CN107158092A - A kind of pure Chinese medicine toothache drops and preparation method thereof - Google Patents
A kind of pure Chinese medicine toothache drops and preparation method thereof Download PDFInfo
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- CN107158092A CN107158092A CN201710414598.2A CN201710414598A CN107158092A CN 107158092 A CN107158092 A CN 107158092A CN 201710414598 A CN201710414598 A CN 201710414598A CN 107158092 A CN107158092 A CN 107158092A
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- chinese medicine
- borneol
- pure chinese
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
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Abstract
The invention discloses a kind of pure Chinese medicine toothache drops and preparation method thereof, the pure Chinese medicine toothache drops is prepared from by the raw material components of following percentage by weight, borneol 3 5%, Chinese cassia tree 10 20%, anise 6 10%, the ethanol of corydalis tuber 6 10% and 55 75%.The present invention is a kind of toothache drops of high-efficiency low-toxicity, and good mouthfeel, it is easy to receive works well, and periodontitis is relieved pain for general 12 hours, and pain caused by cavity is relieved pain for general 5 10 minutes, no side effects.
Description
Technical field
The present invention relates to toothache treatment technology field, and in particular to a kind of pure Chinese medicine toothache drops and preparation method thereof.
Background technology
Dental pain is the common acute disease of the department of stomatology, and it is the inducement of many diseases, can cause the rapid hair of the diseases such as angiocarpy,
Or even cause more serious consequence.
Current dental disease turns into global disease problem, and the World Health Organization needs emphasis using odontopathy as the 3rd
The disease of preventing and treating.China's odontopathy accounts for 85%, and carious tooth and periodontosis (gingivitis, periodontitis, gingival atrophy in crowd
Deng) the incidence of disease account for first place.Almost there is the stimulation of chemical factors in dental patient, bacterium infection, oral cavity in each family, at any time
Violent toothache may all be caused, patient is suffered untold misery.
Toothache drops being used for above-mentioned toothache at present and carrying out analgesic sedative treatment, effect is more apparent.But, toothache drops
Composition not pure Chinese medicine, the toothache drops of current market circulation has the narcotic analgesic medicine such as asarum, Radix zanthoxyli mostly, and both medicines are that have
Toxicity, many clothes can make one tongue fiber crops, and severe patient can make one respiratory paralysis and dead.
The content of the invention
It is an object of the invention to provide a kind of pure Chinese medicine toothache drops and preparation method thereof, to solve current non-pure Chinese medicine
The problem of toothache drops side effect is big.
To achieve the above object the invention discloses a kind of pure Chinese medicine toothache drops, the pure Chinese medicine toothache drops is by following weight
The raw material components of percentage are prepared from, borneol 3-5%, Chinese cassia tree 10-20%, anise 6-10%, corydalis tuber 6-10% and 55-
75% ethanol.
Further, the pure Chinese medicine toothache drops is prepared from by the raw material components of following percentage by weight, borneol 5%, meat
Osmanthus 15%, anise 10%, the ethanol of corydalis tuber 10% and 60%.
Further, the borneol is artificial synthesized kapur.
Further, the concentration of alcohol is 50-75%.
On the other hand, the invention also discloses a kind of preparation method of pure Chinese medicine toothache drops as described above, methods described bag
Include following steps：
Step one：Borneol, Chinese cassia tree, anise and corydalis tuber are put into ready ethanol, stirring is sufficiently mixed, wherein,
Borneol, Chinese cassia tree, anise, corydalis tuber and ethanol are respectively according to following percentage by weight 3-5%, 10-20%, 6-10%, 6-10%
And 55-75%；
Step 2：Sealing immersion 72 hours in ethanol；
Step 3：Take solution sealing storage standby after filtering.
Further, the mixing, sealing immersion and sealing storage are carried out in the environment of temperature is 0 DEG C -40 DEG C.
