CN107158104B - Chewable tablet for enhancing immunity - Google Patents
Chewable tablet for enhancing immunity Download PDFInfo
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- CN107158104B CN107158104B CN201710302739.1A CN201710302739A CN107158104B CN 107158104 B CN107158104 B CN 107158104B CN 201710302739 A CN201710302739 A CN 201710302739A CN 107158104 B CN107158104 B CN 107158104B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a chewable tablet for enhancing immunity. The chewable tablet for enhancing immunity is prepared by taking the wild jujube meat extract and the ginseng extract as active ingredients, has the characteristics of simple composition, low cost and obvious effect of enhancing immunity, is favorable for dissolving and absorbing the active ingredients by preparing the wild jujube meat extract and the ginseng extract into the chewable tablet, and is more convenient to take, has no bitter taste when in taking, has sour and sweet mouthfeel and high compliance of patients by selecting the type of a flavoring agent and the adding time.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a chewable tablet for enhancing immunity, and a preparation method and application thereof.
Background
Immunity is an important defense mechanism of the human body itself, and generally refers to the ability of the body to resist invasion of pathogenic microorganisms into the human body in medicine. In modern society, due to insufficient sleep, overstrain, lack of exercise, negative pessimistic psychological and dietary imbalance, etc., immunity of the body is easily lowered, so that viruses and the like are easily invaded, and various diseases such as cold, fatigue, gastrointestinal dysfunction and the like are caused continuously and for a long time.
At present, various medicines or health products for enhancing immunity are available, and compared with the single approach and single action target of western medicines, the traditional Chinese medicine emphasizes that a human body is a complete machine, focuses on the balance and regulation of immune functions, and has the advantages of multiple components and multiple targets. Therefore, the function of traditional Chinese medicine for improving the immune function of the body has been generally accepted. Known traditional Chinese medicines with the function of regulating immunity comprise lucid ganoderma, cordyceps sinensis, ginseng, codonopsis pilosula, radix sophorae flavescentis, honeysuckle, scutellaria baicalensis, radix rehmanniae, wolfberry, fructus psoraleae, poria cocos, shiitake mushrooms, schisandra chinensis, angelica sinensis, radix angelicae, ligusticum wallichii, gastrodia elata and the like, and the regulation of immunity by utilizing a traditional Chinese medicine formula is also reported in documents, for example, CN1682983A discloses a pharmaceutical composition for improving immunity, which comprises spina date seeds, lucid ganoderma and ginseng leaves; CN104383287A discloses a pharmaceutical composition for enhancing immunity, which is prepared from ginseng leaves, ginseng fruits, bletilla striata and spina date seeds. Because the traditional Chinese medicine advocates the compatibility of monarch, minister, assistant and guide and has the disadvantages of slow effect and the like, the traditional Chinese medicine usually adopts a formula containing a plurality of traditional Chinese medicines, has complex components, has poor taste and is usually required to be taken for a long time, and the compliance of taking the traditional Chinese medicine by a patient is greatly reduced.
The invention aims to provide the pharmaceutical composition for enhancing the immunity, which has the advantages of simple formula, obvious effect of enhancing the immunity and high patient compliance.
Disclosure of Invention
The invention aims to provide chewable tablets for enhancing immunity, which are prepared from active ingredients and pharmaceutically acceptable auxiliary materials, wherein the active ingredients consist of wild jujube meat extract and ginseng extract.
Preferably, the weight ratio of the wild jujube meat extract to the ginseng extract is 1-5: 3-1.
More preferably, the weight ratio of the wild jujube meat extract to the ginseng extract is 2-4: 2-1.
Most preferably, the weight ratio of the wild jujube meat extract to the ginseng extract is 3: 2.
The pharmaceutically acceptable auxiliary materials are selected from: one or more of fillers, binders, flavoring agents and lubricants.
Preferably, the filler is selected from: one or more of starch, lactose, microcrystalline cellulose, the binder being selected from: one or more of polyvinylpyrrolidone, ethanol and starch slurry, and flavoring agent selected from: one or more of mannitol, sorbitol, citric acid, glycyrrhizin and aspartame, and one or two of magnesium stearate and silica gel micropowder as lubricant.
More preferably, the flavoring agents are citric acid, glycyrrhizin and aspartame.
Most preferably, the weight ratio of citric acid, glycyrrhizin and aspartame is: 1-2: 3-5: 0.1-0.15.
Another object of the present invention is to provide a method for preparing chewable tablets for enhancing immunity, comprising the steps of:
(1) weighing the wild jujube meat extract and the ginseng extract according to the formula, mixing, adding the filler and the flavoring agent in a half amount of the formula, and uniformly stirring to obtain mixed powder for later use;
(2) adding binder into the mixed powder, making into soft material, granulating, drying, sieving with 10-20 mesh sieve, grading, adding lubricant and the rest correctant, and tabletting.
