RU2013103765A - ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; КЛОН Tr1 ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИЙ IL-13 И IL-10; СПОСОБЫ ИДЕНТИФИКАЦИИ И ОБОГАЩЕНИЯ ПОПУЛЯЦИИ Tr1-КЛЕТОК ЧЕЛОВЕКА; ОБОГАЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; НАБОР ДЛЯ ИДЕНТИФИКАЦИИ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13, ДЛЯ ПРОФИЛАКТИКИ И/ИЛИ ЛЕЧЕНИЯ ИММУННОГО ОТВЕТА; СПОСОБ ИСТОЩЕНИЯ ПОПУЛЯЦИИ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ИСТОЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ИСТОЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13, ДЛЯ УСИЛЕНИЯ ИММУННОГО ОТВЕТА - Google Patents
ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; КЛОН Tr1 ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИЙ IL-13 И IL-10; СПОСОБЫ ИДЕНТИФИКАЦИИ И ОБОГАЩЕНИЯ ПОПУЛЯЦИИ Tr1-КЛЕТОК ЧЕЛОВЕКА; ОБОГАЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; НАБОР ДЛЯ ИДЕНТИФИКАЦИИ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13, ДЛЯ ПРОФИЛАКТИКИ И/ИЛИ ЛЕЧЕНИЯ ИММУННОГО ОТВЕТА; СПОСОБ ИСТОЩЕНИЯ ПОПУЛЯЦИИ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ИСТОЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ИСТОЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13, ДЛЯ УСИЛЕНИЯ ИММУННОГО ОТВЕТА Download PDFInfo
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- RU2013103765A RU2013103765A RU2013103765/10A RU2013103765A RU2013103765A RU 2013103765 A RU2013103765 A RU 2013103765A RU 2013103765/10 A RU2013103765/10 A RU 2013103765/10A RU 2013103765 A RU2013103765 A RU 2013103765A RU 2013103765 A RU2013103765 A RU 2013103765A
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- 102000003816 Interleukin-13 Human genes 0.000 title claims abstract 34
- 108090000176 Interleukin-13 Proteins 0.000 title claims abstract 34
- 238000000034 method Methods 0.000 title claims abstract 10
- 230000028993 immune response Effects 0.000 title claims 6
- 230000002265 prevention Effects 0.000 title claims 4
- 210000004027 cell Anatomy 0.000 claims abstract 59
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 claims abstract 10
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims abstract 10
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims abstract 10
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 claims abstract 10
- 102100033467 L-selectin Human genes 0.000 claims abstract 10
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims abstract 10
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims abstract 8
- 108010041390 Collagen Type II Proteins 0.000 claims abstract 8
- 102000000503 Collagen Type II Human genes 0.000 claims abstract 8
- 102000047918 Myelin Basic Human genes 0.000 claims abstract 8
- 102000006386 Myelin Proteins Human genes 0.000 claims abstract 8
- 108010083674 Myelin Proteins Proteins 0.000 claims abstract 8
- 101710107068 Myelin basic protein Proteins 0.000 claims abstract 8
- 108010058846 Ovalbumin Proteins 0.000 claims abstract 8
- 239000000427 antigen Substances 0.000 claims abstract 8
- 102000036639 antigens Human genes 0.000 claims abstract 8
- 108091007433 antigens Proteins 0.000 claims abstract 8
- 210000005012 myelin Anatomy 0.000 claims abstract 8
- 210000004248 oligodendroglia Anatomy 0.000 claims abstract 8
- 229940092253 ovalbumin Drugs 0.000 claims abstract 8
- 102000004169 proteins and genes Human genes 0.000 claims abstract 8
- 108090000623 proteins and genes Proteins 0.000 claims abstract 8
- 208000026935 allergic disease Diseases 0.000 claims 3
