CN107209189B - 通过糖化血红蛋白质谱对糖尿病和前驱糖尿病的快速筛选和评价 - Google Patents

通过糖化血红蛋白质谱对糖尿病和前驱糖尿病的快速筛选和评价 Download PDF

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CN107209189B
CN107209189B CN201580046748.8A CN201580046748A CN107209189B CN 107209189 B CN107209189 B CN 107209189B CN 201580046748 A CN201580046748 A CN 201580046748A CN 107209189 B CN107209189 B CN 107209189B
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globulin
diabetes
sample
blood
beta
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CN107209189A (zh
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R·K·埃尔斯
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Map Diagnostics Ltd
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Map Diagnostics Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
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  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201580046748.8A 2014-08-29 2015-08-27 通过糖化血红蛋白质谱对糖尿病和前驱糖尿病的快速筛选和评价 Active CN107209189B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1415369.6 2014-08-29
GBGB1415369.6A GB201415369D0 (en) 2014-08-29 2014-08-29 Rapid screening and evaluation of diabetes and prediabetes by glycated haemoglobin mass spectrometry
PCT/GB2015/052487 WO2016030687A1 (en) 2014-08-29 2015-08-27 Rapid screening and evaluation of diabetes and prediabetes by glycated hemoglobin mass spectrometry.

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CN107209189A CN107209189A (zh) 2017-09-26
CN107209189B true CN107209189B (zh) 2019-06-14

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US (1) US10161941B2 (enExample)
EP (1) EP3186641B1 (enExample)
JP (1) JP2017525972A (enExample)
CN (1) CN107209189B (enExample)
GB (1) GB201415369D0 (enExample)
WO (1) WO2016030687A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019074954A1 (en) * 2017-10-09 2019-04-18 Lifestory Health, Inc. SELECTING BIOMARKERS IN BODY FLUIDS FOR PATIENT STRATIFICATION AND APPLICATION OF A PRECISION MEDICAMENT THROUGH NOVEL DIAGNOSTIC BIOMARKERS
WO2019099948A1 (en) * 2017-11-17 2019-05-23 Bio-Rad Laboratories, Inc. Smart advisor for blood test evaluation
US20210239717A1 (en) * 2018-08-22 2021-08-05 Quest Diagnostics Investments Llc Microsampling detection in diabetes
CN110133280B (zh) * 2019-04-29 2022-05-20 融智生物科技（青岛）有限公司 一种β链变异的血红蛋白糖化率的测定方法
CN110658251A (zh) * 2019-10-01 2020-01-07 长沙湘华质谱医学科技有限公司 表征地中海贫血症的特征蛋白组合物或质谱模型的用途
CN111638261B (zh) * 2020-04-17 2023-04-07 融智生物科技（青岛）有限公司 一种计算设备、存储介质和地中海贫血筛查装置及系统
CN114527190A (zh) * 2022-01-14 2022-05-24 融智生物科技（青岛）有限公司 一种糖化血红蛋白检测试剂盒及其检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120107859A1 (en) * 2009-07-07 2012-05-03 Petrotchenko Evgeniy V Methods for early detection of blood disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847209A (en) * 1987-11-09 1989-07-11 Miles Inc. Latex agglutination immunoassay in the presence of hemoglobin
US20040171026A1 (en) * 2001-09-05 2004-09-02 Hochstrasser Denis Francois Diagnostic method for transmissible spongiform encephalopathies
TW200538738A (en) * 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005116607A1 (en) * 2004-05-27 2005-12-08 Monash University A method for the rapid analysis of polypeptides
WO2007117794A2 (en) * 2006-03-06 2007-10-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Glycated peptides and methods of use
JP2007263896A (ja) * 2006-03-29 2007-10-11 Univ Nagoya 肺癌患者の術後予後予測のための生物マーカー及びその方法
US7951776B2 (en) * 2006-09-01 2011-05-31 American Type Culture Collection Methods for treatment of type 1 diabetes
US9250248B2 (en) * 2006-11-01 2016-02-02 The Johns Hopkins University Early detection of diabetes
JP2011515680A (ja) * 2008-03-17 2011-05-19 ネルソン，ランドール，ダブリュ． 糖尿病のためのバイオマーカーおよびアッセイ
WO2009144229A1 (en) * 2008-05-27 2009-12-03 F. Hoffmann-La Roche Ag Method for risk reduction in glycemic control
SG195180A1 (en) 2011-05-31 2013-12-30 Singapore Health Serv Pte Ltd Method for detecting disease biomarkers
AU2014210871A1 (en) * 2013-01-31 2015-08-13 Adaerata, Limited Partnership Type 2 diabetes biomarkers and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120107859A1 (en) * 2009-07-07 2012-05-03 Petrotchenko Evgeniy V Methods for early detection of blood disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A matrix-assisted laser desorption/ionization mass spectrometry study of the non-enzymatic glycation products of human globins in diabetes;A. Lapolla et al;<Rapid Commun. Mass Spectrom.>;20050101;第19卷(第2期);第162-168页 *
A quantitative method for the analysis of glycated and glutathionylated hemoglobin by matrix-assisted laser desorption ionization-time of flight mass spectrometry;Antonino Biroccio et al;《ANALYTICAL BIOCHEMISTRY》;20050115;第336卷(第2期);第279-288页 *
Haemoglobin glycation (Hb1Ac) increases during red blood cell storage: a MALDI-TOF mass-spectrometry-based investigation;A. D’Alessandro et al;《VoxSanguinis》;20130822;第105卷(第2期);第177-180页 *
Protein Glycation in Diabetes as Determined by Mass Spectrometry;Annunziata Lapolla et al;《International Journal of Endocrinology》;20130101;第49卷(第9期);第1-12页 *

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Publication number Publication date
US10161941B2 (en) 2018-12-25
US20170254814A1 (en) 2017-09-07
JP2017525972A (ja) 2017-09-07
WO2016030687A1 (en) 2016-03-03
CN107209189A (zh) 2017-09-26
EP3186641B1 (en) 2019-07-17
GB201415369D0 (en) 2014-10-15
EP3186641A1 (en) 2017-07-05

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