CN107073014A - 利用噻吩并三唑并二氮杂*化合物治疗急性髓细胞白血病和/或急性淋巴细胞性白血病的方法 - Google Patents

利用噻吩并三唑并二氮杂*化合物治疗急性髓细胞白血病和/或急性淋巴细胞性白血病的方法 Download PDF

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Publication number
CN107073014A
CN107073014A CN201580036473.XA CN201580036473A CN107073014A CN 107073014 A CN107073014 A CN 107073014A CN 201580036473 A CN201580036473 A CN 201580036473A CN 107073014 A CN107073014 A CN 107073014A
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compound
acute
formula
leukemia
thienotriazolodiazepine
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Chinese (zh)
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凯·诺埃尔
马里亚·E·里韦罗
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Oncoethix GmbH
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Oncoethix GmbH
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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CN201580036473.XA 2014-05-02 2015-05-01 利用噻吩并三唑并二氮杂*化合物治疗急性髓细胞白血病和/或急性淋巴细胞性白血病的方法 Pending CN107073014A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201461987822P 2014-05-02 2014-05-02
US61/987,822 2014-05-02
US201461990465P 2014-05-08 2014-05-08
US61/990,465 2014-05-08
US201462012128P 2014-06-13 2014-06-13
US201462012135P 2014-06-13 2014-06-13
US62/012,128 2014-06-13
US62/012,135 2014-06-13
US201462080771P 2014-11-17 2014-11-17
US201462080804P 2014-11-17 2014-11-17
US62/080,771 2014-11-17
US62/080,804 2014-11-17
US201462086456P 2014-12-02 2014-12-02
US62/086,456 2014-12-02
PCT/US2015/028891 WO2015168621A1 (en) 2014-05-02 2015-05-01 Method of treating acute myeloid leukemia and/or acute lymphoblastic leukemia using thienotriazolodiazepine compounds

Publications (1)

Publication Number Publication Date
CN107073014A true CN107073014A (zh) 2017-08-18

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CN201580036473.XA Pending CN107073014A (zh) 2014-05-02 2015-05-01 利用噻吩并三唑并二氮杂*化合物治疗急性髓细胞白血病和/或急性淋巴细胞性白血病的方法

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Country Link
US (1) US9956228B2 (enExample)
EP (1) EP3137085A4 (enExample)
JP (1) JP2017514909A (enExample)
KR (1) KR20160145833A (enExample)
CN (1) CN107073014A (enExample)
AU (1) AU2015252844A1 (enExample)
CA (1) CA2947601A1 (enExample)
MX (1) MX2016014301A (enExample)
RU (1) RU2016146099A (enExample)
WO (1) WO2015168621A1 (enExample)

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US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
SMT202000133T1 (it) 2014-04-23 2020-05-08 Incyte Corp 1h-pirrolo[2,3-c]piridin-7(6h)-oni e pirazolo[3,4-c]piridin-7(6h)-oni come inibitori di proteine bet
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WO2017075377A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
CN109715625B (zh) 2016-06-20 2022-04-19 因赛特公司 Bet抑制剂的结晶固体形式
CN110573151A (zh) * 2017-04-26 2019-12-13 辛辛那提大学 用于治疗急性髓性白血病的方法、试剂和组合物
EA202092635A1 (ru) 2018-06-13 2021-03-23 Дибли Аг Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
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