeks of storage. The results are shown in the following table:
TABLE 4 stability test
As is clear from the above, in examples 5 and 6, the low-sugar throat-moistening plant beverage showed less precipitation and good stability.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
1. A medicine-food homologous composition with the efficacy of clearing and moistening throat is characterized in that,
the medicinal and edible composition is prepared from 0.1 part by weight of honey, 0.4 part by weight of liquorice, 2 parts by weight of boat-fruited sterculia seed, 0.1 part by weight of lotus seed, 0.4 part by weight of hawthorn, 0.1 part by weight of dried orange peel, 0.1 part by weight of platycodon grandiflorum, 0.1 part by weight of poria cocos, 0.1 part by weight of dried ginger, 3 parts by weight of chrysanthemum, 10 parts by weight of mint, 0.1 part by weight of honeysuckle, 0.1 part by weight of kudzu root and 0.05 part by weight;
or the medicinal and edible composition is prepared from 30 parts by weight of honey, 0.4 part by weight of liquorice, 2 parts by weight of boat-fruited sterculia seed, 2 parts by weight of lotus seed, 0.4 part by weight of hawthorn, 0.1 part by weight of dried orange peel, 0.1 part by weight of platycodon grandiflorum, 0.1 part by weight of poria cocos, 0.1 part by weight of dried ginger, 3 parts by weight of chrysanthemum, 10 parts by weight of mint, 0.1 part by weight of honeysuckle, 0.1 part by weight of kudzu root and 0.05 part by weight of;
or the medicinal and edible composition is prepared from 20 parts by weight of honey, 0.3 part by weight of liquorice, 2.5 parts by weight of boat-fruited sterculia seed, 3 parts by weight of lotus seed, 0.5 part by weight of hawthorn, 0.15 part by weight of dried orange peel, 0.2 part by weight of platycodon grandiflorum, 0.15 part by weight of poria cocos, 0.2 part by weight of dried ginger, 1 part by weight of chrysanthemum, 9 parts by weight of mint, 0.15 part by weight of honeysuckle, 0.2 part by weight of kudzu root and 0.01 part by weight of;
or the medicinal and edible composition is prepared from 0.1 part by weight of honey, 0.5 part by weight of liquorice, 3 parts by weight of boat-fruited sterculia seed, 0.1 part by weight of lotus seed, 0.3 part by weight of hawthorn, 0.2 part by weight of dried orange peel, 0.05 part by weight of platycodon grandiflorum, 0.2 part by weight of poria cocos, 0.15 part by weight of dried ginger, 2 parts by weight of chrysanthemum, 8 parts by weight of mint, 0.2 part by weight of honeysuckle, 0.05 part by weight of kudzu root and 0.15 part by weight of;
the preparation method of the medicinal and edible composition comprises the following steps:
step 1: extracting Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae, and radix Puerariae with water;
step 2: adding mint into the water extract obtained in the step 1 for water extraction to obtain a filtrate;
and step 3: mixing the filtrate with Mel and Mentholum;
step 1 water extraction comprises: adding water which is 20-40 times of the weight of the raw materials to carry out water extraction, wherein the water extraction temperature is 90-95 ℃, and the water extraction time is 18-22 min;
step 2, water extraction comprises the following steps: adding water 30 times the weight of herba Menthae, and extracting with water at 95 deg.C for 20 min.
2. The use of the medicinal and edible composition as claimed in claim 1 in the preparation of a medicament or health food having effects of clearing and moistening throat.
3. A plant beverage is characterized in that each 10000 parts of the plant beverage comprise, by weight, 0.1-20 parts of honey, 0.3-0.5 part of liquorice, 2-3 parts of boat-fruited sterculia seed, 0.1-3 parts of lotus seed, 0.3-0.5 part of hawthorn, 0.1-0.2 part of dried orange peel, 0.05-0.2 part of platycodon root, 0.1-0.2 part of tuckahoe, 0.1-0.2 part of dried ginger, 1-3 parts of chrysanthemum, 8-10 parts of mint, 0.1-0.2 part of honeysuckle, 0.05-0.2 part of kudzu root, 0.01-0.15 part of menthol, 0.1-0.4 part of natural sweetener, 15-40 parts of white granulated sugar and 0.05-0.1 part of sucralose.
4. The plant beverage according to claim 3, wherein the natural sweetener is stevioside and/or mogroside.
5. The plant beverage according to claim 4, wherein the raw materials comprise, by weight, 0.1 part of honey, 0.4 part of liquorice, 2 parts of boat-fruited sterculia seed, 0.1 part of lotus seed, 0.4 part of hawthorn, 0.1 part of dried orange peel, 0.1 part of platycodon grandiflorum, 0.1 part of poria cocos, 0.1 part of dried ginger, 3 parts of chrysanthemum, 10 parts of mint, 0.1 part of honeysuckle, 0.1 part of kudzu root, 0.05 part of menthol, 0.2 part of natural sweetener, 40 parts of white granulated sugar and 0.05 part of sucralose.
6. A method of preparing a vegetable beverage as claimed in any one of claims 3 to 5, comprising the steps of:
step 1: extracting Glycyrrhrizae radix, semen Scaphii Lychnophori, semen Nelumbinis, fructus crataegi, pericarpium Citri Tangerinae, radix Platycodi, Poria, Zingiberis rhizoma, flos Chrysanthemi, flos Lonicerae, and radix Puerariae with water;
step 2: adding mint into the water extract obtained in the step 1 for water extraction to obtain a filtrate;
and step 3: mixing the filtrate with white granulated sugar, honey, menthol, natural sweetener and sucralose, standing, centrifuging, fixing volume, and sterilizing to obtain the plant beverage.
