CN107184902A - A kind of Chinese medicine composition for being used to treat senile dementia - Google Patents
A kind of Chinese medicine composition for being used to treat senile dementia Download PDFInfo
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- CN107184902A CN107184902A CN201710360523.0A CN201710360523A CN107184902A CN 107184902 A CN107184902 A CN 107184902A CN 201710360523 A CN201710360523 A CN 201710360523A CN 107184902 A CN107184902 A CN 107184902A
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- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention discloses a kind of Chinese medicine composition for being used to treat senile dementia, extracted and be made by the bulk drug of following parts by weight of component：40 60 parts of magnolia delavayi；30 50 parts of Herba Casythae Filiformis；40 60 parts of the Radix Astragali；40 60 parts of Radix Codonopsis；25 45 parts of the red sage root；5 15 parts of grass-leaved sweetflag；5 15 parts of root tuber of aromatic turmeric；10 30 parts of the root of herbaceous peony；5 15 parts of Ligusticum wallichii；10 20 parts of the bark of eucommia；25 45 parts of reticulate millettia；10 30 parts of Radix Angelicae Sinensis；10 20 parts of polygala；5 15 parts of radix glycyrrhizae.The present invention, which has, to be shortened water maze incubation period, extends the effect for keeping away camera bellows incubation period and reducing errors number；Give the Yao Hou models animal brain SOD vigor increase, MDA contents reduction, this research demonstrate the present invention have improvement Model of Dementia brain tissue impairment improve the curative effect of its memory function.
Description
Technical field
The invention belongs to pharmaceutical technology field, more particularly to a kind of Chinese medicine composition for being used to treat senile dementia and its
Preparation method and application.
Background technology
Senile dementia is a kind of nervous system degenerative disease of the progress sexual development of onset concealment.Clinically with memory
The generalized dementia such as obstacle, aphasia, appraxia, agnosia, the infringement of visual space technical ability, perform function obstacle and personality and behavior change
Performance is characterized, and the cause of disease is unknown so far.Hair patient before 65 years old, claims alzheimer's disease；Claimed with sequela person within 65 years old senile silly
It is slow-witted.The disease is probably one group of different substantiality disease, is just fallen ill in the presence of many factors (including biological and socio-psychological factor).
From the point of view of current research, the sick possible factor and hypothesis up to more than 30 are planted, such as family history, women, head injury, low education water
Flat, thyropathy, too high or too low, the viral infection of female reproduction age etc..The sick onset is slow or hides, and patient and household are often unable to explain clearly
When onset.More than 70 years old (male is average 73 years old, and women is 75 years old) old man is more common in, a few patients are in physical disease, fracture
Or spirit be upset after symptom it is clear rapidly.Women is more compared with male (female: man is 3: 1).It is mainly shown as under cognitive function
Drop, mental symptom and behavior disorder, activity of daily living are gradually reduced.If any anxiety, intense, insomnia, it is contemplated that use
Short-acting Benzodiazepines medicine, such as alprazolam, Oxazepam (oxazepam), Lorazepam (roller) and triazolam (Hai Le
God).Dosage answers small and unsuitable prolonged application.The pairs such as vigilant excess sedation, drowsiness, glossolalia, incoordination and instability of gait
Effect.But often there is adverse reaction in western medicine, Chinese medicine in senile dementia medication market share critical role because
Chinese medicine Small side effects, determined curative effect, it is adaptable to long-term prescription, have adapted to the characteristics of senile dementia easily recurs, clinical practice
Widely.People in the urgent need to it is a kind of it is effective, oneself by most people confirm can play the treatment senile dementia of good result
The Chinese medicine composition of disease.
The content of the invention
In view of the deficiencies in the prior art, it is an object of the invention to provide a kind of Chinese medicine group for being used to treat senile dementia
Compound and its preparation method and application.
