CN104337822A - Compound tablets containing mebendazole and dipterex and used for deworming on pets, and preparation method thereof - Google Patents
Compound tablets containing mebendazole and dipterex and used for deworming on pets, and preparation method thereof Download PDFInfo
- Publication number
- CN104337822A CN104337822A CN201310315888.3A CN201310315888A CN104337822A CN 104337822 A CN104337822 A CN 104337822A CN 201310315888 A CN201310315888 A CN 201310315888A CN 104337822 A CN104337822 A CN 104337822A
- Authority
- CN
- China
- Prior art keywords
- mebendazole
- metrifonate
- agent
- tablet
- tablet containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of veterinary deworming drugs and preparation methods thereof, particularly to tablets containing mebendazole and dipterex and used for treating and deworming on pets, and a preparation method thereof. The formulation comprises (a) bulk drugs mebendazole and dipterex, (b) a binder, (c) a wetting agent, (d) a disintegrating agent, (e) a filler, and (f) a sweetening agent. According to the present invention, the tablets containing mebendazole and dipterex are prepared by adopting the wet method, are the white tablets, have characteristics of good stability and good palatability, and can be used as the veterinary oral formulation.
Description
Technical field
The invention belongs to analgesia for animals and preparation method technical field, be specifically related to the preparation method of a kind of mebendazole+metrifonate tablet.
Technical background
Mebendazole is a wide spectrum anthelmintic, in body or in vitro tests all prove directly to suppress nematicide to the absorption of glucose, cause glycogen depletion, make it survive, there is the effect killed larva significantly, suppress ovulation development, but do not affect blood in human body in sugar level.Can be used for the intestinal parasitical diseases such as control ancylostome, ascarid, pinworm, whipworm, excrement class loop line worm.
Mebendazole+metrifonate is utilized wet preparation method by prominent features of the present invention exactly, is prepared into oral tablet for animals.The mebendazole prepared by this method+metrifonate tablet stability is good, good palatability, the assimilation effect that tool is good, for China's veterinary clinic utilizes mebendazole+metrifonate to provide a kind of new preparation better.
Summary of the invention
The object of the invention is to develop a kind of mebendazole+metrifonate oral tablet, heighten the effect of a treatment, improve stability and the palatability of medicine, tool long-acting.
The present invention, for achieving the above object, provides a kind of water tablet containing mebendazole+metrifonate, it is characterized in that preparation specifically consists of:
(a) mebendazole+metrifonate crude drug 5-20% (W/W);
(b) binding agent 10-30% (W/W);
(c) wetting agent 5-20% (W/W);
(d) disintegrating agent 20-50% (W/W);
(e) filler 20-30% (W/W);
(f) sweeting agent 2-3% (W/W);
Described a kind of tablet containing mebendazole+metrifonate, it is characterized in that disintegrating agent be selected from replace hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl starch sodium, PVPP, cCMC-Na, cross-linked carboxymethyl cellulose are received, cross linked polyvinyl pyrrolidone, microcrystalline Cellulose one or more;
The tablet of described a kind of mebendazole+metrifonate, it is characterized in that described filler be selected from lactose, amylum pregelatinisatum, dextrin, microcrystalline Cellulose one or more.
Described a kind of tablet containing mebendazole+metrifonate, it is characterized in that described binding agent be selected from polyvidone (PVP), HPMC, PVP, methylcellulose, sodium carboxymethyl cellulose one or more.
Described a kind of tablet containing mebendazole+metrifonate, it is characterized in that described lubricant be selected from magnesium stearate, micropowder silica gel, talcous one or more.
Described a kind of tablet containing mebendazole+metrifonate, is characterized in that one or more that described sweeting agent is selected from aspartame, stevioside, protein sugar.
Described a kind of tablet containing mebendazole+metrifonate, when it is characterized in that granulating, the granularity of granule should control at 30 orders once.
Described a kind of tablet containing mebendazole+metrifonate, is characterized in that preparation method is as follows:
Measure all stock and adjuncts according to prescription, cross 30-120 mesh sieve; Wherein disintegrating agent and filler respectively in add and Extra Section, the ratio 1-4:1 of Nei Jia and Extra Section, weight ratio; Inside add and weigh respectively with Extra Section, and carry out labelling; By mebendazole+metrifonate raw material and all in add adjuvant and put mix homogeneously in mixer altogether; Add binding agent, continue mixing, make soft material, 30 mesh sieves are granulated; By granule after 50 ° of C-55 ° of C are dried, 30 mesh sieve granulate.
