CN107207489A - 作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物 - Google Patents

作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物 Download PDF

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Publication number
CN107207489A
CN107207489A CN201580074696.5A CN201580074696A CN107207489A CN 107207489 A CN107207489 A CN 107207489A CN 201580074696 A CN201580074696 A CN 201580074696A CN 107207489 A CN107207489 A CN 107207489A
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China
Prior art keywords
pyridin
thiadiazol
methoxy
nicotinamide
benzamide
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Pending
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CN201580074696.5A
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English (en)
Chinese (zh)
Inventor
P·梅钦
A·夏普
C·J·洛克
M·S·钱伯斯
A·霍奇斯
V·艾伦
J·M·埃拉德
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Jean Keogh Tex Swiss Ltd By Share Ltd
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Jean Keogh Tex Swiss Ltd By Share Ltd
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Publication of CN107207489A publication Critical patent/CN107207489A/zh
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Immunology (AREA)
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  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
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  • Ophthalmology & Optometry (AREA)
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CN201580074696.5A 2014-12-17 2015-12-16 作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物 Pending CN107207489A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14198597.8A EP3034500A1 (en) 2014-12-17 2014-12-17 Amido thiazole derivatives as NADPH oxidase inhibitors
EP14198597.8 2014-12-17
PCT/IB2015/059659 WO2016098005A1 (en) 2014-12-17 2015-12-16 Amido thiadiazole derivatives as nadph oxidase inhibitors

Publications (1)

Publication Number Publication Date
CN107207489A true CN107207489A (zh) 2017-09-26

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CN201580074696.5A Pending CN107207489A (zh) 2014-12-17 2015-12-16 作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物

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Country Link
US (2) US10130619B2 (enExample)
EP (2) EP3034500A1 (enExample)
JP (1) JP2017537948A (enExample)
KR (1) KR20170094263A (enExample)
CN (1) CN107207489A (enExample)
AU (1) AU2015365465B2 (enExample)
BR (1) BR112017012846A2 (enExample)
CA (1) CA2971357A1 (enExample)
HK (1) HK1245777A1 (enExample)
IL (1) IL252928A0 (enExample)
MX (1) MX2017007884A (enExample)
RU (1) RU2017121044A (enExample)
WO (1) WO2016098005A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN110590706A (zh) * 2019-11-06 2019-12-20 四平市精细化学品有限公司 一种n-甲基吡咯烷的制备方法
CN114174273A (zh) * 2019-03-22 2022-03-11 优曼尼蒂治疗公司 化合物和其用途

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EP3034500A1 (en) * 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors
MA46589A (fr) 2016-10-24 2019-08-28 Yumanity Therapeutics Inc Composés et utilisations de ces derniers
EP3566055B1 (en) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Scd inhibitor for the treatment of neurological disorders
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
EP3479843A1 (en) * 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer
ES3043183T3 (en) 2018-03-23 2025-11-25 Janssen Pharmaceutica Nv Compounds and uses thereof
MX2021008903A (es) 2019-01-24 2021-11-04 Yumanity Therapeutics Inc Compuestos y usos de los mismos.
CA3141134A1 (en) * 2019-05-31 2020-12-03 Ideaya Biosciences, Inc. Thiadiazolyl derivatives as dna polymerase theta inhibitors
EP3980400B1 (en) 2019-06-05 2025-08-06 Emory University Peptidomimetics for the treatment of coronavirus and picornavirus infections
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
TW202237595A (zh) * 2020-12-02 2022-10-01 美商愛德亞生物科學公司 作為DNA聚合酶θ抑制劑之經取代噻二唑基衍生物
CN117083271A (zh) * 2020-12-02 2023-11-17 伊迪亚生物科学有限公司 作为DNA聚合酶θ抑制剂的取代的噻二唑基衍生物
TW202315618A (zh) * 2021-06-11 2023-04-16 美商愛德亞生物科學公司 作為DNA聚合酶θ抑制劑之O-聯結噻二唑基化合物
WO2023060573A1 (en) * 2021-10-15 2023-04-20 Beijing Danatlas Pharmaceutical Co., Ltd. Novel thiadiazolyl derivatives of dna polymerase theta inhibitors
KR102422881B1 (ko) * 2021-11-08 2022-07-20 (주)셀로스바이오텍 신규 옥사다이아졸 유도체 및 이의 용도
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions
TW202448435A (zh) * 2023-02-28 2024-12-16 美商賽堤爾醫療公司 經取代之噻二唑基化合物
EP4695241A1 (en) * 2023-04-13 2026-02-18 Danatlas Pharmaceuticals Co., Ltd. Thiadiazolone derivatives, compositions and uses thereof

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WO2004041813A1 (en) * 2002-10-30 2004-05-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
WO2010086551A1 (fr) * 2009-01-28 2010-08-05 Sanofi-Aventis Dérivés de thiadiazoles et d'oxadiazoles, leur préparation et leur application en thérapeutique
WO2012170752A1 (en) * 2011-06-10 2012-12-13 Glaxo Wellcome Manufacturing Pte Ltd Novel compounds
WO2013038136A1 (en) * 2011-09-16 2013-03-21 The University Of Surrey BI-AROMATIC AND TRI-AROMATIC COMPOUNDS AS NADPH OXIDASE 2 (Nox2) INHIBITORS
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