CN104274475A - Gentamicin sulfate and betamethasone valerate containing compound tablet for treating skin infection of dogs - Google Patents
Gentamicin sulfate and betamethasone valerate containing compound tablet for treating skin infection of dogs Download PDFInfo
- Publication number
- CN104274475A CN104274475A CN201310288945.3A CN201310288945A CN104274475A CN 104274475 A CN104274475 A CN 104274475A CN 201310288945 A CN201310288945 A CN 201310288945A CN 104274475 A CN104274475 A CN 104274475A
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- China
- Prior art keywords
- betamethasone valerate
- tablet
- gentamycin
- agent
- sulfur acid
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Abstract
The invention belongs to the technical field of veterinary anti-infective drugs and preparation methods thereof and particularly relates to a gentamicin sulfate and betamethasone valerate containing tablet for treating skin infection of dogs and a preparation method of the gentamicin sulfate and betamethasone valerate containing tablet. The gentamicin sulfate and betamethasone valerate containing tablet is composed of crude drugs (a) of gentamicin sulfate and betamethasone valerate, a binding agent (b), a wetting agent (c), a disintegrating agent (d), a filling agent (e) and a sweetening agent (f). The gentamicin sulfate and betamethasone valerate containing tablet provided by the invention is prepared by using a wet method and is a white-like tablet. The gentamicin sulfate and betamethasone valerate containing tablet researched by the invention is good in stability and palatability and can be used as a veterinary oral preparation.
Description
Technical field
The invention belongs to bacterial-infection resisting for animals and preparation method technical field, be specifically related to the preparation method of a kind of gentamycin sulfate+betamethasone valerate tablet.
Technical background
Gentamycin sulfate is aminoglycosides broad ectrum antibiotic, all has antibacterial and bactericidal action to multiple gram-negative bacteria and positive bacteria.Stronger to effects such as gram-negative bacteria and S. aureus L-forms such as bacillus pyocyaneus, aerobacteria, pneumobacillus, Salmonella, escherichia coli and Bacillus proteuss.Its mechanism of action is and the specific proteins strong bonded on antibacterial nucleoglucoprotein body subunit, interference nucleoglucoprotein body function, stop protein synthesis, and cause the mistake of the upper password of translation Messenger RNA (mRNA) and synthesize non-functioning protein.Clinically for illness such as the septicemia caused by S. aureus L-forms, bacillus pyocyaneus, escherichia coli, dysentery bacterium, klebsiella bacillus, Bacillus proteus and other sensitive organism, respiratory tract infection, biliary tract infection, purulent peritonitis, intracranial infection, urinary tract infection and bacillary dysentery.
The symptoms such as betamethasone valerate is mainly used in skin inflammation, suppresses and alleviate the pruritus of skin, red and swollen.As eczema, psoriasis and dermatitis.Celestone-V is easily absorbed by body.
Gentamycin sulfate+betamethasone valerate is utilized wet preparation method by prominent features of the present invention exactly, is prepared into oral tablet for animals.The gentamycin sulfate prepared by this method+betamethasone valerate tablet stability is good, good palatability, the assimilation effect that tool is good, for China's veterinary clinic utilizes gentamycin sulfate+betamethasone valerate to provide a kind of new preparation better.
summary of the invention
The object of the invention is to develop a kind of gentamycin sulfate+betamethasone valerate oral tablet, heighten the effect of a treatment, improve stability and the palatability of medicine, tool long-acting.
The present invention, for achieving the above object, provides the water tablet of a kind of sulfur acid gentamycin+betamethasone valerate, it is characterized in that preparation specifically consists of:
(a) gentamycin sulfate+betamethasone valerate crude drug 5-20% (W/W);
(b) binding agent 10-30% (W/W);
(c) wetting agent 5-20% (W/W);
(d) disintegrating agent 20-50% (W/W);
(e) filler 20-30% (W/W);
(f) sweeting agent 2-3% (W/W);
The tablet of described a kind of sulfur acid gentamycin+betamethasone valerate, it is characterized in that disintegrating agent be selected from replace hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl starch sodium, PVPP, cCMC-Na, cross-linked carboxymethyl cellulose are received, cross linked polyvinyl pyrrolidone, microcrystalline Cellulose one or more;
The tablet of described a kind of gentamycin sulfate+betamethasone valerate, it is characterized in that described filler be selected from lactose, amylum pregelatinisatum, dextrin, microcrystalline Cellulose one or more.
The tablet of described a kind of sulfur acid gentamycin+betamethasone valerate, it is characterized in that described binding agent be selected from polyvidone (PVP), HPMC, PVP, methylcellulose, sodium carboxymethyl cellulose one or more.
The tablet of described a kind of sulfur acid gentamycin+betamethasone valerate, it is characterized in that described lubricant be selected from magnesium stearate, micropowder silica gel, talcous one or more.