- 230000001363 autoimmune Effects 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 230000004968 inflammatory condition Effects 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 101001076430 Homo sapiens Interleukin-13 Proteins 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 102000019207 human interleukin-13 Human genes 0.000 claims 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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- A61K40/418—Antigens related to induction of tolerance to non-self
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- A61K40/48—Allergens
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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- Immunology (AREA)
- Biomedical Technology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Rheumatology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35988510P | 2010-06-30 | 2010-06-30 | |
| US61/359,885 | 2010-06-30 | ||
| EP10368030A EP2412802A1 (en) | 2010-07-29 | 2010-07-29 | IL-13 producing TR1-like cells and use thereof |
| EP10368030.2 | 2010-07-29 | ||
| PCT/IB2011/002269 WO2012001533A2 (en) | 2010-06-30 | 2011-06-30 | Il-13 producing tr1-like cells and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013103765A true RU2013103765A (ru) | 2014-08-10 |
Family
ID=43099691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013103765/10A RU2013103765A (ru) | 2010-06-30 | 2011-06-30 | ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; КЛОН Tr1 ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИЙ IL-13 И IL-10; СПОСОБЫ ИДЕНТИФИКАЦИИ И ОБОГАЩЕНИЯ ПОПУЛЯЦИИ Tr1-КЛЕТОК ЧЕЛОВЕКА; ОБОГАЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; НАБОР ДЛЯ ИДЕНТИФИКАЦИИ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13, ДЛЯ ПРОФИЛАКТИКИ И/ИЛИ ЛЕЧЕНИЯ ИММУННОГО ОТВЕТА; СПОСОБ ИСТОЩЕНИЯ ПОПУЛЯЦИИ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ИСТОЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13; ИСТОЩЕННАЯ ПОПУЛЯЦИЯ Tr1-КЛЕТОК ЧЕЛОВЕКА, ПРОДУЦИРУЮЩИХ IL-13, ДЛЯ УСИЛЕНИЯ ИММУННОГО ОТВЕТА |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130101568A1 (enExample) |
| EP (2) | EP2412802A1 (enExample) |
| JP (2) | JP2013539356A (enExample) |
| KR (1) | KR20130093083A (enExample) |
| CN (2) | CN107189983A (enExample) |
| AU (1) | AU2011273103B2 (enExample) |
| BR (1) | BR112012033727A2 (enExample) |
| CA (1) | CA2803779A1 (enExample) |
| CL (1) | CL2012003705A1 (enExample) |
| MX (1) | MX347533B (enExample) |
| NZ (1) | NZ605088A (enExample) |
| RU (1) | RU2013103765A (enExample) |
| WO (1) | WO2012001533A2 (enExample) |
| ZA (1) | ZA201209758B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019106207A1 (en) * | 2017-12-01 | 2019-06-06 | General Electric Company | Methods for cell enrichment and isolation |
| US11920119B2 (en) | 2018-02-09 | 2024-03-05 | Global Life Sciences Solutions Usa Llc | Systems and methods for bioprocessing |
| US11932842B2 (en) | 2018-02-09 | 2024-03-19 | Global Life Sciences Solutions Usa Llc | Bioprocessing apparatus |
| US12077743B2 (en) | 2018-02-09 | 2024-09-03 | Global Life Sciences Solutions Usa Llc | Apparatus for fluid line management in a bioprocessing system |
| US10889792B2 (en) | 2018-02-09 | 2021-01-12 | Global Life Sciences Solutions Usa Llc | Cell expansion vessel systems and methods |
| US12252682B2 (en) | 2018-02-09 | 2025-03-18 | Global Life Sciences Solutions Usa Llc | System and method for fluid flow management in a bioprocessing system |
