CN102100674A - Febantel chewable tablets for dogs and cats - Google Patents
Febantel chewable tablets for dogs and cats Download PDFInfo
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- CN102100674A CN102100674A CN 200910255663 CN200910255663A CN102100674A CN 102100674 A CN102100674 A CN 102100674A CN 200910255663 CN200910255663 CN 200910255663 CN 200910255663 A CN200910255663 A CN 200910255663A CN 102100674 A CN102100674 A CN 102100674A
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- febantel
- chewable tablet
- essence
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- lubricant
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Abstract
The invention discloses febantel chewable tablets for dogs and cats. The active ingredient of the chewable tablets is febantel serving as a broad-spectrum nematodes dispelling medicament. The chewable tablets overcome the defect of poor palatability of the traditional tablets, enable the dogs and the cats to fully chew medicaments, ensure that the medicaments are fully absorbed, and exert good medicinal effect. The tablets comprise the following components in percentage by mass: 20 to 40 percent of febantel, 50 to 70 percent of filling agent, 0.5 to 3 percent of adhesive, and 5 to 15 percent of flavoring agent. The preparation process is simple, and the prepared product has good mouthfeel and stable quality and is suitable for industrialized production.
Description
Technical field
The present invention relates to a kind of febantel chewable tablet that is used to drive away nematicide in dog, the cat body and preparation method thereof.
Background technology
Nematicide is dog, cat common parasitic disease.Often cause the dysplasia of dog and cat, particularly young animal, poor growth, the toxin that a large amount of nematicides discharge even can cause pup cat quadriplegia can cause death when serious.Febantel belongs to benzimidazole precursor anthelmintic, is used for the antinematodal agent of various animals at U.S.'s approved.The physiological characteristics that absorbs at dog, cat in order to increase the absorption to oral drugs of dog, cat, has been developed the chewable tablet of suitable dog, cat taste, can make dog, cat fully chew medicine, guarantees that medicine is fully absorbed, and brings into play good drug effect.
Summary of the invention
The present invention provides first and has related to a kind of febantel chewable tablet that is used to drive away nematicide in dog, the cat body.
An object of the present invention is to provide a kind of febantel chewable tablet, active component is a febantel, and it has good palatability, advantage that curative effect is high.
Another object of the present invention provides a kind of preparation method of described febantel chewable tablet.
Tablet of the present invention is formed and is comprised: represent to be respectively febantel 20%-40% with mass percent, filler 50%-70%, binding agent 0.5%-3%, correctives 5%-15%.
The lubricant that also contains 0.1%-2% in the described chewable tablet.
Wherein said filler is one or more in sucrose, sucrose mixture, starch, microcrystalline Cellulose, glucose, lactose, amylum pregelatinisatum, Icing Sugar, inorganic salt, the mannitol.
In the polyvidone aqueous solution that adhesive is water, percent by volume are the ethanol water of 5%-30%, starch slurry that mass percent is 1%-15%, mass percentage concentration is 1%-15% a cellulose derivative aqueous solution, mass percentage concentration is 1%-15%, the aqueous gelatin solution that mass percentage concentration is 1%-15%, the Polyethylene Glycol aqueous solution that mass percentage concentration is 1%-15% any.
Correctives is one or more in beef flavor, chicken essence, shrimp flavor essence, Carnis caprae seu ovis essence, duck meat essence, Carnis Anseris domestica essence, crab meat essence, the smart cream.
Lubricant is one or more in magnesium stearate, micropowder silica gel, the Pulvis Talci.
The invention also discloses a kind of preparation method of febantel chewable tablet: febantel and the filler back of sieving is respectively mixed, add adhesive system soft material, granulate, drying, granulate, adding correctives, lubricant are with dried granule mixing, tabletting, promptly.
Most preferred preparation method is that febantel and filler are crossed mix homogeneously behind 100 mesh sieves respectively, with an amount of ethanol system soft material, and the granulation of 20 mesh sieves, drying, 20 mesh sieve granulate, adding correctives, lubricant, mixing, tabletting, promptly.
Febantel chewable tablet of the present invention, the taste design at dog, cat are liked has good mouthfeel, and dog, cat compliance are increased, and improves the oral administration biaavailability of medicine.
The specific embodiment
The following embodiment that provides just in order to help to understand the present invention, rather than constitutes protection domain of the present invention is played restrictive effect, under design prerequisite of the present invention the present invention is simply changed, and all belongs to the scope of protection of present invention.
Embodiment 1:
Prescription is formed:
Febantel 20mg
Microcrystalline Cellulose 23mg
Starch 40mg
Magnesium stearate 2mg
Beef flavor 15mg
Every total amount 100mg
Preparation method: febantel and microcrystalline Cellulose, starch are crossed mix homogeneously behind 100 mesh sieves respectively, with an amount of ethanol system soft material, and the granulation of 20 mesh sieves, drying, 20 mesh sieve granulate, adding beef flavor, magnesium stearate, mixing, tabletting, promptly.