The tablet of described a kind of sulfur acid gentamycin+betamethasone valerate, is characterized in that one or more that described sweeting agent is selected from aspartame, stevioside, protein sugar.
The tablet of described a kind of sulfur acid gentamycin+betamethasone valerate, when it is characterized in that granulating, the granularity of granule should control at 30 orders once.
The tablet of described a kind of sulfur acid gentamycin+betamethasone valerate, is characterized in that preparation method is as follows:
Measure all stock and adjuncts according to prescription, cross 30-120 mesh sieve; Wherein disintegrating agent and filler respectively in add and Extra Section, the ratio 1-4:1 of Nei Jia and Extra Section, weight ratio; Inside add and weigh respectively with Extra Section, and carry out labelling; By gentamycin sulfate+betamethasone valerate raw material and all in add adjuvant and put mix homogeneously in mixer altogether; Add binding agent, continue mixing, make soft material, 30 mesh sieves are granulated; By granule after 50 ° of C-55 ° of C are dried, 30 mesh sieve granulate.
Detailed description of the invention
Be explained the present invention with example below, but example does not limit the scope of the invention, scope of the present invention and core content are determined according to claims.
Example: 10% gentamycin sulfate+betamethasone valerate water tablet
[prescription] gentamycin sulfate+betamethasone valerate 5+10% (W/W)
Microcrystalline Cellulose 20% (W/W)
PVP 15% (W/W)
Lactose 30% (W/W)
Aluminium stearate 10% (W/W)
Aspartame 15% (W/W)
[preparation]
Get prescription and measure gentamycin sulfate+betamethasone valerate and above-mentioned various adjuvant is prepared according to aforementioned preparation process, be i.e. obtained gentamycin sulfate+betamethasone valerate water tablet.
Claims (5)
1. a tablet for sulfur acid gentamycin+betamethasone valerate, is characterized in that preparation specifically consists of:
(a) gentamycin sulfate+betamethasone valerate crude drug 5-20% (W/W);
(b) binding agent 10-30% (W/W);
(c) wetting agent 5-20% (W/W);
(d) disintegrating agent 20-50% (W/W);
(e) filler 20-30% (W/W);
(f) sweeting agent 2-3% (W/W);
By the tablet of a kind of sulfur acid gentamycin+betamethasone valerate according to claim 1, it is characterized in that disintegrating agent be selected from replace hydroxypropyl cellulose, carboxymethyl cellulose, carboxymethyl starch sodium, PVPP, cCMC-Na, cross-linked carboxymethyl cellulose are received, cross linked polyvinyl pyrrolidone, microcrystalline Cellulose one or more;
By the tablet of a kind of gentamycin sulfate+betamethasone valerate according to claim 1, it is characterized in that described filler be selected from lactose, amylum pregelatinisatum, dextrin, microcrystalline Cellulose one or more.
2. by the tablet of a kind of sulfur acid gentamycin+betamethasone valerate according to claim 1, it is characterized in that described binding agent be selected from polyvidone (PVP), HPMC, PVP, methylcellulose, sodium carboxymethyl cellulose one or more.
3. by the tablet of a kind of sulfur acid gentamycin+betamethasone valerate according to claim 1, it is characterized in that described lubricant be selected from magnesium stearate, micropowder silica gel, talcous one or more.
4., by the tablet of a kind of sulfur acid gentamycin+betamethasone valerate according to claim 1, it is characterized in that one or more that described sweeting agent is selected from aspartame, stevioside, protein sugar.
5., by the tablet of a kind of sulfur acid gentamycin+betamethasone valerate according to claim 1, when it is characterized in that granulating, the granularity of granule should control at 30 orders once.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310288945.3A CN104274475A (en) | 2013-07-11 | 2013-07-11 | Gentamicin sulfate and betamethasone valerate containing compound tablet for treating skin infection of dogs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310288945.3A CN104274475A (en) | 2013-07-11 | 2013-07-11 | Gentamicin sulfate and betamethasone valerate containing compound tablet for treating skin infection of dogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104274475A true CN104274475A (en) | 2015-01-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310288945.3A Pending CN104274475A (en) | 2013-07-11 | 2013-07-11 | Gentamicin sulfate and betamethasone valerate containing compound tablet for treating skin infection of dogs |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104274475A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101674A (en) * | 2019-05-07 | 2019-08-09 | 安徽金太阳生化药业有限公司 | A kind of preparation method of betamethasone piece |
-
2013
- 2013-07-11 CN CN201310288945.3A patent/CN104274475A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101674A (en) * | 2019-05-07 | 2019-08-09 | 安徽金太阳生化药业有限公司 | A kind of preparation method of betamethasone piece |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150114 |