Still another object of the present invention is to provide a use of the meat extract of zizyphus jujube and the extract of ginseng for preparing chewable tablets for enhancing immunity.
Preferably, the weight ratio of the wild jujube meat extract to the ginseng extract is 1-5: 3-1.
More preferably, the weight ratio of the wild jujube meat extract to the ginseng extract is 2-4: 2-1.
Most preferably, the weight ratio of the wild jujube meat extract to the ginseng extract is 3: 2.
The invention has the beneficial effects that:
the medicine for enhancing immunity is simple in formula, only contains the wild jujube meat extract and the ginseng extract, but has a very obvious effect of enhancing immunity, and is even superior to similar medicines with more components.
Detailed Description
The invention may be further understood by reference to the following examples, which illustrate some methods of making or using. However, it is to be understood that these examples do not limit the present invention. Variations of the invention, now known or further developed, are considered to fall within the scope of the invention as described herein and claimed below.
Example 1: a chewable tablet for enhancing immunity is provided.
The composition comprises the following components in parts by weight:
3 parts of wild jujube meat extract, 2 parts of ginseng extract, 20 parts of microcrystalline cellulose, 1 part of polyvinylpyrrolidone, 0.1 part of citric acid, 0.4 part of glycyrrhizin, 0.01 part of aspartame and 0.06 part of magnesium stearate, and the preparation method comprises the following steps:
(1) weighing the wild jujube meat extract and the ginseng extract according to the formula, mixing, adding the filler and the flavoring agent in a half amount of the formula, and uniformly stirring to obtain mixed powder for later use;
(2) adding binder into the mixed powder, making into soft material, granulating, drying, sieving with 20 mesh sieve, grading, adding lubricant and the rest correctant, and tabletting.
Example 2: a chewable tablet for enhancing immunity is provided.
The composition comprises the following components in parts by weight:
2 parts of wild jujube meat extract, 2 parts of ginseng extract, 16 parts of microcrystalline cellulose, 1 part of polyvinylpyrrolidone, 0.1 part of citric acid, 0.4 part of glycyrrhizin, 0.01 part of aspartame and 0.06 part of magnesium stearate, and the preparation method is carried out according to the method in the example 1.
Comparative example 1: a chewable tablet for enhancing immunity is provided.
The composition comprises the following components in parts by weight:
3 parts of spina date seed extract, 2 parts of ginseng leaf extract, 1 part of lucid ganoderma, 20 parts of microcrystalline cellulose, 1 part of polyvinylpyrrolidone, 0.1 part of citric acid, 0.4 part of glycyrrhizin, 0.01 part of aspartame and 0.06 part of magnesium stearate, and the preparation method is carried out according to the method in the embodiment 1.
Comparative example 2: a chewable tablet for enhancing immunity is provided.
The composition comprises the following components in parts by weight:
5 parts of spina date seed extract, 20 parts of microcrystalline cellulose, 1 part of polyvinylpyrrolidone, 0.1 part of citric acid, 0.4 part of glycyrrhizin, 0.01 part of aspartame and 0.06 part of magnesium stearate, and the preparation method is carried out according to the method in the example 1.
Comparative example 3: a chewable tablet for enhancing immunity is provided.
The composition comprises the following components in parts by weight:
5 parts of ginseng extract, 20 parts of microcrystalline cellulose, 1 part of polyvinylpyrrolidone, 0.1 part of citric acid, 0.4 part of glycyrrhizin, 0.01 part of aspartame and 0.06 part of magnesium stearate, and the preparation method is carried out according to the method in the example 1.
Effect example 1: influence on mice hypoimmunity caused by cyclophosphamide
Experimental animals: 70 Kunming mice, males, weighing 21.0 + -2.3 g, were randomly divided into 7 groups, specifically a normal group, a blank group, an example 1 group, an example 2 group, a comparative example 1 group, a comparative example 2 group and a comparative example 3 group.
The experimental method comprises the following steps: after the mice are adaptively raised for 3 days, all the rest mice except a normal group are subjected to intraperitoneal injection of 40mg/Kg of cyclophosphamide for five consecutive days for modeling of a mouse model with low immunity, all the mice are subjected to intragastric administration from the 9 th day, wherein the normal group and a blank group are pure water, the administration amount of the corresponding drugs for intragastric administration of the groups of examples 1-2 and comparative examples 1-3 is 40mg/Kg, after one week of continuous administration, the weight of all the mice is weighed, then eyeballs are subjected to blood taking for routine test, the mice are killed by decapitation after blood taking, thymus and spleens are dissected and separated, weighed, and the organ index is calculated. Wherein the organ index is organ weight (mg)/body weight (g) × 100%.