7. The method of claim 6, wherein the water extraction of step 1 is: adding water which is 20-40 times of the weight of the raw materials to carry out water extraction, wherein the water extraction temperature is 90-95 ℃, and the water extraction time is 18-22 min; step 2, the water extraction comprises the following steps: adding water with the weight 20-40 times that of the mint for water extraction, wherein the water extraction temperature is 90-95 ℃, and the water extraction time is 18-22 min.
8. The preparation method according to claim 6, further comprising a step of standing between the water extraction and the filtrate obtaining in the step 2, wherein the standing temperature is 80-85 ℃, and the standing time is 30-40 min.
9. The preparation method according to claim 6, wherein the temperature of the standing in the step 3 is 80 to 85 ℃, and the time of the standing is 30 to 40 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710617528.7A CN107212414B (en) | 2017-07-26 | 2017-07-26 | Medicinal and edible composition and application thereof, plant beverage and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710617528.7A CN107212414B (en) | 2017-07-26 | 2017-07-26 | Medicinal and edible composition and application thereof, plant beverage and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107212414A CN107212414A (en) | 2017-09-29 |
| CN107212414B true CN107212414B (en) | 2021-02-02 |
Family
ID=59953940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710617528.7A Active CN107212414B (en) | 2017-07-26 | 2017-07-26 | Medicinal and edible composition and application thereof, plant beverage and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107212414B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116058501A (en) * | 2021-11-02 | 2023-05-05 | 宜兰食品工业股份有限公司 | Sugar-free antioxidant and antibacterial plant composition and application thereof, and plant beverage and preparation method and application thereof |
| CN116439334A (en) * | 2023-03-24 | 2023-07-18 | 云南贝泰妮生物科技集团股份有限公司 | Plant concentrated drink for improving respiratory tract immunity and preparation process thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912010A (en) * | 2010-08-24 | 2010-12-15 | 王艳华 | Health-care tea |
| CN103416574A (en) * | 2012-05-23 | 2013-12-04 | 李家波 | Chinese herbal medicine throat benefiting sugar |
| CN103392869B (en) * | 2013-07-17 | 2015-03-18 | 张晓涛 | Throat-clearing tea |
| CN105456682A (en) * | 2014-08-18 | 2016-04-06 | 邹本鉴 | Traditional Chinese medicine composition for treating chronic pharyngitis |
| CN106819731A (en) * | 2016-12-25 | 2017-06-13 | 李柳蓉 | A kind of drink of throat of releiving |
-
2017
- 2017-07-26 CN CN201710617528.7A patent/CN107212414B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107212414A (en) | 2017-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102293303B (en) | Fire-clearing health-care tea | |
| CN104041650A (en) | Heat-removing throat-smoothing lozenges containing traditional Chinese medicine plant extracts and preparation method thereof | |
| CN104012720A (en) | Tea capable of moistening throat | |
| CN103598370B (en) | Lung-clearing and throat-moistening tea bag and preparation method thereof | |
| CN112022957A (en) | Traditional Chinese medicine lung moistening, toxin expelling and lung clearing tea | |
| CN104041649B (en) | Breath-freshening and throat-wetting sugar containing Chinese medicinal herb extracts and preparation method of breath-freshening and throat-wetting sugar | |
| CN107212414B (en) | Medicinal and edible composition and application thereof, plant beverage and preparation method thereof | |
| CN102687889A (en) | Plant drink and preparation method and application thereof | |
| CN108174945B (en) | Throat clearing food for smokers and preparation method thereof | |
| CN103689163A (en) | Tea for clearing throat and benefiting lung | |
| CN109464540A (en) | A kind of alleviation oral cavity and the spray of throat discomfort and preparation method thereof | |
| CN110151851A (en) | Compound and its application based on a kind of Radix Glycyrrhizae medicine pair by honeysuckle | |
| KR101731899B1 (en) | health supplement food to Improve Respiratory Diseases and method for manufacturing the same | |
| CN101601491B (en) | Chinese medicinal beverage for dispelling summer-heat and damp, eliminating vexation and allaying thirst | |
| CN104971322A (en) | Chinese wampee fruit tablet for clearing and moistening throat | |
| CN109662184A (en) | A kind of candy and preparation method thereof that suitable smoking personage eats | |
| CN104206939A (en) | Kidney-tonifying tortoise herb jelly | |
| CN103919891A (en) | Traditional Chinese medicine composition used for cough relief of children | |
| CN106260434A (en) | A kind of heat-clearing and toxic substances removing Flos Trollii larynx moistening candy and preparation method thereof | |
| CN107582796A (en) | A kind of pure and fresh cough relief traditional Chinese medicine lozenge of diminishing inflammation and clearing pharynx and preparation method thereof | |
| CN106260427A (en) | One is regulated the flow of vital energy and middle Flos Jasmini Sambac larynx moistening candy and preparation method thereof | |
| CN106260431A (en) | A kind of looks improving and the skin nourishing Flos persicae larynx moistening candy and preparation method thereof | |
| CN106260430A (en) | A kind of blood pressure lowering Pitaya Flower larynx moistening candy and preparation method thereof | |
| CN106260425A (en) | A kind of depressed liver-energy dispersing and QI regulating Citrus aurantium L. var. amara Engl. larynx moistening candy and preparation method thereof | |
| CN106260429A (en) | A kind of moistening throat and clearing lung type Flos Eriobotryae larynx moistening candy and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |