CN107137604A - A kind of cannabidiol liquid preparation with angst resistance effect and preparation method thereof - Google Patents

A kind of cannabidiol liquid preparation with angst resistance effect and preparation method thereof Download PDF

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Publication number
CN107137604A
CN107137604A CN201710173495.1A CN201710173495A CN107137604A CN 107137604 A CN107137604 A CN 107137604A CN 201710173495 A CN201710173495 A CN 201710173495A CN 107137604 A CN107137604 A CN 107137604A
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parts
cannabidiol
ethanol
preparation
resistance effect
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孙欣
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Harbin Huimeijia Biological Technology Co Ltd
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Harbin Huimeijia Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/618Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/37Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/38Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract

A kind of cannabidiol liquid preparation with angst resistance effect and preparation method thereof, is prepared from following components in parts by weight by raw material:5 10 parts of cannabidiol, 35 parts of rhizome of chuanxiong, 35 parts of spina date seed, 35 parts of moutan bark, 12 parts of corydalis tuber, 12 parts of Rumex madaio, 12 parts of hypericum perforatum, 12 parts of rhizoma Gastrodiae, 12 parts of safflower, 12 parts of schizonepeta, 12 parts of fringed pink, 12 parts of, Thlaspis, 12 parts of Ramulus euonymi, 12 parts of jasmine, 12 parts of sea Piao sheath, 13 parts of essence, 25 30 parts of gaultherolin, 600 650 parts of ethanol, 282 355 parts of purified water.A kind of cannabidiol liquid preparation with angst resistance effect of the present invention and preparation method thereof, takes full advantage of cannabidiol pharmacological action antianxity, and compatibility kinds of traditional Chinese medicines, can effectively releive spirit, alleviates anxiety.

