CN109512791A - A kind of pet Cefadroxil chewable tablets and preparation method thereof - Google Patents
A kind of pet Cefadroxil chewable tablets and preparation method thereof Download PDFInfo
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- CN109512791A CN109512791A CN201910019758.2A CN201910019758A CN109512791A CN 109512791 A CN109512791 A CN 109512791A CN 201910019758 A CN201910019758 A CN 201910019758A CN 109512791 A CN109512791 A CN 109512791A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
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- A61K9/20—Pills, tablets, discs, rods
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The present invention provides a kind of pet Cefadroxil chewable tablets and preparation method thereof.Pet is mainly prepared from the following raw materials with Cefadroxil chewable tablets: cefadroxil, filler, disintegrating agent, phagostimulant, lubricant；Phagostimulant includes: phagostimulant a, phagostimulant b, one or more of phagostimulant c.After taste masking is handled, the fragrance for having refrigerant mouthfeel and dog cat to like, flavoring works well chewable tablets of the present invention, and it is good that dog cat takes compliance, and medication is convenient.Preparation process of the present invention avoids the working condition of high temperature and humidity, and gained chewable tablets product quality indices are stablized, and is conducive to storage, guarantees safety, the validity of drug.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, in particular to a kind of pet Cefadroxil chewable tablets and its system
Preparation Method.
Background technique
Cefadroxil is semi-synthetic first generation oral cephalosporin, is broad-spectrum antibiotic, to staphylococcus, pneumonia streptococcus
Bacterium and Escherichia coli etc. are effectively, also effective to the staphylococcus of penicillin resistant.Oral absorption is good, steady in gastric acid after taking orally
It is fixed, and absorb rapidly, not by food effect.Blood medicine peak after dog 22mg/kg for oral administration in 1~2 hour up to 18.6 μ g/ml is dense
Degree, only 20% drug is largely discharged in urine in conjunction with plasma protein, half-life period 2 hours, occurs in urine in 24 hours after dispensing
50% proto-drug；The half-life period of cat was close to 3 hours.It is mainly used for dog cat by sensitive staphylococcus, streptococcus, Pasteur's bar
The urinary tract caused by bacterium and klebsiella etc., respiratory tract, Skin and soft tissue infection.
Cefadroxil has one specific stink, make one to generate uncomfortable feeling, and dog, cat have a sharp sense of smell, and has especially
Taste preference.Currently, commercially available Cefadroxil chewable tablets are people's medication, it is not directed to pet palatability demand and special
The pet that do not design cephalo azanol benzyl tablet.In existing preparation method, Cefadroxil tablets are to pass through cefadroxil
The wet granular of certain mesh number is made in raw material after mixing with filler, disintegrating agent, adhesive, add mix lubricant after dry,
It is formed through tabletting.However, since raw material cefadroxil is unstable under the condition of high temperature and high humidity, it is degradable, so that tablet
Stable product quality is poor, is unfavorable for storing for a long time, also brings hidden danger to the safety in clinical use.Meanwhile use is wet
Method granulating process, disintegrating agent effect is limited, and by binder concn, the wet mixing time, it is dry after the other factors such as moisture content shadow
Sound is larger, and the conditions such as intermediate product moisture and hardness control slight difference, and it is poor to will result in disintegration effect, causes dissolution rate unstable
It is fixed.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of pet Cefadroxil chewable tablets, cefadroxil nozzle of the present invention
It is good to chew piece palatability, dog cat drug compliance is high.
The second object of the present invention is to provide the preparation method of pet Cefadroxil chewable tablets described in one kind.
