CN107189983A - 产生IL‑13的Tr1‑样细胞及其用途 - Google Patents

产生IL‑13的Tr1‑样细胞及其用途 Download PDF

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Publication number
CN107189983A
CN107189983A CN201710492673.7A CN201710492673A CN107189983A CN 107189983 A CN107189983 A CN 107189983A CN 201710492673 A CN201710492673 A CN 201710492673A CN 107189983 A CN107189983 A CN 107189983A
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cells
cell
producing
people
trl
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Chinese (zh)
Inventor
阿尔诺·福萨特
埃尔韦·巴斯蒂安
瓦莱丽·布鲁恩
布里吉特·夸坦尼恩斯
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Sangamo Therapeutics SA
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TxCell SA
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/418Antigens related to induction of tolerance to non-self
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/48Allergens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
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    • G01MEASURING; TESTING
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses

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  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
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  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201710492673.7A 2010-06-30 2011-06-30 产生IL‑13的Tr1‑样细胞及其用途 Pending CN107189983A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35988510P 2010-06-30 2010-06-30
US61/359,885 2010-06-30
EP10368030A EP2412802A1 (en) 2010-07-29 2010-07-29 IL-13 producing TR1-like cells and use thereof
EP10368030.2 2010-07-29
CN201180042091XA CN103080303A (zh) 2010-06-30 2011-06-30 产生IL-13的Tr1-样细胞及其用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201180042091XA Division CN103080303A (zh) 2010-06-30 2011-06-30 产生IL-13的Tr1-样细胞及其用途

Publications (1)

Publication Number Publication Date
CN107189983A true CN107189983A (zh) 2017-09-22

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CN201710492673.7A Pending CN107189983A (zh) 2010-06-30 2011-06-30 产生IL‑13的Tr1‑样细胞及其用途
CN201180042091XA Pending CN103080303A (zh) 2010-06-30 2011-06-30 产生IL-13的Tr1-样细胞及其用途

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US (1) US20130101568A1 (enExample)
EP (2) EP2412802A1 (enExample)
JP (2) JP2013539356A (enExample)
KR (1) KR20130093083A (enExample)
CN (2) CN107189983A (enExample)
AU (1) AU2011273103B2 (enExample)
BR (1) BR112012033727A2 (enExample)
CA (1) CA2803779A1 (enExample)
CL (1) CL2012003705A1 (enExample)
MX (1) MX347533B (enExample)
NZ (1) NZ605088A (enExample)
RU (1) RU2013103765A (enExample)
WO (1) WO2012001533A2 (enExample)
ZA (1) ZA201209758B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113461822A (zh) * 2021-05-21 2021-10-01 深圳市新产业生物医学工程股份有限公司 Scl-70抗体或其结合片段、其筛选方法及包含其的检测试剂盒

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019106207A1 (en) * 2017-12-01 2019-06-06 General Electric Company Methods for cell enrichment and isolation
US11920119B2 (en) 2018-02-09 2024-03-05 Global Life Sciences Solutions Usa Llc Systems and methods for bioprocessing
US11932842B2 (en) 2018-02-09 2024-03-19 Global Life Sciences Solutions Usa Llc Bioprocessing apparatus
US12077743B2 (en) 2018-02-09 2024-09-03 Global Life Sciences Solutions Usa Llc Apparatus for fluid line management in a bioprocessing system
US10889792B2 (en) 2018-02-09 2021-01-12 Global Life Sciences Solutions Usa Llc Cell expansion vessel systems and methods
US12252682B2 (en) 2018-02-09 2025-03-18 Global Life Sciences Solutions Usa Llc System and method for fluid flow management in a bioprocessing system

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409813A (en) 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US6379670B1 (en) * 1994-11-18 2002-04-30 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
EP1248643B1 (en) * 2000-01-20 2005-08-17 YEDA RESEARCH AND DEVELOPMENT Co. LTD. The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy
FR2824567B1 (fr) * 2001-05-11 2003-08-08 Inst Nat Sante Rech Med Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene
EP1712615A1 (en) 2005-04-15 2006-10-18 Txcell In vitro production of a cell population using feeder cells
CN101151275B (zh) * 2005-04-27 2013-07-10 金克克国际有限公司 用于降低细胞因子免疫原性和去除细胞表面标记的方法
US20100034782A1 (en) * 2006-05-31 2010-02-11 Nader Najafian Methods of Using Anti-Thymocyte Globulin and Related Agents
EP2032695B1 (en) * 2006-05-31 2018-08-15 The Regents of The University of California Cd127 expression inversely correlates with foxp3 and suppressive function of cd4+ tregs
EP2050814A1 (en) * 2007-10-17 2009-04-22 Txcell Compositions for treating multiple sclerosis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113461822A (zh) * 2021-05-21 2021-10-01 深圳市新产业生物医学工程股份有限公司 Scl-70抗体或其结合片段、其筛选方法及包含其的检测试剂盒

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AU2011273103B2 (en) 2015-04-16
MX2013000115A (es) 2013-09-13
US20130101568A1 (en) 2013-04-25
RU2013103765A (ru) 2014-08-10
NZ605088A (en) 2015-05-29
EP2412802A1 (en) 2012-02-01
JP2013539356A (ja) 2013-10-24
EP2588595A2 (en) 2013-05-08
CL2012003705A1 (es) 2013-12-13
AU2011273103A1 (en) 2013-01-17
WO2012001533A3 (en) 2012-06-07
BR112012033727A2 (pt) 2017-07-18
JP2017148042A (ja) 2017-08-31
CN103080303A (zh) 2013-05-01
CA2803779A1 (en) 2012-01-05
MX347533B (es) 2017-05-02
WO2012001533A2 (en) 2012-01-05
ZA201209758B (en) 2014-03-26
KR20130093083A (ko) 2013-08-21

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Application publication date: 20170922