| CN113461822B (zh) * | 2021-05-21 | 2022-11-11 | 深圳市新产业生物医学工程股份有限公司 | Scl-70抗体或其结合片段、其筛选方法及包含其的检测试剂盒 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409813A (en) | 1993-09-30 | 1995-04-25 | Systemix, Inc. | Method for mammalian cell separation from a mixture of cell populations |
| US6379670B1 (en) * | 1994-11-18 | 2002-04-30 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
| EP1248643B1 (en) * | 2000-01-20 | 2005-08-17 | YEDA RESEARCH AND DEVELOPMENT Co. LTD. | The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy |
| FR2824567B1 (fr) * | 2001-05-11 | 2003-08-08 | Inst Nat Sante Rech Med | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene |
| EP1712615A1 (en) | 2005-04-15 | 2006-10-18 | Txcell | In vitro production of a cell population using feeder cells |
| CN101151275B (zh) * | 2005-04-27 | 2013-07-10 | 金克克国际有限公司 | 用于降低细胞因子免疫原性和去除细胞表面标记的方法 |
| US20100034782A1 (en) * | 2006-05-31 | 2010-02-11 | Nader Najafian | Methods of Using Anti-Thymocyte Globulin and Related Agents |
| EP2032695B1 (en) * | 2006-05-31 | 2018-08-15 | The Regents of The University of California | Cd127 expression inversely correlates with foxp3 and suppressive function of cd4+ tregs |
| EP2050814A1 (en) * | 2007-10-17 | 2009-04-22 | Txcell | Compositions for treating multiple sclerosis |
-
2010
- 2010-07-29 EP EP10368030A patent/EP2412802A1/en not_active Withdrawn
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2011
- 2011-06-30 BR BR112012033727A patent/BR112012033727A2/pt not_active IP Right Cessation
- 2011-06-30 EP EP11773842.7A patent/EP2588595A2/en not_active Withdrawn
- 2011-06-30 AU AU2011273103A patent/AU2011273103B2/en not_active Ceased
- 2011-06-30 CA CA2803779A patent/CA2803779A1/en not_active Abandoned
- 2011-06-30 US US13/806,158 patent/US20130101568A1/en not_active Abandoned
- 2011-06-30 WO PCT/IB2011/002269 patent/WO2012001533A2/en not_active Ceased
- 2011-06-30 RU RU2013103765/10A patent/RU2013103765A/ru not_active Application Discontinuation
- 2011-06-30 NZ NZ605088A patent/NZ605088A/en not_active IP Right Cessation
- 2011-06-30 KR KR1020137002585A patent/KR20130093083A/ko not_active Ceased
- 2011-06-30 CN CN201710492673.7A patent/CN107189983A/zh active Pending
- 2011-06-30 JP JP2013517589A patent/JP2013539356A/ja active Pending
- 2011-06-30 CN CN201180042091XA patent/CN103080303A/zh active Pending
- 2011-06-30 MX MX2013000115A patent/MX347533B/es active IP Right Grant
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2012
- 2012-12-21 ZA ZA2012/09758A patent/ZA201209758B/en unknown
- 2012-12-27 CL CL2012003705A patent/CL2012003705A1/es unknown
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2017
- 2017-02-24 JP JP2017033061A patent/JP2017148042A/ja active Pending
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|---|---|
| AU2011273103B2 (en) | 2015-04-16 |
| MX2013000115A (es) | 2013-09-13 |
| US20130101568A1 (en) | 2013-04-25 |
| CN107189983A (zh) | 2017-09-22 |
| NZ605088A (en) | 2015-05-29 |
| EP2412802A1 (en) | 2012-02-01 |
| JP2013539356A (ja) | 2013-10-24 |
| EP2588595A2 (en) | 2013-05-08 |
| CL2012003705A1 (es) | 2013-12-13 |
| AU2011273103A1 (en) | 2013-01-17 |
| WO2012001533A3 (en) | 2012-06-07 |
| BR112012033727A2 (pt) | 2017-07-18 |
| JP2017148042A (ja) | 2017-08-31 |
| CN103080303A (zh) | 2013-05-01 |
| CA2803779A1 (en) | 2012-01-05 |
| MX347533B (es) | 2017-05-02 |
| WO2012001533A2 (en) | 2012-01-05 |
| ZA201209758B (en) | 2014-03-26 |
| KR20130093083A (ko) | 2013-08-21 |
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