The third object of the present invention is to provide pet described in one kind with Cefadroxil chewable tablets in preparation pet disease
Application in sick therapeutic agent.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
A kind of pet Cefadroxil chewable tablets, the pet is with Cefadroxil chewable tablets mainly by following raw material system
At: cefadroxil, filler, disintegrating agent, phagostimulant and lubricant；The phagostimulant includes: phagostimulant a, phagostimulant b,
And one or more of phagostimulant c；Wherein, the phagostimulant a includes: chicken meal, and powdered beef braises digested tankage in soy sauce, and beef is fragrant
Essence, chicken essence, chicken liver meal, beef essential oil, chicken essential oil, milk-taste essence, fruit essence, in sweetener or yeast for animal feeds
It is one or more of；The phagostimulant b includes: fish powder, fish raw meat element, one or more of seafood peptide or excellent fresh peptide；It is described to lure
Eating agent c includes: one of dog food phagostimulant/flavouring agent or cat food phagostimulant/flavouring agent.
Meanwhile the present invention also provides the preparation methods of the pet Cefadroxil chewable tablets, comprising: by cephalo
Amoxycillin, filler, disintegrating agent and phagostimulant mixing, obtain cefadroxil and mix powder；Then, gained cefadroxil is mixed
Powder and mix lubricant uniformly rear tabletting, obtain pet Cefadroxil chewable tablets.
Further, present invention provides pet of the present invention Cefadroxil chewable tablets to prepare pet disease treatment
Application in drug.
Likewise, the present invention also provides the pharmaceutical compositions comprising pet Cefadroxil chewable tablets of the present invention.
Compared with prior art, the invention has the benefit that
Chewable tablets of the present invention is after taste masking is handled, and the fragrance for having refrigerant mouthfeel and dog cat to like, flavoring works well, dog cat
It is good to take compliance；Meanwhile chewable tablets dosage form of the present invention is suitble to dog cat to take, and is adapted with dog cat feeding methods, medication is convenient.
In preparation process of the present invention, the working condition of high temperature and humidity is avoided, refers to obtained chewable tablets product quality items
Mark is stablized, and is conducive to storage, guarantees safety, the validity of drug；
Meanwhile preparation process simple process of the present invention, low, saving material amounts and manpower, equipment are required production equipment
Consume cost.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
Pet Cefadroxil chewable tablets provided by the present invention are to solve existing cefadroxil tablet suitable
Deficiency present in mouthful property and stability etc. and propose.In the present invention, by for composition of raw materials and preparation process
Improvement, effectively improve pet (especially dog cat) drug compliance and chewable tablets disintegration and dissolution stability.
Pet provided by the present invention is to be mixed with to obtain by following raw material with Cefadroxil chewable tablets: cefadroxil
Benzyl, filler, disintegrating agent, phagostimulant and lubricant；
The use of phagostimulant can effectively cover the bad smell of cefadroxil, so that chewable tablets palatability of the present invention is more
It is good, it is easier to be received by pet.
In certain embodiments of the present invention, in raw material as above, phagostimulant are as follows: phagostimulant a, phagostimulant b, and lure
Eat one or more of agent c；
Wherein, the phagostimulant a are as follows: chicken meal, powdered beef braise digested tankage, beef flavor, chicken essence, chicken liver meal, ox in soy sauce
Meat essential oil, chicken essential oil, milk-taste essence, fruit essence, sweetener or yeast for animal feeds etc. have in the phagostimulant of similar flavor
It is one or more of；
The phagostimulant b are as follows: fish powder, fish raw meat element, seafood peptide or excellent fresh peptide etc. can increase fishy smell, fishiness or seafood
One or more of other phagostimulants of taste；
The phagostimulant c are as follows: dog food phagostimulant/flavouring agent or cat food phagostimulant/flavouring agent；
It such as can be powdered, paste perhaps liquid dog food phagostimulant/flavouring agent or be powdered, cream
Shape or liquid cat food phagostimulant/flavouring agent；
It is specifically as follows dog food 1, dog food 2, dog food 3, cat food 1, the commercially available dog food such as cat food 2 or cat food 3
Or cat food phagostimulant or other phagostimulants that can be applied in dog food or cat food.
In certain embodiments of the present invention, in raw material as above, raw material filler are as follows: in filler a and filler b
It is one or more of；
Wherein, the filler a are as follows: maltitol, mannitol composites of starch, starch milk saccharide complex, a water grape
Sugar, maltodextrin, starch, glucose, one of xylitol or mannitol or a variety of；
Filler b are as follows: microcrystalline cellulose, one of silicified microcrystalline cellulose or pregelatinized starch or a variety of.
