CN103877092A - Compound niclosamide chewing tablet used for dogs and cats - Google Patents
Compound niclosamide chewing tablet used for dogs and cats Download PDFInfo
- Publication number
- CN103877092A CN103877092A CN201210560573.0A CN201210560573A CN103877092A CN 103877092 A CN103877092 A CN 103877092A CN 201210560573 A CN201210560573 A CN 201210560573A CN 103877092 A CN103877092 A CN 103877092A
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- niclosamide
- chewable tablet
- compound
- pyrantel
- praziquantel
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a compound niclosamide chewing tablet used for dogs and cats. The active components of the chewing tablet comprise praziquantel, pyrantel, niclosamide and halofuginone. The chewing tablet overcomes a disadvantage of poor palatability of traditional tablets, allows the dogs and the cats to fully chew the medicine, and guarantees full adsorption of the medicine and exertion of good medicine effects. The tablet provided by the invention comprises following components by weight: 10-20% of the niclosamide, 5-10% of the praziquantel, 15-25% of the pyrantel, 5-10% of the halofuginone, 30-50% of a filling agent, 0.5-3% of an adhesive and 5-15% of a corrigent. The chewing tablet is simple in preparation process, good in product taste, stable in product quality, and suitable for industrial production.
Description
Technical field
The present invention relates to a kind of for driving away compound niclosamide chewable tablet of nematicide, cestode, protozoon in dog, cat body and preparation method thereof.
Background technology
The medicine for the treatment of at present dog cat nematicide and cestode on house pet market is more, but because the mixed sense of pet body entozoa is serious, lacks on the market a kind of anti-parasite medicine that can simultaneously treat nematicide, cestode, protozoon at present.Therefore we have developed a kind of anti-parasite medicine of efficient comprehensive security.Its main component comprises praziquantel (Praziquantel), pyrantel (Pyrantel), niclosamide (Febental) and halofuginone hydrobromide (Halofuginone).Praziquantel is clinically to schistosomiasis japanica and taeniasis, clonorchiasis sinensis, and paragonimiasis westermani etc. are all effective.Pyrantel is mainly used in driving away ascarid, ancylostome, pinworm clinically.Niclosamide belongs to benzimidazole precursor anthelmintic, the antinematodal agent at U.S.'s approved for various animals.Halofuginone hydrobromide is New-type wide-spectrum anticoccidial drug, does not find at present untoward reaction, with other anticoccidial drug without cross resistance.The physiological characteristics absorbing for dog, cat in addition, in order to increase the absorption of dog, cat oral disposition medicine, has developed the chewable tablet of applicable dog, cat taste, can make dog, cat fully chew medicine, guarantees that medicine is fully absorbed, and brings into play good drug effect.
Summary of the invention
The present invention provide first relate to a kind of for driving away the compound niclosamide chewable tablet of nematicide, cestode, protozoon in dog, cat body.
An object of the present invention is to provide a kind of compound niclosamide chewable tablet, active component is praziquantel, pyrantel, niclosamide and halofuginone hydrobromide, and it has advantages of that good palatability, curative effect are high.
Another object of the present invention is to provide a kind of preparation method of described compound niclosamide chewable tablet.
Tablet composition of the present invention comprises: represent to be respectively niclosamide 10%-20% with mass percent, praziquantel 5%-10%, pyrantel 15%-25%, halofuginone hydrobromide 5%-10%, filler 30%-50%, binding agent 0.5%-3%, correctives 5%-15%.
In described chewable tablet, also contain the lubricant of 0.1%-2%.
Wherein said filler is one or more in sucrose, sucrose mixture, starch, microcrystalline Cellulose, glucose, lactose, amylum pregelatinisatum, Icing Sugar, inorganic salt, mannitol.
Any in the starch slurry that adhesive is water, the percent by volume ethanol water that is 5%-30%, mass percent is 1%-15%, the cellulose derivative aqueous solution that mass percentage concentration is 1%-15%, polyvidone aqueous solution that mass percentage concentration is 1%-15%, aqueous gelatin solution that mass percentage concentration is 1%-15%, Aqueous Solutions of Polyethylene Glycol that mass percentage concentration is 1%-15%.
Correctives is one or more in beef flavor, chicken essence, shrimp flavor essence, mutton flavor, duck meat essence, Carnis Anseris domestica essence, crab meat essence, smart cream.
Lubricant is one or more in magnesium stearate, micropowder silica gel, Pulvis Talci.
The invention also discloses a kind of preparation method of compound niclosamide chewable tablet: after praziquantel, pyrantel, niclosamide and halofuginone hydrobromide and filler are sieved respectively, mix; add adhesive soft material processed; granulate; dry; granulate, adds correctives, lubricant, mixes with dry granule; tabletting, to obtain final product.