Description

A kind of cannabidiol liquid preparation with angst resistance effect and preparation method thereof
Technical field
The present invention relates to liquid preparation field, more particularly to a kind of cannabidiol liquid preparation with angst resistance effect And preparation method thereof.
Background technology
Anxiety disorder is also known as anxiety neurosis, is the neurosis using anxiety as principal character, is presented without true root According to the also mood on tenterhooks and frightened and restless without clear and definite objective objects and concrete idea content, also vegetative nerve symptom and Muscular tone, and motility are uneasy.
With the quickening of modern life rhythm, the stress of people is increasing, in addition the work of excess load, long-term Mental labour and irregular habits and customs, cause increasing people to suffer from different degrees of anxiety disorder.And excessive Jiao Worry can then influence the mood of people, and then influence people's healthy, and be unfavorable for sleep, the life given people, study Different degrees of influence is brought with work.At present, for anxiety disorder treatment mostly using based on western medicine, these medicines into Divide complexity, be also easy to produce drug resistance, there is certain side effect, be unfavorable for the health of people.
The content of the invention
It is an object of the invention to provide a kind of cannabidiol liquid preparation with angst resistance effect and preparation method thereof, fill Divide and make use of cannabidiol pharmacological action antianxity, and compatibility kinds of traditional Chinese medicines, can effectively releive spirit, alleviate anxiety.
The purpose of the present invention is achieved through the following technical solutions:
A kind of cannabidiol liquid preparation with angst resistance effect, is prepared from following components in parts by weight by raw material:
5-10 parts of cannabidiol
3-5 parts of rhizome of chuanxiong
3-5 parts of spina date seed
3-5 parts of moutan bark
1-2 parts of corydalis tuber
1-2 parts of Rumex madaio
1-2 parts of hypericum perforatum
1-2 parts of rhizoma Gastrodiae
1-2 parts of safflower
1-2 parts of schizonepeta
1-2 parts of fringed pink
1-2 parts of Thlaspi
1-2 parts of Ramulus euonymi
1-2 parts of jasmine
1-2 parts of sea Piao sheath
1-3 parts of essence
25-30 parts of gaultherolin
600-650 parts of ethanol
282-355 parts of purified water.
A kind of described cannabidiol liquid preparation with angst resistance effect, raw material presses optimum weight number:
5 parts of cannabidiol
4 parts of rhizome of chuanxiong
4 parts of spina date seed
3 parts of moutan bark
2 parts of corydalis tuber
2 parts of Rumex madaio
1 part of hypericum perforatum
1 part of rhizoma Gastrodiae
1 part of safflower
1 part of schizonepeta
1 part of fringed pink
1 part of Thlaspi
1 part of Ramulus euonymi
1 part of jasmine
1 part of sea Piao sheath
1 part of essence
25 parts of gaultherolin
600 parts of ethanol
351 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
The ethanol is 40%-80% ethanol.
A kind of preparation method of cannabidiol liquid preparation with angst resistance effect, the specific step of its preparation method Suddenly it is:
Step 1, by weight, weighs the cannabidiol of high-quality, rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, passes through leaf It is the capsule of weeping forsythia, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspis, Ramulus euonymi, jasmine, sea Piao sheath, essence, gaultherolin, ethanol, pure Change water, it is standby;
Step 2, take rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, hypericum perforatum, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspi, Ramulus euonymi, jasmine, sea Piao sheath, after mixing, plus the 6-12 times of ethanol for measuring 40%-80% is extracted 1-4 times, and each 0.5-2 is small When, ethanol is recovered under reduced pressure in filtering, merging filtrate, and less than 60 DEG C are dried under reduced pressure, and crushed after being dried is made mixing and extracted into fine powder Powder, it is standby;
Step 3, cannabidiol, mixing extract powder are taken, after being well mixed, add in remaining ethanol, add essence, salicylic acid Methyl esters, purified water, are mixed 1 hour, after being well mixed, finished product.