In certain embodiments of the present invention, raw material disintegrating agent are as follows: sodium carboxymethyl starch, low substituted hydroxy-propyl fiber
Element, cross-linked carboxymethyl cellulose sodium, one of crospovidone or cross-linked carboxymethyl starch sodium or a variety of.
In certain embodiments of the present invention, raw material lubricant are as follows: magnesium stearate, talcum powder, superfine silica gel powder, or it is stearic
One of fumaric acid sodium is a variety of.
In certain embodiments of the present invention, in the present invention, each material quality percentage accounting is as follows: cefadroxil 35
~45%, such as can be, but be not limited to 37,39,41 or 43% etc.；Filler 30~60%, such as can be, but not
It is limited to 32,35,37,40,42,45,50,52,55 or 57% etc.；Disintegrating agent 0.3~5%, such as can be, but be not limited to
0.5,1,2,3 or 4% etc.；Phagostimulant 0.01~20%, such as can be, but be not limited to 0.5,1,3,5,7,10,12,15,
Or 17% etc.；And lubricant 0.1~3%, such as can be, but be not limited to 0.3,0.5,0.7,1,1.2,1.5,2,2.5,
Or 2.7% etc.；
Condition is that the sum of each raw material percentage accounting is 100%；
In per distribution ratio raw material as above, raw material filler is filler a and one kind or two classes in filler b；Likewise,
Raw material phagostimulant is phagostimulant a, one kind in phagostimulant b and phagostimulant c, two classes or three classes.
In currently preferred some embodiments, each raw material percentage accounting is as follows:
Cefadroxil 38~42%, filler 35~55%, disintegrating agent 0.5~3.5%, phagostimulant 0.1~18%, with
And lubricant 0.3~2%；
Condition is that the sum of each raw material percentage accounting is 100%.
In preferred some embodiments of the invention, each raw material percentage accounting is as follows:
Cefadroxil 40~41%, disintegrating agent 0.5~3.5%, lubricant 0.3~2%, phagostimulant and surplus are filled out
Fill agent；
Wherein, phagostimulant is phagostimulant a, one kind in phagostimulant b and phagostimulant c, two classes or three classes；
Wherein, when including at least phagostimulant a in phagostimulant, phagostimulant a raw material (total) quality percentage accounting for 3~
15%；Meanwhile when including at least phagostimulant b in phagostimulant, phagostimulant b raw material (total) quality percentage accounting for 0.01~
0.5%；When including at least phagostimulant c in phagostimulant, phagostimulant c is 0.01~0.8% in raw material (total) quality percentage accounting；
Further, when including at least the different phagostimulant (such as two class of phagostimulant a and phagostimulant b) of two classes in phagostimulant
When, the quality accounting of two class phagostimulants be independently as above comprising at least a kind of phagostimulant quality accounting range (for example,
When phagostimulant is phagostimulant a and phagostimulant b, then the quality accounting of phagostimulant a in the feed is still 3~15%, and phagostimulant b exists
Quality accounting in raw material is still 0.01~0.5%).
Meanwhile raw material filler is filler a and one kind or two classes in filler b, and filler then accounts for each raw material
Than the sum of be supplemented to 100%.
Different from traditional tablet, in chewable tablets provided by the present invention, the material quality of effective component cefadroxil
Accounting is more than 40%, while reducing the dosage of filler and disintegrating agent, and the technique of this raw material proportioning collocation direct tablet compressing,
It can not only guarantee the disintegration and dissolution rate of tablet, while can also guarantee that higher medicament contg is horizontal.
Meanwhile it is different from traditional wet granulation, it is to use the technique of direct tablet compressing to prepare chewable tablets in the present invention, tool
Body includes the following steps:
By cefadroxil, filler is mixed after disintegrating agent and phagostimulant smash it through the screening of 80 mesh screens respectively
It closes, obtains cefadroxil and mix powder；
Then, tabletting after gained cefadroxil being mixed powder and mix lubricant uniformly, obtains pet cefadroxil
Chewable tablets.
