CN107075134A - 制备微粒形式的生物可再吸收聚酯的方法 - Google Patents
制备微粒形式的生物可再吸收聚酯的方法 Download PDFInfo
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- CN107075134A CN107075134A CN201580060769.5A CN201580060769A CN107075134A CN 107075134 A CN107075134 A CN 107075134A CN 201580060769 A CN201580060769 A CN 201580060769A CN 107075134 A CN107075134 A CN 107075134A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B9/00—Making granules
- B29B9/02—Making granules by dividing preformed material
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
- B29B13/00—Conditioning or physical treatment of the material to be shaped
- B29B2013/002—Extracting undesirable residual components, e.g. solvents, unreacted monomers, from material to be moulded
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/001—Combinations of extrusion moulding with other shaping operations
- B29C48/0022—Combinations of extrusion moulding with other shaping operations combined with cutting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2067/00—Use of polyesters or derivatives thereof, as moulding material
- B29K2067/04—Polyesters derived from hydroxycarboxylic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0059—Degradable
- B29K2995/006—Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
- B29L2031/7532—Artificial members, protheses
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
- C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Materials For Medical Uses (AREA)
- Biological Depolymerization Polymers (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
Description
结果的可再现性 | 最小样品重量 |
±0.02% | 10g |
±0.05% | 4g |
±0.1% | 2g |
±0.2% | 1g |
批次 | d10 | d50 | d90 |
本发明的实施例1 | 7.06μm | 23.45μm | 36.61μm |
批次 | d10 | d50 | d90 |
本发明的实施例1 | 7.06μm | 23.45μm | 36.61μm |
对比例C2 | 7.29μm | 50.12μm | 206.128μm |
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14193199 | 2014-11-14 | ||
EP14193199.8 | 2014-11-14 | ||
PCT/EP2015/076040 WO2016075071A1 (en) | 2014-11-14 | 2015-11-09 | Process for preparing a bio-resorbable polyester in particulate form |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107075134A true CN107075134A (zh) | 2017-08-18 |
CN107075134B CN107075134B (zh) | 2021-03-09 |
Family
ID=51897179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201580060769.5A Active CN107075134B (zh) | 2014-11-14 | 2015-11-09 | 制备微粒形式的生物可再吸收聚酯的方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10138333B2 (zh) |
EP (1) | EP3218422B1 (zh) |
JP (1) | JP6707537B2 (zh) |
KR (1) | KR102468902B1 (zh) |
CN (1) | CN107075134B (zh) |
ES (1) | ES2710603T3 (zh) |
WO (1) | WO2016075071A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021534906A (ja) * | 2018-08-31 | 2021-12-16 | ウィスコンシン アラムニ リサーチ ファンデーション | 動脈内皮細胞を播種した血管移植片の生成 |
JP2020041029A (ja) * | 2018-09-07 | 2020-03-19 | 株式会社リコー | 熱可塑性樹脂粉体、造形装置、及び造形方法 |
KR102294373B1 (ko) * | 2018-09-07 | 2021-08-26 | (주)엘엑스하우시스 | 폴리락트산 입자 및 이의 제조방법 |
WO2021229111A1 (es) * | 2020-05-12 | 2021-11-18 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento para la purificación de partículas poliméricas termoplásticas biodegradables para uso médico y/o farmacéutico |
Citations (5)
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CN1115252A (zh) * | 1993-01-06 | 1996-01-24 | 开纳顿有限公司 | 可生物降解聚酯和生物活性多肽的离子性分子轭合物 |
WO2007088135A1 (en) * | 2006-01-31 | 2007-08-09 | Purac Biochem Bv | Method for the purification of resorbable polymers from residual monomers |
CN101180119A (zh) * | 2005-04-21 | 2008-05-14 | 普拉克生化公司 | 通过本体聚合制备可再吸收的聚酯的方法 |
CN101222945A (zh) * | 2005-07-15 | 2008-07-16 | 贝林格尔英格海姆法玛两合公司 | 用于制备药用植入体的可吸收的聚醚酯 |
CN105492503A (zh) * | 2013-08-29 | 2016-04-13 | 赢创罗姆有限公司 | 粉末形式生物可吸收聚酯的制备方法 |
Family Cites Families (8)
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DE3708916A1 (de) | 1987-03-19 | 1988-09-29 | Boehringer Ingelheim Kg | Verfahren zur reinigung resorbierbarer polyester |
DE3937272A1 (de) | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Neue copolymere aus trimethylencarbonat und optisch inaktiven laktiden |
US5007923A (en) | 1990-01-31 | 1991-04-16 | Ethicon, Inc. | Crystalline copolyesters of amorphous (lactide/glycolide) and p-dioxanone |
US6706854B2 (en) | 2002-01-11 | 2004-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing reabsorbable polyesters by mass polymerization |
DE10200738A1 (de) | 2002-01-11 | 2003-08-07 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von resorbierbaren Polyestern durch Massepolymerisation |
DE102007020951A1 (de) | 2007-05-04 | 2008-11-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren und Vorrichtung zur Reinigung eines resorbierbaren Polyesters |
WO2012029448A1 (ja) * | 2010-09-03 | 2012-03-08 | 株式会社クレハ | 顆粒状脂肪族ポリエステル粒子、及び、その製造方法 |
EP2455414A1 (de) * | 2010-11-17 | 2012-05-23 | Evonik Röhm GmbH | Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung |
-
2015
- 2015-11-09 ES ES15791606T patent/ES2710603T3/es active Active
- 2015-11-09 US US15/524,412 patent/US10138333B2/en active Active
- 2015-11-09 CN CN201580060769.5A patent/CN107075134B/zh active Active
- 2015-11-09 JP JP2017525837A patent/JP6707537B2/ja active Active
- 2015-11-09 KR KR1020177012075A patent/KR102468902B1/ko active IP Right Grant
- 2015-11-09 WO PCT/EP2015/076040 patent/WO2016075071A1/en active Application Filing
- 2015-11-09 EP EP15791606.5A patent/EP3218422B1/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1115252A (zh) * | 1993-01-06 | 1996-01-24 | 开纳顿有限公司 | 可生物降解聚酯和生物活性多肽的离子性分子轭合物 |
CN101180119A (zh) * | 2005-04-21 | 2008-05-14 | 普拉克生化公司 | 通过本体聚合制备可再吸收的聚酯的方法 |
CN101222945A (zh) * | 2005-07-15 | 2008-07-16 | 贝林格尔英格海姆法玛两合公司 | 用于制备药用植入体的可吸收的聚醚酯 |
WO2007088135A1 (en) * | 2006-01-31 | 2007-08-09 | Purac Biochem Bv | Method for the purification of resorbable polymers from residual monomers |
CN105492503A (zh) * | 2013-08-29 | 2016-04-13 | 赢创罗姆有限公司 | 粉末形式生物可吸收聚酯的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
ES2710603T3 (es) | 2019-04-26 |
JP2018501333A (ja) | 2018-01-18 |
WO2016075071A1 (en) | 2016-05-19 |
US10138333B2 (en) | 2018-11-27 |
EP3218422A1 (en) | 2017-09-20 |
KR20170084061A (ko) | 2017-07-19 |
CN107075134B (zh) | 2021-03-09 |
US20180282489A1 (en) | 2018-10-04 |
KR102468902B1 (ko) | 2022-11-18 |
EP3218422B1 (en) | 2018-11-07 |
JP6707537B2 (ja) | 2020-06-10 |
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