The statistical method comprises the following steps:
SPSS17.0 statistical software is adopted, data are expressed by x +/-s (s is standard deviation), single factor analysis is adopted, Student's-ttest is adopted for comparison between two groups, variance analysis is adopted for comparison between the mean values of a plurality of samples, and P is less than 0.05 and is used as a significance test standard.
The experimental results are as follows:
the results of the effects of each group of experimental drugs on the hypoimmunity of mice caused by cyclophosphamide are shown in table 1.
TABLE 1 Effect on hypoimmunity in mice caused by Dry Cyclophosphamide
Note: p model group compared to normal group, examples 1-2, comparative examples 1-3 compared to model group, P < 0.05, P model group compared to normal group, examples 1-2, for examples 1-3 compared to model group, P < 0.01.
The experimental results in the table 1 show that the mice in the model group have weight loss, thymus index, spleen index and leukocyte number which are obviously reduced compared with the mice in the normal group, and the cyclophosphamide induced hypoimmunity model building of the mice is successful. Compared with the model group, the body weight of the mice of the groups of examples 1-2 and comparative examples 1-3 is increased, and the thymus index, the spleen index and the white blood cell number are increased to a certain extent, which shows that the medicaments of the examples 1-2 and the comparative examples 1-3 have certain effect of enhancing immunity, wherein the group of example 1 has the strongest immune enhancement effect, and the effect is even stronger than that of the group of comparative example 1 with more components and stronger than that of the groups of comparative examples 2-3 with only the wild jujube seed extract and the ginseng extract as the active components, which shows that the chewable tablets for enhancing the immunity with the wild jujube seed extract and the ginseng extract as the active components of the invention, although the composition is simpler, the wild jujube meat extract and the ginseng extract synergistically play a role in enhancing immunity, have a remarkable effect of enhancing immunity, and can be used for preventing and treating low immunity clinically.
Claims (3)
1. The chewable tablet for enhancing immunity is characterized by being prepared from the following components in parts by weight:
3 parts of wild jujube meat extract, 2 parts of ginseng extract, 20 parts of microcrystalline cellulose, 1 part of polyvinylpyrrolidone, 0.1 part of citric acid, 0.4 part of glycyrrhizin, 0.01 part of aspartame and 0.06 part of magnesium stearate, and the preparation method comprises the following steps:
(1) weighing the wild jujube meat extract and the ginseng extract according to the formula, mixing, adding microcrystalline cellulose serving as a filler and citric acid, glycyrrhizin and aspartame serving as corrigents half the formula amount, and uniformly stirring to obtain mixed powder for later use;
(2) adding binder polyvinylpyrrolidone into the mixed powder, making into soft material, granulating, drying, sieving with 20 mesh sieve, grading, adding lubricant magnesium stearate and the rest correctant, and tabletting.
2. The method of preparing an immune enhancing chewable tablet of claim 1 comprising the steps of:
(1) weighing the wild jujube meat extract and the ginseng extract according to the formula, mixing, adding microcrystalline cellulose serving as a filler and citric acid, glycyrrhizin and aspartame serving as corrigents half the formula amount, and uniformly stirring to obtain mixed powder for later use;
(2) adding binder polyvinylpyrrolidone into the mixed powder, making into soft material, granulating, drying, sieving with 10-20 mesh sieve, grading, adding lubricant magnesium stearate and the rest correctant, and tabletting.
3. Use of a wild jujube meat extract and a ginseng extract in the preparation of chewable tablets for enhancing immunity is characterized in that the weight ratio of the wild jujube meat extract to the ginseng extract is 3: 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710302739.1A CN107158104B (en) | 2017-05-02 | 2017-05-02 | Chewable tablet for enhancing immunity |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710302739.1A CN107158104B (en) | 2017-05-02 | 2017-05-02 | Chewable tablet for enhancing immunity |
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| CN107158104B true CN107158104B (en) | 2021-02-05 |
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| CN201710302739.1A Active CN107158104B (en) | 2017-05-02 | 2017-05-02 | Chewable tablet for enhancing immunity |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108606319A (en) * | 2018-04-11 | 2018-10-02 | 陈剑军 | A kind of immunopotentiator and its application |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100674A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Febantel chewable tablets for dogs and cats |
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- 2017-05-02 CN CN201710302739.1A patent/CN107158104B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100674A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Febantel chewable tablets for dogs and cats |
Non-Patent Citations (1)
| Title |
|---|
| 酸枣的药理研究综述;葛喜珍等;《首届全国干果生产与科研进展学术研讨会论文集》;19980930;第87-90页，尤其是第87页最后一段和第88页最后一段 * |
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