Since cefadroxil is unstable under high temperature, super-humid conditions, it is easy degradation, especially makes traditional in the present invention
Grain process optimization is direct tablet compressing after raw material mixing.Troublesome operation needed for being granulated this not only reduces tradition, but also can keep away
Exempt from the influence of production technology quality stability caused by Cefadroxil tablets.
The Cefadroxil chewable tablets as obtained by method as above can be further used for pet (especially dog, cat etc.) disease
In disease treatment, and for the urinary tract as caused by sensitive staphylococcus, streptococcus, Pasteurella and klebsiella etc., breathing
Road, Skin and soft tissue infection have good therapeutic effect.
Further, it during actual therapeutic, can be used alone with Cefadroxil chewable tablets of the present invention, or will
It is used cooperatively with other drugs, and the treatment of pet disease is carried out in a manner of pharmaceutical composition.
Embodiment 1-6
According to the raw material proportioning in following examples 1-6, appropriate each raw material is weighed
Cefadroxil, filler, disintegrating agent, phagostimulant in each embodiment group is crossed into 80 meshes respectively, is mixed,
It obtains cefadroxil and mixes powder, add lubricant, be uniformly mixed, tabletting is to get the cefadroxil nozzle for arriving each embodiment group
Chew piece.
Comparative example 1 (coating tablet taste masking):
Formula: with embodiment 2, being a difference in that and do not add phagostimulant 1, and it is 49.2% that 2 additive amount of filler, which increases,.
Preparation process:
(1) it is sieved, mixes: cefadroxil, filler, disintegrating agent, phagostimulant being crossed into 80 meshes respectively, are mixed,
It obtains cefadroxil and mixes powder, add lubricant, be uniformly mixed, tabletting is to get cefadroxil plain piece.
(2) it prepares coating solution: taking 63 parts of film coating powder, add 650 parts of water dispersions to get coating solution.
(3) it being coated: cefadroxil plain piece being taken to be placed in coating pan, revolving speed is 13 turns per minute, and kettle temperature is 33 DEG C,
Constantly on spray coating solution to plain piece, thin film clothing is uniformly wrapped, coating membrane is drying to obtain cefadroxil with a thickness of 1.5 microns
Benzyl coating tablet.
Comparative example 2 (cyclodextrin encapsulated taste masking):
Formula: with embodiment 2, it is a difference in that addition inclusion agents hydroxypropylβ-cyclodextrin 18%, 2 additive amount of filler subtract
It is less 26.2%.
Preparation process:
(1) cyclodextrin encapsulated: cefadroxil, hydroxypropylβ-cyclodextrin and water high speed quickly to be ground 1 hour, vacuum 40
It DEG C dry, pulverize, sieve with 100 mesh sieve to get cefadroxil cyclodextrin inclusion compound.
(2) it is sieved, mixes: filler, disintegrating agent, phagostimulant are crossed into 80 meshes, each auxiliary material and cefadroxil ring respectively
Cyclodextrin inclusion compound be mixed, obtain cefadroxil mix powder, add lubricant, be uniformly mixed, tabletting to get.
Comparative example 3 (wet granulation)
Formula: with embodiment 2, only changing silicified microcrystalline cellulose into microcrystalline cellulose 42.2%, superfine silica gel powder 2%, starches
Liquid is 5% PVP K30 solution.
Preparation process is specific as follows:
(1) it mixes: the chicken liver meal of cefadroxil, microcrystalline cellulose, formula ratio half is crossed into 80 meshes, mix.
(2) slurrying, granulation: preparing 5% PVP K30 solution slurries, and slurries are added in (1) gains, crosses 16 meshes
Granulation.