On the other hand, the invention also discloses a kind of preparation method of pure Chinese medicine toothache drops as described above, methods described bag
Include following steps：
Step one：Chinese cassia tree, anise and corydalis tuber are mixed, the medical ethanol for being 50-75% with concentration carries out two to three-level
Soak extraction, merges the extract solution after collecting two to three-level extraction；
Step 2：Borneol is put into the extract solution for merging and collecting, be sufficiently stirred for, being completely dissolved into ethanol by borneol is defined；
Step 3：Sealing preserve is standby.
Further, every grade in the step one extracts the medical ethanol immersion meat for 50-75% using the concentration of equivalent
The mixture in osmanthus, anise and corydalis tuber 24 hours is simultaneously spaced stirring two to three times.
Further, the stirring and sealing preserve are carried out in the environment of temperature is 0 DEG C -40 DEG C.
The invention has the advantages that：The present invention is a kind of toothache drops of high-efficiency low-toxicity, good mouthfeel, it is easy to receive, effect
Fruit is good, the general 1-2 hours analgesic of periodontitis, the general 5-10 minutes analgesic of pain caused by cavity, no side effects.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Pure Chinese medicine toothache drops in the present embodiment is prepared from by the raw material components of following percentage by weight, borneol 5%, meat
Osmanthus 15%, anise 10%, the ethanol of corydalis tuber 10% and 60%, wherein, borneol is artificial synthesized kapur, and concentration of alcohol is
50-75%.
The method that above-mentioned pure Chinese medicine toothache drops is prepared in the present embodiment comprises the following steps：
Step one：Borneol 50g, Chinese cassia tree 150g, anise 100g and corydalis tuber 100g are put into ready 600ml ethanol
In, it is sufficiently mixed stirring in the environment of temperature is 0 DEG C -40 DEG C；
Step 2：Sealing immersion 72 hours in the environment of temperature is maintained at 0 DEG C -40 DEG C in ethanol；
Step 3：Solution is taken to seal storage under 0 DEG C -40 DEG C of temperature environment after filtering standby.
The dense additive of the tastes such as menthol can be added in above-mentioned preparation.Further, since ethanol and borneol inherently have anti-
Rotten effect, therefore need not add any preservative, as long as preserving, also seal and be kept in dark place just can be with.
Embodiment 2
Pure Chinese medicine toothache drops in the present embodiment is prepared from by the raw material components of following percentage by weight, borneol 5%, meat
Osmanthus 15%, anise 10%, the ethanol of corydalis tuber 10% and 60%, wherein, borneol is artificial synthesized kapur, and concentration of alcohol is
50-75%.
The method that above-mentioned pure Chinese medicine toothache drops is prepared in the present embodiment comprises the following steps：
Step one：Chinese cassia tree 150g, anise 100g and corydalis tuber 100g are mixed, with 600ml 70-75% medical ethanol
Two are carried out to three-level soak extraction, merges the extract solution after collecting two to three-level extraction, wherein, every grade is extracted using the dense of equivalent
Spend the medical ethanol immersion Chinese cassia tree for 50-75%, the mixture 24 hours of anise and corydalis tuber and be spaced stirring two to three times, example
Such as, when carrying out two grades of soak extractions, 600ml concentration is divided into two parts, every part of equivalent for 50-75% medical ethanol
300ml, every grade is extracted using a, when carrying out three-level soak extraction, by medical ethanol point of the 600ml concentration for 50-75%
Into three parts of equivalent, every part of 200ml, every grade of extraction uses a；
Step 2：Borneol is put into the extract solution for merging and collecting, is sufficiently stirred in the environment of temperature is 0 DEG C -40 DEG C,
Ethanol is completely dissolved into by borneol to be defined；
Step 3：It is standby that sealing preserve is carried out in the environment of temperature is 0 DEG C -40 DEG C.
The dense additive of the tastes such as menthol can be added in above-mentioned preparation.Further, since ethanol and borneol inherently have anti-
Rotten effect, therefore need not add any preservative, as long as preserving, also seal and be kept in dark place just can be with.
Although above with general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of pure Chinese medicine toothache drops, it is characterised in that：The pure Chinese medicine toothache drops by following percentage by weight raw material components
It is prepared from, borneol 3-5%, Chinese cassia tree 10-20%, anise 6-10%, corydalis tuber 6-10% and 55-75% ethanol.