In order to realize the purpose of the present invention, inventor is studied by lot of experiments, is finally obtained following technical scheme：
A kind of Chinese medicine composition for being used to treat senile dementia, is extracted by the bulk drug of following parts by weight of component and is made：
40-60 parts of magnolia delavayi；30-50 parts of Herba Casythae Filiformis；40-60 parts of the Radix Astragali；40-60 parts of Radix Codonopsis；25-45 parts of the red sage root；5-15 parts of grass-leaved sweetflag；
5-15 parts of root tuber of aromatic turmeric；10-30 parts of the root of herbaceous peony；5-15 parts of Ligusticum wallichii；10-20 parts of the bark of eucommia；25-45 parts of reticulate millettia；10-30 parts of Radix Angelicae Sinensis；Polygala
10-20 parts；5-15 parts of radix glycyrrhizae.
Preferably, the Chinese medicine composition for being used to treat senile dementia, is carried by the bulk drug of following parts by weight of component
Take and be made：50 parts of magnolia delavayi；40 parts of Herba Casythae Filiformis；50 parts of the Radix Astragali；50 parts of Radix Codonopsis；35 parts of the red sage root；10 parts of grass-leaved sweetflag；10 parts of root tuber of aromatic turmeric；
20 parts of the root of herbaceous peony；10 parts of Ligusticum wallichii；15 parts of the bark of eucommia；35 parts of reticulate millettia；20 parts of Radix Angelicae Sinensis；15 parts of polygala；10 parts of radix glycyrrhizae.
It is further preferred that the Chinese medicine composition for being used to treat senile dementia, preparation method comprises the following steps：
Grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis are taken, steam distillation extraction is carried out, therefrom extracts volatile oil, wrapped up using cyclodextrin,
It is standby；Take grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation extract after the aqueous solution filtering, obtain grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii,
The aqueous solution after Radix Angelicae Sinensis distillation, heating concentration obtains the concentrated liquid after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation, standby；Retain
The dregs of a decoction after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, the extraction of Radix Angelicae Sinensis steam distillation, it is standby；By gained grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis
The dregs of a decoction after steam distillation is extracted are mixed with other medicinal materials, add 90% alcohol refluxs of 3 times of amounts to extract secondary thereto, every time
Refluxing extraction 2 hours, merges ethanol extract, and filtration obtains mixed ethanol extract solution, reclaims ethanol and concentrates, obtains mixed ethanol
Concentrate is extracted, it is standby；Retain the dregs of a decoction after ethanol is extracted, it is standby；The dregs of a decoction after gained ethanol is extracted add 4 times of amount decoctings to boil
Three times, 2 hours every time, merge aqueous extract, filtration obtains mixing aqueous extract, and heating concentration obtains mixing water and extracts concentrate；
Concentrated liquid after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation, mixed ethanol are extracted into concentrate, mixing water and extract concentrate conjunction
And be spray-dried, above-mentioned cyclodextrin of volatile oil wrappage is added, addition auxiliary material is prepared into granule, tablet, capsule.
It is further preferred that the Chinese medicine composition for being used to treat senile dementia, auxiliary material is described in preparation method
For dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, methylcellulose, hydroxypropyl cellulose, carboxymethyl
The one or more of cellulose and stevioside.
It is further preferred that the Chinese medicine composition for being used to treat senile dementia is preparing treatment senile dementia medicine
Application in thing.
It should be noted that according to the historical records of Chinese medicine, the Chinese medicine selected by the present invention has following major function
And source：Magnolia delavayi, Classification system Magnolia delavayi Franch., Magnoliaceae Magnolia, bark：Middle benefit gas qi-regulating, is good for
Spleen dampness removing.For indigestion, chronic gastritis is vomitted, stomachache, abdominal distension, diarrhoea.Flower (or bud)：Facilitaing lung cough-relieving.For nose
Inflammation, nasosinusitis, bronchitis, cough.The present invention is used as medicine with bark.Herba Casythae Filiformis are the herb of canella dodder laurel.Latin name：
Cassytha filiformis L. clearing heat and promoting diuresis；Removing pattogenic heat from the blood and toxic material from the body.Cure mainly cold, fever, heat gonorrhea, urolithiasis, jaundice with damp-heat pathogen, diarrhea,
Dysentery, spitting of blood, bleeding from five sense organs or subcutaneous tissue, wind-fire red eye, traumatic injury, traumatism and bleeding, sore festers, scald, scabies tinea leprosy.Remaining is
Standards of pharmacopoeia.