(3) dry, whole grain: wet granular is made in (2) and sets drying 3 hours in 40 DEG C of baking ovens, per half an hour is stirred once, control
Moisture processed obtains dry particl in 3%~5% range, crosses 20 mesh whole grains.
(4) total mix: by the dry particl and mannitol composites of starch, superfine silica gel powder, low-substituted hydroxypropyl fiber after (3) whole grain
Element, the other half chicken liver meal of formula ratio are uniformly mixed, and add sodium stearyl fumarate, are uniformly mixed.
(5) by the granulation after (4) total mix, Cefadroxil chewable tablets tabletting: are obtained.
The experiment of 1 palatability of experimental example
Example 1~6 prepare Cefadroxil chewable tablets and comparative example 1, tablet 1 prepared by comparative example 2, comparative example 3,
Tablet 2, tablet 3 carry out palatability testing.
(1) in Quan Mao farm, Yunfu City Xinxing County, respiratory tract, the urinary tract, skin or soft tissue sense are chosen
The dog of dye only 49, further microscopy is judged as to be caused by sensitive staphylococcus, streptococcus, Pasteurella or klebsiella etc.
Sick dog choose 45, every 5 are included into one group, respectively A, B, C, D, E, F, G, H and I group.A~I group successively with embodiment 1~
6 and comparative example 1, comparative example 2, comparative example 3 be administered, testing result is as shown in table 1.
(2) cat 53 for choosing respiratory tract, the urinary tract, skin or soft tissue infection, further microscopy is judged as by sensitivity
Staphylococcus, streptococcus, Pasteurella or klebsiella etc. caused by disease cat choose 40, every 5 are included into one group, respectively
A, B, C, D, E, F, G and H group.A~H group is successively administered with Examples 1 to 6 and comparative example 1, comparative example 2, testing result such as table 2
It is shown.
By table 1 as above, table 2 data it is found that Examples 1 to 6 preparation Cefadroxil chewable tablets compared to comparative example
1, for tablet prepared by comparative example 2, palatability better effect, the tablet palatability effect of comparative example 3 and Examples 1 to 6 preparation
Fruit is close.Further, it was observed that the compliance of cat medication does not have dog good, it may be possible to which because cat lacks sweet receptor, but palatability is imitated
Fruit is obviously more preferable than coating tablet or cyclodextrin encapsulated.It can be seen that improvement of the tablet produced by the present invention in terms of palatability
Effectively.
2 tablet general indicator of test example is investigated
Overall merit, testing result such as table 3 are carried out using mouthfeel, color, formability, friability, finish, smell as index
It is shown.Wherein, friability standard: fine powder less loss limit palpus≤1%
By the data of table 3 as above it is found that the Cefadroxil chewable tablets and comparative example 1, comparative example of Examples 1 to 6 preparation
2, tablet prepared by comparative example 3 can cover the stink of main ingredient, but the tablet of Examples 1 to 6 preparation is compared to comparative example 1, right
For ratio 2, unique perfume is increased.
The 3 tablet content uniformity of test example is investigated
10 progress contents in the tablet for respectively preparing Examples 1 to 6 and comparative example 1, comparative example 2, comparative example 3 are equal
Evenness test, by external standard method with calculated by peak area every content, and calculates deviation and the uniformity.Test result such as 4 institute of table
Show.
4 uniformity of dosage units test result of table
| Group | Deviation | The uniformity |
| Embodiment 1 | 0.91 | 9.334 |
| Embodiment 2 | 0.20 | 6.982 |
| Embodiment 3 | 0.32 | 7.515 |
| Embodiment 4 | 0.70 | 7.363 |
| Embodiment 5 | 0.87 | 8.727 |
| Embodiment 6 | 0.01 | 8.530 |
| Comparative example 1 | 0.54 | 7.320 |
| Comparative example 2 | 0.06 | 11.092 |
| Comparative example 3 | 0.22 | 7.25 |
By the data of table 4 as above it is found that the Cefadroxil chewable tablets of Examples 1 to 6 preparation are compared to comparative example 1, right
For tablet prepared by ratio 2, the uniformity is suitable or more excellent, and respectively less than 15, meets uniformity requirements, with 3 wet process of comparative example
The tablet uniformity of granulating process preparation is suitable, does not almost have difference.
