CN107106708B - 使用脂质体进行的淀粉样蛋白斑mri成像 - Google Patents

使用脂质体进行的淀粉样蛋白斑mri成像 Download PDF

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CN107106708B
CN107106708B CN201580066712.6A CN201580066712A CN107106708B CN 107106708 B CN107106708 B CN 107106708B CN 201580066712 A CN201580066712 A CN 201580066712A CN 107106708 B CN107106708 B CN 107106708B
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phospholipid
polymer
liposomal composition
aromatic
represented
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CN107106708A (zh
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A·安娜普拉戈达
E·A·塔尼芬
M·斯里瓦斯塔瓦
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Texas Childrens Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580066712.6A 2014-10-08 2015-10-08 使用脂质体进行的淀粉样蛋白斑mri成像 Active CN107106708B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462061514P 2014-10-08 2014-10-08
US62/061,514 2014-10-08
US201562111057P 2015-02-02 2015-02-02
US62/111,057 2015-02-02
PCT/US2015/054732 WO2016057812A1 (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes

Publications (2)

Publication Number Publication Date
CN107106708A CN107106708A (zh) 2017-08-29
CN107106708B true CN107106708B (zh) 2021-06-18

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US (4) US9744251B2 (cg-RX-API-DMAC7.html)
EP (3) EP3204051B1 (cg-RX-API-DMAC7.html)
JP (1) JP6505235B2 (cg-RX-API-DMAC7.html)
KR (1) KR102409017B1 (cg-RX-API-DMAC7.html)
CN (1) CN107106708B (cg-RX-API-DMAC7.html)
AU (2) AU2015330824A1 (cg-RX-API-DMAC7.html)
CA (1) CA2963941C (cg-RX-API-DMAC7.html)
ES (2) ES3032054T3 (cg-RX-API-DMAC7.html)
MX (1) MX371295B (cg-RX-API-DMAC7.html)
WO (1) WO2016057812A1 (cg-RX-API-DMAC7.html)

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US20200261605A1 (en) * 2019-01-24 2020-08-20 Alzeca Biosciences, LLC Functionalized liposomes for imaging misfolded proteins
KR20220054288A (ko) * 2019-07-08 2022-05-02 알제카 바이오사이언시스, 엘엘씨 타우 병리를 위한 표적화 리간드
US11614451B2 (en) 2019-07-08 2023-03-28 Alzeca Biosciences, LLC Targeting ligands for tau pathology
KR102546470B1 (ko) * 2020-01-29 2023-06-21 텍사스 칠드런스 하스피탈 아밀로이드 침착의 mri용 표적 조영제
US11779664B2 (en) 2020-02-12 2023-10-10 Texas Children's Hospital Targeted contrast agents for MRI of alpha-synuclein deposition
JP2023514991A (ja) * 2020-02-12 2023-04-12 テキサス チルドレンズ ホスピタル α－シンヌクレイン沈着物のＭＲＩのための標的造影剤
CN115970009A (zh) * 2023-02-08 2023-04-18 丽水市中心医院 Vhpk多肽修饰的荧光纳米脂质体给药系统、其制备方法及应用
CN116869938A (zh) * 2023-07-26 2023-10-13 安徽医科大学 一种1,2,4-噁二唑-吡啶脂质体及其制备方法和应用

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US20200069820A1 (en) 2020-03-05
WO2016057812A1 (en) 2016-04-14
US10537649B2 (en) 2020-01-21
JP6505235B2 (ja) 2019-04-24
ES3032054T3 (en) 2025-07-15
EP3204051A1 (en) 2017-08-16
AU2021203388A1 (en) 2021-06-24
US20160101197A1 (en) 2016-04-14
US9744251B2 (en) 2017-08-29
AU2015330824A1 (en) 2017-05-25
HK1243335A1 (zh) 2018-07-13
EP4035688C0 (en) 2025-03-26
EP4035688A1 (en) 2022-08-03
CA2963941C (en) 2023-08-01
EP3542828A1 (en) 2019-09-25
EP3204051B1 (en) 2019-05-29
KR102409017B1 (ko) 2022-06-16
MX2017004695A (es) 2018-01-24
EP4035688B1 (en) 2025-03-26
CA2963941A1 (en) 2016-04-14
US11141495B2 (en) 2021-10-12
BR112017007238A2 (pt) 2018-01-16
EP3204051A4 (en) 2018-06-27
ES2743704T3 (es) 2020-02-20
AU2021203388B2 (en) 2024-05-30
KR20170103748A (ko) 2017-09-13
JP2017532378A (ja) 2017-11-02
US20170080111A1 (en) 2017-03-23
CN107106708A (zh) 2017-08-29
MX371295B (es) 2020-01-24
US20200179540A1 (en) 2020-06-11

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