Senile dementia is a kind of chronic Aging disease, belongs to the diseases such as the traditional Chinese medical science " dementia ", " forgetful ", " insane disease "
The category of card.Although sick position is in brain, root is the visceral dysfunctions such as the heart, spleen, kidney, especially in close relations with kidney.The traditional Chinese medical science is recognized
For brain being the marrow sea, kidney storing essence, main bone, raw marrow.The sufficient then brain biochemistry of essence in kidney is active, mental strong.With human senility,
Kidney essense constantly decays, cause it is mental weaken, it is dimmed forgetful.Secondly, " heart person, the viscus likened to the monarch in the body, gods go out here." mean people's
Memory, cognitive, emotion and language are dominated by the heart." idea stored in the spleen ", thinking, memory are therefore the strong fortune of taste, qi and blood based on qi and blood
Filling Sheng, then memory is vigorous, resourceful；Conversely, then failure of memory, thought slowness.Therefore, senile dementia and the heart, spleen,
Kidney is closely related.The present invention selects magnolia delavayi；Herba Casythae Filiformis middle benefit gas qi-regulating, invigorating spleen to remove dampness is monarch drug in a prescription, the Radix Astragali；Radix Codonopsis；The red sage root；Stone Chang
Pu；Root tuber of aromatic turmeric；The root of herbaceous peony；Ligusticum wallichii；The bark of eucommia；Reticulate millettia；Radix Angelicae Sinensis；It is milkwort plaster for nourishing kidney strengthening the essence, strengthening the spleen and reducing phlegm, mental-tranquilization, dispersing stagnated hepatoqi, clear
Hot purging intense heat and it is promoting blood circulation and removing obstruction in channels be ministerial drug, radix glycyrrhizae is adjuvant, and full side's treatment senile dementia works well, and without occurring not
Good reaction.
Specific embodiment
We have found that the consumption of every kind of traditional Chinese medicinal material raw materials slightly becomes in a small range in inventive formulation in screening experiment
Dynamic, it has the bioactivity for the treatment of senile dementia.The drug regimen of the present invention is now further illustrated by the following examples
Thing and preparation method thereof and therapeutic effect, but protection scope of the present invention is not limited to embodiment.
Embodiment 1：Take 40 parts of magnolia delavayi；50 parts of Herba Casythae Filiformis；40 parts of the Radix Astragali；60 parts of Radix Codonopsis；25 parts of the red sage root；Grass-leaved sweetflag 15
Part；5 parts of root tuber of aromatic turmeric；30 parts of the root of herbaceous peony；5 parts of Ligusticum wallichii；20 parts of the bark of eucommia；25 parts of reticulate millettia；30 parts of Radix Angelicae Sinensis；10 parts of polygala；15 parts of radix glycyrrhizae, system
Preparation Method comprises the following steps：Grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis are taken, steam distillation extraction is carried out, therefrom extracts and waves
Hair oil, is wrapped up using cyclodextrin, standby；The aqueous solution filtering after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, the extraction of Radix Angelicae Sinensis steam distillation is taken,
The aqueous solution after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation is obtained, heating concentration is obtained after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation
Concentrated liquid, it is standby；Retain the dregs of a decoction after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted, it is standby；By gained stone
The dregs of a decoction after calamus, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted are mixed with other medicinal materials, and 90% second of 3 times of amounts are added thereto
Alcohol reflux extracts secondary, each refluxing extraction 2 hours, merges ethanol extract, and filtration obtains mixed ethanol extract solution, reclaims second
Alcohol is simultaneously concentrated, and is obtained mixed ethanol and is extracted concentrate, standby；Retain the dregs of a decoction after ethanol is extracted, it is standby；After gained ethanol is extracted
The dregs of a decoction add 4 times of amount decoctings to boil three times, 2 hours every time, merge aqueous extract, filtration obtains mixing aqueous extract, heating concentration,
Obtain mixing water and extract concentrate；Concentrated liquid after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation, mixed ethanol are extracted into concentration
Liquid, mixing water extract concentrate and merge spray drying, add above-mentioned cyclodextrin of volatile oil wrappage, and addition dextrin prepares in blocks
Agent.