4 Dissolution of Tablet of test example is investigated
6 progress dissolution rate tests in tablet that respectively prepared by Example 1~6 and comparative example 1, comparative example 2, by outer
Mark method is the 75% of labelled amount with calculated by peak area every the amount of dissolution, limit, and test result is as shown in table 5.
5 dissolution rate test result of table
By the data of table 5 it is found that the Cefadroxil chewable tablets of Examples 1 to 6 preparation and comparative example 1, comparative example 2 are made
The dissolution rate of standby tablet is suitable, and the Dissolution of Tablet compared with wet granulation technology preparation is slightly good.
The test of the extraordinary environment stability inferior of test example 5
In order to verify stability of the Cefadroxil chewable tablets under extraordinary environment in the present invention, Example 2, embodiment
5 and comparative example 1, comparative example 2, comparative example 3 prepare tablet, respectively carry out hot test, intense light irradiation test and high humidity test, tool
Body test method is as follows:
(1) hot test
The good sample of bubble-cap is placed 10 days at a temperature of 60 DEG C, in the 5th day and the 10th day sampling analysis.
(2) intense light irradiation is tested
The good sample of bubble-cap is placed in sample to stablize in case, is placed 10 days under the conditions of 4500 ± 500lx of Yu Zhaodu, the 5th
It and the 10th day sampling analysis.
(3) high humidity test
The good sample of bubble-cap is placed under 90% damp condition and places the decentralization of 10 days conditions and sets 10 days, at the 5th day and the 10th
Its sampling analysis.
Table 6 is stability test result of the Cefadroxil chewable tablets under extraordinary environment.
Stability test result under the extraordinary environment of table 6
By 6 detection data of table as above it is found that the Cefadroxil chewable tablets that prepare of embodiment 2 and embodiment 5 are in 60 DEG C of height
Temperature, the intense light irradiation of 4500 ± 500lx and 90% ± 5% high humidity environment under every Testing index have no significant change, quality compared with
For stabilization, meet stability requirement, for the tablet prepared compared to comparative example 1, comparative example 2, comparative example 3, in stability
It is suitable or more excellent.
In summary, for compared to existing cefadroxil tablet, product of the present invention palatability is more preferable, and pet is taken medicine
Compliance monitoring is high；Meanwhile compared to existing tablet producing technology for, the obtained tablet of the method for the present invention is in the uniformity, steady
Qualitative, stripping property etc. effect is suitable, or can show better performance, and the actual use that can satisfy pet drug is wanted
It asks.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of pet Cefadroxil chewable tablets, which is characterized in that the pet with Cefadroxil chewable tablets mainly by
Following raw material is made:
Cefadroxil, filler, disintegrating agent, phagostimulant and lubricant；
The phagostimulant includes: phagostimulant a, one or more of phagostimulant b and phagostimulant c；
Wherein, the phagostimulant a includes: chicken meal, and powdered beef braises digested tankage, beef flavor, chicken essence, chicken liver meal, beef in soy sauce
Essential oil, chicken essential oil, milk-taste essence, fruit essence, one or more of sweetener or yeast for animal feeds；
The phagostimulant b includes: fish powder, fish raw meat element, one or more of seafood peptide or excellent fresh peptide；
The phagostimulant c includes: one of dog food phagostimulant/flavouring agent or cat food phagostimulant/flavouring agent.
2. pet Cefadroxil chewable tablets according to claim 1, which is characterized in that the filler includes: to fill out
Fill one or more of agent a and filler b；
Wherein, the filler a includes: maltitol, mannitol composites of starch, starch milk saccharide complex, Dextrose Monohydrate,
Maltodextrin, starch, glucose, one of xylitol or mannitol or a variety of；
Filler b includes: microcrystalline cellulose, one of silicified microcrystalline cellulose or pregelatinized starch or a variety of.
