CN107155304A - 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途 - Google Patents

开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途 Download PDF

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Publication number
CN107155304A
CN107155304A CN201580028874.0A CN201580028874A CN107155304A CN 107155304 A CN107155304 A CN 107155304A CN 201580028874 A CN201580028874 A CN 201580028874A CN 107155304 A CN107155304 A CN 107155304A
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sdg
subject
radiation
exposed
cells
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CN201580028874.0A
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Chinese (zh)
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迈尔波·赫里斯托费多-所罗米多
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University of Pennsylvania Penn
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University of Pennsylvania Penn
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Priority to CN202010760162.0A priority Critical patent/CN112336736A/zh
Publication of CN107155304A publication Critical patent/CN107155304A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580028874.0A 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途 Pending CN107155304A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010760162.0A CN112336736A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462005330P 2014-05-30 2014-05-30
US62/005,330 2014-05-30
US201562101296P 2015-01-08 2015-01-08
US62/101,296 2015-01-08
PCT/US2015/033501 WO2015184441A2 (en) 2014-05-30 2015-06-01 USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202010760162.0A Division CN112336736A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途

Publications (1)

Publication Number Publication Date
CN107155304A true CN107155304A (zh) 2017-09-12

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Family Applications (2)

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CN202010760162.0A Pending CN112336736A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途
CN201580028874.0A Pending CN107155304A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷（sdg）和相关化合物用于防护辐射和化学损害的用途

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CN202010760162.0A Pending CN112336736A (zh) 2014-05-30 2015-06-01 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途

Country Status (9)

Country Link
EP (1) EP3148560A4 (enExample)
JP (2) JP2017520620A (enExample)
KR (1) KR20170010019A (enExample)
CN (2) CN112336736A (enExample)
AU (2) AU2015266614A1 (enExample)
CA (1) CA2950744A1 (enExample)
IL (1) IL249219A0 (enExample)
MA (1) MA39899A (enExample)
WO (1) WO2015184441A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112601462A (zh) * 2018-08-31 2021-04-02 伊诺弗斯公司 植物抗氧化剂
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11071746B2 (en) 2016-06-07 2021-07-27 The Trustees Of The University Of Pennsylvania Compositions and methods for protecting organs from ischemia/reperfusion injury associated with transplantation
EP3606325B1 (en) 2017-04-03 2024-09-04 Gusto Global, LLC Rational design of microbial-based biotherapeutics
EP3687545A4 (en) * 2017-09-27 2021-06-09 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION-INDUCED CARDIOVASCULAR DYSFUNCTION
US20210128596A1 (en) * 2017-09-27 2021-05-06 University Of Pennsylvania Compositions and methods for treating septic cardiomyopathy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1447689A (zh) * 2000-06-14 2003-10-08 阿拉·夏皮罗 辐射保护剂
CN1814608A (zh) * 2006-03-02 2006-08-09 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
CN101578042A (zh) * 2006-06-16 2009-11-11 Ip-6研究公司 预防核辐射、太阳辐射及其他辐射诱导的组织损害
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2312164C (en) * 1999-06-30 2009-12-15 University Of Saskatchewan Technologies Inc. Antioxidant activity in sdg metabolites
WO2010017332A2 (en) * 2008-08-07 2010-02-11 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health & Human Services Radioprotectants targeting thrombospondin-1 and cd47
CN101759731B (zh) * 2008-12-25 2011-10-19 中国科学院兰州化学物理研究所 亚麻籽胶和开环异落叶松树脂酚二葡萄糖苷的提取方法
PT3007557T (pt) * 2013-06-10 2018-11-09 Scripps Research Inst Preparação do diglucosídeo (s,s)-secoisolariciresinol e do diglucosídeo (r,r)-secoisolariciresinol

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1447689A (zh) * 2000-06-14 2003-10-08 阿拉·夏皮罗 辐射保护剂
CN1814608A (zh) * 2006-03-02 2006-08-09 江南大学 一种从亚麻籽中提取纯化开环异落叶松树脂酚二葡萄糖苷的方法
CN101578042A (zh) * 2006-06-16 2009-11-11 Ip-6研究公司 预防核辐射、太阳辐射及其他辐射诱导的组织损害
US20100239696A1 (en) * 2007-05-25 2010-09-23 The Trustees Of The University Of Pennsylvania Flaxseed lignan complex, methods of using amd compositions thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
OM P. MISHRA，等: "Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs)", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
左玉，等: "脂质的氧化及其对DNA损伤的研究进展", 《河南工业大学学报（自然科学版）》 *
杨宏志等: "开环异落叶松树脂酚二葡萄糖苷(SDG)抗氧化活性研究", 《中国食品学报》 *
郁军超，等: "机体ROS的产生及对生物大分子的", 《山东医药》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112601462A (zh) * 2018-08-31 2021-04-02 伊诺弗斯公司 植物抗氧化剂
CN112601462B (zh) * 2018-08-31 2023-10-31 伊诺弗斯公司 植物抗氧化剂
CN116850162A (zh) * 2023-08-08 2023-10-10 南通大学附属医院 肠二醇在制备治疗放射性肠炎药物中的应用

Also Published As

Publication number Publication date
AU2015266614A1 (en) 2016-12-15
CN112336736A (zh) 2021-02-09
WO2015184441A2 (en) 2015-12-03
JP2020121987A (ja) 2020-08-13
CA2950744A1 (en) 2015-12-03
MA39899A (fr) 2021-05-26
KR20170010019A (ko) 2017-01-25
IL249219A0 (en) 2017-02-28
JP2017520620A (ja) 2017-07-27
WO2015184441A9 (en) 2016-01-21
AU2020270469A1 (en) 2020-12-17
EP3148560A4 (en) 2018-04-25
EP3148560A2 (en) 2017-04-05
WO2015184441A3 (en) 2016-03-10

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