CN107184766A - 一种和脾益肾组合物 - Google Patents
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Abstract
本发明公开了一种和脾益肾组合物，该组合物由下述组分组成：生黄芪25‑35g，丹参10‑20g，生地黄10‑20g，山药10‑20g，山茱萸10‑20g，泽泻10‑20g，茯苓10‑20g，牡丹皮10‑20g，当归10‑20g，白芍10‑20g，清水半夏10‑20g，炒白术10‑20g，柴胡10‑15g，陈皮10‑20g，枳壳10‑20g，鸡内金10‑20g和莱菔子15‑20g。实验结果表明，本发明药物组合物具有平稳血压、控制血糖、改善高脂血症、显著降低蛋白尿水平并改善患者临床自觉症状等作用，治疗效果明显。
Description
技术领域
本发明属于中药领域，特别是涉及一种和脾益肾组合物。
背景技术
终末期肾脏病发病率在全球范围内迅速增加，严重威胁人类健康、降低生活质量及社会回归率，而糖尿病肾病又是仅次于肾小球疾病导致终末期肾脏病的第二大病因。多数糖尿病肾病患者常伴有高血脂、高血压，诸多病理因素相互助推，呈多因素致病特点。
中医理论认为，糖、脂为人体必需营养物质，属脾气化生的水谷精微范畴，糖、脂超标即精微物质的异常积聚，当责脾失运化、输布失常或脾肾两虚、日久痰湿瘀血壅滞，病理因素复杂，日久化郁，阻遏气机，病久可见气郁不舒，助推上述病理环节。
因此，亟需一种和脾益肾组合物。
发明内容
本发明的目的是克服现有技术的不足，提供一种和脾益肾组合物。
本发明的技术方案概述如下：
一种和脾益肾组合物，由下述组分组成：生黄芪25-35g，丹参10-20g，生地黄10-20g，山药10-20g，山茱萸10-20g，泽泻10-20g，茯苓10-20g，牡丹皮10-20g，当归10-20g，白芍10-20g，清水半夏10-20g，炒白术10-20g，柴胡10-15g，陈皮10-20g，枳壳10-20g，鸡内金10-20g和莱菔子15-20g。
优选地，生黄芪30g，丹参15g，生地黄15g，山药15g，山茱萸10g，泽泻10g，茯苓10g，牡丹皮10g，当归15g，白芍10g，清水半夏10g，炒白术10g，柴胡10g，陈皮10g，枳壳10g，鸡内金10g和莱菔子15g。
本发明的优点：
实验结果表明，本发明药物组合物具有平稳血压、控制血糖、改善高脂血症、显著降低蛋白尿水平并改善患者临床自觉症状等作用，治疗效果明显。
具体实施方式
下面结合具体实施例对本发明作进一步的说明。
本发明的和脾益肾组合物，以益气补肾为主，辅以健脾、消瘀、畅郁，以鼓动中焦，促进运化水谷精微，使三焦通调，气机畅达。
方中生黄芪、丹参为君，益气活血；地黄、山药、山茱萸三药相配滋养肝脾肾，泽泻、茯苓、牡丹皮三者渗湿浊、促运化，六者为臣药；当归、白芍、清水半夏、炒白术、柴胡、陈皮、枳壳，助君健脾渗湿，益气开瘀，共为佐药；鸡内金、莱菔子是为使药，助佐消积导滞，畅达三焦气机。
肾小球硬化是糖尿病肾病特征性病理改变，把握“气阴两虚、痰湿瘀血壅滞”病机关键，我们认为基于“益气补肾、健脾消瘀法”组方的“和脾益肾方”通过调整机体代谢，改善代谢紊乱综合征，可以有效地阻抑糖尿病肾病肾小球硬化的病理进程。
和脾益肾组合物经临床应用，结果显示益气补肾、健脾消瘀法可有效改善糖、脂代谢紊乱，有助于控制血糖、改善高脂血症，显著降低糖尿病肾病患者尿蛋白水平，并通过畅达三焦气机，在一定程度上对患者久病之后产生的负面情绪具有疏肝解郁的缓解作用。
实施例1
一种和脾益肾组合物，按重量由下述组分组成：生黄芪30g，丹参15g，生地黄15g，山药15g，山茱萸10g，泽泻10g，茯苓10g，牡丹皮10g，当归15g，白芍10g，清水半夏10g，炒白术10g，柴胡10g，陈皮10g，枳壳10g，鸡内金10g和莱菔子15g。
实施例2
一种和脾益肾组合物，按重量由下述组分组成：生黄芪25g，丹参20g，生地黄10g，山药20g，山茱萸10g，泽泻20g，茯苓10g，牡丹皮20g，当归10g，白芍20g，清水半夏10g，炒白术20g，柴胡10g，陈皮20g，枳壳10g，鸡内金20g和莱菔子15g。
实施例3
一种和脾益肾组合物，按重量由下述组分组成：生黄芪35g，丹参10g，生地黄20g，山药10g，山茱萸20g，泽泻10g，茯苓20g，牡丹皮10g，当归20g，白芍10g，清水半夏20g，炒白术10g，柴胡15g，陈皮10g，枳壳20g，鸡内金10g和莱菔子20g。
实验
制备方法：将以上各实施例的中药组分加水浸泡20～30min，取中药各组分总质量的8倍的水，将其中的70％用于头煎，剩下的30％用于第二煎，煎煮时间从沸腾后计算，头煎30min，二煎20min，过滤药渣，合并滤液约300ml，分一天两次服用。
(1)选择80例年龄在30-70岁的糖尿病肾病患者，同时伴有2级及以下高血压病、轻度高脂血症及肾功能不全。
(2)方法：
80例患者随机分为4组：
治疗1组服用实施例1的组合物制备的汤剂配合厄贝沙坦150mg Qd；
治疗2组服用实施例2的组合物制备的汤剂配合厄贝沙坦150mg Qd，
治疗3组服用实施例3的组合物制备的汤剂配合厄贝沙坦150mg Qd，
对照组单用厄贝沙坦150mg Qd。疗程45天。
(3)疗效判定标准：根据《中医病症诊断疗效标准》结合临床拟定。观察患者临床症状、血压、血脂、血糖、24小时尿蛋白测定结果等指标的治疗前后对比。
治愈：血压控制平稳，血脂、血糖水平趋于正常，蛋白尿消失，患者自觉症状明显好转；
好转：血压控制基本平稳，血脂、血糖水平、蛋白尿在一定程度上好转，患者自觉症状有好转；
未愈：血压控制不理想，血脂、血糖、蛋白尿水平、患者自觉症状未见好转或出现恶化。
(4)结果
临床疗效见表1。
3个治疗组疗效分别于对照组比较，治疗组疗效均优于对照组。实验结果表明，本发明药物组合物具有平稳血压、控制血糖、改善高脂血症、显著降低蛋白尿水平并改善患者临床自觉症状等作用，治疗效果明显。
表1治疗效果比较
本发明活血化瘀、健脾益肾，可从多种途径抑制肾小球细胞外基质合成，清除氧自由基、对抗脂质过氧化反应，以及改善受损血管内皮功能等，其多途径、多靶点治疗疾病的特点，在防治糖尿病肾病肾小球硬化的发生、发展及延缓疾病进展方面具有一定优势，通过调节整体而达到局部效应，疗效肯定，且无明显毒副作用。
Claims (2)
1.一种和脾益肾组合物，其特征是由下述组分组成：生黄芪25-35g，丹参10-20g，生地黄10-20g，山药10-20g，山茱萸10-20g，泽泻10-20g，茯苓10-20g，牡丹皮10-20g，当归10-20g，白芍10-20g，清水半夏10-20g，炒白术10-20g，柴胡10-15g，陈皮10-20g，枳壳10-20g，鸡内金10-20g和莱菔子15-20g。
2.根据权利要求1所述的组合物，其特征是所述生黄芪30g，丹参15g，生地黄15g，山药15g，山茱萸10g，泽泻10g，茯苓10g，牡丹皮10g，当归15g，白芍10g，清水半夏10g，炒白术10g，柴胡10g，陈皮10g，枳壳10g，鸡内金10g和莱菔子15g。
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| CN116098958A (zh) * | 2021-11-11 | 2023-05-12 | 首都医科大学附属北京朝阳医院 | 一种治疗气阴两虚兼血瘀型早期糖尿病肾病的中药组合物及其制备方法 |
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| CN116098958B (zh) * | 2021-11-11 | 2024-05-28 | 首都医科大学附属北京朝阳医院 | 一种治疗气阴两虚兼血瘀型早期糖尿病肾病的中药组合物及其制备方法 |
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