3. pet Cefadroxil chewable tablets according to claim 1, which is characterized in that the disintegrating agent includes:
Sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose sodium, crospovidone, or crosslinking carboxylic first are formed sediment
One of powder sodium is a variety of.
4. pet Cefadroxil chewable tablets according to claim 1, which is characterized in that the lubricant includes:
Magnesium stearate, talcum powder, one of superfine silica gel powder or sodium stearyl fumarate or a variety of.
5. pet Cefadroxil chewable tablets described in any one of -4 according to claim 1, which is characterized in that according to weight
Percentage meter, each raw material dosage are as follows:
Cefadroxil 35~45%, filler 30~60%, disintegrating agent 0.3~5%, phagostimulant 0.01~20%, Yi Jirun
Lubrication prescription 0.1~3%.
6. pet Cefadroxil chewable tablets according to claim 5, which is characterized in that according to percent by weight,
Each raw material dosage is as follows:
Cefadroxil 38~42%, filler 35~55%, disintegrating agent 0.5~3.5%, phagostimulant 0.1~18%, Yi Jirun
Lubrication prescription 0.3~2%.
7. the preparation method of pet Cefadroxil chewable tablets of any of claims 1-6, which is characterized in that packet
It includes:
By cefadroxil, filler, disintegrating agent and phagostimulant mixing, obtains cefadroxil and mix powder；
Then, tabletting after gained cefadroxil being mixed powder and mix lubricant uniformly, obtains pet and is chewed with cefadroxil
Piece.
8. preparation method according to claim 7 characterized by comprising by what is mixed again after each material screening
Step；
Wherein, the screening includes the steps that being sieved with 80 mesh screens.
9. pet of any of claims 1-6 is with Cefadroxil chewable tablets in preparation pet disease therapeuticing medicine
Application.
10. including the pharmaceutical composition of pet Cefadroxil chewable tablets of any of claims 1-6.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910019758.2A CN109512791A (en) | 2019-01-09 | 2019-01-09 | A kind of pet Cefadroxil chewable tablets and preparation method thereof |
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|---|---|---|---|
| CN201910019758.2A CN109512791A (en) | 2019-01-09 | 2019-01-09 | A kind of pet Cefadroxil chewable tablets and preparation method thereof |
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Family
ID=65799212
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Cited By (5)
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| CN110859813A (en) * | 2019-11-27 | 2020-03-06 | 河北远征药业有限公司 | Polyciclovir hydrochloride tablet for pets and preparation method thereof |
| CN111388432A (en) * | 2020-03-19 | 2020-07-10 | 潍坊富邦药业有限公司 | Cefadroxil tablet for pets and preparation method thereof |
| CN114681452A (en) * | 2020-12-31 | 2022-07-01 | 佛山市南海东方澳龙制药有限公司 | Compound fenbendazole chewable tablet for dogs and preparation method thereof |
| CN114947018A (en) * | 2022-06-09 | 2022-08-30 | 浙江万方生物科技有限公司 | Pet nutrition supplementing soft chewable tablet and preparation method thereof |
| CN115607519A (en) * | 2022-11-15 | 2023-01-17 | 江苏南京农大动物药业有限公司 | Cefadroxil tablet for pets and preparation method thereof |
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| CN111388432A (en) * | 2020-03-19 | 2020-07-10 | 潍坊富邦药业有限公司 | Cefadroxil tablet for pets and preparation method thereof |
| CN114681452A (en) * | 2020-12-31 | 2022-07-01 | 佛山市南海东方澳龙制药有限公司 | Compound fenbendazole chewable tablet for dogs and preparation method thereof |
| CN114947018A (en) * | 2022-06-09 | 2022-08-30 | 浙江万方生物科技有限公司 | Pet nutrition supplementing soft chewable tablet and preparation method thereof |
| CN115607519A (en) * | 2022-11-15 | 2023-01-17 | 江苏南京农大动物药业有限公司 | Cefadroxil tablet for pets and preparation method thereof |
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Application publication date: 20190326 |