In the feed, rhizome of chuanxiong has the effect of promoting blood circulation, promote breath and open depression, wind-expelling pain-stopping, and energy tonifying liver blood, profit liver is dry, mends Wind is empty;Spina date seed is used for restlessness of asrhenia type and insomnia, palpitation with fear palpitation, the effect with antitoxic heart-soothing and sedative, nourishing the liver;Moutan bark has heat-clearing cool Blood, promoting blood circulation and removing blood stasis, reducing the asthenic fever effect;Corydalis tuber has promoting blood circulation, dissipates the stasis of blood, qi-regulating, the effect of analgesic;Rumex madaio has heat-clearing solution Poison, hemostasis, dissolving stasis, defaecation, disinsection efficiency;Hypericum perforatum has convergence, antibacterial, hemostasis, clearing and activating the channels and collaterals and antiviral swollen with anti- Knurl is acted on;Rhizoma Gastrodiae is used for the diseases such as dizziness of having a headache, extremity numbness, child convulsion;Safflower has promoting blood circulation to remove blood stasis, tranquilizing and blood nourishing Effect;Schizonepeta energy wind-dispelling, inducing diaphoresis, promoting eruption, hemostasis, cure cold heating, headache, eye itching, cough, abscess of throat, measles, carbuncle swells, Sore scabies, bleeding from five sense organs or subcutaneous tissue, spit blood, have blood in stool, uterine bleeding, postpartum anemic fainting;Fringed pink energy diuresis, clearing away damp-heat, invigorate blood circulation, control urinary obstruction, heat Pouring, blood strangury, urolithiasis, amenorrhoea, red eye, swell pain, carbuncle sore tumefacting virus, wet sore itch, inducing diuresis for treating strangurtia, blood-breaking are stimulated the menstrual flow;Thlaspi energy heat-clearing solution Poison, inducing diuresis for removing edema.Main red eye, swell pain;Lung carbuncle;Acute appendicitis;Diarrhea;Dysentery;Leukorrhea;Postpartum blood stasis is suffered from abdominal pain;Indigestion;Ephritis water It is swollen;Cirrhotic ascites;Ulcerative carbuncle pyogenic infections.For appendicitis, lung abscess, carbuncle furuncle poison, erysipelas, endometritis;Ramulus euonymi can be broken Blood stimulates the menstrual flow, removing toxicity for detumescence, desinsection, controls abdominal mass caking, trusted subordinate's pain, amenorrhoea, dysmenorrhoea, metrorrhagia and metrostaxis, postpartum stasis of blood, lochia Under not, hernia, severe and migratory arthralgia numbness pain, sore swells, injuries from falls as well, abdominal pain due to enterositosis, burn and scald, venomous snake bite;Jasmine energy liver soothing and depression relief, OK Gas is relieved pain, and the side of body rib gastral cavity abdomen caused by controlling stagnation of QI due to depression of the liver has a pain, diarrhea stomachache, stomachache, under hepatitis, irregular menstruation, dysmenorrhoea, band, mouth Chamber inflammation, skin itching, orchitis, mastitis, scrofula;Sea Piao sheath energy astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving haperacidity analgesic, receipts Wet sore, main spitting blood, uterine bleeding, have blood in stool, bleeding from five sense organs or subcutaneous tissue, traumatic bleeding, emission due to the kidney deficiency involuntary emission, leukorrhea with reddish discharge, have a stomachache it is noisy, Gas pantothenic acid, eczema ulcer.
Cannabidiol (CBD) be extracted from hemp floral leaf a kind of it is nontoxic can be used for medicine, cosmetics, the one of health food Plant the aldehydes matter of high added value.CBD is the non-additive composition in hemp, and THC can be hindered to influence nerve system of human body, and With pharmacological activity such as anti-spasm, resisting rheumatoid arthritis, antianxieties.
Beneficial effects of the present invention:A kind of cannabidiol liquid preparation with angst resistance effect of the present invention, fully profit With cannabidiol pharmacological action antianxity, and compatibility kinds of traditional Chinese medicines, can effectively releive spirit, alleviate anxiety;Secondly, originally Invention also has the effect that antitoxic heart-soothing and sedative, tranquilizing and blood nourishing, nourishing the liver are moisturized, and body health can be adjusted rapidly, so as to effectively alleviate Anxiety.
The present invention is through two groups of clinical verifications, and one of which is cannabidiol liquid preparation of the treatment group using the present invention, often It uses the present invention once, is within 7 days a course for the treatment of, and another group of control group uses mental-tranquilization oral liquid, used once daily, 7 It is a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 35 In year, clinical manifestation is has no peace of mind, headache and insomnia, amnesia, and table 1 is to take the contrasting data after a course for the treatment of:
Table 1 takes front and rear two groups of courses for the treatment of and compares (unit:People)
There were significant differences for treatment group and control group, it will thus be seen that the application of the present invention clinically has significant curative effect.
Embodiment
Embodiment 1
A kind of cannabidiol liquid preparation with angst resistance effect, is prepared from following components in parts by weight by raw material:
5-10 parts of cannabidiol
3-5 parts of rhizome of chuanxiong
3-5 parts of spina date seed
3-5 parts of moutan bark
1-2 parts of corydalis tuber
1-2 parts of Rumex madaio
1-2 parts of hypericum perforatum