Embodiment 2:
Prescription is formed:
Prescription is formed:
Febantel 20mg
Microcrystalline Cellulose 23mg
Starch 15mg
Sucrose 25mg
Magnesium stearate 2mg
Beef flavor 15mg
Every total amount 100mg
Preparation method: febantel and microcrystalline Cellulose, starch, sucrose are crossed mix homogeneously behind 100 mesh sieves respectively, with an amount of ethanol system soft material, and the granulation of 20 mesh sieves, drying, 20 mesh sieve granulate, adding beef flavor, magnesium stearate, mixing, tabletting, promptly.
Claims (9)
1. a dog, cat are used the febantel chewable tablet, it is characterized in that component and mass percent are respectively febantel 20%-40%, filler 50%-70%, binding agent 0.5%-3%, correctives 5%-15%.
2. according to the described febantel chewable tablet of claim 1, it is characterized in that containing the lubricant of 0.1%-2%.
3. according to the described febantel chewable tablet of claim 1, it is characterized in that containing febantel 20mg-40mg.
4. according to the described febantel chewable tablet of claim 1, it is characterized in that described filler is one or more in sucrose, sucrose mixture, starch, microcrystalline Cellulose, glucose, lactose, amylum pregelatinisatum, Icing Sugar, inorganic salt, the mannitol.
5. according to the described febantel chewable tablet of claim 1, it is characterized in that in described adhesive is water, percent by volume are the ethanol water of 5%-30%, starch slurry that mass percent is 1%-15%, mass percentage concentration is 1%-15% a cellulose derivative aqueous solution, mass percentage concentration is 1%-15% polyvidone aqueous solution, aqueous gelatin solution that mass percentage concentration is 1%-15%, the Polyethylene Glycol aqueous solution that mass percentage concentration is 1%-15% any.
6. according to the described febantel chewable tablet of claim 1, it is characterized in that described correctives is one or more in beef flavor, chicken essence, shrimp flavor essence, Carnis caprae seu ovis essence, duck meat essence, Carnis Anseris domestica essence, crab meat essence, the smart cream.
7. according to the described febantel chewable tablet of claim 2, it is characterized in that described lubricant is one or more in magnesium stearate, micropowder silica gel, the Pulvis Talci.
8. according to the preparation method of the described febantel chewable tablet of claim 1, it is characterized in that febantel and the filler back of sieving is respectively mixed, add adhesive system soft material, granulate, drying, granulate, adding correctives, lubricant, mixing, tabletting, promptly.
9. according to the preparation method of the described febantel chewable tablet of claim 1, it is characterized in that febantel and filler are crossed mix homogeneously behind 100 mesh sieves respectively, add adhesive system soft material, the granulation of 20 mesh sieves, drying, 20 mesh sieve granulate add correctives, lubricant, mixing, tabletting, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910255663 CN102100674A (en) | 2009-12-16 | 2009-12-16 | Febantel chewable tablets for dogs and cats |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910255663 CN102100674A (en) | 2009-12-16 | 2009-12-16 | Febantel chewable tablets for dogs and cats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102100674A true CN102100674A (en) | 2011-06-22 |
Family
ID=44153874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910255663 Pending CN102100674A (en) | 2009-12-16 | 2009-12-16 | Febantel chewable tablets for dogs and cats |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102100674A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106580896A (en) * | 2016-12-07 | 2017-04-26 | 成都乾坤动物药业股份有限公司 | Febantel dispersible tablet and preparation method thereof |
| CN107158104A (en) * | 2017-05-02 | 2017-09-15 | 河北省农林科学院经济作物研究所 | It is a kind of to strengthen immune chewable tablets |
| WO2018119837A1 (en) * | 2016-12-29 | 2018-07-05 | 刘�文 | Cat feed containing nanocrystalline cellulose |
| CN111494327A (en) * | 2020-06-23 | 2020-08-07 | 瑞阳制药有限公司 | Preparation method of mebendazole chewable tablet |
-
2009
- 2009-12-16 CN CN 200910255663 patent/CN102100674A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106580896A (en) * | 2016-12-07 | 2017-04-26 | 成都乾坤动物药业股份有限公司 | Febantel dispersible tablet and preparation method thereof |
| WO2018119837A1 (en) * | 2016-12-29 | 2018-07-05 | 刘�文 | Cat feed containing nanocrystalline cellulose |
| CN107158104A (en) * | 2017-05-02 | 2017-09-15 | 河北省农林科学院经济作物研究所 | It is a kind of to strengthen immune chewable tablets |
| CN107158104B (en) * | 2017-05-02 | 2021-02-05 | 河北省农林科学院经济作物研究所 | Chewable tablet for enhancing immunity |
| CN111494327A (en) * | 2020-06-23 | 2020-08-07 | 瑞阳制药有限公司 | Preparation method of mebendazole chewable tablet |
| CN111494327B (en) * | 2020-06-23 | 2023-09-05 | 瑞阳制药股份有限公司 | Preparation method of mebendazole chewable tablet |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110622 |