Detailed description of the invention
Be explained the present invention with example below, but example does not limit the scope of the invention, scope of the present invention and core content are determined according to claims.
Example: 10% mebendazole+metrifonate water tablet
[prescription] mebendazole+metrifonate 5+10% (W/W)
Microcrystalline Cellulose 20% (W/W)
PVP 15% (W/W)
Lactose 30% (W/W)
Aluminium stearate 10% (W/W)
Aspartame 15% (W/W)
[preparation]
Get prescription and measure mebendazole+metrifonate and above-mentioned various adjuvant is prepared according to aforementioned preparation process, be i.e. obtained mebendazole+metrifonate water tablet.
Claims (5)
1., containing a tablet for mebendazole+metrifonate, it is characterized in that preparation specifically consists of:
(a) mebendazole+metrifonate crude drug 5-20% (W/W);
(b) binding agent 10-30% (W/W);
(c) wetting agent 5-20% (W/W);
(d) disintegrating agent 20-50% (W/W);
(e) filler 20-30% (W/W);
(f) sweeting agent 2-3% (W/W);
By a kind of tablet containing mebendazole+metrifonate according to claim 1, it is characterized in that disintegrating agent be selected from replace hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl starch sodium, PVPP, cCMC-Na, cross-linked carboxymethyl cellulose are received, cross linked polyvinyl pyrrolidone, microcrystalline Cellulose one or more;
By the tablet of a kind of mebendazole+metrifonate according to claim 1, it is characterized in that described filler be selected from lactose, amylum pregelatinisatum, dextrin, microcrystalline Cellulose one or more.
2. by a kind of tablet containing mebendazole+metrifonate according to claim 1, it is characterized in that described binding agent be selected from polyvidone (PVP), HPMC, PVP, methylcellulose, sodium carboxymethyl cellulose one or more.
3. by a kind of tablet containing mebendazole+metrifonate according to claim 1, it is characterized in that described lubricant be selected from magnesium stearate, micropowder silica gel, talcous one or more.
4., by a kind of tablet containing mebendazole+metrifonate according to claim 1, it is characterized in that one or more that described sweeting agent is selected from aspartame, stevioside, protein sugar.
5., by a kind of tablet containing mebendazole+metrifonate according to claim 1, when it is characterized in that granulating, the granularity of granule should control at 30 orders once.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310315888.3A CN104337822A (en) | 2013-07-25 | 2013-07-25 | Compound tablets containing mebendazole and dipterex and used for deworming on pets, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310315888.3A CN104337822A (en) | 2013-07-25 | 2013-07-25 | Compound tablets containing mebendazole and dipterex and used for deworming on pets, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104337822A true CN104337822A (en) | 2015-02-11 |
Family
ID=52494815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310315888.3A Pending CN104337822A (en) | 2013-07-25 | 2013-07-25 | Compound tablets containing mebendazole and dipterex and used for deworming on pets, and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104337822A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420733A (en) * | 2016-10-17 | 2017-02-22 | 朱隆娅 | Mebendazole-levamisole tablet and preparation method thereof |
| CN106665645A (en) * | 2016-12-22 | 2017-05-17 | 德州京新药业有限公司 | Refined trichlorfon composition and preparation method and application thereof |
| CN111494327A (en) * | 2020-06-23 | 2020-08-07 | 瑞阳制药有限公司 | Preparation method of mebendazole chewable tablet |
-
2013
- 2013-07-25 CN CN201310315888.3A patent/CN104337822A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420733A (en) * | 2016-10-17 | 2017-02-22 | 朱隆娅 | Mebendazole-levamisole tablet and preparation method thereof |
| CN106665645A (en) * | 2016-12-22 | 2017-05-17 | 德州京新药业有限公司 | Refined trichlorfon composition and preparation method and application thereof |
| CN106665645B (en) * | 2016-12-22 | 2019-08-27 | 德州京信药业有限公司 | A kind of refining dipterex composition and the preparation method and application thereof |
| CN111494327A (en) * | 2020-06-23 | 2020-08-07 | 瑞阳制药有限公司 | Preparation method of mebendazole chewable tablet |
| CN111494327B (en) * | 2020-06-23 | 2023-09-05 | 瑞阳制药股份有限公司 | Preparation method of mebendazole chewable tablet |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150211 |