RU2725807C2 - Растворимый универсальный усиливающий adcc синтетический слитный ген, пептидная технология и их применение - Google Patents
Растворимый универсальный усиливающий adcc синтетический слитный ген, пептидная технология и их применение Download PDFInfo
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- RU2725807C2 RU2725807C2 RU2017124141A RU2017124141A RU2725807C2 RU 2725807 C2 RU2725807 C2 RU 2725807C2 RU 2017124141 A RU2017124141 A RU 2017124141A RU 2017124141 A RU2017124141 A RU 2017124141A RU 2725807 C2 RU2725807 C2 RU 2725807C2
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- cells
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
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- Communicable Diseases (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| US201462089097P | 2014-12-08 | 2014-12-08 | |
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| US201562200557P | 2015-08-03 | 2015-08-03 | |
| US62/200,557 | 2015-08-03 | ||
| PCT/US2015/064572 WO2016094456A1 (en) | 2014-12-08 | 2015-12-08 | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
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| RU2017124141A RU2017124141A (ru) | 2019-01-10 |
| RU2017124141A3 RU2017124141A3 (enExample) | 2019-06-19 |
| RU2725807C2 true RU2725807C2 (ru) | 2020-07-06 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| MX370449B (es) | 2013-12-12 | 2019-12-13 | Shanghai hengrui pharmaceutical co ltd | Anticuerpo pd-1, fragmento de unión al antígeno de este y uso médico de este. |
| NZ732073A (en) | 2014-12-08 | 2019-04-26 | 1Globe Biomedical Co Ltd | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
| CN112512573A (zh) * | 2018-05-23 | 2021-03-16 | 百提威生技股份有限公司 | 双特异性t细胞衔接蛋白及其用途 |
| KR102503349B1 (ko) | 2019-05-14 | 2023-02-23 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| IL298999A (en) | 2020-06-11 | 2023-02-01 | Provention Bio Inc | Methods and compositions for the prevention of type 1 diabetes |
| JP7748944B2 (ja) * | 2020-06-30 | 2025-10-03 | 株式会社ガイアバイオメディシン | Ｎｋ細胞と抗体との結合を安定化する方法、及びその利用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2161044C2 (ru) * | 1991-03-07 | 2000-12-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ направления (индукции) иммунного ответа, днк, вектор, способ лечения |
| US20070292416A1 (en) * | 2003-06-02 | 2007-12-20 | Alexion Pharmaceuticals, Inc. | De-Immunized Anti-Cd3 Antibody |
| US20120294857A1 (en) * | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
| US20130281677A1 (en) * | 2010-12-22 | 2013-10-24 | Cephalon Australia Pty, Ltd. | Modified antibody with improved half-life |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223426A (en) * | 1988-12-15 | 1993-06-29 | T Cell Sciences, Inc. | Monoclonal antibodies reactive with defined regions of the t-cell antigen receptor |
| EP0826696B1 (de) * | 1996-09-03 | 2002-05-29 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität |
| EP1946775A3 (en) * | 1998-08-11 | 2008-08-06 | Biogen Idec Inc. | Combination therapies for B-cell lymphomas comprising administration of anti-CD20 antibody |
| SK288342B6 (en) * | 2000-12-07 | 2016-03-01 | Lilly Co Eli | GLP-1 fusion proteins |
| MXPA03010804A (es) * | 2001-06-01 | 2004-11-22 | Cornell Res Foundation Inc | Anticuerpos modificados para antigeno de membrana especifico de la prostata y usos de los mismos. |
| EP1597350B1 (en) * | 2003-02-27 | 2015-04-08 | Yeda Research And Development Co., Ltd. | Nucleic acid molecules, and compositions containing same useful for treating and detecting influenza virus infection |
| DK1673398T3 (da) * | 2003-10-16 | 2011-04-18 | Micromet Ag | Multispecifikke, deimmuniserede CD3-bindere |
| KR20060131892A (ko) * | 2004-02-16 | 2006-12-20 | 마이크로메트 에이지 | 덜 면역원성인 결합 분자 |
| US20080003225A1 (en) * | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
| AU2008209436A1 (en) * | 2007-01-23 | 2008-07-31 | Zymogenetics, Inc. | Soluble Fc gamma R1a for reducing inflammation |
| US8043621B2 (en) * | 2007-05-10 | 2011-10-25 | Ramot At Tel Aviv University Ltd. | Recombinant fusion protein and polynucleotide construct for immunotoxin production |
| WO2013086636A1 (en) * | 2011-12-15 | 2013-06-20 | The Royal Institution For The Advancement Of Learning/Mcgill University | Soluble igf receptor fc fusion proteins and uses thereof |
| US20150037334A1 (en) * | 2012-03-01 | 2015-02-05 | Amgen Research (Munich) Gmbh | Long life polypeptide binding molecules |
| NZ732073A (en) | 2014-12-08 | 2019-04-26 | 1Globe Biomedical Co Ltd | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
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2015
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- 2015-12-08 CN CN201580064820.XA patent/CN107108718B/zh active Active
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- 2015-12-08 SG SG11201704124YA patent/SG11201704124YA/en unknown
- 2015-12-08 RU RU2017124141A patent/RU2725807C2/ru active
- 2015-12-08 KR KR1020177018958A patent/KR102654033B1/ko active Active
- 2015-12-08 WO PCT/US2015/064572 patent/WO2016094456A1/en not_active Ceased
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2020
- 2020-11-30 JP JP2020198225A patent/JP2021035994A/ja active Pending
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2022
- 2022-04-12 US US17/719,194 patent/US20220235115A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2161044C2 (ru) * | 1991-03-07 | 2000-12-27 | Дзе Дженерал Хоспитал Корпорейшн | Способ направления (индукции) иммунного ответа, днк, вектор, способ лечения |
| US20070292416A1 (en) * | 2003-06-02 | 2007-12-20 | Alexion Pharmaceuticals, Inc. | De-Immunized Anti-Cd3 Antibody |
| US20120294857A1 (en) * | 2010-01-11 | 2012-11-22 | Trustees Of Dartmouth College | Monomeric Bi-Specific Fusion Protein |
| US20130281677A1 (en) * | 2010-12-22 | 2013-10-24 | Cephalon Australia Pty, Ltd. | Modified antibody with improved half-life |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7095992B2 (ja) | 2022-07-05 |
| US20170362299A1 (en) | 2017-12-21 |
| EP3230311B1 (en) | 2022-01-26 |
| US20220235115A1 (en) | 2022-07-28 |
| CA2968987C (en) | 2022-05-10 |
| AU2015360642A1 (en) | 2017-06-08 |
| EP3230311A1 (en) | 2017-10-18 |
| RU2017124141A (ru) | 2019-01-10 |
| US12247062B2 (en) | 2025-03-11 |
| RU2017124141A3 (enExample) | 2019-06-19 |
| EP3230311A4 (en) | 2018-05-30 |
| JP2021035994A (ja) | 2021-03-04 |
| KR102654033B1 (ko) | 2024-04-02 |
| SG11201704124YA (en) | 2017-06-29 |
| NZ732073A (en) | 2019-04-26 |
| JP2018502068A (ja) | 2018-01-25 |
| KR20170089003A (ko) | 2017-08-02 |
| CN107108718A (zh) | 2017-08-29 |
| AU2015360642B2 (en) | 2019-04-04 |
| WO2016094456A1 (en) | 2016-06-16 |
| CN107108718B (zh) | 2022-07-22 |
| CA2968987A1 (en) | 2016-06-16 |
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