CN107108718B - 可溶性通用的增强adcc的合成融合基因和融合肽的技术及其应用 - Google Patents

可溶性通用的增强adcc的合成融合基因和融合肽的技术及其应用 Download PDF

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CN107108718B
CN107108718B CN201580064820.XA CN201580064820A CN107108718B CN 107108718 B CN107108718 B CN 107108718B CN 201580064820 A CN201580064820 A CN 201580064820A CN 107108718 B CN107108718 B CN 107108718B
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cells
adcc
antibody
fusion protein
binding domain
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CN107108718A (zh
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C·J·李
S·乌尼拉曼
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1Globe Biomedical Co Ltd
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201580064820.XA 2014-12-08 2015-12-08 可溶性通用的增强adcc的合成融合基因和融合肽的技术及其应用 Active CN107108718B (zh)

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Application Number Priority Date Filing Date Title
US201462089097P 2014-12-08 2014-12-08
US62/089,097 2014-12-08
US201562200557P 2015-08-03 2015-08-03
US62/200,557 2015-08-03
PCT/US2015/064572 WO2016094456A1 (en) 2014-12-08 2015-12-08 Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof

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CN107108718B true CN107108718B (zh) 2022-07-22

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ES2746805T3 (es) 2013-12-12 2020-03-06 Shanghai hengrui pharmaceutical co ltd Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo
WO2016094456A1 (en) 2014-12-08 2016-06-16 1Globe Health Institute Llc Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof
EP3796934A4 (en) * 2018-05-23 2022-04-06 Manysmart Therapeutics, Inc. BISPECIFIC T-LYMPHOCYTE ACTIVATOR AND USES THEREOF
IL288024B2 (en) 2019-05-14 2025-12-01 Provention Bio Inc Methods and compositions for preventing type
US12006366B2 (en) 2020-06-11 2024-06-11 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
WO2022004805A1 (ja) * 2020-06-30 2022-01-06 株式会社ガイアバイオメディシン Ｎｋ細胞と抗体との結合を安定化する方法、及びその利用
MX2023013851A (es) 2021-05-24 2023-12-08 Provention Bio Inc Metodos para el tratamiento de diabetes tipo 1.

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CA2968987C (en) 2022-05-10
JP2018502068A (ja) 2018-01-25
CN107108718A (zh) 2017-08-29
US20220235115A1 (en) 2022-07-28
EP3230311A1 (en) 2017-10-18
EP3230311B1 (en) 2022-01-26
AU2015360642A1 (en) 2017-06-08
US12247062B2 (en) 2025-03-11
KR102654033B1 (ko) 2024-04-02
EP3230311A4 (en) 2018-05-30
RU2017124141A (ru) 2019-01-10
KR20170089003A (ko) 2017-08-02
SG11201704124YA (en) 2017-06-29
CA2968987A1 (en) 2016-06-16
JP7095992B2 (ja) 2022-07-05
JP2021035994A (ja) 2021-03-04
WO2016094456A1 (en) 2016-06-16
NZ732073A (en) 2019-04-26
AU2015360642B2 (en) 2019-04-04
RU2017124141A3 (enExample) 2019-06-19
RU2725807C2 (ru) 2020-07-06
US20170362299A1 (en) 2017-12-21

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