Embodiment 2：Take 60 parts of magnolia delavayi；30 parts of Herba Casythae Filiformis；60 parts of the Radix Astragali；40 parts of Radix Codonopsis；45 parts of the red sage root；5 parts of grass-leaved sweetflag；
15 parts of root tuber of aromatic turmeric；10 parts of the root of herbaceous peony；15 parts of Ligusticum wallichii；10 parts of the bark of eucommia；45 parts of reticulate millettia；10 parts of Radix Angelicae Sinensis；20 parts of polygala；5 parts of radix glycyrrhizae, prepares
Method comprises the following steps：Grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis are taken, steam distillation extraction is carried out, volatilization is therefrom extracted
Oil, is wrapped up using cyclodextrin, standby；The aqueous solution filtering after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, the extraction of Radix Angelicae Sinensis steam distillation is taken, is obtained
The aqueous solution after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation, heating concentration is obtained after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation
Concentrated liquid, it is standby；Retain the dregs of a decoction after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted, it is standby；By gained stone Chang
The dregs of a decoction after Pu, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted are mixed with other medicinal materials, and 90% ethanol of 3 times of amounts are added thereto
Refluxing extraction is secondary, each refluxing extraction 2 hours, merges ethanol extract, and filtration obtains mixed ethanol extract solution, reclaims ethanol
And concentrate, obtain mixed ethanol and extract concentrate, it is standby；Retain the dregs of a decoction after ethanol is extracted, it is standby；After gained ethanol is extracted
The dregs of a decoction add 4 times of amount decoctings to boil three times, 2 hours every time, merge aqueous extract, filtration obtains mixing aqueous extract, and heating concentration is obtained
Mixing water extracts concentrate；By grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation after concentrated liquid, mixed ethanol extract concentrate,
Mixing water extracts concentrate and merges spray drying, adds above-mentioned cyclodextrin of volatile oil wrappage, and addition starch is prepared into capsule.
Embodiment 3：Take 50 parts of magnolia delavayi；40 parts of Herba Casythae Filiformis；50 parts of the Radix Astragali；50 parts of Radix Codonopsis；35 parts of the red sage root；Grass-leaved sweetflag 10
Part；10 parts of root tuber of aromatic turmeric；20 parts of the root of herbaceous peony；10 parts of Ligusticum wallichii；15 parts of the bark of eucommia；35 parts of reticulate millettia；20 parts of Radix Angelicae Sinensis；15 parts of polygala；10 parts of radix glycyrrhizae,
Preparation method comprises the following steps：Grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis are taken, steam distillation extraction is carried out, therefrom extracted
Volatile oil, is wrapped up using cyclodextrin, standby；Take the aqueous solution mistake after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, the extraction of Radix Angelicae Sinensis steam distillation
Filter, obtains the aqueous solution after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation, and heating concentration obtains grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation
Concentrated liquid afterwards, it is standby；Retain the dregs of a decoction after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted, it is standby；By gained
The dregs of a decoction after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted are mixed with other medicinal materials, and the 90% of 3 times of amounts is added thereto
Alcohol reflux extracts secondary, each refluxing extraction 2 hours, merges ethanol extract, and filtration obtains mixed ethanol extract solution, reclaimed
Ethanol is simultaneously concentrated, and is obtained mixed ethanol and is extracted concentrate, standby；Retain the dregs of a decoction after ethanol is extracted, it is standby；Gained ethanol is extracted
The dregs of a decoction afterwards add 4 times of amount decoctings to boil three times, 2 hours every time, merge aqueous extract, filtration obtains mixing aqueous extract, heated dense
Contracting, obtains mixing water and extracts concentrate；Concentrated liquid after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation, mixed ethanol are extracted dense
Contracting liquid, mixing water extract concentrate and merge spray drying, add above-mentioned cyclodextrin of volatile oil wrappage, and addition lactose is prepared into
Granula.