1-2 parts of rhizoma Gastrodiae
1-2 parts of safflower
1-2 parts of schizonepeta
1-2 parts of fringed pink
1-2 parts of Thlaspi
1-2 parts of Ramulus euonymi
1-2 parts of jasmine
1-2 parts of sea Piao sheath
1-3 parts of essence
25-30 parts of gaultherolin
600-650 parts of ethanol
282-355 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
The ethanol is 40%-80% ethanol.
A kind of preparation method of cannabidiol liquid preparation with angst resistance effect, the specific step of its preparation method Suddenly it is:
Step 1, by weight, weighs the cannabidiol of high-quality, rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, passes through leaf It is the capsule of weeping forsythia, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspis, Ramulus euonymi, jasmine, sea Piao sheath, essence, gaultherolin, ethanol, pure Change water, it is standby;
Step 2, take rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, hypericum perforatum, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspi, Ramulus euonymi, jasmine, sea Piao sheath, after mixing, plus the 6-12 times of ethanol for measuring 40%-80% is extracted 1-4 times, and each 0.5-2 is small When, ethanol is recovered under reduced pressure in filtering, merging filtrate, and less than 60 DEG C are dried under reduced pressure, and crushed after being dried is made mixing and extracted into fine powder Powder, it is standby;
Step 3, cannabidiol, mixing extract powder are taken, after being well mixed, add in remaining ethanol, add essence, salicylic acid Methyl esters, purified water, are mixed 1 hour, after being well mixed, finished product.
Embodiment 2
A kind of described cannabidiol liquid preparation with angst resistance effect, raw material presses optimum weight number:
5 parts of cannabidiol
4 parts of rhizome of chuanxiong
4 parts of spina date seed
3 parts of moutan bark
2 parts of corydalis tuber
2 parts of Rumex madaio
1 part of hypericum perforatum
1 part of rhizoma Gastrodiae
1 part of safflower
1 part of schizonepeta
1 part of fringed pink
1 part of Thlaspi
1 part of Ramulus euonymi
1 part of jasmine
1 part of sea Piao sheath
1 part of essence
25 parts of gaultherolin
600 parts of ethanol
351 parts of purified water.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
The ethanol is 40%-80% ethanol.
A kind of preparation method of cannabidiol liquid preparation with angst resistance effect, the specific step of its preparation method Suddenly it is:
Step 1, by weight, weighs the cannabidiol of high-quality, rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, passes through leaf The capsule of weeping forsythia, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspis, Ramulus euonymi, jasmine, sea Piao sheath essence, gaultherolin, ethanol, purifying Water, it is standby;
Step 2, take rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, hypericum perforatum, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspi, Ramulus euonymi, jasmine, sea Piao sheath, after mixing, plus the 6-12 times of ethanol for measuring 40%-80% is extracted 1-4 times, and each 0.5-2 is small When, ethanol is recovered under reduced pressure in filtering, merging filtrate, and less than 60 DEG C are dried under reduced pressure, and crushed after being dried is made mixing and extracted into fine powder Powder, it is standby;
Step 3, cannabidiol, mixing extract powder are taken, after being well mixed, add in remaining ethanol, add essence, salicylic acid Methyl esters, purified water, are mixed 1 hour, after being well mixed, finished product.
Embodiment 3
A kind of described cannabidiol liquid preparation with angst resistance effect, raw material presses optimum weight number:
Cannabidiol 5g
Rhizome of chuanxiong 4g
Spina date seed 4g
Moutan bark 3g
Corydalis tuber 2g
Rumex madaio 2g
Hypericum perforatum 1g
Rhizoma Gastrodiae 1g
Safflower 1g
Essence 1g
Gaultherolin 25g
Ethanol 600g
Purified water 351g.
The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
The ethanol is 40%-80% ethanol.
A kind of preparation method of cannabidiol liquid preparation with angst resistance effect, the specific step of its preparation method Suddenly it is:
Step 1, the cannabidiol for weighing high-quality, rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, hypericum perforatum, rhizoma Gastrodiae, Safflower, essence, gaultherolin, ethanol, purified water, it is standby;
Step 2, rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, hypericum perforatum, rhizoma Gastrodiae, safflower are taken, after mixing, plus 6- 12 times of amount 40%-80% ethanol are extracted 1-4 time, each 0.5-2 hours, are filtered, and merging filtrate is recovered under reduced pressure ethanol, 60 DEG C with Under be dried under reduced pressure, crushed after being dried into fine powder, be made mixing extract powder, it is standby;
Step 3, cannabidiol, mixing extract powder are taken, after being well mixed, add in remaining ethanol, add essence, salicylic acid Methyl esters, purified water, are mixed 1 hour, after being well mixed, finished product.

Claims (5)

1. a kind of cannabidiol liquid preparation with angst resistance effect, it is characterised in that following parts by weight numeral system is pressed by raw material It is standby to form:
5-10 parts of cannabidiol
3-5 parts of rhizome of chuanxiong
3-5 parts of spina date seed
3-5 parts of moutan bark
1-2 parts of corydalis tuber
1-2 parts of Rumex madaio
1-2 parts of hypericum perforatum
1-2 parts of rhizoma Gastrodiae
1-2 parts of safflower
1-2 parts of schizonepeta
1-2 parts of fringed pink
1-2 parts of Thlaspi
1-2 parts of Ramulus euonymi
1-2 parts of jasmine
1-2 parts of sea Piao sheath
1-3 parts of essence
25-30 parts of gaultherolin
600-650 parts of ethanol
282-355 parts of purified water.
2. a kind of cannabidiol liquid preparation with angst resistance effect according to claim 1, it is characterised in that raw material By optimum weight number:
5 parts of cannabidiol
4 parts of rhizome of chuanxiong
4 parts of spina date seed
3 parts of moutan bark
2 parts of corydalis tuber
2 parts of Rumex madaio
1 part of hypericum perforatum
1 part of rhizoma Gastrodiae
1 part of safflower
1 part of schizonepeta
1 part of fringed pink
1 part of Thlaspi
1 part of Ramulus euonymi
1 part of jasmine
1 part of sea Piao sheath
1 part of essence
25 parts of gaultherolin
600 parts of ethanol
351 parts of purified water.
3. a kind of cannabidiol liquid preparation with angst resistance effect according to claim 1 or 2, it is characterised in that The cannabidiol extracts from industrial hemp " cloud fiber crops No. 1 ".
4. a kind of cannabidiol liquid preparation with angst resistance effect according to claim 1 or 2, it is characterised in that The ethanol is 40%-80% ethanol.
5. a kind of preparation method of cannabidiol liquid preparation with angst resistance effect according to claim 1 or claim 2, it is special Levy and be, its preparation method is concretely comprised the following steps:
Step 1, by weight, weighs the cannabidiol of high-quality, rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, passes through leaf It is the capsule of weeping forsythia, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspis, Ramulus euonymi, jasmine, sea Piao sheath, essence, gaultherolin, ethanol, pure Change water, it is standby;
Step 2, take rhizome of chuanxiong, spina date seed, moutan bark, corydalis tuber, Rumex madaio, hypericum perforatum, rhizoma Gastrodiae, safflower, schizonepeta, fringed pink, Thlaspi, Ramulus euonymi, jasmine, sea Piao sheath, after mixing, plus the 6-12 times of ethanol for measuring 40%-80% is extracted 1-4 times, and each 0.5-2 is small When, ethanol is recovered under reduced pressure in filtering, merging filtrate, and less than 60 DEG C are dried under reduced pressure, and crushed after being dried is made mixing and extracted into fine powder Powder, it is standby;
Step 3, cannabidiol, mixing extract powder are taken, after being well mixed, add in remaining ethanol, add essence, salicylic acid Methyl esters, purified water, are mixed 1 hour, after being well mixed, finished product.
CN201710173495.1A 2017-03-22 2017-03-22 A kind of cannabidiol liquid preparation with angst resistance effect and preparation method thereof Pending CN107137604A (en)

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US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
US11084770B2 (en) 2016-12-07 2021-08-10 Treehouse Biotech, Inc. Cannabis extracts
US11202771B2 (en) 2018-01-31 2021-12-21 Treehouse Biotech, Inc. Hemp powder

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Publication number Priority date Publication date Assignee Title
US11084770B2 (en) 2016-12-07 2021-08-10 Treehouse Biotech, Inc. Cannabis extracts
US11202771B2 (en) 2018-01-31 2021-12-21 Treehouse Biotech, Inc. Hemp powder
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol

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