2. a kind of pure Chinese medicine toothache drops as claimed in claim 1, it is characterised in that：The pure Chinese medicine toothache drops is by following weight
The raw material components of percentage are prepared from, borneol 5%, Chinese cassia tree 15%, anise 10%, the ethanol of corydalis tuber 10% and 60%.
3. a kind of pure Chinese medicine toothache drops as described in claim 1, it is characterised in that：The borneol is artificial synthesized borneol
It is fragrant.
4. a kind of pure Chinese medicine toothache drops as claimed in claim 1, it is characterised in that：The concentration of alcohol is 50-75%.
5. a kind of pure Chinese medicine toothache drops as described in any one in claim 1-4, it is characterised in that：The pure Chinese medicine toothache
In water flavor additives are used as added with menthol.
6. a kind of preparation method of pure Chinese medicine toothache drops as described in any one in 1-4 such as claim, it is characterised in that the side
Method comprises the following steps：
Step one：Borneol, Chinese cassia tree, anise and corydalis tuber are put into ready ethanol, stirring is sufficiently mixed, wherein, borneol,
Chinese cassia tree, anise, corydalis tuber and ethanol are respectively according to following percentage by weight 3-5%, 10-20%, 6-10%, 6-10% and 55-
75%；
Step 2：Sealing immersion 72 hours in ethanol；
Step 3：Take solution sealing storage standby after filtering.
7. preparation method as claimed in claim 6, it is characterised in that：It is described to mix, seal immersion and seal and deposit equal
Carried out in the environment of temperature is 0 DEG C -40 DEG C.
8. a kind of preparation method of pure Chinese medicine toothache drops as described in any one in 1-4 such as claim, it is characterised in that the side
Method comprises the following steps：
Step one：Chinese cassia tree, anise and corydalis tuber are mixed, the medical ethanol for being 50-75% with concentration carries out two to three-level immersion
Extract, merge the extract solution after collecting two to three-level extraction；
Step 2：Borneol is put into the extract solution for merging and collecting, be sufficiently stirred for, being completely dissolved into ethanol by borneol is defined；
Step 3：Sealing preserve is standby.
9. preparation method as claimed in claim 8, it is characterised in that：Every grade in the step one is extracted using the dense of equivalent
Spend the medical ethanol immersion Chinese cassia tree for 50-75%, the mixture 24 hours of anise and corydalis tuber and be spaced stirring two to three times.
10. preparation method as claimed in claim 8, it is characterised in that：It is described stirring and sealing preserve temperature for 0 DEG C-
Carried out in the environment of 40 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710414598.2A CN107158092A (en) | 2017-06-05 | 2017-06-05 | A kind of pure Chinese medicine toothache drops and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710414598.2A CN107158092A (en) | 2017-06-05 | 2017-06-05 | A kind of pure Chinese medicine toothache drops and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107158092A true CN107158092A (en) | 2017-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710414598.2A Pending CN107158092A (en) | 2017-06-05 | 2017-06-05 | A kind of pure Chinese medicine toothache drops and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1204515A (en) * | 1997-07-07 | 1999-01-13 | 张希武 | Chinese medicinal preparation for treatment of toothache and method for preparation thereof |
| CN1736402A (en) * | 2004-08-18 | 2006-02-22 | 安季蓓 | Quick-acting liquid preparation for toothache |
-
2017
- 2017-06-05 CN CN201710414598.2A patent/CN107158092A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1204515A (en) * | 1997-07-07 | 1999-01-13 | 张希武 | Chinese medicinal preparation for treatment of toothache and method for preparation thereof |
| CN1736402A (en) * | 2004-08-18 | 2006-02-22 | 安季蓓 | Quick-acting liquid preparation for toothache |
Non-Patent Citations (1)
| Title |
|---|
| 贺升效: "《中医临床诊治续集》", 31 December 1990, 四川大学出版社 * |
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Application publication date: 20170915 |
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