CN107073085B - 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶 - Google Patents

用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶 Download PDF

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CN107073085B
CN107073085B CN201580057712.XA CN201580057712A CN107073085B CN 107073085 B CN107073085 B CN 107073085B CN 201580057712 A CN201580057712 A CN 201580057712A CN 107073085 B CN107073085 B CN 107073085B
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CN107073085A (zh
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R·肖沃尔特
R·阿尔马西
J·A·汤姆森
W·西森
W-J·西亚
L-C·陈
Y·李
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Polaris Pharmaceutical Group Co ltd
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Polaris Group Cayman Islands
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/03—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amidines (3.5.3)
    • C12Y305/03006—Arginine deiminase (3.5.3.6)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580057712.XA 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶 Active CN107073085B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210112607.3A CN114522225B (zh) 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051182P 2014-09-16 2014-09-16
US62/051,182 2014-09-16
PCT/US2015/050354 WO2016044376A1 (en) 2014-09-16 2015-09-16 Arginine deiminase with reduced cross-reactivity toward adi - peg 20 antibodies for cancer treatment

Related Child Applications (1)

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CN202210112607.3A Division CN114522225B (zh) 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶

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CN107073085A CN107073085A (zh) 2017-08-18
CN107073085B true CN107073085B (zh) 2022-02-18

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CN201580057712.XA Active CN107073085B (zh) 2014-09-16 2015-09-16 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶

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US (1) US9789170B2 (cg-RX-API-DMAC7.html)
EP (2) EP4104853A1 (cg-RX-API-DMAC7.html)
JP (2) JP6782230B2 (cg-RX-API-DMAC7.html)
KR (1) KR102730989B1 (cg-RX-API-DMAC7.html)
CN (2) CN114522225B (cg-RX-API-DMAC7.html)
AU (1) AU2015317848B2 (cg-RX-API-DMAC7.html)
CA (1) CA2961602A1 (cg-RX-API-DMAC7.html)
ES (1) ES2915382T3 (cg-RX-API-DMAC7.html)
SG (2) SG10202002557SA (cg-RX-API-DMAC7.html)
TW (2) TWI775160B (cg-RX-API-DMAC7.html)
WO (1) WO2016044376A1 (cg-RX-API-DMAC7.html)

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KR102455753B1 (ko) 2013-03-15 2022-10-17 티디더블유 그룹 암치료를 위한 ａｄｉ-ｐｅｇ 20 항체에 대해 감소된 교차반응성을 지니는 아르기닌 탈이민효소
CN106794229B (zh) 2014-03-18 2020-12-18 瑞华药业集团 工程化嵌合聚乙二醇化adi和使用方法
CN114522225B (zh) 2014-09-16 2025-07-25 瑞华药业集团 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶
TW202440153A (zh) 2016-07-05 2024-10-16 開曼群島商北極星藥業集團股份有限公司 用精胺酸耗盡劑進行之組合癌症免疫療法
MX2019001770A (es) 2016-08-18 2019-12-05 Meharry Medical College Inhibidores de la invasion intracelular.
MX2019003475A (es) * 2016-09-29 2019-11-28 Meharry Medical College Inhibidores bacterianos.
TWI867355B (zh) 2016-11-02 2024-12-21 開曼群島商北極星藥業集團股份有限公司 聚乙二醇化精胺酸脫亞胺酶之調配物
EP3609527B1 (en) * 2017-03-29 2025-07-30 Polaris Group Protein conjugates

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CN114522225B (zh) 2014-09-16 2025-07-25 瑞华药业集团 用于癌症治疗的对adi-peg20抗体具有降低的交叉反应性的精氨酸脱亚氨酶

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CN114522225B (zh) 2025-07-25
JP6782230B2 (ja) 2020-11-11
EP3193913A1 (en) 2017-07-26
TW201625295A (zh) 2016-07-16
KR102730989B1 (ko) 2024-11-14
EP4104853A1 (en) 2022-12-21
CA2961602A1 (en) 2016-03-24
WO2016044376A1 (en) 2016-03-24
CN107073085A (zh) 2017-08-18
TWI775160B (zh) 2022-08-21
JP2017529366A (ja) 2017-10-05
AU2015317848B2 (en) 2021-04-22
CN114522225A (zh) 2022-05-24
JP6961061B2 (ja) 2021-11-05
SG10202002557SA (en) 2020-04-29
EP3193913B1 (en) 2022-05-11
EP3193913A4 (en) 2018-07-18
TW202103730A (zh) 2021-02-01
AU2015317848A1 (en) 2017-04-20
JP2021004268A (ja) 2021-01-14
KR20170104986A (ko) 2017-09-18
SG11201702103XA (en) 2017-04-27
TWI708612B (zh) 2020-11-01
ES2915382T3 (es) 2022-06-22
US20160074487A1 (en) 2016-03-17
US9789170B2 (en) 2017-10-17

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