CN107110873B - 检测血红蛋白中异常的方法 - Google Patents

检测血红蛋白中异常的方法 Download PDF

Info

Publication number
CN107110873B
CN107110873B CN201580059324.5A CN201580059324A CN107110873B CN 107110873 B CN107110873 B CN 107110873B CN 201580059324 A CN201580059324 A CN 201580059324A CN 107110873 B CN107110873 B CN 107110873B
Authority
CN
China
Prior art keywords
sample
purposes
mass
spectrum
globulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580059324.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN107110873A (zh
Inventor
R·K·埃尔斯
J·K·埃尔斯
T·阿邦
S·M·E·多彻蒂
M·纳瑟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Map Diagnostics Ltd
Original Assignee
Map Diagnostics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Diagnostics Ltd filed Critical Map Diagnostics Ltd
Publication of CN107110873A publication Critical patent/CN107110873A/zh
Application granted granted Critical
Publication of CN107110873B publication Critical patent/CN107110873B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201580059324.5A 2014-08-29 2015-08-27 检测血红蛋白中异常的方法 Active CN107110873B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1415367.0 2014-08-29
GBGB1415367.0A GB201415367D0 (en) 2014-08-29 2014-08-29 Methods for detecting abnormalities in haemoglobin
PCT/GB2015/052491 WO2016030688A1 (en) 2014-08-29 2015-08-27 Method for detecting abnormalities in hemoglobin

Publications (2)

Publication Number Publication Date
CN107110873A CN107110873A (zh) 2017-08-29
CN107110873B true CN107110873B (zh) 2019-07-05

Family

ID=51752371

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580059324.5A Active CN107110873B (zh) 2014-08-29 2015-08-27 检测血红蛋白中异常的方法

Country Status (10)

Country Link
US (1) US10359431B2 (https=)
EP (1) EP3186640B1 (https=)
JP (1) JP2017525971A (https=)
CN (1) CN107110873B (https=)
CY (1) CY1122239T1 (https=)
DK (1) DK3186640T3 (https=)
ES (1) ES2751480T3 (https=)
GB (1) GB201415367D0 (https=)
PT (1) PT3186640T (https=)
WO (1) WO2016030688A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3047542A1 (en) * 2016-12-19 2018-06-28 The Uab Research Foundation Mass spectrometric standards for hemoglobin beta and hemoglobin beta sickle and uses thereof
WO2019022189A1 (ja) * 2017-07-27 2019-01-31 国立大学法人九州大学 グロビンタイピングペプチド
CN108062977A (zh) * 2017-12-18 2018-05-22 广东祥岳生物技术有限公司 一种新生儿地中海贫血筛查结果自动判断系统
CN110658251A (zh) * 2019-10-01 2020-01-07 长沙湘华质谱医学科技有限公司 表征地中海贫血症的特征蛋白组合物或质谱模型的用途
CN110632326A (zh) * 2019-10-01 2019-12-31 北京毅新博创生物科技有限公司 用于质谱诊断地中海贫血症的特征蛋白标记组合物及其诊断产品
CN110658252A (zh) * 2019-10-01 2020-01-07 长沙湘华质谱医学科技有限公司 用于质谱诊断地中海贫血症的特征蛋白质谱模型及其用途
CN111638261B (zh) * 2020-04-17 2023-04-07 融智生物科技（青岛）有限公司 一种计算设备、存储介质和地中海贫血筛查装置及系统
CN111948404B (zh) * 2020-08-03 2023-04-07 融智生物科技（青岛）有限公司 用于筛查地中海贫血的特征蛋白标记组合物、质谱模型及其应用
CN117825542B (zh) * 2022-05-11 2024-10-29 重庆医科大学附属儿童医院 血红蛋白病的标志物组合物及其筛查试剂与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002757A1 (en) * 2001-06-28 2003-01-09 Monash University Method for kidney disease detection by protein profiling
CN1882840A (zh) * 2003-09-23 2006-12-20 沃拉克有限公司 用于新生儿筛选的血红蛋白检定
CN101128739A (zh) * 2005-02-01 2008-02-20 伦敦国王学院 一种筛选方法
CN103278574A (zh) * 2013-04-26 2013-09-04 首都医科大学附属北京朝阳医院 利用液相色谱串联三重四级杆质谱仪检测糖化血红蛋白的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492095A (en) * 1967-10-05 1970-01-27 Harold B Tillen Product for and method of testing blood for the presence of hemoglobin s
US4847209A (en) 1987-11-09 1989-07-11 Miles Inc. Latex agglutination immunoassay in the presence of hemoglobin
FR2821428B1 (fr) * 2001-02-23 2004-08-06 Abx Sa Reactif et procede pour l'identification et le comptage de cellules biologiques
US20040171026A1 (en) 2001-09-05 2004-09-02 Hochstrasser Denis Francois Diagnostic method for transmissible spongiform encephalopathies
EP1533617A1 (en) * 2003-11-19 2005-05-25 RMF Dictagene S.A. Angiogenesis inhibiting molecules, their selection, production and their use in the treatment and diagnosis of cancer
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
US20080108144A1 (en) * 2004-05-27 2008-05-08 Alam Muhammad A Method for the Rapid Analysis of Polypeptides
US8309313B2 (en) 2006-03-06 2012-11-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Glycated peptides and methods of use
JP2007263896A (ja) * 2006-03-29 2007-10-11 Univ Nagoya 肺癌患者の術後予後予測のための生物マーカー及びその方法
MX2009000685A (es) * 2006-07-21 2009-01-30 Amgen Inc Metodo para detectar y/o cuantificar hepcidina en una muestra.
US7951776B2 (en) 2006-09-01 2011-05-31 American Type Culture Collection Methods for treatment of type 1 diabetes
US9250248B2 (en) 2006-11-01 2016-02-02 The Johns Hopkins University Early detection of diabetes
JP2011515680A (ja) 2008-03-17 2011-05-19 ネルソン，ランドール，ダブリュ． 糖尿病のためのバイオマーカーおよびアッセイ
EP2294426A1 (en) 2008-05-27 2011-03-16 F. Hoffmann-La Roche AG Method for risk reduction in glycemic control
WO2011003182A1 (en) 2009-07-07 2011-01-13 University Of Victoria Innovation And Development Corporation Methods for early detection of blood disorders
SG195180A1 (en) * 2011-05-31 2013-12-30 Singapore Health Serv Pte Ltd Method for detecting disease biomarkers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002757A1 (en) * 2001-06-28 2003-01-09 Monash University Method for kidney disease detection by protein profiling
CN1882840A (zh) * 2003-09-23 2006-12-20 沃拉克有限公司 用于新生儿筛选的血红蛋白检定
CN101128739A (zh) * 2005-02-01 2008-02-20 伦敦国王学院 一种筛选方法
CN103278574A (zh) * 2013-04-26 2013-09-04 首都医科大学附属北京朝阳医院 利用液相色谱串联三重四级杆质谱仪检测糖化血红蛋白的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MALDI-TOF MS profiling as the first-tier screen for sickle cell disease in neonates: Matching throughput to objectives;Hachani, J等;《PROTEOMICS CLINICAL APPLICATIONS》;20110831;第5卷(第7-8期);第405-414页 *
两种血红蛋白病的分子生物学基础的比较;陈玉芹;《生物学通报》;20031020;第38卷(第10期);第21-23页 *