Embodiment 4：The stability test of Chinese herbal granules
(1) accelerated test：The sample (being prepared by the method for above-described embodiment 3) for simulating listing packaging is put into temperature for 30 DEG C,
Relative humidity is in 60% climatic chamber, sampled and detected respectively at 1,2,3,6 month, its outward appearance, content and relevant material
Compared with when 0, significant change is showed no.
(2) room temperature keeps sample investigation：The sample (being prepared by the method for above-described embodiment 3) for simulating listing packaging is put into room temperature condition
It is lower to place 24 months, the separately sampled detection in 3,6,9,12,18 and 24 months, its outward appearance, content and about material and 0 phase
Than being showed no significant change.
Embodiment 5：Pharmacodynamic study
Experimental animal：Mouse, cleaning grade, 18~22g of body weight, purchased from Nanjing University of Traditional Chinese Medicine's Experimental Animal Center.
Experimental agents：Granule sample is prepared by above-described embodiment 3, (the multiple magnificent medicine company of Shanghai Fudan University has huperzine A capsule
Limit company), lot number 20150902,；Aβ25-35, provided by Singma companies of the U.S., article No.：A4559, physiological saline, poly first
The conventional reagents such as aldehyde, chloraldurate are commercially available.
Laboratory apparatus：Stereotaxic apparatus, model：The ST51600 U.S.；Program control water maze, model：SMG-2 Chinese medicines
Academy of sciences's drug research is made；It is program control to keep away camera bellows, model：SBA-2 institute of Materia Medica,Chinese Academy of Medical Sciences systems；Semiautomatic biochemistry
Instrument, model：70VB0370 France.
Experimentation：
1st, the present invention is on the preclinical influence of AD model mices water maze：Mouse is with yellow Jackets (40mg/kg) fiber crops
It is fixed on after liquor-saturated on stereotaxic apparatus, cuts off overhead skin, alcohol swab is wiped, and exposes bregma, fixed using ventriculus dexter cerebri
Position, from bregma 1.8mm backward, opened by sagittal suture 3 μ LA β 25-35 of injection 1.5mm, skull surface downward 2.5mm at (2 μ g/ μ L,
Sterile saline is prepared), sham-operation group injects isometric sterile saline with same method.Pin is pulled out after let the acupuncture needle remain at a certain point 2min,
Suture scalp.Aforesaid operations are aseptically carried out.The mouse 50 that modulus type is successfully prepared, adaptability raise 1w after with
Machine is divided into 5 groups：AD model groups, basic, normal, high dosage group (2g/kg, 4g/kg, 8g/kg) of the invention, huperzine A capsule are positive
Control group (0.2g/kg).The another mouse for taking 10 same method operations but injecting normal saline is as sham-operation group.Sham-operation group
And model group gives isometric physiological saline.Each group is administered 20 days.Carry out mouse learning training (training side within postoperative 3rd day
Method：Mouse is inserted after water by fixed bit, the time i.e. incubation period of its arrival platform that found an exit in 300s is observed, if mouse is not
Platform can be reached in 300s, then leads it to reach by experimenter.Experimental learning and test process keep indoor quiet, surrounding
Experimenter and object space immobilize), 1 time a day, each 300s, continuous 2 days.Determine within postoperative 6th day mouse study feelings
Condition, records the incubation period of every mouse, is used as mouse memory school grade.
2nd, camera bellows preclinical influence is kept away AD model mices：Model preparation, animal packet and medication are ibid.It is postoperative
Carry out within 7th day mouse and keep away camera bellows test training.One time a day, continuous 2 days, each 180s.Training and test process keep indoor peace
Quiet, surrounding experimenter and object space immobilize.Mouse study situation is determined within postoperative 9th day, every mouse is recorded for the first time
It is the errors number in incubation period and 180s into the camera bellows time, is used as learning and memory achievement.
As a result：Compared with sham-operation group, model group keeps away camera bellows errors number and incubation period and water maze incubation period is obvious
Increase, difference has significant (P<0.05), illustrate that AD models are successfully prepared；Compared with model group, each administration group is kept away secretly
Case errors number decreases, and high dose group, sun have significant (P to group and model group comparing difference<0.05).With mould
Type group compares, and each administration group is kept away camera bellows incubation period and increased, and height, middle dose group, sun have to group with model group comparing difference
Significant (P<0.05).Compared with model group, each administration group water maze incubation period decreases, height, middle dose group, sun
There is pole significant (P to group and model group comparing difference<0.01).Illustrate the present invention to AD model mice passive avoidance bars
Part, which reflects memory function and spatial memory function, has certain improvement result, see the table below.
Granule of the present invention to AD model mice water maze incubation periods, keep away the influence of camera bellows incubation period and errors number
Note：Compared * P with model group<0.05**P<0.01；Compared with sham-operation group, ▲ p<0.05,▲▲p<0.01
3rd, influence of the present invention to AD model mice brain tissue SOD, MDA contents：Brain tissue SOD assays：Finish dark
Case is tested and each experimental mice broken end of water maze, is taken brain on ice pan, is discarded olfactory bulb and cerebellum, weigh left side cortex brain tissue
100mg or so, 1% homogenate is made of the physiological saline of precooling, and 3000r/min centrifuges 10min, takes supernatant, assay method is pressed
According to kit specification.Brain tissue MDA assays：Ibid, 10% homogenate is made in materials, and 3000r/min centrifuges 10min, taken
Supernatant, assay method see the table below according to kit specification.
Compared with sham-operation group, model group SOD is significantly reduced, MDA significantly increases, difference has significant (P<
0.05), illustrate that AD models are successfully prepared；Compared with model group, each administration group SOD contents have been raised, MDA contents
Reduction, but high dose group, sun have pole significant (P to group SOD contents and model group comparing difference<0.01) in, low dosage
Group has significant (P with model group comparing difference<0.05).The high, medium and low dosage group of MDA contents, sun are to group and model group ratio
There is pole significant (P compared with difference<0.01).
Influence of the granule of the present invention to AD model mice brain tissue SOD, MDA contents(unit：U/mgport)
Note：Compared * P with model group<0.05**P<0.01 is compared with sham-operation group, ▲ p<0.05,▲▲p<0.01
The present invention, which has, to be shortened water maze incubation period, extends the effect for keeping away camera bellows incubation period and reducing errors number；Give
The Yao Hou models animal brain SOD vigor increases, the reduction of MDA contents, and this research, which demonstrates the present invention, has the dull-witted mould of improvement
Type brain tissue impairment improves the curative effect of its memory function.
Claims (5)
1. a kind of Chinese medicine composition for being used to treat senile dementia, it is characterised in that by the bulk drug of following parts by weight of component
Extraction is made：40-60 parts of magnolia delavayi；30-50 parts of Herba Casythae Filiformis；40-60 parts of the Radix Astragali；40-60 parts of Radix Codonopsis；25-45 parts of the red sage root；Stone Chang
5-15 parts of Pu；5-15 parts of root tuber of aromatic turmeric；10-30 parts of the root of herbaceous peony；5-15 parts of Ligusticum wallichii；10-20 parts of the bark of eucommia；25-45 parts of reticulate millettia；Radix Angelicae Sinensis 10-
30 parts；10-20 parts of polygala；5-15 parts of radix glycyrrhizae.