Most preferred preparation method is that praziquantel, pyrantel, niclosamide and halofuginone hydrobromide and filler are crossed respectively to mix homogeneously after 100 mesh sieves, with appropriate alcohol soft material, and 20 mesh sieves granulations, dry, 20 mesh sieve granulate, add correctives, lubricant, mix, tabletting, to obtain final product.
Compound niclosamide chewable tablet of the present invention, the taste of liking for dog, cat design, has good mouthfeel, and dog, cat compliance are increased, and improves the oral administration biaavailability of medicine.
The specific embodiment
The embodiment that provided below, just in order to help to understand the present invention, rather than forms protection domain of the present invention is played to restrictive effect, under design prerequisite of the present invention, the present invention is simply changed, and all belongs to the scope of protection of present invention.
Embodiment 1:
Prescription composition:
Niclosamide 10mg
Praziquantel 5mg
Pyrantel 15mg
Halofuginone hydrobromide 5mg
Microcrystalline Cellulose 23mg
Starch 30mg
Magnesium stearate 2mg
Beef flavor 10mg
Every total amount 100mg
Preparation method: praziquantel, pyrantel, niclosamide and halofuginone hydrobromide and microcrystalline Cellulose, starch are crossed respectively mix homogeneously after 100 mesh sieves, with appropriate alcohol soft material, 20 mesh sieves granulations, dry, 20 mesh sieve granulate, add beef flavor, magnesium stearate, mix, tabletting, to obtain final product.
Claims (8)
1. dog, a cat compound niclosamide chewable tablet, is characterized in that component and mass percent are respectively niclosamide 10%-20%, praziquantel 5%-10%, pyrantel 15%-25%, halofuginone hydrobromide 5%-10%, filler 30%-50%, binding agent 0.5%-3%, correctives 5%-15%.
2. according to compound niclosamide chewable tablet claimed in claim 1, it is characterized in that the lubricant containing 0.1%-2%.
3. according to compound niclosamide chewable tablet claimed in claim 1, it is characterized in that containing niclosamide 10%-20% praziquantel 5%-10%, pyrantel 15%-25%, halofuginone hydrobromide 5%-10%.
4. according to compound niclosamide chewable tablet claimed in claim 1, it is characterized in that described filler is one or more in sucrose, sucrose mixture, starch, microcrystalline Cellulose, glucose, lactose, amylum pregelatinisatum, Icing Sugar, inorganic salt, mannitol.
5. according to compound niclosamide chewable tablet claimed in claim 1, it is characterized in that any in described adhesive is water, the percent by volume ethanol water that is 5%-30%, mass percent is 1%-15% starch slurry, cellulose derivative aqueous solution that mass percentage concentration is 1%-15%, polyvidone aqueous solution that mass percentage concentration is 1%-15%, aqueous gelatin solution that mass percentage concentration is 1%-15%, Aqueous Solutions of Polyethylene Glycol that mass percentage concentration is 1%-15%.
6. according to compound niclosamide chewable tablet claimed in claim 1, it is characterized in that described correctives is one or more in beef flavor, chicken essence, shrimp flavor essence, mutton flavor, duck meat essence, Carnis Anseris domestica essence, crab meat essence, smart cream.
7. according to compound niclosamide chewable tablet claimed in claim 2, it is characterized in that described lubricant is one or more in magnesium stearate, micropowder silica gel, Pulvis Talci.
8. according to the preparation method of compound niclosamide chewable tablet claimed in claim 1, after it is characterized in that praziquantel, pyrantel, niclosamide and halofuginone hydrobromide and filler to sieve respectively, mix, add adhesive soft material processed, granulate, dry, granulate, add correctives, lubricant, mix, tabletting, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210560573.0A CN103877092A (en) | 2012-12-21 | 2012-12-21 | Compound niclosamide chewing tablet used for dogs and cats |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210560573.0A CN103877092A (en) | 2012-12-21 | 2012-12-21 | Compound niclosamide chewing tablet used for dogs and cats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103877092A true CN103877092A (en) | 2014-06-25 |
Family
ID=50946430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210560573.0A Pending CN103877092A (en) | 2012-12-21 | 2012-12-21 | Compound niclosamide chewing tablet used for dogs and cats |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103877092A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512791A (en) * | 2019-01-09 | 2019-03-26 | 佛山市南海东方澳龙制药有限公司 | A kind of pet Cefadroxil chewable tablets and preparation method thereof |
| CN114762690A (en) * | 2021-01-13 | 2022-07-19 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | Compound preparation |
-
2012
- 2012-12-21 CN CN201210560573.0A patent/CN103877092A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109512791A (en) * | 2019-01-09 | 2019-03-26 | 佛山市南海东方澳龙制药有限公司 | A kind of pet Cefadroxil chewable tablets and preparation method thereof |
| CN114762690A (en) * | 2021-01-13 | 2022-07-19 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | Compound preparation |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140625 |