CN104337777A - Tablets containing ketoprofen and having analgesic effect on pets, and preparation method thereof - Google Patents
Tablets containing ketoprofen and having analgesic effect on pets, and preparation method thereof Download PDFInfo
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- CN104337777A CN104337777A CN201310315882.6A CN201310315882A CN104337777A CN 104337777 A CN104337777 A CN 104337777A CN 201310315882 A CN201310315882 A CN 201310315882A CN 104337777 A CN104337777 A CN 104337777A
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- ketoprofen
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- tablet containing
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Abstract
The invention belongs to the technical field of veterinary analgesic drugs and preparation methods thereof, particularly to tablets containing ketoprofen and having the analgesic effect on pets, and a preparation method thereof. The formulation comprises (a) a ketoprofen bulk drug, (b) a binder, (c) a wetting agent, (d) a disintegrating agent, (e) a filler, and (f) a sweetening agent. According to the present invention, the tablets containing ketoprofen are prepared by adopting the wet method, are the white tablets, have characteristics of good stability and good palatability, and can be used as the veterinary oral formulation.
Description
Technical field
The invention belongs to analgesia for animals and preparation method technical field, be specifically related to a kind of preparation method of ketoprofen tablet.
Technical background
Pain is a common multiple problem of horse, and many reasons can cause pain, cause very large misery to pet dog, cat.In recent years, horse pain problem and pain management were subject to the attention of domestic and international veterinary circle day by day, become veterinary must faced by an important topic, and China is also not enough to the research of horse pain problem.
Ketoprofen is utilized wet preparation method by prominent features of the present invention exactly, is prepared into oral tablet for animals.The ketoprofen tablet stability prepared by this method is good, good palatability, the assimilation effect that tool is good, for China's veterinary clinic utilizes ketoprofen to provide a kind of new preparation better.
Summary of the invention
The object of the invention is to develop a kind of ketoprofen oral tablet, heighten the effect of a treatment, improve stability and the palatability of medicine, tool long-acting.
The present invention, for achieving the above object, provides a kind of water tablet containing ketoprofen, it is characterized in that preparation specifically consists of:
(a) ketoprofen crude drug 5-20% (W/W);
(b) binding agent 10-30% (W/W);
(c) wetting agent 5-20% (W/W);
(d) disintegrating agent 20-50% (W/W);
(e) filler 20-30% (W/W);
(f) sweeting agent 2-3% (W/W);
Described a kind of tablet containing ketoprofen, it is characterized in that disintegrating agent be selected from replace hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl starch sodium, PVPP, cCMC-Na, cross-linked carboxymethyl cellulose are received, cross linked polyvinyl pyrrolidone, microcrystalline Cellulose one or more;
The tablet of described a kind of ketoprofen, it is characterized in that described filler be selected from lactose, amylum pregelatinisatum, dextrin, microcrystalline Cellulose one or more.
Described a kind of tablet containing ketoprofen, it is characterized in that described binding agent be selected from polyvidone (PVP), HPMC, PVP, methylcellulose, sodium carboxymethyl cellulose one or more.
Described a kind of tablet containing ketoprofen, it is characterized in that described lubricant be selected from magnesium stearate, micropowder silica gel, talcous one or more.
Described a kind of tablet containing ketoprofen, is characterized in that one or more that described sweeting agent is selected from aspartame, stevioside, protein sugar.
Described a kind of tablet containing ketoprofen, when it is characterized in that granulating, the granularity of granule should control at 30 orders once.
Described a kind of tablet containing ketoprofen, is characterized in that preparation method is as follows:
Measure all stock and adjuncts according to prescription, cross 30-120 mesh sieve; Wherein disintegrating agent and filler respectively in add and Extra Section, the ratio 1-4:1 of Nei Jia and Extra Section, weight ratio; Inside add and weigh respectively with Extra Section, and carry out labelling; By ketoprofen raw material and all in add adjuvant and put mix homogeneously in mixer altogether; Add binding agent, continue mixing, make soft material, 30 mesh sieves are granulated; By granule after 50 ° of C-55 ° of C are dried, 30 mesh sieve granulate.
Detailed description of the invention
Be explained the present invention with example below, but example does not limit the scope of the invention, scope of the present invention and core content are determined according to claims.
Example: 10% ketoprofen water tablet
[prescription] ketoprofen 5+10% (W/W)
Microcrystalline Cellulose 20% (W/W)
PVP 15% (W/W)
Lactose 30% (W/W)
Aluminium stearate 10% (W/W)
Aspartame 15% (W/W)
[preparation]
Get prescription and measure ketoprofen and above-mentioned various adjuvant is prepared according to aforementioned preparation process, be i.e. obtained ketoprofen water tablet.
Claims (5)
1., containing a tablet for ketoprofen, it is characterized in that preparation specifically consists of:
(a) ketoprofen crude drug 5-20% (W/W);
(b) binding agent 10-30% (W/W);
(c) wetting agent 5-20% (W/W);
(d) disintegrating agent 20-50% (W/W);
(e) filler 20-30% (W/W);
(f) sweeting agent 2-3% (W/W);
By a kind of tablet containing ketoprofen according to claim 1, it is characterized in that disintegrating agent be selected from replace hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl starch sodium, PVPP, cCMC-Na, cross-linked carboxymethyl cellulose are received, cross linked polyvinyl pyrrolidone, microcrystalline Cellulose one or more;
By the tablet of a kind of ketoprofen according to claim 1, it is characterized in that described filler be selected from lactose, amylum pregelatinisatum, dextrin, microcrystalline Cellulose one or more.
2. by a kind of tablet containing ketoprofen according to claim 1, it is characterized in that described binding agent be selected from polyvidone (PVP), HPMC, PVP, methylcellulose, sodium carboxymethyl cellulose one or more.
3. by a kind of tablet containing ketoprofen according to claim 1, it is characterized in that described lubricant be selected from magnesium stearate, micropowder silica gel, talcous one or more.
4., by a kind of tablet containing ketoprofen according to claim 1, it is characterized in that one or more that described sweeting agent is selected from aspartame, stevioside, protein sugar.
5., by a kind of tablet containing ketoprofen according to claim 1, when it is characterized in that granulating, the granularity of granule should control at 30 orders once.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310315882.6A CN104337777A (en) | 2013-07-25 | 2013-07-25 | Tablets containing ketoprofen and having analgesic effect on pets, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310315882.6A CN104337777A (en) | 2013-07-25 | 2013-07-25 | Tablets containing ketoprofen and having analgesic effect on pets, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104337777A true CN104337777A (en) | 2015-02-11 |
Family
ID=52494773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310315882.6A Pending CN104337777A (en) | 2013-07-25 | 2013-07-25 | Tablets containing ketoprofen and having analgesic effect on pets, and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104337777A (en) |
-
2013
- 2013-07-25 CN CN201310315882.6A patent/CN104337777A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150211 |