CN107108592B - 吗啉和1,4-氧氮杂环庚烷酰胺作为抑生长素受体亚型4(sstr4)激动剂 - Google Patents

吗啉和1,4-氧氮杂环庚烷酰胺作为抑生长素受体亚型4(sstr4)激动剂 Download PDF

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CN107108592B
CN107108592B CN201580062239.4A CN201580062239A CN107108592B CN 107108592 B CN107108592 B CN 107108592B CN 201580062239 A CN201580062239 A CN 201580062239A CN 107108592 B CN107108592 B CN 107108592B
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CN107108592A (zh
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R·马扎费罗
M·费拉拉
R·乔万尼尼
I·琳加德
K·鲁道夫
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Boehringer Ingelheim International GmbH
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
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CN201580062239.4A 2014-11-14 2015-11-12 吗啉和1,4-氧氮杂环庚烷酰胺作为抑生长素受体亚型4(sstr4)激动剂 Active CN107108592B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14193185.7 2014-11-14
EP14193185 2014-11-14
PCT/EP2015/076440 WO2016075240A1 (en) 2014-11-14 2015-11-12 Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (sstr4) agonists

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Publication Number Publication Date
CN107108592A CN107108592A (zh) 2017-08-29
CN107108592B true CN107108592B (zh) 2021-01-29

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US (2) US10071974B2 (enExample)
EP (1) EP3218372B1 (enExample)
JP (1) JP6641367B2 (enExample)
KR (1) KR20170082632A (enExample)
CN (1) CN107108592B (enExample)
AU (1) AU2015345070A1 (enExample)
BR (1) BR112017009595A2 (enExample)
CA (1) CA2965566A1 (enExample)
CL (1) CL2017001181A1 (enExample)
EA (1) EA032104B1 (enExample)
IL (1) IL251465A0 (enExample)
MX (1) MX370366B (enExample)
PH (1) PH12017500821A1 (enExample)
WO (1) WO2016075240A1 (enExample)

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NO2699580T3 (enExample) 2014-01-24 2018-02-24
EP3053452A1 (en) * 2015-01-16 2016-08-10 Interquim, S.A. Naturally derived colour stabilizer
KR20190035781A (ko) * 2016-07-29 2019-04-03 인스메드 인코포레이티드 기관지확장증을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
US11912687B2 (en) 2017-05-12 2024-02-27 Board of Trustees of the Southern Illinois University 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
US11136312B2 (en) 2017-05-12 2021-10-05 Board of Trustees of the Southern Illinois University 3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
PL3758708T3 (pl) 2018-03-01 2025-03-31 Astrazeneca Ab Kompozycje farmaceutyczne zawierające (2s)-{(1s)-1-cyjano-2-[4-(3-metylo-2-okso-2,3-dihydro-1,3-benzoksazol-5-ilo)fenylo]etylo}-1,4-oksazepano-2-karboksyamid
TWI834637B (zh) * 2018-03-01 2024-03-11 日商武田藥品工業有限公司 六氫吡啶基-3-(芳氧基)丙醯胺及丙酸酯
EP3823627A4 (en) 2018-07-17 2022-04-20 Insmed Incorporated CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES FOR THE TREATMENT OF LUPUS ENEHROPATHY
AR121683A1 (es) * 2020-03-31 2022-06-29 Takeda Pharmaceuticals Co Derivados de n-heteroarilalquil-2-(heterociclil y heterociclilmetil)acetamida como agonistas de sstr4
WO2021233428A1 (zh) * 2020-05-21 2021-11-25 广州费米子科技有限责任公司 含氮饱和杂环化合物及其制备方法、药物组合物和应用
WO2022012534A1 (zh) * 2020-07-13 2022-01-20 广州费米子科技有限责任公司 含氮杂环化合物、药物组合物和应用
AR127055A1 (es) 2021-09-14 2023-12-13 Lilly Co Eli Sales agonistas de sstr4
EP4646265A1 (en) 2023-01-06 2025-11-12 Insmed Incorporated Novel, reversible dpp1 inhibitors and uses thereof
WO2025027049A1 (en) 2023-08-02 2025-02-06 Boehringer Ingelheim International Gmbh (2s,5r)-5-(hydroxymethyl)morpholine-2-carboxamides as agonists of sstr4
WO2025247982A1 (en) 2024-05-29 2025-12-04 Grünenthal GmbH Piperazines which act as sstr4 modulators

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ATE538124T1 (de) * 2004-11-12 2012-01-15 Bristol Myers Squibb Co Imidazokondensierte tricyclische verbindungen auf thiazoloä4,5-büpyridin-basis und pharmazeutische zusammensetzungen damit
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Patent Citations (1)

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Non-Patent Citations (1)

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CL2017001181A1 (es) 2018-02-02
US20170320838A1 (en) 2017-11-09
WO2016075240A1 (en) 2016-05-19
KR20170082632A (ko) 2017-07-14
MX370366B (es) 2019-12-11
PH12017500821A1 (en) 2017-10-02
US20180339971A1 (en) 2018-11-29
US10071974B2 (en) 2018-09-11
IL251465A0 (en) 2017-05-29
EA201791058A1 (ru) 2017-11-30
EA032104B1 (ru) 2019-04-30
CN107108592A (zh) 2017-08-29
EP3218372B1 (en) 2020-05-20
EP3218372A1 (en) 2017-09-20
AU2015345070A1 (en) 2017-04-20
JP6641367B2 (ja) 2020-02-05
CA2965566A1 (en) 2016-05-19
MX2017006231A (es) 2017-07-31
JP2017533930A (ja) 2017-11-16
US10577336B2 (en) 2020-03-03
BR112017009595A2 (pt) 2017-12-19

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