Also Published As

Publication number Publication date
CY1122239T1 (el) 2020-11-25
ES2751480T3 (es) 2020-03-31
DK3186640T3 (da) 2019-10-21
US20180224462A1 (en) 2018-08-09
US10359431B2 (en) 2019-07-23
PT3186640T (pt) 2019-10-30
EP3186640B1 (en) 2019-07-24
JP2017525971A (ja) 2017-09-07
EP3186640A1 (en) 2017-07-05
CN107110873A (zh) 2017-08-29
GB201415367D0 (en) 2014-10-15
WO2016030688A1 (en) 2016-03-03

Similar Documents

Publication Publication Date Title
CN107110873B (zh) 检测血红蛋白中异常的方法
CN105452868B (zh) 产前筛查
EP3186641B1 (en) Rapid screening and evaluation of diabetes and prediabetes by glycated hemoglobin mass spectrometry
Tian et al. The growing role of structural mass spectrometry in the discovery and development of therapeutic antibodies
JP2006518448A (ja) 糖ペプチドの同定および解析
WO2014040042A2 (en) Diagnostic assay for alzheimer's disease
CN111948404B (zh) 用于筛查地中海贫血的特征蛋白标记组合物、质谱模型及其应用
CN110658252A (zh) 用于质谱诊断地中海贫血症的特征蛋白质谱模型及其用途
WO2014130627A1 (en) Glycopeptide identification
CN105308455B (zh) 用于诊断先兆子痫的方法和组合物
Tuchtenhagen et al. A novel approach for the determination of exchangeable copper in serum using protein precipitation
EP2451966A1 (en) Methods for early detection of blood disorders
Lapolla et al. A matrix‐assisted laser desorption/ionization mass spectrometry study of the non‐enzymatic glycation products of human globins in diabetes
CN102401813B (zh) 变异血红素的快速分析方法
EP1749197A1 (en) A method for the rapid analysis of polypeptides
TR et al. NAAs, Mahmoud| G| 28 Morley Drive, Ely cam
CN116574795A (zh) 基于飞行时间质谱法的地中海贫血症基因分型引物组和试剂盒
Kubba et al. Hyperprolactinemia Causes Primary and Secondary Infertility in Women of raqi Patients
Bhattarai et al. Variation of HbA1c with Hemoglobin level: A comparative study between High Performance liquid chromatography and immunochromatography Analyzer
Bhattarai et al. RETRACTED: Variation of HbA1c with Hemoglobin level: A comparative study betweenD10 Biorad (HpLC) and Nycocard (Immunochromatography) analyser.
BR112014003159B1 (pt) Método de diagnóstico sorológico neonatal
WO2023238005A1 (en) A method for screening hemoglobinopathies by globin chain analysis using electrospray tandem quadrupole mass spectrometry.
Gim et al. A normalization method for multiple reaction monitoring (MRM) data
Heller et al. Discovery of serum proteomic patterns for lung cancer

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant