CN107137701A - 一种提高dc疫苗抗肝癌效果的基因靶标、抑制剂和dc肿瘤疫苗 - Google Patents
一种提高dc疫苗抗肝癌效果的基因靶标、抑制剂和dc肿瘤疫苗 Download PDFInfo
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- CN107137701A CN107137701A CN201710314783.4A CN201710314783A CN107137701A CN 107137701 A CN107137701 A CN 107137701A CN 201710314783 A CN201710314783 A CN 201710314783A CN 107137701 A CN107137701 A CN 107137701A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
组别 | SOCS2 mRNA相对表达量 |
阴性对照组 | 1.24 |
siRNA沉默组 | 0.32 |
外源肽沉默组 | 0.39 |
组别 | 体内抑瘤率(%) |
阴性对照组 | 35 |
siRNA沉默组 | 73 |
外源肽沉默组 | 67 |
Claims (10)
Priority Applications (1)
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CN201710314783.4A CN107137701B (zh) | 2017-05-07 | 2017-05-07 | 一种提高dc疫苗抗肝癌效果的基因靶标、抑制剂和dc肿瘤疫苗 |
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CN201710314783.4A CN107137701B (zh) | 2017-05-07 | 2017-05-07 | 一种提高dc疫苗抗肝癌效果的基因靶标、抑制剂和dc肿瘤疫苗 |
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CN107137701A true CN107137701A (zh) | 2017-09-08 |
CN107137701B CN107137701B (zh) | 2020-07-14 |
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Citations (7)
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CN101437834A (zh) * | 2004-07-19 | 2009-05-20 | 贝勒医学院 | 细胞因子信号转导调节剂的调节和用于免疫治疗的应用 |
CN101501055A (zh) * | 2005-06-23 | 2009-08-05 | 贝勒医学院 | 负性免疫调节因子的调节和免疫疗法应用 |
US20100255023A1 (en) * | 2007-11-30 | 2010-10-07 | Si-Yi Chen | Dendritic cell vaccine compositions and uses of same |
WO2012156473A2 (en) * | 2011-05-16 | 2012-11-22 | University Of Tartu | A set of micrornas as markers and targets in cancer and immune system related diseases, methods for their application and a kit |
US20130317087A1 (en) * | 2011-02-09 | 2013-11-28 | University Of Rochester | Methods and compositions related to staufen 1 binding sites formed by duplexing alu elements |
CN104508149A (zh) * | 2012-07-27 | 2015-04-08 | 诺华股份有限公司 | 对jak/stat抑制剂治疗响应的预测 |
CN105247371A (zh) * | 2013-06-17 | 2016-01-13 | 德国癌症研究公共权益基金会 | 通过转录因子tsc22d4的抑制剂治疗胰岛素抵抗 |
-
2017
- 2017-05-07 CN CN201710314783.4A patent/CN107137701B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101437834A (zh) * | 2004-07-19 | 2009-05-20 | 贝勒医学院 | 细胞因子信号转导调节剂的调节和用于免疫治疗的应用 |
CN101501055A (zh) * | 2005-06-23 | 2009-08-05 | 贝勒医学院 | 负性免疫调节因子的调节和免疫疗法应用 |
US20100255023A1 (en) * | 2007-11-30 | 2010-10-07 | Si-Yi Chen | Dendritic cell vaccine compositions and uses of same |
CN101932339A (zh) * | 2007-11-30 | 2010-12-29 | 贝勒医学院 | 树突细胞疫苗组合物及其应用 |
US20130317087A1 (en) * | 2011-02-09 | 2013-11-28 | University Of Rochester | Methods and compositions related to staufen 1 binding sites formed by duplexing alu elements |
WO2012156473A2 (en) * | 2011-05-16 | 2012-11-22 | University Of Tartu | A set of micrornas as markers and targets in cancer and immune system related diseases, methods for their application and a kit |
CN104508149A (zh) * | 2012-07-27 | 2015-04-08 | 诺华股份有限公司 | 对jak/stat抑制剂治疗响应的预测 |
CN105247371A (zh) * | 2013-06-17 | 2016-01-13 | 德国癌症研究公共权益基金会 | 通过转录因子tsc22d4的抑制剂治疗胰岛素抵抗 |
Non-Patent Citations (4)
Title |
---|
GENBANK: ""MULTISPECIES: DNA polymerase III subunit gamma/tau[Aerococcus],ACCESSION WP_070431481 "", 《GENBANK》 * |
JIN HU ET AL.: ""SOSC2 Influences LPS Induced Human Monocyte-Derived Dendritic Cell Maturation"", 《PLOS ONE》 * |
师文楷: ""SOCS-2和STAT-5在肝细胞癌组织中的表达及临床意义"", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
王莉等: ""树突状细胞肿瘤疫苗研究进展"", 《癌症进展杂志》 * |
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Denomination of invention: A gene target, inhibitor and DC tumor vaccine for improving the anti liver cancer effect of DC vaccine Effective date of registration: 20210915 Granted publication date: 20200714 Pledgee: Shandong Gaomi rural commercial bank Limited by Share Ltd. Pledgor: SHANDONG XINRUI BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021370010092 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
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Date of cancellation: 20220905 Granted publication date: 20200714 Pledgee: Shandong Gaomi rural commercial bank Limited by Share Ltd. Pledgor: SHANDONG XINRUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2021370010092 |
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Denomination of invention: A gene target, inhibitor and DC tumor vaccine to improve the effect of DC vaccine against liver cancer Effective date of registration: 20220906 Granted publication date: 20200714 Pledgee: Shandong Gaomi rural commercial bank Limited by Share Ltd. Pledgor: SHANDONG XINRUI BIOTECHNOLOGY CO.,LTD. Registration number: Y2022370010139 |