2. it is used for the Chinese medicine composition for treating senile dementia according to claim 1, it is characterised in that by following parts by weight
The bulk drug of component is extracted and is made：50 parts of magnolia delavayi；40 parts of Herba Casythae Filiformis；50 parts of the Radix Astragali；50 parts of Radix Codonopsis；35 parts of the red sage root；Grass-leaved sweetflag
10 parts；10 parts of root tuber of aromatic turmeric；20 parts of the root of herbaceous peony；10 parts of Ligusticum wallichii；15 parts of the bark of eucommia；35 parts of reticulate millettia；20 parts of Radix Angelicae Sinensis；15 parts of polygala；Radix glycyrrhizae 10
Part.
3. it is used for the Chinese medicine composition for treating senile dementia according to claim 1, it is characterised in that preparation method includes
Following steps：Grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis are taken, steam distillation extraction is carried out, therefrom extracts volatile oil, use ring
Dextrin is wrapped up, standby；Take grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation extract after aqueous solution filtering, obtain grass-leaved sweetflag, strongly fragrant
The aqueous solution after gold, Ligusticum wallichii, Radix Angelicae Sinensis distillation, heating concentration obtains the concentrated liquid after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation,
It is standby；Retain the dregs of a decoction after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted, it is standby；By gained grass-leaved sweetflag, root tuber of aromatic turmeric,
The dregs of a decoction after Ligusticum wallichii, Radix Angelicae Sinensis steam distillation are extracted are mixed with other medicinal materials, add 90% alcohol refluxs of 3 times of amounts to extract thereto
Secondary, each refluxing extraction 2 hours merges ethanol extract, and filtration obtains mixed ethanol extract solution, reclaims ethanol and concentrates, obtains
Mixed ethanol extracts concentrate, standby；Retain the dregs of a decoction after ethanol is extracted, it is standby；The dregs of a decoction after gained ethanol is extracted add 4 times
Amount decocting is boiled three times, 2 hours every time, merges aqueous extract, filtration obtains mixing aqueous extract, and heating concentration obtains mixing water extraction
Concentrate；Concentrated liquid after grass-leaved sweetflag, root tuber of aromatic turmeric, Ligusticum wallichii, Radix Angelicae Sinensis distillation, mixed ethanol are extracted concentrate, mixing water and extracted
Concentrate merges spray drying, adds above-mentioned cyclodextrin of volatile oil wrappage, and addition auxiliary material is prepared into granule, tablet, capsule
Agent.
4. it is used for the Chinese medicine composition for treating senile dementia according to claim 1, it is characterised in that institute in preparation method
It is dextrin, lactose, starch, sucrose, glucose, microcrystalline cellulose, mannose, methylcellulose, hydroxy propyl cellulose to state auxiliary material
The one or more of element, carboxymethyl cellulose and stevioside.
5. the Chinese medicine composition for being used to treat senile dementia according to claim 1 is preparing treatment senile dementia
In application.
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| CN103705845A (en) * | 2013-12-17 | 2014-04-09 | 吉林大学 | Traditional Chinese medicinal composition preparation for preventing and treating senile dementia and preparation method thereof |
| CN104623154A (en) * | 2015-01-23 | 2015-05-20 | 王爱梅 | Chinese herbal medicine composition for treating alzheimer's disease and preparation method thereof |
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| CN103705845A (en) * | 2013-12-17 | 2014-04-09 | 吉林大学 | Traditional Chinese medicinal composition preparation for preventing and treating senile dementia and preparation method thereof |
| CN104623154A (en) * | 2015-01-23 | 2015-05-20 | 王爱梅 | Chinese herbal medicine composition for treating alzheimer's disease and preparation method thereof |
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